Dr Michael Perrins
- W/3.25, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
I have a keen interest in the importance that imaging has in the understanding and dissemination of scientific work. At Cardiff University my research explores the development of organs through the use of ‘POLCA’ – a recently developed imaging pipeline. The images produced by this pipeline allow for visualisation of proliferation patterns and offer detailed spatial quantification of growth.
During my undergraduate degree at Bangor University (2010-2013) I was based at the School of Psychology, with a focus in cognition, more specifically the role that sleep has on working memory, within the lab of Dr. Giovanni d’Avossa. During this time, I worked as a Research Assistant in a number of labs and developed a wide range of academic skills and interests. For my MSc I remained at Bangor University (2013-2014), where I studied Clinical Neuropsychology and developed a keen interest in clinical research. In association with Ysbyty Gwynedd and the lab of Professor Robert Rafal I explored the impact of Traumatic Brain Injury (TBI) on non-conscious saccadic eye movements. A key aspect of this research was the quantification of behavioural neurology alongside the analysis of brain data through Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging (DTI), and Tractography of subcortical structures.
With my interest in clinical imaging, I pursued a PhD at the University of Edinburgh (2015-2019), under the guidance of Professor Edwin van Beek and Professor Neil Roberts, where in 2018 I submitted my thesis titled “Magnetic Resonance Elastography Studies of the Musculoskeletal System”. As part of my PhD I developed an imaging pipeline utilising Magnetic Resonance Elastography (MRE) to quantify the mechanical pathophysiology of the musculoskeletal system, and in part the human brain. The key application of this pipeline was the non-invasive quantification of patient recovery at the Royal Infirmary of Edinburgh (RIE). As part of the development of the pipeline, I worked alongside of a number of clinical research teams investigating the topics of ageing, peak sports performance, critical care, total knee surgery, as well as muscle loading, and the impact that these elicited on lower limb musculature. Further information of my PhD can be found at: https://www.ed.ac.uk/clinical-sciences/edinburgh-imaging/news/2019-news/18-jul-19-congrats-dr-mike-perrins , in addition to oral presentations of some of my work: https://elastography.de/mre-workshop/.
I am currently a Post-Doctoral Research Associate (since April 2019) within the lab of Fisun Hamaratoglu, where the focus of the lab is on cell pattern formation during growth. Building on my image analysis background, my research at Cardiff University is centred around the development of a custom-made Pipeline of Larval Clone Analysis (otherwise known as POLCA). The utilisation of POLCA, in conjunction with a multi-colour lineage tracing tool known as Raeppli, allows for the quantification of growth parameters and proliferation patterns in the development of organs, and was recently demonstrated at EDRC 2019.