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Dr Lowri Thomas

Dr Lowri Thomas

Lecturer

School of Pharmacy and Pharmaceutical Sciences

  • Lecturer, school of Pharmacy and Pharmaceutical Sciences, 2018 – present
  • Research Fellow and co-applicant on BHF Programme grant [Predicting anti-arrhythmic drug efficacy from the divergent molecular basis of RyR2 dysfunction in genetic arrhythmia syndromes (£995,228)], Swansea University Medical School, 2016-2018
  • Senior research associate in the group of Prof Alan Williams, Wales Heart Institute, UHW, Cardiff University School of Medicine 2007 -2016.

During this time I was awarded several BHF research grants as principal investigator [Functional assessment of cardiac ryanodine receptor Ca2+ release channel populations: a direct demonstration of coupled gating? (Project grant, 2016-2019, £223,056) and Resolving the contribution of luminal and cytosolic Ca2+ in the dysfunction of sudden cardiac death-linked mutant RyR2 channels (Studentship, 2014- 2017, (£102,393) and co-investigator [Uncovering the mechanisms involved in the block of Ca2+ release from the cardiac sarcoplasmic reticulum by flecainide (Project grant, 2011-2013,£274,862)], supervised 4 PhD students to completion as well as the work of PDRAs.

  • Research associate in the group of Prof Tony Lai, Wales Heart Institute, UHW, Cardiff University School of Medicine, 2006-2007
  • PhD, Cardiac calcium signalling, Cardiff University, 2005
  • BSc (hons) Genetics, Cardiff University, 2001

Engagement

Having been fortunate enough to receive the support of the BHF throughout my career I have been involved in a number of engagement opportunities with fundraisers and members of the general public to raise awareness of the research they fund, including: school visits, presentations at the National Eisteddfod, lab tours, radio and television interviews.

2013

My research focusses on the massive intracellular cardiac ion channel, the ryanodine receptor (RyR2) and its role in health and disease - in particular the generation of cardiac arrhythmia. I use mutagenesis and expression techniques to make recombinant ion channel proteins and assess their gating behaviour (i.e. the pattern of opening and closing) using single channel recording in artificial planar lipid bilayers. I'm also looking at in how these molecular events translate into calcium release dysfunction at the cellular level using calcium imaging in live cell systems.