Dr Catrin Williams

Biography

During my research career to date, I have developed a strong cross-disciplinary theme, applying novel physico-chemical techniques to address important questions in biology.

Education and qualifications

2009-2013: PhD (Microbiology), Cardiff School of Biosicences

2005-2008: BSc (hons) Microbiology, Cardiff University

Career overview

2016-present: Sêr Cymru II Research Fellow, Cardiff School of Engineering

2014-2016: Sêr Cymru (NRN) Postdoctoral Research Associate, Cardiff Schools of Bioscience & Engineering

2013-2014: KTP Postdoctoral Research Associate, Cultech Ltd. & University of Reading

Honours and awards

2017: Wales Online’s Top 35 Business and Professional Women Under 35 award

2017: Telegraph’s Top 50 Women in Engineering award, see Figure 4

2015 & 2012: Awarded 1st prize for student poster presentations at the NRN Distinguished Lecture and All Wales and South West Microbiology Forum, respectively, both at Swansea University

2013: Certificate of Commendation by the Zoological Society of London for the Thomas Henry Huxley award

2009: City and Guilds Professional Development Award

Professional memberships

• Institute of Electrical and Electronics Engineers (IEEE), membership number: 93806199
• Society for General Microbiology (SGM), membership number: 1081390
• Society for Applied Microbiology (SfAM), membership number: 504010
• Associate Fellow of The Higher Education Academy, recognition reference: 51715
• STEM Ambassador: ID number 211056

Speaking engagements

Oral presentations

2017: International Microwave Symposium (Invited Speaker), Honolulu, USA, and GW4 Biosensors Workshop, Bristol and Exeter, UK

2016: International Microwave Symposium, San Francisco, USA

2014: Edward Llwyd Society (Invited Speaker), National Eisteddfod, Llanelli, UK

2011: Plant-Micro Wales, Bangor, UK, and European Congress of Protistologists, Berlin, Germany

2010: Plant-Micro Wales, Aberystwyth, UK, and International Society of Protistologists, Canterbury, UK

Poster presenations

2017: Microbiology Society Annual Meeting, Edinburgh, UK

2015: Society for General Microbiology Annual Conference, Birmingham, UK; GW4 Biosensors Workshop, Bath, UK and NRN Distinguished Lecture Event, Swansea University, UK

2013: European Netowrk for Gastrointestinal Health Research, Valencia, Spain

2012: 5th International Conference on Anaerobic Protists, Los Angeles, USA, and All Wales and SOuth West Microbiology Forum, Swansea, UK

2011: European Congress of Protistologists, Berlin, Germany and Nano Meets Spectroscopy, London, UK

2010: British Society for Parasitology, Cardiff, UK, and South Wales and South West Microbiology Forum, Cardiff, UK

Committees and reviewing

2016-present: Member of the Athena Swan Self-Assessment Committee

2015-present: Review Editor for Frontiers in Microbiology

Publications

• Date
• Type
• Selected

Teaching

Outreach

2017: National Eisteddfod of Wales: NRN exhibitor in the Science Pavilion

2017: Soapbox Science presenter, Swansea, see Figure 5.

2016-present: Various outreach activities within the School of Engineering and in collaboration with Science Made Simple, e.g. ‘Skype and Engineer’, ‘Superheros’ engineering videos and Smallpiece tours.

2013: Contributor for a BAFTA-nominated documentary on the life of Alfred Russel Wallace: “Darwin, y Cymro a’r cynllwyn” (S4C).

2009-2013: Various outreach activities within the School of Biosciences, including National Science Week activities and University open days.

My Sêr Cymru II fellowship aims to address a fundamental biophysical question: how do microwave fields interact with biological systems?

Radio frequency and microwave-based technologies have become ubiquitous in our modern, urban environment and play a critical role in society as a whole. These technologies have shaped the way we communicate (e.g. radio, telephones and Wi-Fi), travel (e.g. radar and GPS) and treat diseases (e.g. thermal ablation of cancer and heart disease). However, despite their widespread use, we do not have a thorough understanding of how the microwave fields emitted from these devices affect processes at the molecular level, leading to therapeutic or destructive biological effects.

This gap in our knowledge is reflected in the International Agency for Research on Cancer classification of microwave radiation from mobile phones as ‘possibly carcinogenic to humans’. Furthermore, current safety standards for human exposure to microwaves, set by government agencies, vary across the world. Moreover, these safety standards only consider the thermal effects of microwaves to be relevant, despite the fact that there is mounting evidence which supports non-thermal mechanism(s) of interaction of microwaves in biology. Conversely, microwaves also have therapeutic value, and are used clinically in the ablation of tumours and cardiac arrhythmias.

Understanding the biophysical and molecular basis behind this non-thermal mechanism of action, as well as the induced biological consequences, will facilitate further research into optimizing the microwave dose required for therapeutic applications and serve to better inform government agencies on safety limits for human exposure.

During my previous position as a National Research Network Postdoctoral Research Associate (NRN 062), we showed that light emission from the bioluminescent marine bacterium, Vibrio fischeri (see Figure 1) is rapidly increased in pulsed microwave electric fields, but diminished at higher power levels. Whereas in pulsed microwave magnetic fields at 100-fold higher powers there are no short-term detectable effects (see Williams et al. Appl. Phys. Lett. 109 (9), 093701, 2016).

I am building on this research in order to address the following aims:

1. Optimize and validate the use of a coplanar waveguide device to allow microscopic observation of the real-time effects of low and high frequency electromagnetic fields (EMFs, see Figure 2).
2. Investigate non-thermal biological effects of EMFs and characterise the molecular and biophysical mechanisms which lead to therapeutic and/ or pathophysiological outcomes.
3. Determine whether the same mechanism of action is transferrable across two domains of life: from bacterial organisms to the complex network of cells which comprises the human heart, separated by ~3-4 billion years of evolution.

My work utilizes a combination of engineering, applied biology and physico-chemical techniques in order to address the following objectives:

1. To develop a standardised methodology for comparing the effects of different EMF-utilizing devices in terms of pulse patterns, frequency and power intensity on Vibrio fischeri and hESC-CM cells using the coplanar waveguide launchers integrated into the microscope set-up.
2. To separate the thermal and non-thermal effects of EMFs by measuring localized intra-and extra-cellular temperature changes during EMF irradiation by developing novel ruthenium and europium-based luminescent temperature probes.
3. To determine whether exposure of biological systems to 50 Hz and 2.45 GHz frequency EMFs disrupt or enhance cell-cell communication, and to probe the biochemical and molecular pathways involved in eliciting these effects.

This work is sponsored by the European Regional Development Fund (see Figure 3), the Welsh Government and Cardiff University.

Contracts

Title	People	Sponsor	Value	Duration
National Eisteddfod Outreach Fund	Dr CF Williams	National Research Network in Advanced Engineering and Materials	£500	August 2017
Small Equipment Research Fund	Dr CF Williams	Cardiff School of Engineering	£5700	July 2017
Conference Grant	Dr CF Williams	Microbiology Society	£270	April 2017
Ser Cymru II Fellowship	Dr CF Williams	European Regional Development Fund, Welsh Government and Cardiff University	£185,298	2016-2019
Small Equipment Research Fund	Prof A Porch and Dr CF Williams	Cardiff School of Engineering	£16,932.73	July 2015
Conference Grant	Dr CF Williams	Microbiology Society	£350	April, 2015
Scientific Meeting Travel Grant	Dr CF Williams	Microbiology Society	£350	July, 2011
Charles Coles Travelling Scholarship	Dr CF Williams	Cardiff University	£400	March 2011
Travel Scholarship	Dr CF Williams	Welsh Livery Guild	£500	2010
Travelling Fellowship	Dr CF Williams	Journal of Experimental Biology	$800	August, 2010
Travel Award for Students and Postdocs	Dr CF Williams	International Society for Protistologists	$500	July, 2010
Gillian Powell Memorial Travel Scholarship	Dr CF Williams	Cardiff University	£100	January, 2010

Supervised Students

Title	Student	Status	Degree