Professor Neil Harrison
Clinical Professor in Neuroimaging
- harrisonn4@cardiff.ac.uk
- +44 (0)29 2087 6785
- 1.076, Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
Neil Harrison leads the Immunopsychiatry Research Group based at the Cardiff University Brain Research Imaging Centre (CUBRIC) and the Haydn Ellis Building (HEB).
Prior to moving to Cardiff he spent 10 years in Sussex where he established the first UK Clinical Immunopsychiatry Service providing bespoke treatments for people with difficult-to-treat depression in the context of inflammation. He completed a PhD in Neuroscience at the Wellcome Trust Centre for Neuroimaging (UCL), and psychiatry training at the Maudsley Hospital and National Hospital for Neurology, Queen Square.
His research investigates how the body's immune system interacts with the brain to alter mood, motivation and cognition and contribute to common mental illnesses such as Depression and Alzheimer’s disease.
His research has been funded through grants from the MRC, Wellcome Trust, Arthritis Research UK (now Versus Arthritis) and Janssen Pharmaceutics.
He has just been elected as ‘President Elect for the Psychoneuroimmunology Research Society’. He will take up this position in June 2019 and will be president of PNIRS – the leading international society for research into the bidirectional interactions between the immune system and the brain from June 2020-2021.
2019
- Lynall, M.et al. 2019. Peripheral blood cell-stratified subgroups of inflamed depression. Biological Psychiatry (10.1016/j.biopsych.2019.11.017)
- Mancuso, R.et al. 2019. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain 142(10), pp. 3243-3264. (10.1093/brain/awz241)
- Whale, R.et al. 2019. Factor analyses differentiate clinical phenotypes of idiopathic and interferon-alpha-induced depression.. Brain, Behavior, and Immunity 80, pp. 519-524. (10.1016/j.bbi.2019.04.035)
- Harrison, N. A. 2019. Disentangling the effects of peripheral inflammatory markers on brain functional connectivity. Biological Psychiatry 86(2), pp. 84-86. (10.1016/j.biopsych.2019.05.013)
- Hoogman, M.et al. 2019. Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples. American Journal of Psychiatry 176(7), pp. 531-542. (10.1176/appi.ajp.2019.18091033)
- Morgan, A. R.et al. 2019. Inflammatory biomarkers in Alzheimer's disease plasma. Alzheimer's & Dementia 15(6), pp. 776-787. (10.1016/j.jalz.2019.03.007)
- Manjaly, Z.et al. 2019. Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 90(6), pp. 642-651. (10.1136/jnnp-2018-320050)
- Pariante, C. M.et al. 2019. What's in a name? How about being listed in the "Psychiatry" category in Clarivate's Journal Citation Index!. Brain, Behavior, and Immunity 78, pp. 3-4. (10.1016/j.bbi.2019.01.005)
- Dowell, N. G.et al. 2019. Interferon-alpha induced changes in NODDI predispose to the development of fatigue. Neuroscience 403, pp. 111-117. (10.1016/j.neuroscience.2017.12.040)
- Russell, A.et al. 2019. Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome. Psychoneuroendocrinology 100, pp. 276-285. (10.1016/j.psyneuen.2018.11.032)
- Chamberlain, S. R.et al. 2019. Treatment-resistant depression and peripheral C-reactive protein. British Journal of Psychiatry 224(1), pp. 11-19. (10.1192/bjp.2018.66)
2018
- Mancini, M.et al. 2018. Introducing axonal myelination in connectomics: a preliminary analysis of g-ratio distribution in healthy subjects. NeuroImage 182, pp. 351-.359. (10.1016/j.neuroimage.2017.09.018)
- Rae, C. L.et al. 2018. Face perception enhances insula and motor network reactivity in Tourette syndrome. Brain: A Journal of Neurology 141(11), pp. 3249-3261. (10.1093/brain/awy254)
- Harrison, N. A. and Davies, K. 2018. DMARDs for mental health symptoms in RA. Nature Reviews Rheumatology 14, pp. 507-508. (10.1038/s41584-018-0063-z)
- Savitz, J. and Harrison, N. A. 2018. Interoception and inflammation in psychiatric disorders. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3(6), pp. 514-524. (10.1016/j.bpsc.2017.12.011)
- Khalsa, S. S.et al. 2018. Interoception and mental Health: a roadmap. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3(6), pp. 501-513. (10.1016/j.bpsc.2017.12.004)
- Sethi, A.et al. 2018. A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder. Brain 141(5), pp. 1545-1557. (10.1093/brain/awy048)
- Regan, T.et al. 2018. Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophagesryptophan‐metabolism genes by human macrophages. Journal of Leukocyte Biology 103(4), pp. 681-692. (10.1002/JLB.3A0617-261R)
- Borsini, A.et al. 2018. Interferon-alpha reduces human hippocampal neurogenesis and increases apoptosis via activation of distinct STAT1-dependent mechanisms. International Journal of Neuropsychopharmacology 21(2), pp. 187. (10.1093/ijnp/pyx083)
- Morris, L. S.et al. 2018. Binge drinking differentially affects cortical and subcortical microstructure. Addiction Biology 23(1), pp. 403-411. (10.1111/adb.12493)
- Leday, G. G.et al. 2018. Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biological Psychiatry 83(1), pp. 70-80. (10.1016/j.biopsych.2017.01.021)
2017
- Harrison, N. A.et al. 2017. Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia. Brain 140(9), pp. 2498-2510. (10.1093/brain/awx186)
- Bell, J. A.et al. 2017. Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry 7(8), article number: e1208. (10.1038/tp.2017.155)
- Fialho, R.et al. 2017. Co-infection with HIV associated with reduced vulnerability to symptoms of depression during antiviral treatment for hepatitis C. Psychiatry Research 253, pp. 150-157. (10.1016/j.psychres.2017.03.049)
- Sethi, A.et al. 2017. Magnetization transfer imaging identifies basal ganglia abnormalities in adult ADHD that are invisible to conventional T1 weighted voxel-based morphometry. NeuroImage: Clinical 15, pp. 8-14. (10.1016/j.nicl.2017.03.012)
- Dipasquale, O.et al. 2017. Comparing resting state fMRI de-noising approaches using multi-and single-echo acquisitions. PloS One 12(3), article number: e0173289. (10.1371/journal.pone.0173289)
- Cercignani, M.et al. 2017. Characterizing axonal myelination within the healthy population: a tract-by-tract mapping of effects of age and gender on the fiber g-ratio. Neurobiology of Aging 49, pp. 109-118. (10.1016/j.neurobiolaging.2016.09.016)
2016
- Harrison, N. A. 2016. Commentary on the 2016 named series: Neuroimaging, inflammation and behavior. Brain, Behavior, and Immunity 58, pp. 48-51. (10.1016/j.bbi.2016.08.010)
- Dipasquale, O.et al. 2016. Interferon-α acutely impairs whole-brain functional connectivity network architecture – a preliminary study. Brain, Behavior, and Immunity 58, pp. 31-39. (10.1016/j.bbi.2015.12.011)
- Banca, P., Voon, V. and Harrison, N. A. 2016. Compulsivity across the pathological misuse of drug and non-drug rewards. Frontiers in Behavioral Neuroscience 10, article number: 154. (10.3389/fnbeh.2016.00154)
- Morris, L.et al. 2016. Biases in the explore-exploit tradeoff in addictions: the role of avoidance of uncertainty. Neuropsychopharmacology 41(4), pp. 940-948. (10.1038/npp.2015.208)
- Harrison, N.et al. 2016. A neurocomputational account of how inflammation enhances sensitivity to punishments versus rewards. Biological Psychiatry 80(1), pp. 73-81. (10.1016/j.biopsych.2015.07.018)
- Harrison, N. A. 2016. Brain structures implicated in inflammation associated depression. In: Dantzer, R. and Capuron, L. eds. Inflammation-Associated Depression: Evidence, Mechanisms and Implications., Vol. 31. Current Topics in Behavioral Neurosciences Cham: Springer, pp. 221-248., (10.1007/7854_2016_30)
- Krishnadas, R. and Harrison, N. A. 2016. Depression phenotype, inflammation, and the brain: implications for future research.. Psychosomatic Medicine 78(4), pp. 384-388. (10.1097/PSY.0000000000000339)
- Duka, T., Harrison, N. and Howes, O. 2016. Immune influences on the brain: new findings and implications for treatment. Psychopharmacology 233(9), pp. 1539-1541. (10.1007/s00213-016-4287-9)
- Jenkins, V.et al. 2016. A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’ in breast cancer patients. SpringerPlus 5, article number: 390. (10.1186/s40064-016-2030-y)
- Harrison, N. A. 2016. Feeling cold is contagious. Temperature 3(1), pp. 20-22. (10.1080/23328940.2015.1042567)
- Morris, L.et al. 2016. Jumping the gun: mapping neural correlates of waiting impulsivity and relevance across alcohol misuse. Biological Psychiatry 79(6), pp. 499-507. (10.1016/j.biopsych.2015.06.009)
- Banca, P.et al. 2016. Reflection impulsivity in binge drinking: behavioural and volumetric correlates. Addiction Biology 21(2), pp. 504-515. (10.1111/adb.12227)
- Dowell, N. G.et al. 2016. Acute changes in striatal microstructure predict the development of interferon-alpha induced fatigue. Biological Psychiatry 79(4), pp. 320-328. (10.1016/j.biopsych.2015.05.015)
- Garfinkel, S. N.et al. 2016. Discrepancies between dimensions of interoception in autism: implications for emotion and anxiety.. Biological Psychology 114, pp. 117-126. (10.1016/j.biopsycho.2015.12.003)
- Yoshie, M.et al. 2016. Why i tense up when you watch me: Inferior parietal cortex mediates an audience's influence on motor performance. Scientific Reports 6, pp. -., article number: 19305. (10.1038/srep19305)
- Voon, V.et al. 2016. Waiting impulsivity: the influence of acute methylphenidate and feedback. International Journal of Neuropsychopharmacology 19(1), pp. 1-10. (10.1093/ijnp/pyv074)
- Banca, P.et al. 2016. Novelty, conditioning and attentional bias to sexual rewards. Journal of Psychiatric Research 72, pp. 91-101. (10.1016/j.jpsychires.2015.10.017)
- Morris, L. S.et al. 2016. Fronto-striatal organization: defining functional and microstructural substrates of behavioural flexibility.. Cortex 74, pp. 118-133. (10.1016/j.cortex.2015.11.004)
2015
- Voon, V.et al. 2015. Motivation and value influences in the relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorder. Translational Psychiatry 5, pp. -. (10.1038/tp.2015.165)
- Harrison, N.et al. 2015. Quantitative magnetization transfer imaging as a biomarker for effects of systemic inflammation on the brain. Biological Psychiatry 78(1), pp. 49-57. (10.1016/j.biopsych.2014.09.023)
- Umeda, S.et al. 2015. Structural brain abnormalities in postural tachycardia syndrome: a VBM-DARTEL study. Frontiers in Neuroscience 9(MAR), pp. -., article number: 34. (10.3389/fnins.2015.00034)
- Mavromihelaki, E.et al. 2015. Cyberball3D+: A 3D serious game for fMRI investigating social exclusion and empathy. Presented at: 6th International Conference on Games and Virtual Worlds for Serious Applications (VS-GAMES), Valletta, Malta, 9-12 September 20142014 6th International Conference on Games and Virtual Worlds for Serious Applications (VS-GAMES). IEEE pp. 1-8., (10.1109/VS-Games.2014.7012032)
- Eccles, J.et al. 2015. Sensations of skin infestation linked to abnormal frontolimbic brain reactivity and differences in self-representation. Neuropsychologia 77, pp. 90-96. (10.1016/j.neuropsychologia.2015.08.006)
- Mole, T.et al. 2015. Impulsivity in disorders of food and drug misuse. Psychological Medicine 45(4), pp. 771-782. (10.1017/S0033291714001834)
- Voon, V.et al. 2015. Disorders of compulsivity: a common bias towards learning habits. Molecular Psychiatry 20(3), pp. 345-352. (10.1038/mp.2014.44)
- Voon, V.et al. 2015. Risk-taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence, and magnitude. Neuropsychopharmacology 40(4), pp. 804-812. (10.1038/npp.2014.242)
- Harrison, N.et al. 2015. Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology 40(4), pp. 831-838. (10.1038/npp.2014.222)
- Jones, C.et al. 2015. Neuroanatomical substrates for the volitional regulation of heart rate. Frontiers in Psychology 6(MAR), article number: 300. (10.3389/fpsyg.2015.00300)
2014
- Fialho, R.et al. 2014. HCV triple therapy in co-infection HIV/HCV is not associated with a different risk of developing major depressive disorder. Journal of the International AIDS Society 17(453), article number: 19629. (10.7448/IAS.17.4.19629)
- Worbe, Y.et al. 2014. Neuronal correlates of risk-seeking attitudes to anticipated losses in binge drinkers. Biological Psychiatry 76(9), pp. 717-724. (10.1016/j.biopsych.2013.11.028)
- Harrison, N.et al. 2014. Peripheral inflammation acutely impairs human spatial memory via actions on medial temporal lobe glucose metabolism. Biological Psychiatry 76(7), pp. 585-593. (10.1016/j.biopsych.2014.01.005)
- Voon, V.et al. 2014. Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours. PLoS ONE 9(7), pp. -., article number: e102419. (10.1371/journal.pone.0102419)
- Eccles, J. A.et al. 2014. Joint hypermobility and autonomic hyperactivity: relevance to neurodevelopmental disorders. Journal of Neurology, Neurosurgery and Psychiatry 85(8), pp. e3. (10.1136/jnnp-2014-308883.9)
- Voon, V.et al. 2014. Impulse control disorders in Parkinson's disease: Decreased striatal dopamine transporter levels. Journal of Neurology, Neurosurgery & Psychiatry 85(2), pp. 148-152. (10.1136/jnnp-2013-305395)
- Cooper, E.et al. 2014. You turn me cold: evidence for temperature contagion. PLoS One 9(12), pp. e116126. (10.1371/journal.pone.0116126)
- Mechelmans, D.et al. 2014. Enhanced attentional bias towards sexually explicit cues in individuals with and without compulsive sexual behaviours. PLoS One 9(8), pp. e105476. (10.1371/journal.pone.0105476)
- Voon, V.et al. 2014. Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task. Biological Psychiatry 75(2), pp. 148-155. (10.1016/j.biopsych.2013.05.013)
2013
- Voon, V.et al. 2013. Response inhibition in motor conversion disorder. Movement Disorders 28(5), pp. 612-618. (10.1002/mds.25435)
- Critchley, H. D. and Harrison, N. 2013. Visceral influences on brain and behavior. Neuron 77(4), pp. 624-638. (10.1016/j.neuron.2013.02.008)
- Radulescu, E.et al. 2013. Gray matter textural heterogeneity as a potential in-vivo biomarker of fine structural abnormalities in Asperger syndrome. Pharmacogenomics Journal 13(1), pp. 70-79. (10.1038/tpj.2012.3)
- Harrison, N. A. 2013. Inflammation and mental illness. J Neurol Neurosurg Psychiatry 84(9), pp. e1--e1. (10.1136/jnnp-2013-306103.4)
- Harrison, N.et al. 2013. Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?. Brain, Behavior, and Immunity 31, pp. 189-196. (10.1016/j.bbi.2013.02.001)
- Howell, N.et al. 2013. Increased ventral striatal volume in college-aged binge drinkers. PLos ONE 8(9), article number: e74164. (10.1371/journal.pone.0074164)
- Irvine, M.et al. 2013. Impaired decisional impulsivity in pathological videogamers. PLoS ONE 8(10), article number: e75914. (10.1371/journal.pone.0075914)
- Kranick, S.et al. 2013. Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. Movement Disorders 28(8), pp. 1110-1116. (10.1002/mds.25408)
- Harrison, N. A., Kreibig, S. D. and Critchley, H. D. 2013. A two-way road. In: Armony, J. and Vuilleumier, P. eds. The Cambridge handbook of human affective neuroscience. Cambridge:, pp. 82-106., (10.1017/CBO9780511843716.006)
- Radulescu, E.et al. 2013. Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome. NeuroImage: Clinical 2(1), pp. 716-726. (10.1016/j.nicl.2013.05.010)
2012
- Beacher, F.et al. 2012. Sex differences and autism: brain function during verbal fluency and mental rotation. PLoS One 7(6), article number: e38355. (10.1371/journal.pone.0038355)
- Gray, M.et al. 2012. Emotional appraisal is influenced by cardiac afferent information. Emotion 12(1), pp. 180-191. (10.1037/a0025083)
- Minati, L.et al. 2012. Neural signatures of economic parameters during decision-making: a functional MRI (fMRI), electroencephalography (EEG) and autonomic monitoring study. Brain Topography 25(1), pp. 73-96. (10.1007/s10548-011-0210-1)
- Eccles, J.et al. 2012. Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. British Journal of Psychiatry 200(6), pp. 508-509. (10.1192/bjp.bp.111.092460)
- Beacher, F.et al. 2012. Autism attenuates sex differences in brain structure: a combined voxel-based morphometry and diffusion tensor imaging study. American Journal of Neuroradiology 33(1), pp. 83-89. (10.3174/ajnr.A2880)
2011
- Centeno, M.et al. 2011. Epilepsy causing pupillary hippus: An unusual semiology. Epilepsia 52(8), pp. e93-e96. (10.1111/j.1528-1167.2011.03137.x)
- Beacher, F.et al. 2011. Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers. Psychopharmacology 213(2-3), pp. 603-613. (10.1007/s00213-010-1897-5)
- Jones, C.et al. 2011. Under pressure: response urgency modulates striatal and insula activity during decision-making under risk. PLoS ONE 6(6), article number: e20942. (10.1371/journal.pone.0020942)
2010
- Harrison, N. and Critchley, H. 2010. Neuroimaging and emotion. In: Fink, G. ed. Encyclopedia of Stress. Academic Press, pp. 870-878., (10.1016/B978-012373947-6.00577-8)
- Harrison, N.et al. 2010. The embodiment of emotional feelings in the brain. The Journal of Neuroscience 30(38), pp. 12878-12884. (10.1523/JNEUROSCI.1725-10.2010)
- Harrison, N., Morgan, R. and Critchley, H. 2010. From facial mimicry to emotional empathy: a role for norepinephrine?. Social Neuroscience 5(4), pp. 393-400. (10.1080/17470911003656330)
2009
- Gray, M.et al. 2009. Physiological recordings: basic concepts and implementation during functional magnetic resonance imaging. NeuroImage 47(3), pp. 1105-1115. (10.1016/j.neuroimage.2009.05.033)
- Harrison, N.et al. 2009. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biological Psychiatry 66(5), pp. 407-414. (10.1016/j.biopsych.2009.03.015)
- Harrison, N. and Kopelman, M. 2009. Endocrine diseases and metabolic disorders. In: David, A. S. et al. eds. Lishman's Organic Psychiatry: A Textbook of Neuropsychiatry. Chichester: John Wiley & Sons, pp. 617-688., (10.1002/9781444316803.ch10)
- Gray, M.et al. 2009. Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes. Journal of Neuroscience 29(6), pp. 1817-1825. (10.1523/JNEUROSCI.3363-08.2009)
- Minati, L.et al. 2009. Emotional modulation of visual cortex activity: a functional near-infrared spectroscopy study. NeuroReport 20(15), pp. 1344-1350. (10.1097/WNR.0b013e328330c751)
- Umeda, S.et al. 2009. Functional MRI investigations of emotional processing and autonomic responses in patients with autonomic hyperactivity. NeuroImage 47(Supp 1), pp. S39--S41. (10.1016/S1053-8119(09)72001-4)
- Harrison, N., Gray, M. and Critchley, H. 2009. Dynamic pupillary exchange engages brain regions encoding social salience. Social Neuroscience 4(3), pp. 233-243. (10.1080/17470910802553508)
- Harrison, N.et al. 2009. Neural origins of human sickness in interoceptive responses to inflammation. Biological Psychiatry 66(5), pp. 415-422. (10.1016/j.biopsych.2009.03.007)
2008
- De Martino, B.et al. 2008. Explaining enhanced logical consistency during decision making in autism. The Journal of Neuroscience 28(42), pp. 10746-10750. (10.1523/JNEUROSCI.2895-08.2008)
- Brydon, L.et al. 2008. Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biological Psychiatry 63(11), pp. 1022-1029. (10.1016/j.biopsych.2007.12.007)
2007
- Harrison, N. A. and Critchley, H. D. 2007. Affective neuroscience and psychiatry. British Journal of Psychiatry 191(3), pp. 192-194. (10.1192/bjp.bp.107.037077)
- Gray, M.et al. 2007. Modulation of emotional appraisal by false physiological feedback during fMRI. PLoS One 2(6), article number: e546. (10.1371/journal.pone.0000546)
- Harrison, N., Wilson, C. and Critchley, H. 2007. Processing of observed pupil size modulates perception of sadness and predicts empathy. Emotion 7(4), pp. 724-729. (10.1037/1528-3542.7.4.724)
2006
- Harrison, N.et al. 2006. Pupillary contagion: central mechanisms engaged in sadness processing.. Social Cognitive and Affective Neuroscience 1(1), pp. 5-17. (10.1093/scan/nsl006)
2005
- Hill, D. L. G.et al. 2005. A strategy for automated multimodality image registration incorporating anatomical knowledge and imager characteristics. Presented at: Biennial International Conference on Information Processing in Medical Imaging, 1993Information processing in medical imaging, Vol. 687. Lecture Notes in Computer Science Berlin: Springer pp. 182-196., (10.1007/BFb0013788)
2004
- Harrison, N.et al. 2004. Late recurrences of Sydenham's chorea are not associated with anti-basal ganglia antibodies. Journal of Neurology, Neurosurgery and Psychiatry 75(10), pp. 1478-1479. (10.1136/jnnp.2003.030775)
2003
- Harrison, N.et al. 2003. Atypical herpes type 2 encephalitis associated with normal MRI imaging. Journal of Neurology Neurosurgery and Psychiatry 74(7), pp. 974-976. (10.1136/jnnp.74.7.974)
- Harrison, N.et al. 2003. Case report: dural metastasis in prostate cancer. UroOncology 3(2), pp. 85-91. (10.1080/15610950310001610010)
2001
- Rugg-Gunn, F., Harrison, N. and Duncan, J. 2001. Evaluation of the accuracy of seizure descriptions by the relatives of patients with epilepsy. Epilepsy Research 43(3), pp. 193-199. (10.1016/S0920-1211(00)00209-6)