Dr Kimberley Kendall
Wellcome Trust Clinical Research Fellow, Division of Psychological Medicine and Clinical Neurosciences
- kendallkm@cardiff.ac.uk
- +44 (0)29 2068 8418
- 2.01 - Desk 36, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Overview
I am a general adult psychiatrist on the Wales Clinical Academic Track. I work on the role of rare genetic variants in psychiatric disorders and the translation of related findings to the clinic. I have a special interest in negative symptoms.
Biography
I am a general adult psychiatrist on the Wales Clinical Academic Track and I currently work in rehabilitation psychiatry in the South Wales Valleys. I completed my PhD on the Phenotypic Expression of Neuropsychiatric Copy Number variants at the MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University - funded by a Wellcome Trust Clinical Research Fellowship. I have been a member of the Royal College of Psychiatrists since 2015.
I undertook Core Psychiatry Training, Core Medical Training and the Foundation Programme in South Wales. I did my undergraduate Medicine (MBBCh) and Medical Genetics (BSc) training at the University of Wales College of Medicine / Cardiff University.
Honours and awards
2020 European Psychiatric Society Research Prize - I won this prize for my paper the role of neurodevelopmental copy number variants in depression in the clinical psychopathology and refinement of diagnostic categories section.
2018 UK Biobank Early Career Researcher of the Year Competition - I had two abstracts in the top 20 entries.
2016 Wellcome Trust Clinical Research Training Fellowship
2012 Cardiff MRC Centre Clinical Academic Mentorship Scheme
2007 Wellcome Trust Vacation Scholarship
Professional memberships
Member of the Royal College of Psychiatrists (MRCPsych)
Registered with the General Medical Council (7047089)
Speaking engagements
2020 World Congress of Psychiatric Genetics - the return of neurodevelopmental CNV results to research participants – ethical issues and protocol development.
2020 Royal Society of Medicine Webinar - the genetics of mental health – rare CNVs.
2020 Psychiatric Genomics Consortium Worldwide Lab - an introduction to the depression phenotype and its epidemiology.
2020 Social, Genetic & Developmental Psychiatry Centre, King’s College London - the phenotypic expression of neuropsychiatric CNVs.
2019 Birmingham MRCPsych Midlands Core Psychiatry Trainee Conference - what a psychiatrist needs to know about genetics.
2019 Association for Clinical Genomic Science Conference - cognitive performance and functional outcomes of carriers of pathogenic CNVs: analysis of UK Biobank.
2018 World Congress of Psychiatric Genetics - the role of neurodevelopmental CNVs in depression.
Committees and reviewing
Peer review activity - Practical Neurology, PLoS One, Journal of Psychiatric Research, Journal of Affective Disorders, Scientific Reports, Psychological Medicine, British Journal of Psychiatry
MRC Neuroscience and Mental Health Board grant review
Medical student MCQ book, Royal College of Psychiatrists
Publications
2022
- Wadon, M., Fenner, E., Kendall, K., Bailey, G., Sandor, C., Rees, E. and Peall, K. J. 2022. Clinical and genotypic analysis in determining dystonia non-motor phenotypic heterogeneity: a UK Biobank study. Journal of Neurology 269, pp. 6436-6451. (10.1007/s00415-022-11307-4)
2021
- Kendall, K. M., Van Assche, E., Andlauer, T. F. M., Choi, K. W., Luykx, J. J., Schulte, E. C. and Lu, Y. 2021. The genetic basis of major depression. Psychological Medicine 51(13), pp. 2217-2230. (10.1017/S0033291721000441)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Silva, A. I. et al. 2021. Analysis of diffusion tensor imaging data from the UK Biobank confirms dosage effect of 15q11.2 copy number variation on white matter and shows association with cognition. Biological Psychiatry 90(5), pp. 307-316. (10.1016/j.biopsych.2021.02.969)
- Caseras, X. et al. 2021. Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank. British Journal of Psychiatry 218(2), pp. 104-111. (10.1192/bjp.2020.139)
- Kendall, K. 2021. The phenotypic expression of neuropsychiatric copy number variants. PhD Thesis, Cardiff University.
2020
- Kendall, K. M. et al. 2020. Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: a data linkage study. BJPsych Open 6(6), article number: e139. (10.1192/bjo.2020.42)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Warland, A., Kendall, K. M., Rees, E., Kirov, G. and Caseras, X. 2020. Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank. Molecular Psychiatry 25(4), pp. 854-862. (10.1038/s41380-019-0355-y)
2019
- Legge, S. E. et al. 2019. Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry 76(12), pp. 1256-1265. (10.1001/jamapsychiatry.2019.2508)
- Escott-Price, V. et al. 2019. Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort. Psychological Medicine 49(15), pp. 2499-2504. (10.1017/S0033291718000454)
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
- Kendall, K. M. et al. 2019. Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank. British Journal of Psychiatry 214(5), pp. 297-304. (10.1192/bjp.2018.301)
- Kendall, K. M. et al. 2019. Association of rare copy number variants with risk of depression. JAMA Psychiatry 76(8), pp. 818-825. (10.1001/jamapsychiatry.2019.0566)
- Crawford, K. et al. 2019. Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank. Journal of Medical Genetics 56, pp. 131-138. (10.1136/jmedgenet-2018-105477)
2018
- Owen, D. et al. 2018. Effects of pathogenic CNVs on physical traits in participants of the UK Biobank. BMC Genomics 19(1), article number: 867. (10.1186/s12864-018-5292-7)
2017
- Cosgrove, D. et al. 2017. Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of CACNA1C's role in working memory. Neuropsychopharmacology 42, pp. 2612-2622. (10.1038/npp.2017.123)
- Keynejad, R. C. et al. 2017. Docbate: a National Medical Student Debate. Academic Psychiatry 41(6), pp. 839-841. (10.1007/s40596-017-0697-1)
- Kendall, K. M. et al. 2017. Cognitive performance among carriers of pathogenic copy number variants: analysis of 152,000 UK Biobank subjects. Biological Psychiatry 82(2), pp. P103-110. (10.1016/j.biopsych.2016.08.014)
- Kendall, K., Kirov, G. and Owen, M. 2017. Schizophrenia Genetics. In: Benjamin, S., Virginia, S. and Pedro, R. eds. Kaplan and Sadock?s Comprehensive Textbook of Psychiatry. Wolters Kluwer
- Kendall, K. 2017. Clinical genetics. Royal College of Psychiatrists. - teaching_resource
- McMillan, K. and Kendall, K. 2017. Basic genetics. Royal College of Psychiatrists. - teaching_resource
2016
- Whitton, L. et al. 2016. Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(8), pp. 1170-1179. (10.1002/ajmg.b.32503)
- Rees, E. et al. 2016. Analysis of intellectual disability copy number variants for association with schizophrenia. JAMA Psychiatry 73(9), pp. 963-969. (10.1001/jamapsychiatry.2016.1831)
2015
- Kendall, K. and Owen, M. J. 2015. Intellectual disability and psychiatric comorbidity: challenges and clinical issues. Psychiatric Times 32(5)
2012
- Kendall, K. and Robertson, N. 2012. Neuroimaging. Journal of Neurology 259(9), pp. 2009-2011. (10.1007/s00415-012-6652-x)
- Kendall, K., Thomas, R., Corkill, R. G. and Robertson, N. 2012. A neurological presentation of intravascular B-cell lymphoma. Case Reports (10.1136/bcr-2012-006439)
2009
- Carroll, L. S., Kendall, K., O'Donovan, M. C., Owen, M. J. and Williams, N. M. 2009. Evidence that putative ADHD low risk alleles atSNAP25may increase the risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(7), pp. 893-899. (10.1002/ajmg.b.30915)
Teaching
I teach psychiatry on the Cardiff University Medicine MBBCh course, including small group teaching on suicide and self harm and communication skills. I also examine formative and summative psychiatry ISCE examinations. I am an academic mentor to students on the course and I'm involved in peer review for scientific journals.
Rare genetic variants, such as copy number variants (CNVs), are associated with an increased risk of neurodevelopmental disorders including autism spectrum disorder, intellectual disability and schizophrenia and these associations cross traditional diagnostic boundaries. Most of what we know about the effects of rare variants is from those at the more severely affected end of the spectrum. We know relatively little about the effects of these variants in those without a neurodevelopmental diagnosis and individuals with psychiatric disorders.
In my recent Wellcome Trust Fellowship, I examined the effects of neurodevelopmental CNVs in psychiatric, cognitive and physical health domains for i) individuals without a neurodevelopmental diagnosis and ii) individuals with psychiatric disorders.
I am now continuing my work on rare variants in psychiatry and developing proposals for intermediate fellowships.