![Daniel Turnham](https://profiles-cardiff.imgix.net/attachments/1239?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Daniel Turnham
Research Associate
School of Biosciences
- TurnhamD@cardiff.ac.uk
- Hadyn Ellis Building, Room ECSCRI, Maindy Road, Cardiff, CF24 4HQ
Overview
My research focuses on developing new therapeutic strategies to treat aggressive, hard to treat prostate cancers.
In the UK around 1 in 8 men will develop prostate cancer within their lifetime. A high proportion of these men will present with localised disease and outlive their cancer without the need for invasive therapy, however for those with late stage prostate cancer that has spread beyond the prostate the prognosis is poor with the disease no longer curable.
Through my work I hope to improve our understanding of late stage prostate cancer and to develop novel targeted therapies that may one day be used in the clinic to improve outlook for men with this disease.
Publication
2024
- Turnham, D. J., Smith, H. and Clarkson, R. W. E. 2024. Suppression of Bcl3 disrupts viability of breast cancer cells through both p53-dependent and p53-independent mechanisms via loss of NF-κB signalling. Biomedicines 12(1), article number: 143. (10.3390/biomedicines12010143)
2023
- Chessa, T. A. et al. 2023. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular Cell 83(16), pp. 2991-3009., article number: E13. (10.1016/j.molcel.2023.07.015)
2021
- Soukupova, J. et al. 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10(5), pp. 775-786. (10.1158/1535-7163.MCT-20-0283)
2020
- Turnham, D. J., Yang, W. W., Davies, J., Varnava, A., Ridley, A. J., Conlan, R. S. and Clarkson, R. W. E. 2020. Bcl-3 promotes multi-modal tumour cell migration via NF-kB1 mediated regulation of Cdc42. Carcinogenesis 41(10), pp. 1432-1443. (10.1093/carcin/bgaa005)
- Turnham, D. J., Bullock, N., Dass, M. S., Staffurth, J. N. and Pearson, H. B. 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9(11), article number: 2342. (10.3390/cells9112342)
- Kiraga, L. et al. 2020. Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice. International Journal of Molecular Sciences 21(14), article number: 4991. (10.3390/ijms21144991)
2017
- Turnham, D. 2017. Understanding the role of Bcl-3 in breast cancer metastasis. PhD Thesis, Cardiff University.
Erthyglau
- Turnham, D. J., Smith, H. and Clarkson, R. W. E. 2024. Suppression of Bcl3 disrupts viability of breast cancer cells through both p53-dependent and p53-independent mechanisms via loss of NF-κB signalling. Biomedicines 12(1), article number: 143. (10.3390/biomedicines12010143)
- Chessa, T. A. et al. 2023. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular Cell 83(16), pp. 2991-3009., article number: E13. (10.1016/j.molcel.2023.07.015)
- Soukupova, J. et al. 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10(5), pp. 775-786. (10.1158/1535-7163.MCT-20-0283)
- Turnham, D. J., Yang, W. W., Davies, J., Varnava, A., Ridley, A. J., Conlan, R. S. and Clarkson, R. W. E. 2020. Bcl-3 promotes multi-modal tumour cell migration via NF-kB1 mediated regulation of Cdc42. Carcinogenesis 41(10), pp. 1432-1443. (10.1093/carcin/bgaa005)
- Turnham, D. J., Bullock, N., Dass, M. S., Staffurth, J. N. and Pearson, H. B. 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9(11), article number: 2342. (10.3390/cells9112342)
- Kiraga, L. et al. 2020. Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice. International Journal of Molecular Sciences 21(14), article number: 4991. (10.3390/ijms21144991)
Gosodiad
- Turnham, D. 2017. Understanding the role of Bcl-3 in breast cancer metastasis. PhD Thesis, Cardiff University.
