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Dr Thomas Pembroke

Senior Clinical Lecturer

School of Medicine

Email
pembroket@cardiff.ac.uk
Telephone
+44 29206 87078
Campuses
UHW Main Building
Users
Available for postgraduate supervision

Overview

I am a clinical academic hepatologist with an interest in the role of inflammation in controlling and causing liver disease.

During my PhD I investigated the role of natural killer (NK) cells controlling and causing inflammation in chronic hepatitis C virus (HCV) infection in response to interferon alpha treatment. For the first time I demonstrated the innate response to interferon by serial sampling of intrahepatic NK human liver through out treatment.

During the later part of my PhD and with the benefit of an Academy of Medical Sciences Starter Grant for Clinical Lecturers I investigated the impingement of HCV proteins and polyproteins on NKp46 induced NK cell activation and evasion.

I was awarded a Canadian Association for the Study of Liver Disease Fellowship to undertake a clinical Fellowship at McGil University Health Centre in Montreal Canada. As part of the fellowship I investigated the role of contribution of fatty liver disease and HCV co-infection in the development of liver disease in HIV infected individuals.

I currently hold a Ser Cymru Fellowship Precision Medicine Fellowship investigating the biomarkers of bacterial infection in decompensated cirrhosis.

In combination with NHS Wales Informatics Service and the Wales Liver Disease Delivery Group I have developed the Wales Liver Registry of all liver disease diagnoses in Wales from 1999 with a prospective analytic pipeline.

My clinical interests are decompenated cirrhosis and hepatocellular carcinoma.

PLEASE NOTE THIS IS AN ACADEMIC WEBSITE WITH ACADEMIC CONTACT DETAILS. FOR ANY CLINICAL QUERIES PLEASE CONTACT MY NHS SECRETARY THROUGH UNIVERSITY HOSPITAL OF WALES (02921847956)

Biography

2018     Senior Clinical Lecturer, Cardiff University,

Honorary Consultant in Gastroenterology & Hepatology, University Hospital of Wales

2018                 Locum Consultant in Gastroenterology University Hospital of Wales (3 months)

2016-17            Hepatology & Liver Transplantation Fellow McGill University Health Centre Montreal Canada

2009-18            Clinical Lecturer- Welsh Clinical Academic Tract Gastroenterology & Hepatology

Clinical posts: King’s College Hospital London Liver Unit           2017 (3 months)

Royal Gwent Hospital                                        2017-18

University Hospital of Wales                              2013-16

Royal Glamorgan Hospital                                 2009-10

Academic posts: AMS Starter Grant Clinical Lecturer                 2014- 2017

Clinical Fellow TaCTiCC Trial                               2014- 2016

Phase Ib/IIa Immunotherapy study

Cardiff University PhD                                       2010-13

2007-09            Core Medical training South Wales Rotation

2005-07            Foundation Training Program North East Thames Rotation

Education

2015                 MRCP (UK) Gastroenterology Specialty Certificate Examination

2014                 PhD Institute of Infection & Immunity, Cardiff University“The role of lymphocytes in chronic HCV infection”

2008                 MRCP (UK) Royal College of Physicians London

2005                 MBBS St Bartholomew’s and the Royal London, University of London

2004                 Basic Medical Sciences Community Health Sciences: First Class Honours

Queen Mary School of Medicine and Dentistry. University of London

Publications

2020

2019

2018

2017

2016

2014

2013

2012

2006

Areas of expertise

External profiles