Overview
Timothy Walsh is currently Professor of Medical Microbiology and Antibiotic Resistance at Cardiff University, Cardiff, Wales, and leads an active research in antibiotic resistance and evaluating pipeline antibiotics. Previously, he was a Reader in Medical Microbiology at the University of Bristol following several postdoctoral research positions in London, UK. Prof. Walsh is a member of the Australian Society of Microbiology, Society for General Microbiology (UK), British Society of Antimicrobial Chemotherapy, American Society of Microbiology and European Society of Clinical Microbiology and Infectious Diseases. Prof. Walsh’s research is focused on assessing the burden of AMR in low-middle income countries, particularly in the most vulnerable populations. He has published/presented over 600 papers in particular on the characterization of AMR mechanisms in Gram-negative bacteria, and publishes in journals such as Clinical Microbiological Reviews, Microbiology and Molecular Biology Reviews, Clinical Infectious Diseases, Nature, Nature Microbiology, Nature Communications, Lancet and Lancet Infectious Diseases. His research has been funded by the, MRC, EC, GCRF, UKRI, Wellcome Trust, European Bank, BBSRC, and the Gates Foundation. After obtaining a BSc in Applied Laboratory Science and a Post Graduate Diploma of Immunology/Microbiology at the University of Tasmania in Australia, Prof. Walsh read Molecular Microbiology at the University of Bristol under the tutelage of Prof. Peter Bennett, and completed his PhD in 1995.
Biography
I have been studying AMR mechanisms for over 20 years, published over 300 papers and publish regularly in Nature and Lancet journals. I am PI of BARNARDS, the lead Gates Foundation project on clinical AMR, examining the burden of neonatal sepsis in Pakistan, India, Bangladesh, Rwanda, South Africa, Nigeria (Abuja and Kano) and Ethiopia. This project thus far has enrolled 36,000 mothers and analysed over 2000 sepsis cases.
I am also PI of DETER-XDR-CHINA and the recently funded DX-China-HUB, a study examining the spread and burden of AMR in public health sectors and hospitals in 30 provinces in China. I hold an honorary Chair at the Chinese Agricultural University and I am an AMR advisor to the Chinese MoH and was involved in the decision for the Chinese government to ban the use of colistin as a growth-promoter in farming. I am also PI of CUT-SEC, a ‘one-health” project in China and Thailand.
I am also PI of the MRC grant to establish an AMR surveillance system throughout Vietnam in collaboration with NIHE and the Wellcome Trust Center in Hanoi. In addition to BARNARDS, I also have AMR studies in Karachi and Peshawar, Niger (Clean Kids Study) and support MSF Microbiology/AMR lab in Jordan. My lab has provided molecular support for the Russian Federation Reference Laboratory in AMR surveillance that covers Russia, Belarus and Kazakhstan. I also have clinical studies examining the burden of AMR in the community and hospitals San Paolo (Brazil), Phitsanulok (Thailand) and Tanta (Egypt) and Dhaka (Bangladesh).
I have also been appointed as a lead microbiologist to the Fleming Fund Expert Advisory Panel – a £265M AMR capacity building program with special interest in Nigeria, Pakistan and Bangladesh. He is also advisor to the WHO, Chinese CDC and MSF.
Publications
2021
- Sands, K.et al. 2021. Characterization of antimicrobial resistant Gram-negative bacteria that cause neonatal sepsis in seven low and middle-income countries. Nature Microbiology 6, pp. 512–523. (10.1038/s41564-021-00870-7)
- Tansawai, U.et al. 2021. Emergence of mcr-3-mediated IncP and IncFII plasmids in Thailand. Journal of Global Antimicrobial Resistance 24, pp. 446-447. (10.1016/j.jgar.2021.02.006)
- Qamar, M. U.et al. 2021. Clonal relatedness and plasmid profiling of extensively drug-resistant New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae clinical isolates. Future Microbiology 16(4), pp. 229–239. (10.2217/fmb-2020-0315)
- Powell, L. C.et al. 2021. Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes 7, article number: 13. (10.1038/s41522-020-00172-6)
2020
- Zhou, Y.et al. 2020. Mobile oxazolidinone/phenicol resistance gene optrA in chicken Clostridium perfringens. Journal of Antimicrobial Chemotherapy 75(10), pp. 3067-3069. (10.1093/jac/dkaa236)
- Martins, W. M. B. S.et al. 2020. Clinical and molecular description of a high-copy IncQ1 KPC-2 plasmid harbored by the international ST15 Klebsiella pneumoniae clone. mSphere 5, article number: e00756-20. (10.1128/mSphere.00756-20)
- Andrey, D. O.et al. 2020. An emerging clone, KPC-2-producing Klebsiella pneumoniae ST16, associated with high mortality rates in a CC258 endemic setting. Clinical Infectious Diseases 71(7), pp. e141-e150. (10.1093/cid/ciz1095)
- Zhai, R.et al. 2020. Contaminated in-house environment contributes to the persistence and transmission of NDM-producing bacteria in a Chinese poultry farm. Environment International 139, article number: 105715. (10.1016/j.envint.2020.105715)
- Farzana, R.et al. 2020. Molecular and epidemiological analysis of a Burkholderia cepacia sepsis outbreak from a tertiary care hospital in Bangladesh. PLoS Neglected Tropical Diseases 14(4), article number: e0008200. (10.1371/journal.pntd.0008200)
- Yang, Q. E.et al. 2020. Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. ISME Journal 14, pp. 861-865. (10.1038/s41396-019-0578-6)
- Naha, S.et al. 2020. KPC-2-producing Klebsiella pneumoniae ST147 in a neonatal unit: Clonal isolates with differences in colistin susceptibility attributed to AcrAB-TolC pump. International Journal of Antimicrobial Agents 55(3), article number: 105903. (10.1016/j.ijantimicag.2020.105903)
2019
- Wang, L.et al. 2019. Novel plasmid-mediated tet(X5) gene conferring resistance to tigecycline, eravacycline, and omadacycline in a clinical Acinetobacter baumannii Isolate. Antimicrobial Agents and Chemotherapy 64(1), article number: e01326-19. (10.1128/AAC.01326-19)
- Li, J.et al. 2019. Inter-host transmission of carbapenemase-producing escherichia coli among humans and backyard animals. Environmental Health Perspectives 127(10), article number: 107009. (10.1289/EHP5251)
- Kiddee, A.et al. 2019. Risk factors for extended-spectrum β-lactamase-producing Enterobacteriaceae carriage in patients admitted to Intensive Care Unit in a Tertiary Care Hospital in Thailand. Microbial Drug Resistance 25(8), pp. 1182-1190. (10.1089/mdr.2018.0318)
- Shen, Y.et al. 2019. Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain. Environment International 130, article number: 104708. (10.1016/j.envint.2019.03.056)
- Farzana, R.et al. 2019. Emergence of mcr-1 mediated colistin resistant Escherichia coli from a hospitalized patient in Bangladesh. Journal of Infection in Developing Countries 13(8), pp. 773-776. (10.3855/jidc.11541)
- Langley, G. W.et al. 2019. Profiling interactions of vaborbactam with metallo-β-lactamases. Bioorganic and Medicinal Chemistry Letters 29(15), pp. 1981-1984. (10.1016/j.bmcl.2019.05.031)
- Tansawai, U., Walsh, T. R. and Niumsup, P. R. 2019. Extended spectrum ß-lactamase-producing Escherichia coli among backyard poultry farms, farmers, and environments in Thailand. Poultry Science 98(6), pp. 2622-2631. (10.3382/ps/pez009)
- Stewardson, A. J.et al. 2019. Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study. Lancet Infectious Diseases 19(6), pp. 601-610. (10.1016/S1473-3099(18)30792-8)
- He, T.et al. 2019. Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans. Nature Microbiology (10.1038/s41564-019-0445-2)
- Qamar, M. U.et al. 2019. Dissemination of genetically diverse NDM-1, -5, -7 producing-Gram-negative pathogens isolated from pediatric patients in Pakistan. Future Microbiology 14(8) (10.2217/fmb-2019-0012)
- Farzana, R.et al. 2019. Outbreak of hypervirulent multi-drug resistant Klebsiella variicola causing high mortality in neonates in Bangladesh. Clinical Infectious Diseases 7, pp. 1225-1227. (10.1093/cid/ciy778)
- Juhas, M.et al. 2019. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy 74(4), pp. 944-952. (10.1093/jac/dky546)
- Salimraj, R.et al. 2019. Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases. FEBS Journal 286(1), pp. 169-183. (10.1111/febs.14695)
- Wang, Z.et al. 2019. Genetic environment of colistin resistance genes mcr-1 and mcr-3 in Escherichia coli from one pig farm in China. Veterinary Microbiology 230, pp. 56-61. (10.1016/j.vetmic.2019.01.011)
- Tyrrell, J. M.et al. 2019. The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. Peptides 112, pp. 149-153. (10.1016/j.peptides.2018.12.006)
- Yu, Y.et al. 2019. Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model. Journal of Antimicrobial Chemotherapy 74(14), pp. 87-95. (10.1093/jac/dky413)
- Yang, Q. E.et al. 2019. Environmental dissemination of mcr-1 positive Enterobacteriaceae by Chrysomya spp. (common blowfly): An increasing public health risk. Environment International 122, pp. 281-290. (10.1016/j.envint.2018.11.021)
2018
- Shen, Z.et al. 2018. Emerging carriage of NDM-5 and MCR-1 in Escherichia coli from healthy people in multiple regions in China: a cross sectional observational study. EClinicalMedicine 6, pp. 11-20. (10.1016/j.eclinm.2018.11.003)
- Qamar, M. U.et al. 2018. First identification of clinical isolate of a Novel “NDM-4” producing Escherichia coli ST405 from urine sample in Pakistan. Brazilian Journal of Microbiology 49(4), pp. 949-950. (10.1016/j.bjm.2018.02.009)
- Shen, Y.et al. 2018. Prevalence and genetic analysis of mcr-3-Positive aeromonas species from humans, retail meat, and environmental water samples. Antimicrobial Agents and Chemotherapy 62(9), article number: e00404-18. (10.1128/AAC.00404-18)
- Collignon, P.et al. 2018. Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis. The Lancet Planetary Health 2(9), pp. e398-e405. (10.1016/S2542-5196(18)30186-4)
- Walsh, T. R. 2018. A one-health approach to antimicrobial resistance. Nature Microbiology 3(8), pp. 854-855. (10.1038/s41564-018-0208-5)
- Shen, Y.et al. 2018. Anthropogenic and environmental factors associated with high incidence of mcr-1 carriage in humans across China. Nature Microbiology 3(9), pp. 1054-1062. (10.1038/s41564-018-0205-8)
- Li, H.et al. 2018. Molecular insights into functional differences between mcr-3- and mcr-1-mediated colistin resistance. Antimicrobial Agents and Chemotherapy, article number: AAC.00366. (10.1128/AAC.00366-18)
- Kiddee, A.et al. 2018. Risk factors for gastrointestinal colonization and acquisition of carbapenem-resistant gram-negative bacteria among patients in intensive care units in Thailand. Antimicrobial Agents and Chemotherapy 62(8), article number: e00341. (10.1128/AAC.00341-18)
- Zowawi, H. M.et al. 2018. Identification of carbapenem-resistant Pseudomonas aeruginosa in selected hospitals of the Gulf Cooperation Council States: dominance of high-risk clones in the region. Journal of Medical Microbiology 67(6), pp. 846-853. (10.1099/jmm.0.000730)
- Yu, Y.et al. 2018. Combination therapy strategies against multiple-resistant streptococcus suis. Frontiers in Pharmacology 9, article number: 489. (10.3389/fphar.2018.00489)
- Yang, Q. E.et al. 2018. Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 62(5), article number: e02642-17. (10.1128/AAC.02642-17)
- Carretto, E.et al. 2018. Clinical validation of sensitest colistin, a broth microdilution-based method to evaluate colistin MICs. Journal of Clinical Microbiology 56(4), article number: e01523-17. (10.1128/JCM.01523-17)
- Nadimpalli, M.et al. 2018. Combating global antibiotic resistance: emerging one health concerns in lower- and middle-income countries. Clinical Infectious Diseases 66(6), pp. 963-969. (10.1093/cid/cix879)
- Niumsup, P. R.et al. 2018. Prevalence and risk factors for intestinal carriage of CTX-M-type ESBLs in Enterobacteriaceae from a Thai community. European Journal of Clinical Microbiology and Infectious Diseases 37(1), pp. 69-75. (10.1007/s10096-017-3102-9)
- Shen, Y.et al. 2018. Heterogeneous and flexible transmission of mcr-1 in hospital-associated escherichia coli. mBio 9(4), article number: e00943-18. (10.1128/mBio.00943-18)
2017
- Djoko, K. Y.et al. 2017. Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy 61(12), article number: AAC.02280-17. (10.1128/AAC.02280-17)
- Tian, G.et al. 2017. MCR-1-producing Klebsiella pneumoniae outbreak in China. Lancet Infectious Diseases 17(6) (10.1016/S1473-3099(17)30266-9)
- Yin, W.et al. 2017. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio 8(3), pp. e00543-17. (10.1128/mBio.00543-17)
- Yang, Q. and Walsh, T. 2017. Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance. FEMS Microbiology Reviews 41(3), pp. 343-353. (10.1093/femsre/fux006)
- Zhang, R.et al. 2017. Presence of VIM-positive pseudomonas species in chickens and their surrounding environment. Antimicrobial Agents and Chemotherapy 61(7), article number: e00167-17. (10.1128/AAC.00167-17)
- Lei, L.et al. 2017. mcr-1 in Enterobacteriaceae from Companion Animals,Beijing, China, 2012–2016. Emerging Infectious Diseases 23(4), pp. 710-711. (10.3201/eid2304.161732)
- Wang, Y.et al. 2017. Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1 -positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study. Lancet Infectious Diseases 17(4), pp. 390-399. (10.1016/S1473-3099(16)30527-8)
- Liu, Z.et al. 2017. Plasmid-mediated novel blaNDM-17 gene encoding a Carbapenemase with enhanced activity in a sequence type 48 Escherichia coli strain. Antimicrobial Agents and Chemotherapy 61(5), article number: e02233-16. (10.1128/AAC.02233-16)
- Chen, X.et al. 2017. Detection and dissemination of the colistin resistance gene, mcr-1, from isolates and faecal samples in China. Journal of Medical Microbiology 66(2), pp. 119-125. (10.1099/jmm.0.000425)
- Wang, Y.et al. 2017. Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production. Nature Microbiology 2, article number: 16260. (10.1038/nmicrobiol.2016.260)
- Grundmann, H.et al. 2017. Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study. Lancet Infectious Diseases 17(2), pp. 153-163. (10.1016/S1473-3099(16)30257-2)
- Hancock, S. J.et al. 2017. Identification of IncA/C plasmid replication and maintenance genes and development of a plasmid multilocus sequence typing scheme. Antimicrobial Agents and Chemotherapy 61(2), article number: e01740-16. (10.1128/AAC.01740-16)
- Hinchliffe, P.et al. 2017. Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1. Scientific Reports 7, article number: 39392. (10.1038/srep39392)
- Coates, K.et al. 2017. 1.12 A˚ resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2. Acta Crystallographica Section F Structural Biology Communications 73(8), pp. 443-449. (10.1107/S2053230X17009669)
2016
- Walsh, T. R. and Wu, Y. 2016. China bans colistin as a feed additive for animals [Comment]. Lancet Infectious Diseases 16(10), pp. 1102-1103. (10.1016/S1473-3099(16)30329-2)
- Wailan, A. M.et al. 2016. Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and IncFIIY plasmids. Antimicrobial Agents and Chemotherapy 60(7), pp. 4082-4088. (10.1128/AAC.00368-16)
- Yang, Q. E.et al. 2016. Complete sequence of the FII plasmid p42-2, carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli. Antimicrobial Agents and Chemotherapy 60(7), pp. 4336-4338. (10.1128/AAC.00475-16)
- Tyrrell, J. M.et al. 2016. Genetic & virulence profiling of ESBL-positive E. coli from nosocomial & veterinary sources. Veterinary Microbiology 186, pp. 37-43. (10.1016/j.vetmic.2016.02.007)
- Walsh, T. R., Efthimiou, J. and Dréno, B. 2016. Systematic review of antibiotic resistance in acne: an increasing topical and oral threat. The Lancet Infectious Diseases 16(3), pp. e23-e33. (10.1016/S1473-3099(15)00527-7)
- Liu, Y.et al. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infectious Diseases 16(2), pp. 161-168. (10.1016/S1473-3099(15)00424-7)
- Chen, D.et al. 2016. Infection by and dissemination of NDM-5-producing Escherichia coli in China. Journal of Antimicrobial Chemotherapy 71(2), pp. 563-565. (10.1093/jac/dkv352)
2015
- Qamar, M. U.et al. 2015. Prevalence and clinical burden of NDM-1 positive infections in pediatric and neonatal patients in pakistan. The Pediatric Infectious Disease Journal 34(4), pp. 452-454. (10.1097/INF.0000000000000582)
- Zowawi, H. M.et al. 2015. Molecular epidemiology of carbapenem-resistant acinetobacter baumannii isolates in the Gulf cooperation council states: dominance of OXA-23-type producers. Journal of Clinical Microbiology 53(3), pp. 896-903. (10.1128/JCM.02784-14)
- Jones, L. S.et al. 2015. Characterization of plasmids in extensively drug-resistant acinetobacter strains isolated in India and Pakistan. Antimicrobial Agents and Chemotherapy 59(2), pp. 923-929. (10.1128/AAC.03242-14)
2014
- Ferguson, E. L.et al. 2014. Dextrin-Colistin conjugates as a model bioresponsive treatment for multidrug resistant bacterial infections. Molecular Pharmaceutics 11(12), pp. 4437-4447. (10.1021/mp500584u)
- Jones, L. S.et al. 2014. Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India. Antimicrobial Agents and Chemotherapy 58(7), pp. 4211-4213. (10.1128/AAC.02500-14)
- King, A. M.et al. 2014. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature 510, pp. 503-506. (10.1038/nature13445)
- Zowawi, H. M.et al. 2014. Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers.. Antimicrobial Agents and Chemotherapy 58(6), pp. 3085-3090. (10.1128/AAC.02050-13)
- Petty, N. K.et al. 2014. Global dissemination of a multidrug resistant Escherichia coli clone. Proceedings of the National Academy of Sciences of the United States of America 111(15), pp. 5694-5699. (10.1073/pnas.1322678111)
- Gould, I. M.et al. 2014. MDRO Beijing Consensus Meeting Report: Global burden of multidrug-resistant organisms' current antimicrobial resistance problems in Asia-Pacific. Journal of Antimicrobial Resistance 2(1), pp. 7-9. (10.1016/j.jgar.2013.10.005)
2013
- Edelstein, M. V.et al. 2013. Spread of extensively resistant VIM-2-positive ST235 Pseudomonas aeruginosa in Belarus, Kazakhstan, and Russia: a longitudinal epidemiological and clinical study. The Lancet Infectious Diseases 13(10), pp. 867-876. (10.1016/S1473-3099(13)70168-3)
- Zowawi, H.et al. 2013. β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula. Clinical Microbiology Reviews 26(3), pp. 361-380. (10.1128/CMR.00096-12)
2012
- Khan, S.et al. 2012. Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics. Antimicrobial Agents and Chemotherapy 56(10), pp. 5134-5141. (10.1128/AAC.00525-12)
- Darley, E.et al. 2012. NDM-1 polymicrobial infections including 'Vibrio cholerae'. The Lancet 380(9850), pp. 1358. (10.1016/S0140-6736(12)60911-8)
- El Salabi, A., Walsh, T. R. and Chouchani, C. 2012. Extended spectrum β -lactamases, carbapenemases and mobile genetic elements responsible for antibiotics resistance in Gram-negative bacteria. Critical Reviews in Microbiology 39(2), pp. 113-122. (10.3109/1040841X.2012.691870)
- El Salabi, A.et al. 2012. Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy 56(5), pp. 2241-2245. (10.1128/AAC.05640-11)
- Giske, C. G.et al. 2012. Diverse sequence types of klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrobial Agents and Chemotherapy 56(5), pp. 2735-2738. (10.1128/AAC.06142-11)
- Toleman, M. A. H.et al. 2012. blaNDM-1 is a chimera likely constructed in acinetobacter baumannii. Antimicrobial Agents and Chemotherapy 56(5), pp. 2773-2776. (10.1128/AAC.06297-11)
- Walsh, T. R.et al. 2012. Dissemination of NDM-1 - authors' reply [Letter]. The Lancet Infectious Diseases 12(2), pp. 101-102. (10.1016/S1473-3099(11)70372-3)
2011
- Toleman, M. A. H. and Walsh, T. R. 2011. Combinatorial events of insertion sequences and ICE in Gram-negative bacteria. FEMS Microbiology Reviews 35(5), pp. 912-935. (10.1111/j.1574-6976.2011.00294.x)
- Davey, M. S.et al. 2011. A promising target for treatment of multidrug-resistant bacterial infections [Letter]. Antimicrobial Agents and Chemotherapy 55(7), pp. 3635-3636. (10.1128/AAC.00382-11)
- Walsh, T. R.et al. 2011. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. The Lancet Infectious Diseases 11(5), pp. 355-362. (10.1016/S1473-3099(11)70059-7)
- Livermore, D. M.et al. 2011. Balkan NDM-1: Escape or transplant? [Correspondence]. The Lancet Infectious Diseases 11(3), pp. 164. (10.1016/S1473-3099(11)70048-2)
- Walsh, T. R. and Toleman, M. A. H. 2011. The new medical challenge: why NDM-1? Why Indian?. Expert Review of Anti-infective Therapy 9(2), pp. 137-141. (10.1586/eri.10.159)
- Samuelsen, ?.et al. 2011. Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. Clinical Microbiology and Infection 17(12), pp. 1811-1816. (10.1111/j.1469-0691.2011.03532.x)
- Mata, C.et al. 2011. Association of blaDHA-1 and qnrB genes carried by broad-host-range plasmids among isolates of Enterobacteriaceae at a Spanish hospital. Clinical Microbiology and Infection 17(10), pp. 1514-1517. (10.1111/j.1469-0691.2011.03539.x)
- Nordmann, P.et al. 2011. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. Journal of Antimicrobial Chemotherapy 66(4), pp. 689-692. (10.1093/jac/dkq520)
- Mata, C.et al. 2011. Prevalence of SXT/R391-like integrative and conjugative elements carrying blaCMY-2 in Proteus mirabilis. Journal of Antimicrobial Chemotherapy 66(10), pp. 2266-2270. (10.1093/jac/dkr286)
- Walsh, T. R. and Toleman, M. A. H. 2011. The emergence of pan-resistant Gram-negative pathogens merits a rapid global political response. Journal of Antimicrobial Chemotherapy 67(1), pp. 1-3. (10.1093/jac/dkr378)
- Mata, C.et al. 2011. Plasmid typing and genetic context of AmpC β-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: findings from a Spanish hospital 1999-2007. Journal of Antimicrobial Chemotherapy 67(1), pp. 115-122. (10.1093/jac/dkr412)
- Sidjabat, H.et al. 2011. Carbapenem resistance in "Klebsiella pneumoniae" due to the New Delhi Metallo-β-lactamase. Clinical Infectious Diseases 52(4), pp. 481-484. (10.1093/cid/ciq178)
2010
- Davey, M. S.et al. 2010. Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria [Abstract]. Immunology 131, pp. 63-63. (10.1111/j.1365-2567.2010.03390.x)
- Hammerum, A. M.et al. 2010. Global spread of New Delhi metallo-β-lactamase 1. The Lancet Infectious Diseases 10(12), pp. 829-830. (10.1016/S1473-3099(10)70276-0)
- Kumarasamy, K. K.et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. The Lancet Infectious Diseases 10(9), pp. 597-602. (10.1016/S1473-3099(10)70143-2)
- Hawrani, A.et al. 2010. Thermodynamics of RTA3 peptide binding to membranes and consequences for antimicrobial activity. Biochimica et Biophysica Acta - Biomembranes 1798(6), pp. 1254-1262. (10.1016/j.bbamem.2010.03.017)
- Walsh, T. R.et al. 2010. New Delhi metallo-beta-lactamase 1 [Authors' reply]. The Lancet Infectious Diseases 10(11), pp. 752-754. (10.1016/S1473-3099(10)70245-0)
- Ferreira, S.et al. 2010. Carriage of qnrA1 and qnrB2, blaCTX-M15, and complex class 1 integron in a clinical multiresistant Citrobacter freundii isolate. Diagnostic Microbiology and Infectious Disease 67(2), pp. 188-190. (10.1016/j.diagmicrobio.2010.01.003)
- Ferreira, S.et al. 2010. First description of klebsiella pneumoniae clinical isolates carrying both qnrA and qnrB genes in Portugal. International Journal of Antimicrobial Agents 35(6), pp. 584-586. (10.1016/j.ijantimicag.2010.01.019)
- Wootton, M.et al. 2010. Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins. Journal of Antimicrobial Chemotherapy 65(1), pp. 79-81. (10.1093/jac/dkp404)
- Toleman, M. A. H., Walsh, T. R. and Call, D. R. 2010. ISCR elements are key players in IncA/C plasmid evolution [Letter]. Antimicrobial Agents and Chemotherapy 54(8), pp. 3534. (10.1128/AAC.00383-10)
- Nordmann, P.et al. 2010. How to detect NDM-1 producers. Journal of Clinical Microbiology 49(2), pp. 718-721. (10.1128/JCM.01773-10)
2009
- Yong, D.et al. 2009. Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in klebsiella pneumoniae sequence Type 14 from India. Antimicrobial Agents and Chemotherapy 53(12), pp. 5046-5054. (10.1128/AAC.00774-09)
- El Salabi, A.et al. 2009. First report of the metallo-β-lactamase SPM-1 in Europe. Antimicrobial Agents and Chemotherapy 54(1), pp. 582. (10.1128/AAC.00719-09)
- Wootton, M.et al. 2009. Evaluation of the Effectiveness of Common Hospital Hand Disinfectants Against Methicillin-Resistant Staphylococcus aureus, Glycopeptide-Intermediates, S aureus, and Heterogeneous Glycopeptide-Intermediate S. aureus. Infection Control and Hospital Epidemiology 30(3), pp. 226-232. (10.1086/595691)
- Patzer, J. A.et al. 2009. Emergence and persistence of integron structures harbouring VIM genes in the Children's Memorial Health Institute, Warsaw, Poland, 1998-2006. Journal of Antimicrobial Chemotherapy 63(2), pp. 269-273. (10.1093/jac/dkn512)
- Giske, C. G.et al. 2009. Redefining extended-spectrum β-lactamases: balancing science and clinical need - authors' response. Journal of Antimicrobial Chemotherapy 64(1), pp. 213-215. (10.1093/jac/dkp143)
- Poirel, L.et al. 2009. ISCR2, another vehicle for blaVEB gene acquisition. Antimicrobial Agents and Chemotherapy 53(11), pp. 4940-4943. (10.1128/AAC.00414-09)
- Samuelsen, O.et al. 2009. Molecular epidemiology of metallo-β-lactamase-producing pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. Antimicrobial Agents and Chemotherapy 54(1), pp. 346-352. (10.1128/AAC.00824-09)
- Aktas, Z.et al. 2009. CTX-M-15 carried on Incn-type plasmids in Klebsiella pneumoniae. Turkiye Klinikleri Journal of Medical Sciences 29(6), pp. 1355-1364.
2008
- Hawrani, A.et al. 2008. Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. Journal of Biological Chemistry 283(27), pp. 18636-18645. (10.1074/jbc.M709154200)
- Haldorsen, B.et al. 2008. The AmpC phenotype in Norwegian clinical isolates of Escherichia coli is associated with an acquired ISEcp1-like ampC element or hyperproduction of the endogenous AmpC. Journal of Antimicrobial Chemotherapy 62(4), pp. 694-702. (10.1093/jac/dkn257)
- Giske, C. G.et al. 2008. Redefining extended-spectrum β-lactamases: balancing science and clinical need. Journal of Antimicrobial Chemotherapy 63(1), pp. 1-4. (10.1093/jac/dkn444)
- Samuelsen, O.et al. 2008. Kinetic characterization of VIM-7, a divergent member of the VIM metallo-β-lactamase family. Antimicrobial Agents and Chemotherapy 52(8), pp. 2905-2908. (10.1128/AAC.00166-08)
- Toleman, M. A. H. and Walsh, T. R. 2008. Evolution of the ISCR3 group of ISCR elements. Antimicrobial Agents and Chemotherapy 52(10), pp. 3789-3791. (10.1128/AAC.00479-08)
- Li, H., Walsh, T. R. and Toleman, M. A. H. 2008. Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by pseudomonas aeruginosa via a novel ISCR element, ISCR5. Antimicrobial Agents and Chemotherapy 53(3), pp. 1248-1251. (10.1128/AAC.00480-08)
- Samuelsen, O.et al. 2008. The first metallo-β-lactamase identified in Norway is associated with a TniC-like transposon in a pseudomonas aeruginosa isolate of sequence type 233 imported from Ghana. Antimicrobial Agents and Chemotherapy 53(1), pp. 331-332. (10.1128/AAC.00785-08)
- Li, H.et al. 2008. Complete sequence of p07-406, a 24,179-base-pair plasmid harboring the blaVIM-7 metallo-β-lactamase gene in a pseudomonas aeruginosa isolate from the United States. Antimicrobial Agents and Chemotherapy 52(9), pp. 3099-3105. (10.1128/AAC.01093-07)
- Yusof, A.et al. 2008. Evaluation of a new etest vancomycin-teicoplanin strip for detection of glycopeptide-intermediate staphylococcus aureus (GISA), in particular, heterogeneous GISA. Journal of Clinical Microbiology 46(9), pp. 3042-3047. (10.1128/JCM.00265-08)
- Gonullu, N.et al. 2008. Dissemination of CTX-M-15 β-lactamase genes carried on inc FI and FII plasmids among clinical isolates of escherichia coli in a university hospital in Istanbul, Turkey. Journal of Clinical Microbiology 46(3), pp. 1110-1112. (10.1128/JCM.01974-07)
- Walsh, T. R. 2008. Clinically significant carbapenemases: an update. Current Opinion in Infectious Diseases 21(4), pp. 367-371. (10.1097/QCO.0b013e328303670b)
2007
- Toleman, M. . A. H.et al. 2007. Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes. Emerging infectious diseases 13, pp. 559-65.
2006
- Murphy, T. A.et al. 2006. Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases. Journal of Molecular Biology 357(3), pp. 890-903. (10.1016/j.jmb.2006.01.003)
2005
- Simm, A. M.et al. 2005. Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases. Biochemical Journal 387(3), pp. 585-590. (10.1042/BJ20041542)
2002
- Simm, A. M.et al. 2002. Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysis. Journal of Biological Chemistry 277(27), pp. 24744-24752. (10.1074/jbc.M201524200)
