# Dr Ganna Leonenko

Research Associate, Division of Psychological Medicine and Clinical Neurosciences

- leonenkog1@cardiff.ac.uk
- +44 (0)29 2068 8421
- 2.29, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

## Overview

- Statistics and bioinformatics
- Genetic association studies in Schizophrenia
- Application of statistics in Remote Sensing (Distances, Information and Spectral measures)
- Fokker-Planck equation and its numerical solution using reduced basis method in spectral domain with applications to non-newtonian fluid dynamics and financial mathematics
- Queueing systems and Markov chains

## Biography

- Bachelor Degree in Mathematics from Kyiv National Taras Shevchenko University, 2001
- Master Degree in Statistics from Kyiv National Taras Shevchenko University, 2002
- PhD Degree in Statistics and Operation Research, from School of Mathematics, Cardiff, 2006

### Work experience

- Research associate (2005-2008) in non-Newtonian fluid dynamics in School of Mathematics, Cardiff University
- Research officer (2008-2011) in Geography department, Swansea University
- Research associate (2011-present) in school of medicine, Cardiff University

## Publications

### 2021

- Di Florio, A.et al. 2021. Postpartum psychosis and its relationship with bipolar disorder: a polygenic risk score analysis in the UK. The Lancet Psychiatry
- Harwood, J.et al. 2021. Defining functional variants associated with Alzheimer's disease in the induced immune response. Brain Communications 3(2), article number: fcab083. (10.1093/braincomms/fcab083)
- Leonenko, G.et al. 2021. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nature Communications

### 2020

- Bellou, E.et al. 2020. Age-dependent effect of APOE and polygenic component on Alzheimer's disease. Neurobiology of Aging 93, pp. 69-77., article number: Neurobiology of Aging Volume 93, September 2020, Pages 69-77. (10.1016/j.neurobiolaging.2020.04.024)
- Swaden Lewis, K. J.et al. 2020. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 77(3), pp. 303-310. (10.1001/jamapsychiatry.2019.4079)

### 2019

- Leonenko, G.et al. 2019. Genetic risk for Alzheimer's disease is distinct from genetic risk for amyloid deposition. Annals of Neurology 86(3), pp. 427-435. (10.1002/ana.25530)
- Baker, E.et al. 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14(7), article number: e0218111. (10.1371/journal.pone.0218111)
- Escott-Price, V.et al. 2019. Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls. Neurobiology of Aging 77, pp. 178-182. (10.1016/j.neurobiolaging.2018.12.002)
- Kunkle, B. W.et al. 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51(3), pp. 414-430. (10.1038/s41588-019-0358-2)
- Leonenko, G.et al. 2019. Polygenic risk and hazard scores for Alzheimer's disease prediction. Annals of Clinical and Translational Neurology 6(3), pp. 456-465. (10.1002/acn3.716)

### 2018

- Leonenko, G.et al. 2018. A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(4), pp. 468-475. (10.1002/ajmg.b.32635)
- Allardyce, J.et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)
- Sims, R.et al. 2018. Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing. bioRxiv (10.1101/294629)

### 2017

- Leonenko, G.et al. 2017. Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(7), pp. 724-731. (10.1002/ajmg.b.32560)
- Legge, S. E.et al. 2017. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry 22, pp. 1502-1508. (10.1038/mp.2016.97)
- Leonenko, G.et al. 2017. Investigation of relationships between bipolar disorder phenotypes and genome-wide significant loci from PGC2 schizophrenia. European Neuropsychopharmacology 27(S3), pp. S383-S384. (10.1016/j.euroneuro.2016.09.416)

### 2016

- Richards, A.et al. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. Human Molecular Genetics 25(5), pp. 1001-1007. (10.1093/hmg/ddv620)

### 2015

- Loohuis, L. M. O.et al. 2015. Genome-wide burden of deleterious coding variants increased in schizophrenia. Nature Communications 6, article number: 7501. (10.1038/ncomms8501)
- Leonenko, G. M. and Phillips, T. N. 2015. Numerical approximation of high-dimensional Fokker-Planck equations with polynomial coefficients. Journal of computational and applied mathematics 273, pp. 296-312. (10.1016/j.cam.2014.05.024)

### 2014

- Verrelst, J.et al. 2014. Optimizing LUT-based RTM inversion for semiautomatic mapping of crop biophysical parameters from Sentinel-2 and -3 Data: role of cost functions. IEEE Transactions on Geoscience and Remote Sensing 52(1), pp. 257-269. (10.1109/TGRS.2013.2238242)

### 2013

- Rivera, J. P.et al. 2013. Multiple cost functions and regularization options for improved retrieval of leaf chlorophyll content and LAI through inversion of the PROSAIL model. Remote Sensing 5(7), pp. 3280-3304. (10.3390/rs5073280)
- Leonenko, G. M., Los, S. and North, P. 2013. Statistical distances and their applications to biophysical parameter estimation: information measures, m-estimates, and minimum contrast methods. Remote Sensing 5(3), pp. 1355-1388. (10.3390/rs5031355)
- Leonenko, G. M., Los, S. O. and North, P. R. J. 2013. Retrieval of leaf area index from MODIS surface reflectance by model inversion using different minimization criteria. Remote Sensing of Environment 139, pp. 257-270. (10.1016/j.rse.2013.07.012)

### 2012

- Leonenko, G. M. and Phillips, T. N. 2012. High-order approximation of Pearson diffusion processes. Journal of Computational and Applied Mathematics 236(11), pp. 2853-2868. (10.1016/j.cam.2012.01.022)
- Verrelst, J.et al. 2012. Optimizing LUT-based radiative transfer model inversion for retrieval of biophysical parameters using hyperspectral data. Presented at: 2012 IEEE International Geoscience and Remote Sensing Symposium (IGARSS), Munich, Germany, 22-27 July 20122012 IEEE International Geoscience and Remote Sensing Symposium (IGARSS). Picastaway, NJ: IEEE pp. 7325-7328., (10.1109/IGARSS.2012.6351969)

### 2011

- Leonenko, G. M. and Phillips, T. N. 2011. The prediction of plane Couette flow for a FENE fluid using a reduced basis approximation of the Fokker-Planck equation. International Journal for Multiscale Computational Engineering 9(1), pp. 73-88. (10.1615/IntJMultCompEng.v9.i1.60)

### 2009

- Leonenko, G. M. and Phillips, T. N. 2009. On the solution of the Fokker-Planck equation using a high-order reduced basis approximation. Computer Methods in Applied Mechanics and Engineering 199(1-4), pp. 158-168. (10.1016/j.cma.2009.09.028)
- Leonenko, G. M. 2009. A new formula for the transient solution of the Erlang queueing model. Statistics & Probability Letters 79(3), pp. 400-406. (10.1016/j.spl.2008.09.014)

### 2008

- Griffiths, J. D., Leonenko, G. M. and Williams, J. E. 2008. Time-dependent analysis of non-empty M/E k/1 queue. Quality Technology and Quantitative Management 5(3), pp. 309-320.
- Leonenko, G. M. and Phillips, T. N. 2008. Reduced basis function method for solving the 2D Fokker-Planck equation. Presented at: SASOR 2008: 2nd Southern African Conference of Rheology, Cape Town, South Africa, 6-8 October 2008.
- Griffiths, J. D., Leonenko, G. M. and Williams, J. E. 2008. Approximation to the Transient Solution of the M/Ek/1 Queue. INFORMS Journal on Computing 20(4), pp. 510-515. (10.1287/ijoc.1070.0262)
- Griffiths, J. D., Leonenko, G. M. and Williams, J. E. 2008. Time-dependent analysis of non-empty M/Ek/1 queue. Quality Technology and Quantitative Management 5(3), pp. 309-320.

### 2006

- Griffiths, J. D., Leonenko, G. M. and Williams, J. E. 2006. The transient solution to M/Ek/1 queue. Operations Research Letters 34(3), pp. 349-354. (10.1016/j.orl.2005.05.010)
- Kozachenko, Y. V. and Leonenko, G. M. 2006. Extremal behavior of the heat random field. Extremes 8(3), pp. 191-205. (10.1007/s10687-006-7967-8)

### 2005

- Griffiths, J. D., Leonenko, G. M. and Williams, J. E. 2005. Generalization of the modified Bessel function and its generating function. Fractional Calculus and Applied Analysis 8(3), pp. 267-276.
- Leonenko, G. 2005. Transient solution of the M/Ek/1 queueing system. PhD Thesis, Cardiff University.

### 2002

- Kozachenko, Y. V. and Leonenko, G. M. 2002. Large deviation type inequality for the supremum of the heat random fields. Methods of Functional Analysis and Topology 8(3), pp. 46-49.