Dr Carmine Varricchio

2024

• Lucero, B. et al. 2024. Design, synthesis, and evaluation of an anti‐trypanosomal [1,2,4]triazolo[1,5‐ a ]pyrimidine probe for photoaffinity labeling studies. ChemMedChem, article number: e202300656. (10.1002/cmdc.202300656)

2023

• Monti, L. et al. 2023. Structure‐activity relationships, tolerability and efficacy of microtubule‐active 1,2,4‐Triazolo[1,5‐ a ]pyrimidines as potential candidates to treat human African trypanosomiasis. ChemMedChem 18(20), article number: e202300193. (10.1002/cmdc.202300193)
• Lambourne, O. A. et al. 2023. PINK1-Dependent mitophagy inhibits elevated ubiquitin phosphorylation caused by mitochondrial damage. Journal of Medicinal Chemistry 66(11), pp. 7645-7656. (10.1021/acs.jmedchem.3c00555)
• Xiang, H. et al. 2023. Biocatalytic and chemo-enzymatic synthesis of quinolines and 2‑quinolones by monoamine oxidase (MAO-N) and horseradish peroxidase (HRP) biocatalysts. ACS Catalysis 13(5), pp. 3370-3378. (10.1021/acscatal.2c05902)
• Salerno, M. et al. 2023. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry 246, article number: 114942. (10.1016/j.ejmech.2022.114942)
• Alle, T. et al. 2023. Microtubule-stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as candidate therapeutics for neurodegenerative disease: Matched molecular pair analyses and computational studies reveal new structure-activity insights. Journal of Medicinal Chemistry 66(1), pp. 435-459. (10.1021/acs.jmedchem.2c01411)

2022

• Wong, A. et al. 2022. A composite system based upon hydroxypropyl cyclodextrins and soft hydrogel contact lenses for the delivery of therapeutic doses of econazole to the cornea, in vitro. Pharmaceutics 14(8), article number: e1631. (10.3390/pharmaceutics14081631)
• Narayanan, A. et al. 2022. Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay. Communications Biology 5(1), article number: 169. (10.1038/s42003-022-03090-9)

2021

• Alrashidi, A. et al. 2021. A time-kill assay study on the synergistic bactericidal activity of pomegranate rind extract and Zn (II) against Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Biomolecules 11(12), article number: 1889. (10.3390/biom11121889)
• Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A. and Bassetto, M. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226, article number: 113841. (10.1016/j.ejmech.2021.113841)
• Francisco, K. R., Varricchio, C., Paniak, T. J., Kozlowski, M. C., Brancale, A. and Ballatore, C. 2021. Corrigendum to "structure property relationships of N-Acylsulfonamides and related bioisosteres" European journal of medicinal chemistry, 218 (2021), 113399. European Journal of Medicinal Chemistry 226, article number: 113894. (10.1016/j.ejmech.2021.113894)
• Ferla, S. et al. 2021. Structure-activity relationship studies on novel antiviral agents for norovirus infections. Microorganisms 9(9), article number: 1795. (10.3390/microorganisms9091795)
• Francisco, K. R., Varricchio, C., Paniak, T. J., Kozlowski, M. C., Brancale, A. and Ballatore, C. 2021. Structure property relationships of N-acylsulfonamides and related bioisosteres. European Journal of Medicinal Chemistry 218, article number: 113399. (10.1016/j.ejmech.2021.113399)
• Eigel, D. et al. 2021. Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures. Biomaterials 271, article number: 120712. (10.1016/j.biomaterials.2021.120712)
• Oukoloff, K. et al. 2021. Evaluation of the structure-activity relationship of microtubule-targeting 1,2,4-Triazolo[1,5-a]pyrimidines identifies new candidates for neurodegenerative tauopathies. Journal of Medicinal Chemistry 64(2), pp. 1073-1102. (10.1021/acs.jmedchem.0c01605)

2020

• Varricchio, C., Beirne, K., Aeschlimann, P., Heard, C., Rozanowska, M., Votruba, M. and Brancale, A. 2020. Discovery of Novel 2-Aniline-1,4-naphthoquinones as potential new drug treatment for Leber’s hereditary optic neuropathy (LHON). Journal of Medicinal Chemistry 63(22), pp. 13638 -13655. (10.1021/acs.jmedchem.0c00942)
• Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25(21), article number: 4904. (10.3390/molecules25214904)
• Newland, B. et al. 2020. Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis. Carbohydrate Polymers 245, article number: 116504. (10.1016/j.carbpol.2020.116504)
• Zhao, F. et al. 2020. Monoamine oxidase (MAO-N) biocatalyzed synthesis of indoles from indolines prepared via photocatalytic cyclization/arylative dearomatization. ACS Catalysis 10(11), pp. 6414-6421. (10.1021/acscatal.0c01351)
• Varricchio, C., Beirne, K., Heard, C., Newland, B., Rozanowska, M., Brancale, A. and Votruba, M. 2020. The ying and yang of idebenone: Not too little, not too much - cell death in NQO1 deficient cells and the mouse retina. Free Radical Biology and Medicine 152, pp. 551-560. (10.1016/j.freeradbiomed.2019.11.030)
• Bender, L. et al. 2020. A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. European Journal of Pharmaceutics and Biopharmaceutics 149, pp. 85-94. (10.1016/j.ejpb.2020.01.007)
• Hewitt, M. G. et al. 2020. In Vitro Topical Delivery of Chlorhexidine to the Cornea: Enhancement Using Drug-Loaded Contact Lenses and β-Cyclodextrin Complexation, and the Importance of Simulating Tear Irrigation. Molecular Pharmaceutics 17(4), pp. 1428-1441. (10.1021/acs.molpharmaceut.0c00140)

2019

• Varricchio, C. 2019. Novel drug therapy for mitochondrial optic neuropathy. PhD Thesis, Cardiff University.