![Marion Bonnet PhD](https://profiles-cardiff.imgix.net/attachments/2394?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Marion Bonnet
PhD
MRC Research Fellow
- BonnetM@cardiff.ac.uk
- +44 29206 87302
- Henry Wellcome Building for Biomedical Research, Room 3F08, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Overview
I am an MRC Research Fellow in Molecular and Cellular Medicine in the Division of Infection & Immunity at the School of Medicine. My laboratory studies the role of programmed necrosis cell death, alarmins and innate immunity in skin and joint inflammation.
Publication
2023
- Fernandez-Nasarre, A. et al. 2023. Epidermal IL-33 drives inflammation in necroptosis-induced skin inflammation by recruiting TNF-producing immune cells.. [Online]. bioRXiv: bioRXiv. (10.1101/2023.07.28.550963)
2021
- Chinnery, P. F. et al. 2021. Choosing drugs for UK COVID-19 treatment trials. Nature Reviews Drug Discovery (10.1038/d41573-021-00203-7)
- Kervevan, J. et al. 2021. Targeting human langerin promotes HIV-1 specific humoral immune responses. PLoS Pathogens 17(7), article number: e1009749. (10.1371/journal.ppat.1009749)
- Eugénio, M. S. et al. 2021. TRIM21, a new component of the TRAIL-induced endogenous necrosome complex. Frontiers in Molecular Biosciences 8, article number: 645134. (10.3389/fmolb.2021.645134)
2017
- Michel, L. et al. 2017. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways. British Journal of Dermatology 177(5), pp. 1322-1336. (10.1111/bjd.15577)
- Delehouze, C. et al. 2017. 6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Scientific Reports 7, article number: 12931. (10.1038/s41598-017-12788-4)
- Le Cann, F. et al. 2017. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. FEBS Journal 284(18), pp. 3050-3068. (10.1111/febs.14176)
2014
- Eguether, T. et al. 2014. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nature Communications 5, article number: 4585. (10.1038/ncomms5585)
2013
- Kumari, S. et al. 2013. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39(5), pp. 899-911. (10.1016/j.immuni.2013.10.009)
2011
- Wullaert, A., Bonnet, M. and Pasparakis, M. 2011. NF-kB in the regulation of epithelial homeostasis and inflammation.. Cell Research 21, pp. 146-158. (10.1038/cr.2010.175)
- Bonnet, M. C. et al. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35(4), pp. 572-582. (10.1016/j.immuni.2011.08.014)
2009
- Clerzius, G., Gelinas, J., Daher, A., Bonnet, M., Meurs, E. and Gatignol, A. 2009. ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.. Journal of Virology 83, pp. 10119-10128. (10.1128/JVI.02457-08)
2006
- Bonnet, M., Daurat, C., Ottone, C. and Meurs, E. F. 2006. The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cellular Signalling 18(11), pp. 1865-1875. (10.1016/j.cellsig.2006.02.010)
- Puel, A. et al. 2006. The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. American Journal of Human Genetics 78(4), pp. 691-701. (10.1086/501532)
2003
- Courtois, G. et al. 2003. A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. Journal of Clinical Investigation 112(7), pp. 1108-1115. (10.1172/JCI18714)
- Picard, C. et al. 2003. Pyogenic bacterial infections in humans with IRAK-4 deficiency.. Science 299(5615), pp. 2076-2079. (10.1126/science.1081902)
2002
- Wecker, K., Bonnet, M., Meurs, E. and Delepierre, M. 2002. The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex.. Nucleic Acids Research 30(20), pp. 4452-4459. (10.1093/nar/gkf559)
2000
- Bonnet, M., Weil, R., Dam, E., Hovanessian, A. and Meurs, E. 2000. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.. Molecular and Cellular Biology 20(3), pp. 4532-4542. (10.1128/mcb.20.13.4532-4542.2000)
Articles
- Chinnery, P. F. et al. 2021. Choosing drugs for UK COVID-19 treatment trials. Nature Reviews Drug Discovery (10.1038/d41573-021-00203-7)
- Kervevan, J. et al. 2021. Targeting human langerin promotes HIV-1 specific humoral immune responses. PLoS Pathogens 17(7), article number: e1009749. (10.1371/journal.ppat.1009749)
- Eugénio, M. S. et al. 2021. TRIM21, a new component of the TRAIL-induced endogenous necrosome complex. Frontiers in Molecular Biosciences 8, article number: 645134. (10.3389/fmolb.2021.645134)
- Michel, L. et al. 2017. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways. British Journal of Dermatology 177(5), pp. 1322-1336. (10.1111/bjd.15577)
- Delehouze, C. et al. 2017. 6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Scientific Reports 7, article number: 12931. (10.1038/s41598-017-12788-4)
- Le Cann, F. et al. 2017. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. FEBS Journal 284(18), pp. 3050-3068. (10.1111/febs.14176)
- Eguether, T. et al. 2014. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nature Communications 5, article number: 4585. (10.1038/ncomms5585)
- Kumari, S. et al. 2013. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39(5), pp. 899-911. (10.1016/j.immuni.2013.10.009)
- Wullaert, A., Bonnet, M. and Pasparakis, M. 2011. NF-kB in the regulation of epithelial homeostasis and inflammation.. Cell Research 21, pp. 146-158. (10.1038/cr.2010.175)
- Bonnet, M. C. et al. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35(4), pp. 572-582. (10.1016/j.immuni.2011.08.014)
- Clerzius, G., Gelinas, J., Daher, A., Bonnet, M., Meurs, E. and Gatignol, A. 2009. ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.. Journal of Virology 83, pp. 10119-10128. (10.1128/JVI.02457-08)
- Bonnet, M., Daurat, C., Ottone, C. and Meurs, E. F. 2006. The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cellular Signalling 18(11), pp. 1865-1875. (10.1016/j.cellsig.2006.02.010)
- Puel, A. et al. 2006. The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. American Journal of Human Genetics 78(4), pp. 691-701. (10.1086/501532)
- Courtois, G. et al. 2003. A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. Journal of Clinical Investigation 112(7), pp. 1108-1115. (10.1172/JCI18714)
- Picard, C. et al. 2003. Pyogenic bacterial infections in humans with IRAK-4 deficiency.. Science 299(5615), pp. 2076-2079. (10.1126/science.1081902)
- Wecker, K., Bonnet, M., Meurs, E. and Delepierre, M. 2002. The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex.. Nucleic Acids Research 30(20), pp. 4452-4459. (10.1093/nar/gkf559)
- Bonnet, M., Weil, R., Dam, E., Hovanessian, A. and Meurs, E. 2000. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.. Molecular and Cellular Biology 20(3), pp. 4532-4542. (10.1128/mcb.20.13.4532-4542.2000)
Websites
- Fernandez-Nasarre, A. et al. 2023. Epidermal IL-33 drives inflammation in necroptosis-induced skin inflammation by recruiting TNF-producing immune cells.. [Online]. bioRXiv: bioRXiv. (10.1101/2023.07.28.550963)
Research
Our lab uses in vivo models together with clinical samples to decipher the molecular mechanisms of cell death-induced skin and joint inflammation.
Programmed necrosis and alarmins in inflammation
Long considered a passive form of cell death, necrosis has recently been shown to be a regulated process, activated by a variety of endogenous or exogenous stimuli, such a Death Receptors (DRs), interferons (IFNs), or Toll-like Receptor (TLRs). Necrotic death is highly pro-inflammatory due to the release of intracellular molecules, called alarmins or Danger Associated Molecular Patterns (DAMPs). Necroptosis is the best characterised form of programmed necrosis and has been shown to trigger inflammation in numerous organs, in particular in barrier epithelia (skin, colon, kidney). It is regulated by the necrosome complex, composed of kinases RIPK1 and RIPK3 and their substrate, pseudo-kinase MLKL.
Using genetic approaches and in vivo models, our work aims at elucidating the role of programmed necrosis and alarmins, as well as deciphering the molecular regulation of programmed necrosis in inflammatory diseases, in collaboration with clinicians, to identify early biomarkers and novel therapeutic targets for personalised medicine.
Biography
Honours and awards
- 2017: MRC New Investigator Research Grant
- 2014: Excellence Research Chair (Co-I), Universite Europeenne de Bretagne
- 2012: European Skin Research Foundation Award
Professional memberships
- British Society for Investigative Dermatology (BSID)
- European Society for Dermatological Research (ESDR)
- European Cell Death Organisation (ECDO)
Academic positions
- Excellence Research Chair (Co-I), Institut de Recherche Sante-Environnmenet-Travail IRSET), Universite Rennes-I (Rennes, France)
- Senior Scientist, INSERM U976, Hopital St-Louis (Paris, France)
- Post-doctoral Fellow, University of Cologne (Cologne, Germany)
Committees and reviewing
- 2023: DII EDHR Committee
- 2022: Guest Editor and Review Editor, Frontiers in Immunology
Supervisions
Cell death
Inflammation
Skin biology
Arthritis
Current supervision
Africa Fernandez Nasarre
Research student
Past projects
Damage-associated molecular patterns in necroptosis-dependent skin inflammation.
Research themes
Specialisms
- Genetic immunology
- Molecular biology
- Cell Biology
- Dermatology