Georgina Menzies

Sêr Cymru Fellow, Dementia Research Institute

Email:
menziesg@cardiff.ac.uk
Location:
1.03, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

Structural and functional investigations into the outcomes of genetic studies

My main research interests involve studying biological structures such as proteins, DNA, and mucins using molecular modelling techniques. This involves techniques including molecular dynamics, coarse grain modelling and mathematical modelling. I use these models resulting from these studies to elucidate information as to how structural changes may be affecting the function of the biological system. A large part of this is data analysis, all model systems produce 'large data' sets and I utilise multivariate analysis tools to decipher patterns and correlate this back to biological answers.

Building on the vast genetic research carried out in Cardiff University by Prof Julie Williams, and colleagues, the Cardiff-UKDRI is a great environment for me to delve into the genetic outcomes of Alzheimer GWAS, exome chip, and whole genome studies, as well as those of other dementias. My fellowship will involve modelling exonic changes in newly discovered dementia linked proteins. This work will generate theories as to how these protein coding changes are preventing or adding to dementia risk.

Honours and awards

CLIRSPC attendance and travel bursary for SPEC2016

SDMF seed corn grant 2015 (£2,500)

UKEMS conference attendance bursary for EEMS 2014 and UKEMS 2013

EuroTox bursary for conference fees 2014

Professional memberships

Royal Society of Chemistry (RSC)

United Kingdom Environmental Mutagenesis Society (UKEMS)

Molecular Graphics and Modelling Society (MGMS)

The International Society for Clinical Spectroscopy (CLIRSPEC)

Academic positions

  • December 2016 – June 2018. Post-Doctoral Research Associate– Cardiff University. MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine and Clinical Neurosciences
  • July 2014 – December 2016 Post-Doctoral Research Assistant– Swansea University
  • Tailored OligoG Project - Funded by - Norwegian Research Council
  • Jan 2015 – Jan 2016 Developer-MutAIT project (http://mutait.org/home.html)
  • June 2012 – June 2014 Research Assistant– Swansea University
  • Celtic Alliance for NanoHealth Project - Funded by - INTERREG IVA Ireland Wales Program

Speaking engagements

Oral Presentations;

  • DPUK – AAIC 2017 - the DPUK genetics platform
  • DPUK-EMIF – 2017, Manchester UK – the DPUK genetics platform
  • CLIRSPEC 2015 - Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer
  • GE and Swansea University 2014, GE Cardiff – FTIR for detection of changes in respiratory disease
  • NanoScience Event 2014, Liberty Stadium – two talks, 1. FTIR in nano, 2. Big Data
  • Dentist CPD course 2014, Swansea University - Head and Neck Cancer, Detection of biological changes by FTIR
  • CAN Event 2014, Dublin Aviva Stadium – The CAN project so far and how we can work with you
  • Four Projects, One Goal 2013, Swansea University - How Supercomputing has changed my world...
  • HPC Wales Workshop 2012, Glamorgan University - A Molecular Modelling Study into the Structural and Curvature Differences in DNA

Poster Presentations;

  • AAIC 2018, Chicago, MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER’S DISEASE
  • AAIC 2017, London, Molecular dynamic modelling of a novel PLCG2 variant reveals key protein structural differences
  • SPEC2016, Montreal - Evaluation of a handheld ATR-FTIR spectrometer to determine lung cancer specific diagnostic metabolic changes in sputum.
  • 1st Student Symposium on Computational Biology and Life Sciences 2014, Glamorgan – The possible use of Molecular Dynamics to improve understanding of mucin structure in Cystic Fibrosis
  • EuroTox 2014, Edinburgh International Conference Centre - Molecular Dynamics modelling of local 3D structural differences in genes when carcinogens are bound at mutation hotspots – The link between structural change and mutation hotspot status
  • EEMS 2014, Lancaster University - Methylation may play an important role in structural change and consequential mutation status in cancer genes
  • UKEMS 2013, Bristol University - Molecular dynamical modelling of local 3D structural differences in TP53 when a number of different carcinogens are bound at mutation hotspots *POSTER PRIZE*
  • Conversazione 2012, Swansea University – Evaluation of FTIR Spectroscopy of mucus samples for the differentiation of Head and Neck Cancer subtypes
  • MGMS Computational Chemical Biology Meeting 2012, Manchester- Molecular Dynamics Modelling of Local 3D structural differences in genes when carcinogens are bound at mutation hotspots

2018

2017

2016

2015

2014

My research looks to identify possible reasons behind the effect genetic changes are having on dementia risk

Funding

2018-21     SER CYMRU II FELLOWSHIP

"Structural and functional investigations into the outcomes of genetic studies" (PI: £173,375)

2018-19     MRC subaward 

"Expanding DPUK genetics and integrating with inflammation/immunity research"   (Co-PI: £100,000)

2017-18      ARUK PUMP PRIMING AWARD

“Defining the role of PLCG2 in Calcium Signalling in relation to Alzheimer’s disease” (Co-PI: £4,400)