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 Dr Malik Zaben

Dr Malik Zaben

Lecturer, Neuroscience & Mental Health Research Institute

Email:
zabenm@cardiff.ac.uk
Telephone:
+44 02920 688 333
Location:
3.40, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Available for postgraduate supervision

I am a lecturer in neurosurgery with a special interest in understanding neurogenesis and neuroplasticity after traumatic brain injury (TBI). My research explores potential therapeutic approaches targeting neuroinflmmatory pathways to limit brain damage after injury, and more importantly enhance repair. Unfolding such neurobiological mechanisms will provide better understanding of how we can harness treatments that enhance patients' functional recovery and clinical outcomes. This is relevant to the treatment of many neurobehavioral sequelae that survivors of brain injury often suffer including cognitive/memory impairments, psychiatric disorders (depression/psychosis) and neurodegenerative diseases (Chronic Traumatic Encephalopathy & Alzheimer's Disease).

Education and Professional Qualifications

2004-2007

PhD

University of Southampton, UK

1995-2002

MD

Al-Quds University- Jerusalem

1995

SSC

Average grade of 96.6% (A**)

Professional memberships

Member of Royal College of Surgeons of England

Academic positions

August 2014-present

Lecturer in Neurosurgery

StR in Neurosurgery

Wales Deanery and Cardiff University

Apr2012-Agust 2016

ERUK Clinical Research Fellowship

University Hospital of Wales-Cardiff and Cardiff University

Aug2009-Apr2012

Neurosurgery Senior House Officer

Southampton University Hospitals NHS Trust

Sep2007-Aug2009

EPSRC Post Doctoral Research Fellow

University of Southampton

Sep2003-July2004

Teaching and Research Assistant

Al-Quds University-Jerusalem

Sep2002-Sep2003

House Officer

Al-Makassed Teaching Hospital-Jerusalem

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2007

TBI is the leading cause of death and disability in those younger than 45yrs. Recent advances in TBI management have reduced mortality rate however led to little improvement in clinical functional outcomes. Increasing numbers of post-TBI survivors therefore live with significant physical and mental deficits. Post-TBI inflammation is an important secondary process that starts immediately after injury and may persist for years. My research focuses on mechanisms of enhancing neuronal repair and regenration and axonal plasticity after injury.

My reseach can be divided into the following key project areas:

1. Neuroinflammation

I am interested in investigating the molecular mechanisms that underlie the role brain inflammation in perpetuating the secondary neuronal and axonal injury after TBI both (a) acutely and (b) chronically (degeneration over time). My research focuses on identifying novel early biomarkers of injury/recovery, and the development of novel therapeutics targeting brain immune response after TBI. I am examining the possibility that such interventions may (i) slow neurodegeneration, (ii) improve neurogenesis-associated recovery and (iii) prevent normal neuronal repair that contribute to the development of post-TBI epilepsy.

2. Biomarkers of White Matter Injury

I am interested in studying the relationship between white matter (WM) injury and memory impairment/ recovery after traumatic brain injury.

3. Functional Recovery and Cilinical Outcomes

I am trainee co-PI on two neurosurgical RCTs:

(i) DEXamethasone in Chronic SubDural Haematoma (DEX-CSDH) http://www.dexcsdh.org

(ii) Randomised Evaluation of Surgery with Craniectomy for patients Undergoing Evacuation of Acute SubDural Haematoma (RESCUE ASDH) http://www.rescueasdh.org

1. Neuroinflammation

2. Tissue repair

3. Neuro-imaging