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Dr Marion Bonnet

Dr Marion Bonnet

MRC Research Fellow

School of Medicine

Email
bonnetm@cardiff.ac.uk
Telephone
+44 (0)29 2068 7302
Campuses
Henry Wellcome Building for Biomedical Research, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN

Biography

Publications

2021

2017

2014

2013

2011

2009

2006

2003

2002

2000

Programmed necrosis and alarmins in inflammation

Long considered a passive form of cell death, necrosis has recently been shown to be a regulated process, activated by a variety of endogenous or exogenous stimuli, such a Death Receptor, interferons, or Toll-like Receptor (TLRs). Necrotic death is highly pro-inflammatory due to the release of intracellular molecules, called alarmins or Danger Associated Molecular Patterns (DAMPs). Necroptosis is the best characterised form of programmed necrosis and has been shown to trigger inflammation in numerous organs, in particular in barrier epithelia (skin, colon, kidney). It is regulated by the necrosome complex, composed of kinases RIPK1 and RIPK3 and their substrate, pseudo-kinase MLKL.

Our work aims at elucidating the role of programmed necrosis and alarmins in inflammatory diseases, in collaboration with clinicians, as well as deciphering the molecular regulation of programmed necrosis.