Professor Andrew Quantock

2021

• Ashworth, S.et al. 2021. Chondroitin sulfate as a potential modulator of the stem cell niche in cornea. Frontiers in Cell and Developmental Biology 8, article number: 567358. (10.3389/fcell.2020.567358)

2020

• Young, R. D.et al. 2020. Observations on nascent matrix structures in embryonic cornea: Important in cell interactions, or merely vestiges of the lens surface?. Archives of Clinical and Experimental Ophthalmology 2(2), pp. 67-72. (10.46439/ophthalmology.2.014)
• Hammond, G. M.et al. 2020. The microanatomy of Bowman’s layer in the cornea of the pig: changes in collagen fibril architecture at the corneoscleral limbus. European Journal of Anatomy 24(5), pp. 399-406.
• Wang, K.et al. 2020. Cell compaction is not required for the development of gradient refractive index profiles in the embryonic chick lens. Experimental Eye Research 197, article number: 108112. (10.1016/j.exer.2020.108112)
• Kobayashi, Y.et al. 2020. Ocular surface ectoderm instigated by WNT inhibition and BMP4. Stem Cell Research 46, article number: 101868. (10.1016/j.scr.2020.101868)
• Meek, K. M.et al. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols., Vol. 2145. Methods in Molecular Biology New York, NY, USA: Humana, pp. 231-247., (10.1007/978-1-0716-0599-8_16)
• Baba, K.et al. 2020. Cell jamming, stratification and p63 expression in cultivated human corneal epithelial cell sheets. Scientific Reports 10(1), article number: 9282. (10.1038/s41598-020-64394-6)
• Morgan, S. R.et al. 2020. Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics 579, article number: 119102. (10.1016/j.ijpharm.2020.119102)
• Hewitt, M. G.et al. 2020. In Vitro Topical Delivery of Chlorhexidine to the Cornea: Enhancement Using Drug-Loaded Contact Lenses and β-Cyclodextrin Complexation, and the Importance of Simulating Tear Irrigation. Molecular Pharmaceutics 17(4), pp. 1428-1441. (10.1021/acs.molpharmaceut.0c00140)
• Matsushita, K.et al. 2020. Assessment of a self-assembling peptide gel, SPG-178, in providing a clear operative field for trabeculectomy surgery for glaucoma in an animal model. Scientific Reports 10(1), article number: 11326. (10.1038/s41598-020-68171-3)

2019

• Young, R. D.et al. 2019. Cell-independent matrix configuration in early corneal development. Experimental Eye Research 187, article number: 107772. (10.1016/j.exer.2019.107772)
• Bains, K. K.et al. 2019. Recovering vision in corneal epithelial stem cell deficient eyes. Contact Lens and Anterior Eye 42(4), pp. 350-358. (10.1016/j.clae.2019.04.006)

2018

• Hayashi, R.et al. 2018. CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells. Scientific Reports 8(1), article number: 16550. (10.1038/s41598-018-34845-2)
• Shibata, S.et al. 2018. Selective laminin-directed differentiation of human induced pluripotent stem cells into distinct ocular lineages. Cell Reports 25(6), pp. 1668-1679. (10.1016/j.celrep.2018.10.032)
• Koudouna, E.et al. 2018. Cell regulation of collagen fibril macrostructure during corneal morphogenesis. Acta Biomaterialia 79, pp. 96-112. (10.1016/j.actbio.2018.08.017)
• Morgan, S.et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8, article number: 13742. (10.1038/s41598-018-32110-0)
• Littlechild, S.et al. 2018. Keratan sulfate phenotype in the β-1,3-N-acetylglucosaminyltransferase-7-null mouse cornea. Investigative Ophthalmology and Visual Science 59, pp. 1641-1651. (10.1167/iovs.17-22716)

2017

• Kobayashi, Y.et al. 2017. Generation of a TALEN-mediated, p63 knock-in in human induced pluripotent stem cells. Stem Cell Research 25, pp. 256-265. (10.1016/j.scr.2017.10.015)
• Soma, T.et al. 2017. A new graft insertion device for descemet stripping automated endothelial keratoplasty. Cornea 36(11), pp. 1432-1436. (10.1097/ICO.0000000000001302)
• Okumura, N.et al. 2017. Sustained activation of the unfolded protein response induces cell death in Fuchs' endothelial corneal dystrophy. Investigative Ophthalmology & Visual Science 58(9), pp. 3697-3707. (10.1167/iovs.16-21023)
• Akhbanbetova, A.et al. 2017. A surgical cryoprobe for targeted transcorneal freezing and endothelial cell removal. Journal of Ophthalmology 2017, article number: 5614089. (10.1155/2017/5614089)
• Hayashi, R.et al. 2017. Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nature Protocols 12(4), pp. 683-696. (10.1038/nprot.2017.007)

2016

• Chan, W.et al. 2016. Topical delivery of a Rho-kinase inhibitor to the cornea via mucoadhesive film. European Journal of Pharmaceutical Sciences 91, pp. 256-264. (10.1016/j.ejps.2016.05.016)
• Hayashi, R.et al. 2016. Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature 531, pp. 376-380. (10.1038/nature17000)
• Sasamoto, Y.et al. 2016. PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes. Scientific Reports 6, article number: 20807. (10.1038/srep20807)

2015

• Yamada, K.et al. 2015. Mesenchymal-epithelial cell interactions and proteoglycan matrix composition in the presumptive stem cell niche of the rabbit corneal limbus. Molecular Vision 21, pp. 1328-1329.
• Okumura, N.et al. 2015. Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy. Laboratory Investigation 95, pp. 1291-1304. (10.1038/labinvest.2015.111)
• Quantock, A. J.et al. 2015. From nano to macro: Studying the hierarchical structure of the corneal extracellular matrix. Experimental Eye Research 133, pp. 81-99. (10.1016/j.exer.2014.07.018)

2014

• Ho, L. T. Y.et al. 2014. A comparison of glycosaminoglycan distributions, keratan sulphate sulphation patterns and collagen fibril architecture from central to peripheral regions of the bovine cornea. Matrix Biology 38, pp. 59-68. (10.1016/j.matbio.2014.06.004)
• Forrest, M.et al. 2014. The emerging roles of TCF4 in disease and development. Trends in Molecular Medicine 20(6), pp. 322-331. (10.1016/j.molmed.2014.01.010)
• Young, R. D.et al. 2014. Three-dimensional aspects of matrix assembly by cells in the developing cornea. Proceedings of the National Academy of Sciences 111(2), pp. 687-692. (10.1073/pnas.1313561110)

2013

• Hayes, S.et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8(1), article number: e52860. (10.1371/journal.pone.0052860)

2012

• Doutch, J. J.et al. 2012. Ultraviolet transmission through the human corneal stroma. Biophysical Journal 102(6), pp. 1258-1264. (10.1016/j.bpj.2012.02.023)

2011

• Koudouna, E.et al. 2011. Preliminary electron microscopical studies of connective tissue in the human lamina cribrosa [Abstract]. International Journal of Experimental Pathology 92(6), pp. A26. (10.1111/j.1365-2613.2011.00780.x)
• Khan, I. M.et al. 2011. Fibroblast growth factor 2 and transforming growth factor β1 induce precocious maturation of articular cartilage. Arthritis & Rheumatism 63(11), pp. 3417-3427. (10.1002/art.30543)
• Veronesi, G.et al. 2011. X-ray spectro-microscopy at ID21: mapping of elements and chemical states at subcellular level [Abstract]. European Biophysics Journal 40(S1), pp. S130-S131. (10.1007/s00249-011-0734-z)
• Bushby, A. J.et al. 2011. Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy. Nature Protocols 6(6), pp. 845-858. (10.1038/nprot.2011.332)
• Parfitt, G.et al. 2011. Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas. Journal of Structural Biology 174(3), pp. 536-541. (10.1016/j.jsb.2011.03.015)
• Jones, F. E.et al. 2011. Investigation into endothelial cell morphology following new methods of posterior corneal surgery [Abstract]. International Journal of Experimental Pathology 92(3), pp. A24. (10.1111/j.1365-2613.2010.00759.x)
• Tanaka, Y.et al. 2011. Transparent, tough collagen laminates prepared by oriented flow casting, multi-cyclic vitrification and chemical cross-linking. Biomaterials 32(13), pp. 3358-3366. (10.1016/j.biomaterials.2010.11.011)
• Hayes, S.et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
• Young, R. D.et al. 2011. Large Proteoglycan Complexes and Disturbed Collagen Architecture in the Corneal Extracellular Matrix of Mucopolysaccharidosis Type VII (Sly Syndrome). Investigative Ophthalmology & Visual Science 52(9), pp. 6720-6728. (10.1167/iovs.11-7377)
• Tanaka, Y.et al. 2011. Anisotropic mechanical properties of collagen hydrogels induced by uniaxial-flow for ocular applications. Journal of Biomaterials Science. Polymer Edition 22(11), pp. 1427-1442. (10.1163/092050610X510542)

2010

• Duncan, T.et al. 2010. Flow-manipulated, crosslinked collagen gels for use as corneal equivalents. Biomaterials 31(34), pp. 8996-9005. (10.1016/j.biomaterials.2010.08.042)
• Parfitt, G. J.et al. 2010. Three-dimensional reconstruction of collagen-proteoglycan interactions in the mouse corneal stroma by electron tomography. Journal of Structural Biology 170(2), pp. 392-397. (10.1016/j.jsb.2010.01.019)
• Liles, M.et al. 2010. Differential relative sulfation of keratan sulfate glycosaminoglycan in the chick cornea during embryonic development. Investigative Ophthalmology and Visual Science 51(3), pp. 1365-1372. (10.1167/iovs.09-4004)
• Lewis, P.et al. 2010. Structural interactions between collagen and proteoglycans are elucidated by three-dimensional electron tomography of bovine cornea. Structure 18(2), pp. 239-245. (10.1016/j.str.2009.11.013)
• Quantock, A. J., Young, R. D. and Akama, T. O. 2010. Structural and biochemical aspects of keratan sulphate in the cornea. Cellular and Molecular Life Sciences 67(6), pp. 891-906. (10.1007/s00018-009-0228-7)
• Palka, B. P.et al. 2010. Structural Collagen Alterations in Macular Corneal Dystrophy Occur Mainly in the Posterior Stroma. Current Eye Research 35(7), pp. 580-586. (10.3109/02713681003760150)
• Kamma-Lorger, C. S.et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)

2009

• Palka, B. P.et al. 2009. Depth-profiled synchrotron microbeam analysis of collagen fibril ultrastructure in the developing chick cornea [Abstract]. International Journal of Experimental Pathology 90(2), pp. A126. (10.1111/j.1365-2613.2009.00644.x)
• Gealy, E. C.et al. 2009. Actin and type I collagen propeptide distribution in the developing chick cornea. Investigative Ophthalmology & Visual Science 50(4), pp. 1653 -1658. (10.1167/iovs.08-2554)
• Young, R. D.et al. 2009. Stromal Edema in Klf4 Conditional Null Mouse Cornea Is Associated with Altered Collagen Fibril Organization and Reduced Proteoglycans. Investigative Ophthalmology & Visual Science 50(9), pp. 4155-4161. (10.1167/iovs.09-3561)
• Knupp, C.et al. 2009. The architecture of the cornea and structural basis of its transparency. In: McPherson, A. ed. Advances in Protein Chemistry and Structural Biology., Vol. 78. London: Academic Press, pp. 25-49., (10.1016/S1876-1623(08)78002-7)

2008

• Doutch, J. J.et al. 2008. Light transmission in the human cornea as a function of position across the ocular surface: theoretical and experimental aspects. Biophysical Journal 95(11), pp. 5092-5099. (10.1529/biophysj.108.132316)
• Boote, C.et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
• Yamasaki, K.et al. 2008. Genomic Aberrations and Cellular Heterogeneity in SV40-Immortalized Human Corneal Epithelial Cells. Investigative Ophthalmology & Visual Science 50(2), pp. 604-613. (10.1167/iovs.08-2239)
• Saito, T.et al. 2008. Sulfation patterns of keratan sulfate in different macular corneal dystrophy immunophenotypes using three different probes [Letter]. British Journal of Ophthalmology 92(10), pp. 1434-1436. (10.1136/bjo.2008.139527)
• Quantock, A. J. and Young, R. D. 2008. Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function. Developmental Dynamics 237(10), pp. 2607-2621. (10.1002/dvdy.21579)

2007

• Connon, C. J.et al. 2007. The biomechanics of amnion rupture: An X-Ray diffraction study. PLoS ONE 2(11), article number: e1147. (10.1371/journal.pone.0001147)
• Young, R. D.et al. 2007. Keratan sulfate glycosaminoglycan and the association with collagen fibrils in rudimentary lamellae in the developing avian cornea. Investigative Ophthalmology and Visual Science 48(7), pp. 3083-3088. (10.1167/iovs.06-1323)
• Regini, J. W.et al. 2007. X-Ray- and Neutron-Scattering Studies of α-Crystallin and Evidence That the Target Protein Sits in the Fenestrations of the α-Crystallin Shell. Investigative Ophthalmology & Visual Science 48(6), pp. 2695-2700. (10.1167/iovs.06-0559)
• Hayes, S.et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
• Young, R. D.et al. 2007. Differential immunogold localisation of sulphated and unsulphated keratan sulphate proteoglycans in normal and macular dystrophy cornea using sulphation motif-specific antibodies. Histochemistry and Cell Biology 127(1), pp. 115-120. (10.1007/s00418-006-0228-8)
• Hayes, S.et al. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
• Doutch, J. J., Quantock, A. J. and Meek, K. M. A. 2007. Changes in visible light transmission across the corneal stroma - art. no. 65350Q. Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII 6535, pp. Q5350-Q5350.
• Quantock, A. J.et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40(S1), pp. S335-S340. (10.1107/S0021889807005523)
• Gealy, E. C.et al. 2007. Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochemistry and Cell Biology 128(6), pp. 551-555. (10.1007/s00418-007-0332-4)

2006

• Hayashida, Y.et al. 2006. Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. PNAS 103(36), pp. 13333-13338. (10.1073/pnas.0605441103)
• Young, R. D.et al. 2006. Sulphation patterns of keratan sulphate proteoglycan in sclerocornea resemble cornea rather than sclera [Letter]. British Journal of Ophthalmology 90(3), pp. 391-393. (10.1136/bjo.2005.085803)
• Young, R. D.et al. 2006. Immunogold localization of keratan sulphate in macular corneal dystrophy using monoclonal antibodies to specific sulphation motifs [Abstract]. International Journal of Experimental Pathology 87(1), pp. A49-A50. (10.1111/j.0959-9673.2006.00458.x)
• Gealy, E. C.et al. 2006. Association between the cytoskeleton and collagen secretion in the developing cornea [Abstract]. International Journal of Experimental Pathology 87(1), pp. A43-A44. (10.1111/j.0959-9673.2006.00458.x)
• Doutch, J. J.et al. 2006. Propagation of infrared wavelengths through the corneal stroma with reference to hydration changes. Presented at: Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, Saratov, Russia, 26-29 September 2006 Presented at Tuchin, V. V. ed.Saratov Fall Meeting 2006: optical technologies in biophysics and medicine VIII. Proceedings of the SPIE Vol. 6535. Bellingham, WA: SPIE, (10.1117/12.740963)
• Beecher, N.et al. 2006. Neonatal development of the corneal stroma in wild-type and lumican-null mice. Investigative Ophthalmology and Visual Science 47(1), pp. 146-150. (10.1167/iovs.05-0907)

2005

• Assiri, A. A.et al. 2005. Incidence and severity of keratoconus in Asir province, Saudi Arabia. British Journal of Ophthalmology 89(11), pp. 1403-1406. (10.1136/bjo.2005.074955)
• Beecher, N.et al. 2005. An x-ray diffraction study of corneal structure in mimecan-deficient mice. Investigative Ophthalmology and Visual Science 46(11), pp. 4046-4049. (10.1167/iovs.05-0325)
• Quantock, A. J.et al. 2005. Stromal architecture and immune tolerance in additive corneal xenografts in rodents. Acta Ophthalmologica Scandinavica 83(4), pp. 462-466. (10.1111/j.1600-0420.2005.00509.x)
• Young, R. D.et al. 2005. Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Investigative Ophthalmology and Visual Science 46(6), pp. 1973-1978. (10.1167/iovs.04-1309)
• Boote, C.et al. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)

2004

• Connon, C. J.et al. 2004. Spatial and temporal alterations in the collagen fibrillar array during the onset of transparency in the avian cornea. Experimental Eye Research 78(5), pp. 909-915. (10.1016/j.exer.2004.01.005)
• Connon, C. J.et al. 2004. Understanding the function and location of a calcium activated chloride channel in ocular surface epithelium [Abstract]. Investigative Ophthalmology and Visual Science 45, pp. U388-U388.

2003

• Connon, C. J.et al. 2003. Proteoglycan alterations and collagen reorganisation in the secondary avian cornea during development. Ophthalmic Research 35(4), pp. 177-184. (10.1159/000071168)
• Meek, K. M. A.et al. 2003. Collagen fibril disorganisation in the corneas of keratocan-deficient mice as revealed by synchrotron X-ray diffraction [Abstract]. Investigative Ophthalmology and Visual Science 44, pp. U245-U245.
• Hayes, S.et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11, pp. 135.
• Quantock, A. J.et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44(5), pp. 1906-1911. (10.1167/iovs.02-0884)
• Quantock, A. J.et al. 2003. Collagen organization in the secondary chick cornea during development. Investigative Ophthalmology and Visual Science 44(1), pp. 130-136.
• Boote, C.et al. 2003. Collagen orientation during development of the embryonic avian cornea. Fibre Diffraction Review 11(1), pp. 130.
• Boote, C.et al. 2003. A wide-angle x-ray diffraction study of the developing embryonic chicken cornea. Fibre Diffraction Review 11(1), pp. 123-129.
• Quantock, A. J.et al. 2003. Collagen Organization in the Secondary Chick Cornea during Development. Investigative Ophthalmology & Visual Science 44(1), pp. 130-136. (10.1167/iovs.02-0544)

2002

• Kostyuk, O.et al. 2002. Transparency of the bovine corneal stroma at physiological hydration and its dependence on concentration of the ambient anion. The Journal of Physiology 543(2), pp. 633-642. (10.1113/jphysiol.2002.021527)
• Quantock, A., Koizumi, N. and Kinoshita, S. 2002. Limbal stem cell deficiencies and ocular surface reconstruction. Optometry Today 30, pp. 27-30.
• Boote, C.et al. 2002. Collagen orientation during development of the embryonic avian cornea [Abstract]. Investigative Ophthalmology and Visual Science 43, article number: E-Abstract 3214.
• Quantock, A. J.et al. 2002. Keratan sulphate levels during development of the embryonic avian cornea. Investigative Ophthalmology and Visual Science 43(E-Abst)

2001

• Kinoshita, S.et al. 2001. Characteristics of the human ocular surface epithelium. Progress in Retinal and Eye Research 20(5), pp. 639-673. (10.1016/S1350-9462(01)00007-6)
• Quantock, A. J., Meek, K. M. A. and Chakravarti, S. 2001. An X-ray diffraction investigation of corneal structure in lumican-deficient mice. Investigative Ophthalmology and Visual Science 42(8), pp. 1750-1756.
• Sugita, J.et al. 2001. The detection of bacteria and bacterial biofilms in punctal plug holes. Cornea 20(4), pp. 362-365.