Dr Tom Massey
WCAT Fellow, Division of Psychological Medicine and Clinical Neurosciences
We are interested in the role of DNA repair pathways in the pathogenesis of trinucleotide repeat disorders, particularly Huntington’s Disease and the Spinocerebellar Ataxias. Recent human genomic association data have linked various DNA repair pathways to disease onset, fitting with previous work in animal models. We are using a combination of next-generation sequencing, iPS cell modelling, and biochemistry to try to unpick how DNA repair intersects with trinucleotide repeats to cause disease. Understanding these areas will hopefully enable the generation of novel therapeutics.
My work is supported by the Medical Research Council (post-doctoral research training Fellowship), Association of British Neurologists (Patrick Berthoud Charitable Trust Fellowship), and the European Huntington’s Disease Network.