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Dr Eunju Jenny Shin

Dr Eunju Jenny Shin

Lecturer, Neuroscience & Mental Health Research Institute

School of Medicine

+44 (0)29 2068 8332
3.40, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

My research is to study the functions of the genes found to increase the risk of schizophrenia on human neurons and their precursors. Human neurons can be differentiated from human pluripotent stem cells or from fibroblast directly. So far DLG2 (one of the postsynaptic protein) has been my main focus and has been studied on human embryonic stem cell background. Recently I started to investigate direct conversion of neurons from fibroblasts in order to obtain more mature neurons in a shorter time and to handle more lines at the same time. Generated neurons and precursors have been studied in terms of gene expression and protein expression. Physiological measures will be added in the near future. Phenotypes and underlying mechanisms in knockout neurons and precursors will help understanding the disease mechanisms and delineate the possible drug targets.





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