
Professor Stanley Zammit
Professor of Psychiatric Epidemiology, Division of Psychological Medicine and Clinical Neurosciences
- Media commentator
Overview
I hold a joint appointment as Professor of Psychiatric Epidemiology across Cardiff University and the University of Bristol
My main research interest is studying the epidemiology of psychiatric disorders, especially psychosis. I am particularly interested in the following areas of research:
- The relationship between cannabis use and risk of developing psychotic disorders
- The genetic epidemiology of schizophrenia, including the study of gene-environment interactions
- The development and life course trajectory of psychotic experiences in the general population
- The role of modifiable cognitive processes in the aetiology of psychosis
- The role of psychological trauma on incidence of psychosis, and impact of trauma-focused interventions in treating and preventing psychosis
Biography
Professional memberships
1998: Member of the Royal College of Psychiatrists
Publications
2021
- Mongan, D.et al. 2021. Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence. JAMA Psychiatry 78(1), pp. 77-90. (10.1001/jamapsychiatry.2020.2459)
2020
- Hubbard, L.et al. 2020. Rare copy number variations are associated with poorer cognition in schizophrenia. Biological Psychiatry (10.1016/j.biopsych.2020.11.025)
- Strelchuk, D.et al. 2020. PTSD as a mediator of the relationship between trauma and psychotic experiences. Psychological Medicine (10.1017/S0033291720004821)
- Jones, R.et al. 2020. The relationship between the Big Five personality factors, anger-hostility, and alcohol and violence in men and women: A nationally representative cohort of 15,701 young adults. Journal of Interpersonal Violence (10.1177/0886260520978178)
- Strelchuk, D.et al. 2020. Identifying patients at risk of psychosis: a qualitative study of GP views in South West England. British Journal of General Practice (10.3399/bjgp20X713969)
- Kwong, A. S. F.et al. 2020. Mental health before and during COVID-19 in two longitudinal UK population cohorts. British Journal of Psychiatry (10.1192/bjp.2020.242)
- Khandaker, G. M.et al. 2020. Association between circulating levels of C-reactive protein and positive and negative symptoms of psychosis in adolescents in a general population birth cohort. Journal of Psychiatric Research (10.1016/j.jpsychires.2020.11.028)
- Astill Wright, L.et al. 2020. Disturbed sleep connects symptoms of PTSD and somatisation: a network analysis approach. Journal of Traumatic Stress (10.1002/jts.22619)
- Agha, S. S.et al. 2020. Parent psychopathology and neurocognitive functioning in children with ADHD. Journal of Attention Disorders 24(13), pp. 1836-1846. (10.1177/1087054717718262)
- Wootton, R.et al. 2020. Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: A Mendelian randomisation study. Psychological Medicine 50(14), pp. 2435-2443. (10.1017/S0033291719002678)
- Thompson, A.et al. 2020. Omega-3 and Omega-6 Fatty acids and risk of psychotic outcomes in the ALSPAC birth cohort. Schizophrenia Research (10.1016/j.schres.2020.09.018)
- Strelchuk, D.et al. 2020. Feasibility study of eye movement desensitisation and reprocessing (EMDR) in people with an at-risk mental state (ARMS) for psychosis: study protocol. BMJ Open 10(10), article number: e038620. (10.1136/bmjopen-2020-038620)
- Perry, B. I.et al. 2020. Common mechanisms for type 2 diabetes and psychosis: findings from a prospective birth cohort. Schizophrenia Research 223, pp. 227-235. (10.1016/j.schres.2020.08.006)
- Jones, H. J.et al. 2020. A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 183(6), pp. 360-369. (10.1002/ajmg.b.32808)
- Jones, R.et al. 2020. Change in the relationship between drinking alcohol and risk of violence among adolescents and young adults: a nationally representative longitudinal study. Alcohol and Alcoholism 55(4), pp. 439-447. (10.1093/alcalc/agaa020)
- Jones, H. J.et al. 2020. Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence. Psychological Medicine (10.1017/S0033291720001798)
- Holland, J. F.et al. 2020. Effects of early life adversity on immune function and cognitive performance: results from the ALSPAC cohort. Social Psychiatry and Psychiatric Epidemiology 55, pp. 723-733. (10.1007/s00127-019-01813-8)
- Perry, B.et al. 2020. Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large U.K. birth cohort. Psychological Medicine 50(4), pp. 556-565. (10.1017/S0033291719000308)
- Solmi, F.et al. 2020. Neighbourhood characteristics at birth and positive and negative psychotic symptoms in adolescence: findings from the ALSPAC birth cohort. Schizophrenia Bulletin 46(3), pp. 581-591. (10.1093/schbul/sbz049)
- Sullivan, S. A.et al. 2020. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. American Journal of Psychiatry 177(4), pp. 308-317. (10.1176/appi.ajp.2019.19060654)
- Sallis, H.et al. 2020. Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood. Psychological Medicine (10.1017/S0033291720000537)
- Davis, K.et al. 2020. Mental Health in UK Biobank – development, implementation and results from an online questionnaire completed by 157,366 participants: a reanalysis(a). BJPsych Open 6(2), article number: e18. (10.1192/bjo.2019.100)
- Carnegie, R.et al. 2020. Mendelian randomization for nutritional psychiatry. Lancet Psychiatry 7(2), pp. 208-216. (10.1016/S2215-0366(19)30293-7)
- Pitt, K.et al. 2020. The coMforT study of a trauma-informed mindfulness intervention for women who have experienced domestic violence and abuse: a protocol for an intervention refinement and individually randomized parallel feasibility trial. Pilot and Feasibility Studies 6(1), article number: 33. (10.1186/s40814-019-0527-1)
- Madley-Dowd, P.et al. 2020. Simulations and directed acyclic graphs explained why assortative mating biases the prenatal negative control design. Journal of Clinical Epidemiology 118, pp. 9-17. (10.1016/j.jclinepi.2019.10.008)
- Martin, D.et al. 2020. Systematic review and meta-analysis of the relationship between genetic risk for schizophrenia and facial emotion recognition. Schizophrenia Research 218, pp. 7-13. (10.1016/j.schres.2019.12.031)
- Hines, L. A.et al. 2020. Association of high-potency cannabis use with mental health and substance use in adolescence. JAMA Psychiatry 77(10), pp. 1044-1051. (10.1001/jamapsychiatry.2020.1035)
- Perry, B.et al. 2020. Longitudinal trends in insulin levels and BMI from childhood and their associations with risks of psychosis and depression in young adults. JAMA Psychiatry
- Perry, B.et al. 2020. The potential shared role of inflammation in insulin resistance and schizophrenia: a bi-directional two-sample Mendelian randomization study. PLoS Medicine
- Liu, Y.et al. 2020. Testing the independent and joint contribution of exposure to neurodevelopmental adversity and childhood trauma to risk of psychotic experiences in adulthood. Schizophrenia Bulletin
2019
- Legge, S. E.et al. 2019. Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits. JAMA Psychiatry 76(12), pp. 1256-1265. (10.1001/jamapsychiatry.2019.2508)
- Mistry, S.et al. 2019. Investigating associations between genetic risk for bipolar disorder and cognitive functioning in childhood. Journal of Affective Disorders 259, pp. 112-120. (10.1016/j.jad.2019.08.040)
- Osimo, E. F.et al. 2019. Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort. Comprehensive Psychiatry, article number: 152143. (10.1016/j.comppsych.2019.152143)
- Datchev, S.et al. 2019. The independent and cumulative effects of sibling and peer bullying in childhood on depression, anxiety, suicidal ideation and self-harm in adulthood.. Frontiers 10, article number: 651. (10.3389/fpsyt.2019.00651)
- Vermeulen, J. M.et al. 2019. Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study. British Journal of Psychiatry (10.1192/bjp.2019.202)
- Sörberg Wallin, A.et al. 2019. Academic performance, externalizing disorders and depression: 26 000 adolescents followed into adulthood. Social Psychiatry and Psychiatric Epidemiology 54(8), pp. 977-986. (10.1007/s00127-019-01668-z)
- Madrid-Gambin, F.et al. 2019. Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children. Biological Psychiatry 86(1), pp. 25-34. (10.1016/j.biopsych.2019.01.018)
- Solmi, F.et al. 2019. Polygenic risk for schizophrenia disordered eating behaviours, and body mass index in a general population sample of adolescents. British Journal of Psychiatry 215(1), pp. 428-433. (10.1192/bjp.2019.39)
- Sabherwal, S.et al. 2019. ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort. Schizophrenia Research 209, pp. 141-147. (10.1016/j.schres.2019.05.002)
- Jones, H. J.et al. 2019. Association of genetic risk for rheumatoid arthritis with cognitive and psychiatric phenotypes across childhood and adolescence. JAMA Network Open 2(6), pp. -., article number: e196118. (10.1001/jamanetworkopen.2019.6118)
- Pardinas, A. F.et al. 2019. Pharmacogenomic variants and drug interactions identified through the genetic analysis of clozapine metabolism. American Journal of Psychiatry 176(6), pp. 477-486. (10.1176/appi.ajp.2019.18050589)
- Kendall, K. M.et al. 2019. Association of rare copy number variants with risk of depression. JAMA Psychiatry 76(8), pp. 818-825. (10.1001/jamapsychiatry.2019.0566)
- Lancaster, T. M.et al. 2019. Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype-based approach. Schizophrenia Bulletin 45(2), pp. 405-414. (10.1093/schbul/sby037)
- Perry, B. I.et al. 2019. Dysglycaemia, inflammation and psychosis: findings from the UK ALSPAC birth cohort. Schizophrenia Bulletin 45(24 Feb), pp. 330-338. (10.1093/schbul/sby040)
- Mistry, S.et al. 2019. Genetic risk for bipolar disorder and psychopathology from childhood to early adulthood. Journal of Affective Disorders 246, pp. 633-639. (10.1016/j.jad.2018.12.091)
- Roberts, S.et al. 2019. Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences. Translational Psychiatry 9(1), article number: 69. (10.1038/s41398-019-0407-8)
- Richards, A.et al. 2019. Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a New Zealand longitudinal population cohort study. British Journal of Psychiatry 214(2), pp. 96-102. (10.1192/bjp.2018.227)
- Chu, A. L.et al. 2019. Longitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort. Brain, Behavior, and Immunity 76, pp. 74-81. (10.1016/j.bbi.2018.11.007)
- Croft, J.et al. 2019. Association of trauma type, age of exposure, and frequency in childhood and adolescence with psychotic experiences in early adulthood. JAMA Psychiatry 76(1), pp. 79-86. (10.1001/jamapsychiatry.2018.3155)
- Reed, Z. E.et al. 2019. Schizophrenia liability shares common molecular genetic risk factors with sleep duration and nightmares in childhood. Wellcome Open Research 4, article number: 15. (10.12688/wellcomeopenres.15060.1)
- Föcking, M.et al. 2019. Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress. Molecular Psychiatry (10.1038/s41380-018-0306-z)
- Fonville, L.et al. 2019. MRI indices of cortical development in young people with psychotic experiences: influence of genetic risk and persistence of symptoms. Schizophrenia Bulletin 45(1), pp. 169-179., article number: sbx195. (10.1093/schbul/sbx195)
2018
- Price, C.et al. 2018. Association of residential mobility over the life course With nonaffective psychosis in 1.4 million young people in Sweden. JAMA Psychiatry 75(11), pp. 1128-1136. (10.1001/jamapsychiatry.2018.2233)
- Dantchev, S., Zammit, S. and Wolke, D. 2018. Sibling bullying in middle childhood and psychotic disorder at 18 years: a prospective cohort study. Psychological Medicine 48(14), pp. 2321-2328. (10.1017/S0033291717003841)
- Rai, D.et al. 2018. Association of autistic traits with depression from childhood to age 18 years. JAMA Psychiatry 75(8), pp. 835-843. (10.1001/jamapsychiatry.2018.1323)
- Jones, H. J.et al. 2018. Investigating the genetic architecture of general and specific psychopathology in adolescence. Translational Psychiatry 8(1), article number: 145. (10.1038/s41398-018-0204-9)
- Taylor, A. E.et al. 2018. Exploring the association of genetic factors with participation in the Avon longitudinal study of parents and children. International Journal of Epidemiology 47(4), pp. 1207-1216., article number: dyy060. (10.1093/ije/dyy060)
- Mistry, S.et al. 2018. The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: systematic review. Schizophrenia Research 197, pp. 2-8. (10.1016/j.schres.2017.10.037)
- Guyatt, A. L.et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Mollon, J., Zammit, S. and Reichenberg, A. 2018. Clinical implications of slower cognitive growth in the psychosis spectrum-reply. JAMA Psychiatry 75(7), pp. 756-757. (10.1001/jamapsychiatry.2018.0816)
- Mistry, S.et al. 2018. The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review. Journal of Affective Disorders 234, pp. 148-155. (10.1016/j.jad.2018.02.005)
- Davis, K. A. S.et al. 2018. Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants [RETRACTED]. Bjpsych Open 4(3), pp. 83-90. (10.1192/bjo.2018.12)
- Curtin, P.et al. 2018. Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Science Advances 4(5), article number: eaat1293. (10.1126/sciadv.aat1293)
- Davies, J., Sullivan, S. and Zammit, S. 2018. Adverse life outcomes associated with adolescent psychotic experiences and depressive symptoms. Social Psychiatry and Psychiatric Epidemiology 53(5), pp. 497-507. (10.1007/s00127-018-1496-z)
- Jones, H. J.et al. 2018. Association of combined patterns of tobacco and cannabis use in adolescence with psychotic experiences. JAMA Psychiatry 75(3), pp. 240-246. (10.1001/jamapsychiatry.2017.4271)
- Mollon, J.et al. 2018. Course of cognitive development from infancy to early adulthood in the psychosis spectrum. JAMA Psychiatry 75(3), pp. 270-279. (10.1001/jamapsychiatry.2017.4327)
- Khandaker, G. M.et al. 2018. Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. Brain, Behavior, and Immunity 69, pp. 264-272. (10.1016/j.bbi.2017.11.020)
- English, J. A.et al. 2018. Blood-Based Protein Changes in Childhood Are Associated With increased risk for later psychotic disorder: evidence from a nested case–control study of the ALSPAC Longitudinal Birth Cohort. Schizophrenia Bulletin 44(2), pp. 297-306. (10.1093/schbul/sbx075)
- Zammit, S.et al. 2018. Undetected post-traumatic stress disorder in secondary-care mental health services: systematic review. British Journal of Psychiatry 212(1), pp. 11-18. (10.1192/bjp.2017.8)
2017
- Mistry, S.et al. 2017. Borderline personality and attention-deficit hyperactivity traits in childhood are associated with hypomanic features in early adulthood. Journal of affective disorders 221, pp. 246-253. (10.1016/j.jad.2017.06.039)
- O'Gorman, A.et al. 2017. Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Translational Psychiatry 7(9), article number: e1240. (10.1038/tp.2017.211)
- Sullivan, S. A.et al. 2017. The longitudinal association between external locus of control, social cognition and adolescent psychopathology. Social Psychiatry and Psychiatric Epidemiology 52(6), pp. 643-655. (10.1007/s00127-017-1359-z)
- Gage, S. H.et al. 2017. Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychological Medicine 47(5), pp. 971-980. (10.1017/S0033291716003172)
- Agha, S. S.et al. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
- Gage, S. H.et al. 2017. Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization. Scientific Reports 7, article number: 40653. (10.1038/srep40653)
- Lewis, C.et al. 2017. Trauma exposure and undetected Post-Traumatic Stress Disorder (PTSD) among adults with a mental disorder. Depression and Anxiety 35(2), pp. 178-184. (10.1002/da.22707)
- St Pourcain, B.et al. 2017. ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties. Molecular Psychiatry 23, pp. 263-270. (10.1038/mp.2016.198)
- Hayes, J. F.et al. 2017. Childhood interleukin-6, C-reactive protein and atopic disorders as risk factors for hypomanic symptoms in young adulthood: a longitudinal birth cohort study. Psychological Medicine 47(1), pp. 1-11. (10.1017/S0033291716001574)
2016
- Bevan-Jones, R.et al. 2016. Prevalence and correlates of psychotic experiences amongst children of depressed parents. Psychiatry Research 243, pp. 81-86. (10.1016/j.psychres.2016.03.012)
- Drakesmith, M.et al. 2016. Volumetric, relaxometric and diffusometric correlates of psychotic experiences in a non-clinical sample of young adults. NeuroImage: Clinical 12, pp. 550-558. (10.1016/j.nicl.2016.09.002)
- Anderson, J. J.et al. 2016. Gestational influenza and risk of hypomania in young adulthood: prospective birth cohort study. Journal of affective disorders 200, pp. 182-188. (10.1016/j.jad.2016.04.048)
- Martin, J.et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Jones, H. J. and Zammit, S. 2016. Measures of psychosis proneness and genetic risk for schizophrenia - Reply. JAMA Psychiatry 73(6), pp. 638-639. (10.1001/jamapsychiatry.2016.0241)
- Siebald, C.et al. 2016. Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study. Comprehensive Psychiatry 69, pp. 45-52. (10.1016/j.comppsych.2016.05.004)
- Sullivan, S. A.et al. 2016. A longitudinal investigation of childhood communication ability and adolescent psychotic experiences in a community sample. Schizophrenia Research 173(1-2), pp. 54-61. (10.1016/j.schres.2016.03.005)
- Drakesmith, M.et al. 2016. Mediation of psychosis risk factors by white-matter microstructure in young adults with psychotic experiences. JAMA Psychiatry 73(4), pp. 396-406. (10.1001/jamapsychiatry.2015.3375)
- de Wit, H.et al. 2016. Psychotic experiences and working memory: a population-based study using signal-detection analysis. PLoS ONE 11(4), article number: e0153148. (10.1371/journal.pone.0153148)
- Gage, S. H., Hickman, M. and Zammit, S. 2016. Association between cannabis and psychosis: epidemiologic evidence. Biological psychiatry 79(7), pp. 549-556. (10.1016/j.biopsych.2015.08.001)
- Jones, H. J.et al. 2016. Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry 73(3), pp. 221-228. (10.1001/jamapsychiatry.2015.3058)
- Khandaker, G. M.et al. 2016. Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort. Neurobiology of Stress 4, pp. 55-61. (10.1016/j.ynstr.2016.02.003)
- Hubbard, L.et al. 2016. Evidence of common genetic overlap between schizophrenia and cognition. Schizophrenia Bulletin 42(3), pp. 832-842. (10.1093/schbul/sbv168)
- Hammerton, G.et al. 2016. Explaining risk for suicidal ideation in adolescent offspring of mothers with depression. Psychological Medicine -London- 46(2), pp. 265-275. (10.1017/S0033291715001671)
2015
- Sullivan, S. A.et al. 2015. The longitudinal association between psychotic experiences, depression and suicidal behaviour in a population sample of adolescents. Social Psychiatry and Psychiatric Epidemiology 50(12), pp. 1809-1917. (10.1007/s00127-015-1086-2)
- Lereya, S. T.et al. 2015. Bully/victims: a longitudinal, population-based cohort study of their mental health. European Child & Adolescent Psychiatry 24(12), pp. 1461-1471. (10.1007/s00787-015-0705-5)
- Fonville, L.et al. 2015. Psychotic Experiences, Working Memory, and the Developing Brain: A Multimodal Neuroimaging Study. Cerebral Cortex 25(12), pp. 4828-4838. (10.1093/cercor/bhv181)
- Hammerton, G.et al. 2015. In Reply. Journal of the American Academy of Child & Adolescent Psychiatry 54(10), pp. 868-869. (10.1016/j.jaac.2015.07.012)
- Lee, S. H.et al. 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44(5), pp. 1706-1721. (10.1093/ije/dyv136)
- Hammerton, G.et al. 2015. Association between maternal depression symptoms across the first eleven years of their child's life and subsequent offspring suicidal ideation. Plos One 10(7), article number: e0131885. (10.1371/journal.pone.0131885)
- Thompson, A.et al. 2015. Childhood sleep disturbance and risk of psychotic experiences at 18: UK birth cohort. British Journal of Psychiatry 207(1), pp. 23-29. (10.1192/bjp.bp.113.144089)
- Drakesmith, M.et al. 2015. Schizophrenia-like topological changes in the structural connectome of individuals with subclinical psychotic experiences. Human Brain Mapping 36(7), pp. 2629-2643. (10.1002/hbm.22796)
- Niarchou, M., Zammit, S. and Lewis, G. 2015. The Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort as a resource for studying psychopathology in childhood and adolescence: a summary of findings for depression and psychosis. Social Psychiatry and Psychiatric Epidemiology 50(7), pp. 1017-1027. (10.1007/s00127-015-1072-8)
- Hammerton, G.et al. 2015. Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry 54(5), pp. 385-393. (10.1016/j.jaac.2015.02.006)
- Fonville, L.et al. 2015. Review of assessment tools for psychotic-like experiences misses the psychosis-like symptoms semi-structured interview (PLIKSi) in ALSPAC. Early Intervention in Psychiatry 11(3), pp. 269-270. (10.1111/eip.12254)
- Stochl, J.et al. 2015. Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychological Medicine 45(7), pp. 1483. (10.1017/S003329171400261X)
- Gage, S. H.et al. 2015. Associations of cannabis and cigarette use with depression and anxiety at age 18: findings from the Avon Longitudinal Study of Parents and Children. PLoS ONE 10(4), article number: e0122896. (10.1371/journal.pone.0122896)
- Khandaker, G. M.et al. 2015. A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis. Annals of Epidemiology 25(4), pp. 236-242. (10.1016/j.annepidem.2014.11.013)
- Dutt, A.et al. 2015. Exploring neural dysfunction in 'clinical high risk' for psychosis: A quantitative review of fMRI studies. Journal of Psychiatric Research 61, pp. 122-134. (10.1016/j.jpsychires.2014.08.018)
- O'Dushlaine, C.et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
2014
- Gage, S. H.et al. 2014. Associations of cannabis and cigarette use with psychotic experiences at age 18: findings from the Avon Longitudinal Study of Parents and Children. Psychological Medicine 44(16), pp. 3435-3444. (10.1017/S0033291714000531)
- Khandaker, G. M.et al. 2014. A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychological Medicine 44(15), pp. 3229-3238. (10.1017/S0033291714000750)
- Khandaker, G. M.et al. 2014. Association of serum interleukin 6 and C-Reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry 71(10), pp. 1121-1128. (10.1001/jamapsychiatry.2014.1332)
- Munafò, M. R., Zammit, S. and Flint, J. 2014. Practitioner Review: A critical perspective on gene-environment interaction models - what impact should they have on clinical perceptions and practice?. Journal of Child Psychology and Psychiatry 55(10), pp. 1092-1101. (10.1111/jcpp.12261)
- Manrique-Garcia, E.et al. 2014. Prognosis of schizophrenia in persons with and without a history of cannabis use. Psychological Medicine 44(12), pp. 2513-2521. (10.1017/S0033291714000191)
- Khandaker, G. M.et al. 2014. Childhood Epstein-Barr Virus infection and subsequent risk of psychotic experiences in adolescence: A population-based prospective serological study. Schizophrenia Research 158(1-3), pp. 19-24. (10.1016/j.schres.2014.05.019)
- Kounali, D.et al. 2014. Common versus psychopathology-specific risk factors for psychotic experiences and depression during adolescence. Psychological Medicine 44(12), pp. 2557-2566. (10.1017/S0033291714000026)
- Niarchou, M.et al. 2014. Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165(5), pp. 410-420. (10.1002/ajmg.b.32245)
- Hammerton, G.et al. 2014. Validation of a composite of suicide items from the Mood and Feelings Questionnaire (MFQ) in offspring of recurrently depressed parents. Psychiatry Research 216(1), pp. 82-88. (10.1016/j.psychres.2014.01.040)
- Fisher, H. L.et al. 2014. Childhood parasomnias and psychotic experiences at age 12 years in a United Kingdom birth cohort. Sleep 37(3), pp. 475-482. (10.5665/sleep.3478)
- Niarchou, M.et al. 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204(1), pp. 46-54. (10.1192/bjp.bp.113.132324)
- Dorrington, S.et al. 2014. Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study. Schizophrenia Research 152(1), pp. 158-163. (10.1016/j.schres.2013.11.006)
- Khandaker, G. M.et al. 2014. A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence. Schizophrenia Research 152(1), pp. 139-45. (10.1016/j.schres.2013.09.021)
- Zammit, S.et al. 2014. Individual- and area-level influence on suicide risk: a multilevel longitudinal study of Swedish schoolchildren. Psychological Medicine 44(2), pp. 267-277. (10.1017/S0033291713000743)
- Munafò, M. R., Zammit, S. and Flint, J. 2014. Commentary: Response to commentary by Rutter on Munafo et al. (2014). Journal of Child Psychology and Psychiatry 55(10), pp. 1105-1106. (10.1111/jcpp.12308)
- Sullivan, S. A.et al. 2014. Longitudinal associations between adolescent psychotic experiences and depressive symptoms. PLoS ONE 9(8), pp. e105758. (10.1371/journal.pone.0105758)
2013
- Wolke, D.et al. 2013. Bullying in elementary school and psychotic experiences at 18 years: a longitudinal, population-based cohort study. Psychological Medicine 44(10), pp. 2199. (10.1017/S0033291713002912)
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- Lewis, S. J.et al. 2013. Approaches for strengthening causal inference regarding prenatal risk factors for childhood behavioural and psychiatric disorders. Journal of Child Psychology and Psychiatry 54(10), pp. 1095-108. (10.1111/jcpp.12127)
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- Lewis, G., Heron, J. and Zammit, S. 2013. Commentary on Griffith-Lenderinget?al. (2013): Cross-lagging cannabis and psychosis vulnerability [Editorial Material]. Addiction 108(4), pp. 741-742. (10.1111/add.12101)
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- Gage, S. H., Zammit, S. and Hickman, M. 2013. Stronger evidence is needed before accepting that cannabis plays an important role in the aetiology of schizophrenia in the population. F1000 Medicine Reports 5, article number: 2. (10.3410/M5-2)
- Zammit, S.et al. 2013. Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study. American Journal of Psychiatry 170(7), pp. 742-750. (10.1176/appi.ajp.2013.12060768)
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2012
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2011
- Zammit, S.et al. 2011. Cannabis, COMT and psychotic experiences. British Journal of Psychiatry 199(5), pp. 380-385. (10.1192/bjp.bp.111.091421)
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2010
- Zammit, S.et al. 2010. Individuals, schools, and neighborhood: a multilevel longitudinal study of variation in incidence of psychotic disorders. Archives of General Psychiatry 67(9), pp. 914-922. (10.1001/archgenpsychiatry.2010.101)
- Zammit, S., Wiles, N. and Lewis, G. 2010. The study of gene-environment interactions in psychiatry: limited gains at a substantial cost? [Editorial]. Psychological Medicine 40(5), pp. 711-716. (10.1017/S0033291709991280)
- Zammit, S., Owen, M. J. and Lewis, G. 2010. Misconceptions about gene-environment interactions in psychiatry. Evidence Based Mental Health 13(3), pp. 65-68. (10.1136/ebmh.13.3.65)
- Glaser, B.et al. 2010. Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort. Schizophrenia Research 120(1-3), pp. 177-183. (10.1016/j.schres.2010.03.006)
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- Zammit, S.et al. 2010. Examining interactions between risk factors for psychosis. British Journal of Psychiatry 197(3), pp. 207-211. (10.1192/bjp.bp.109.070904)
2009
- Zammit, S.et al. 2009. Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort. Psychological Medicine 39(9), pp. 1457-1467. (10.1017/S0033291708005126)
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- Zammit, S.et al. 2009. Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. British Journal of Psychiatry 195(4), pp. 294-300. (10.1192/bjp.bp.108.062471)
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2008
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2007
- Zammit, S., Moore, T. and Lewis, G. 2007. Cannabis and psychosis - Authors' reply [Letter]. The Lancet 370(9598), pp. 1539-1540. (10.1016/S0140-6736(07)61652-3)
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- Zammit, S.et al. 2007. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191(5), pp. 402-407. (10.1192/bjp.bp.107.036129)
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2006
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- Zammit, S. 2006. Stressful life events, 5-HTT genotype and risk of depression. British Journal of Psychiatry 188(3), pp. 199-201. (10.1192/bjp.bp.105.020644)
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2005
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2004
- Zammit, S. and Lewis, G. 2004. Exploring the relationship between cannabis use and psychosis. Addiction 99(10), pp. 1353-1355. (10.1111/j.1360-0443.2004.00843.x)
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- Zammit, S.et al. 2004. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics 128B(1), pp. 19-20. (10.1002/ajmg.b.30021)
- Zammit, S.et al. 2004. Parental age difference and schizophrenia - Reply. British Journal of Psychiatry 184, pp. 540-541.
- Zammit, S.et al. 2004. A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses. Archives of General Psychiatry 61(4), pp. 354-360. (10.1001/archpsyc.61.4.354)
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- Zammit, S. 2004. An investigation into the use of cannabis and tobacco as risk factors for schizophrenia. PhD Thesis, Cardiff University.
2003
- Williams, N. M.et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73(6), pp. 1355-1367. (10.1086/380206)
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2002
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2001
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2000
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My research aims to increase understanding of the aetiology of schizophrenia and other psychotic disorders, and improve treatment outcomes for people with such disorders. My research interests include:
1) Lifecourse epidemiology: I am interested in understanding the development of psychotic experiences, persistence of symptoms, symptom trajectories, and transition to psychotic disorder from childhood through older adulthood. I aim to apply rigorous methodology to examine the role of aetiological factors, operating prenatally through to adulthood, on development of specific symptoms of psychosis, and to understand the pathways mediating causal relationships. The aetiological factors we are examining include genetic variation, prenatal nutrient deficiency and exposure to infection, neurocognitive development, social cognition, social relationships, substance use, trauma and adversity, and the wider social environment.
2) Translation from clinical samples into the general population: I am interested in studying the likely population impact of key findings from clinical samples, for example, how genetic risk for schizophrenia, as determined by cutting-edge findings from collaborative GWA studies, is manifest phenotypically during childhood in the population, and whether this changes during adolescence and adulthood. We are also studying the overlap in genetic and non-genetic factors between psychosis and other disorders, particularly autism spectrum disorders, depression and anxiety.
3) Biomarkers and cognitive markers for psychosis: We are studying the use of genetic, epigenetic, proteomic, neuroimaging and cognitive data to help inform prediction for incident psychotic experiences and transition to clinical disorder to inform early intervention approaches. I am particularly interested in the predictive role of cognitive processes such as reasoning biases and errors in predictive processing that can help bridge the gap between biological abnormalities observed in psychosis and experiences of psychotic phenomena.
4) Psychosis and trauma: As a result of my clinical work in the Cardiff Traumatic Stress Service, I am very interested in the overlap between psychosis, post-traumatic stress disorder and borderline personality disorder, and the common role of trauma in these disorders. We are examining the role of potentially modifiable cognitive processes mediating the impact of trauma on psychotic and quasi-psychotic experiences. Ultimately, our aim is to develop interventions to reduce trauma-related symptoms in people with psychotic disorders and related psychopathology.
The core aim of my research is to apply robust methodology to epidemiological data, and utilise causal analysis methods such as use of negative controls and Mendelian Randomisation approaches to inform causal inference. I am experienced in using epidemiological data from a number of population-based cohort studies, particularly the Avon Longitudinal study of Parents and Children (ALSPAC) and Swedish record-linkage datasets.
My research involves strong collaborations with colleagues at Cardiff University, University of Bristol, and other academic institutions across the UK and internationally, particularly the Karolinska Institute in Sweden.