- Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
Unlocking the mysteries of the brain
My research is dedicated to developing and applying advanced Diffusion-Weighted MR Spectroscopy (DW-MRS) sequences to uncover the specific morphologies of neuronal and glial cells. The findings of this research have the potential to shed new light on the underlying causes of devastating neurodegenerative conditions such as Alzheimer's, Parkinson's, Huntington's Disease and Multiple Sclerosis, all of which are assumed to be association with neuroinflammation. By investigating this association, my work offers new opportunities to study neuroinflammatory processes and identify novel biomarkers that could lead to earlier diagnosis and treatment.
Publications in peer-reviewed scientific journals
Şimşek K, Döring A, Pampel A, Möller HE, Kreis R. Macromolecular background signal and non‐Gaussian metabolite diffusion determined in human brain using ultra‐high diffusion weighting. Magn Reson Med 2022; Early View.
Dziadosz M, Hoefemann M, Döring A, Marjańska M, Auerbach EJ, Kreis R. Quantification of NAD+ in human brain with 1H MR spectroscopy at 3T: Comparison of three localization techniques with different handling of water magnetization. Magn Reson Med 2022; 88:1027-38.
Hoefemann M, Döring A, Fichtner ND, Kreis R. Combining chemical exchange saturation transfer and 1H magnetic resonance spectroscopy for simultaneous determination of metabolite concentrations and effects of magnetization exchange. Magn Reson Med 2020; 85:1766-82
Döring A, Kreis R. Magnetic resonance spectroscopy extended by oscillating diffusion gradients: Cell-specific anomalous diffusion as a probe for tissue microstructure in human brain. Neuroimage 2019; 202:116075.
Kyathanahally SP, Döring A, Kreis R. Deep learning approaches for detection and removal of ghosting artifacts in MR spectroscopy. Magn Reson Med 2018; 80:851-63.
Döring A, Adalid V, Boesch C, Kreis R. Diffusion‐weighted magnetic resonance spectroscopy boosted by simultaneously acquired water reference signals. Magn Reson Med 2018; 80:2326-38.
Adalid V, Döring A, Kyathanahally SP, Bolliger CS, Boesch C, Kreis R. Fitting Interrelated Datasets: Metabolite Diffusion and General Lineshapes. Magn Reson Mater Phy 2017; 30:429-48.
Contributions in international conferences
Döring A, Rösler F, Şimşek K, Jones DK, Valette J, PalomboM. Time dependent diffusion and kurtosis of human brain metabolites using DW-MR spectroscopy on the Connectom. DW-MRI Workshop Amsterdam 2022. (Traditional poster presentation, awarded with poster price) -> here
Najac C, Döring A, Clarke W, Genovese V, Just N, Kreis R, Lundell H, Mosso J, Mougel E, Oeltzschner G, Palombo M, Ligneul C. Differences in diffusion-weighted MRS processing and fitting pipelines, and their effect on tissue modeling: Results from a workshop challenge. 31st Proc Intl Soc Mag Reson Med 2022. (Collaborative Abstract, Digital Poster) -> here
Döring A, Jones DK, Kreis R. Improved motion compensation for water-suppressed diffusion MR Spectroscopy evaluated using synthetic data. 31st Proc Intl Soc Mag Reson Med 2022. (Digital Poster) -> here
Döring A, Afzali M, Kleban E, Kreis R, Jones DK. Realistic simulations of diffusion MR spectroscopy: The effect of glial cell swelling on non-Gaussian and anomalous diffusion. 29th Proc Intl Soc Mag Reson Med 2021. (Digital Poster, awarded with magna cum laude) -> here
Döring A, Rummel C, Röthlisberger SC, Duss S, Roth C, Bassetti C, Kreis R. Investigation of potential effects of sleep on diffusion characteristics of metabolites and water: initial results. 28th Proc Intl Soc Mag Reson Med 2020:860. (Talk, awarded with magna cum laude) -> here
Döring A, Kreis R. MRS Extended by Oscillating Diffusion Gradients as a Probe for Investigation of Human Brain Tissue Microstructure. 27th Proc Intl Soc Mag Reson Med 2019:57. (Talk, awarded with summa cum laude) -> here
Döring A, Adalid VJ, Boesch C, Kreis R. On the exploitation of slow macromolecular diffusion for baseline estimation in MR spectroscopy using 2D simultaneous fitting. 26th Proc Intl Soc Mag Reson Med 2018:1315. (Traditional poster presentation) -> here
Döring A, Adalid VJ, Boesch C, Kreis R. Diffusion characteristics of human brain metabolites determined in vivo in MR experiments. DGMP Meeting – Dresden 2017. (Traditional poster presentation, winning poster in the field of medical physics)
Döring A, Adalid VJ, Boesch C, Kreis R. Pinpointing Differences in Diffusion Characteristics of Metabolites Determined in Human Gray Matter Using Simultaneous Spectral and Diffusion Modeling. 25th Proc Intl Soc Mag Reson Med 2017:2998. (Traditional poster presentation) -> here
Döring A, Adalid V, Brandejsky V, Boesch C, Kreis R. Optimized Estimation of Apparent Diffusion Coefficients of Metabolites. MRS Workshop – Lake Constance 2016. (Power pitch)
Döring A, Adalid V, Brandejsky V, Boesch C, Kreis R. Optimized Estimation of Apparent Diffusion Coefficients of Metabolites. 24th Proc Intl Soc Mag Reson Med 2016. (Talk, winning abstract MRS study group)
Döring A, Adalid V, Brandejsky V, Boesch C, Kreis R. Diffusion weighted MR spectroscopy without water suppression allows to use water as inherent reference signal to correct for motion-related signal drop. 24th Proc Intl Soc Mag Reson Med 2016; 2395. (Traditional poster presentation) -> here