Professor Wen Jiang

Chair

: jiangw@cardiff.ac.uk
: +44 (0)29 2068 7065
: UHW Main Building

I have a long-standing interest in cancer metastasis and from 1987, my main research interest has been on the molecular and cellular basis of cancer invasion and metastasis and therapeutic aspects of targeting cancer metastasis. I have been particularly interested in the bone, peritoneal and brain metastasis from primary tumours including breast, prostate, lung, GI cancers. My research has been conducted in Cardiff's School of Medicine and I have collaborated widely with colleagues in the UK, China, Europe, North America and Asia.

Education and qualifications:

1995, MD research degree, University of Wales College of Medicine
1984, Primary medical degree (MB, BCh) in Clinical Medicine, Peking University Health Science Centre (Previously Beijing Medical University)

Career overview:

2014 - present: Dean of International, Cardiff University
2012 - present: Director of Cardiff China Medical Research Collaborative
2012 - present: Quality and Safety Improvement Faculty, National Health Service/UHB, National Health Service
2012 - present: Academic Director for International Relations, Cardiff University
2004 - present: Professor of Surgery and Tumour Biology, Cardiff University School of Medicine
2003 - 2004: Reader, University of Wales College of Medicine
1997 - 2003: Senior Lecturer, University of Wales College of Medicine
1996 - 1997: Senior Fellow, University of Wales College of Medicine
1989 - 1996: Research Fellow, University of Wales College of Medicine (currently Cardiff University's School of Medicine)
1987 - 1989: Chief Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing
1984 - 1987: Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing

Honours and awards

Fellow of the Royal Society of Biology
Fellow of the Royal Society of Medicine
Honorary professorship at Peking University
Honorary professorship at Capital Medical University
Honorary professorship at Inner Mongolia University
Honorary professorship at QingDao University
International consultant for Beijing Lung Cancer Centre

Recent awards include:

Member of the Most Excellent Order of the British Empire
Marquis Who's Who as Prominent Cancer Researcher
Outstanding Achievement Award, 19th World Congress of Oncology, Athens, Greece, October 2014
Super Professor in America's Academic Row, June 2015

Professional memberships

Member of the American Association for Cancer Research (AACR)
Member of the British Association for Cancer Research (BACR)
Member of the European Association for Cancer Research (EACR)

Academic positions

2014 - present: Dean of International, Cardiff University
2012 - present: Director of Cardiff China Medical Research Collaborative
2012 - present: Quality and Safety Improvement Faculty, National Health Service/UHB, National Health Service
2012 - present: Academic Director for International Relations, Cardiff University
2004 - present: Professor of Surgery and Tumour Biology, Cardiff University School of Medicine
2003 - 2004: Reader, University of Wales College of Medicine
1997 - 2003: Senior Lecturer, University of Wales College of Medicine
1996 - 1997: Senior Fellow, University of Wales College of Medicine
1989 - 1996: Research Fellow, University of Wales College of Medicine (currently Cardiff University's School of Medicine)
1987 - 1989: Chief Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing
1984 - 1987: Surgical Resident, Department of General Surgery, Peking UniversityFirst Hospital, Beijing

Speaking engagements

Recent speaking engagements include:

2017: International Gastic Cancer Conference
2016: Gordon Conference, Gerona, Spain
2016: British Society of Pharmacology
2016: GOC 2016, Prague
2016: 12th International Conference on Collateral Disease (Oncology Forum), Shanghai, China
2015: 11th International Conference on Collateral Disease, Shijiazhuang, China
2014: Peking University Postgraudate Society
2014: 19th World Congress on Advances in Oncology, Athens
2014: 9th International Conference of Anticancer Research, Sithonia
2013: Phoenix TV, Chinese Medicine in cancer therapies
2013: BBC report on new medicine in cancer treatment

Committees and reviewing

2014 - present: Member of the University International Board

Other academic activities:

Editorship:

Editor-in-Chief: World Journal of Oncology
Editor-in-Chief: Cancer Metastasis, Biology and Treatment http://www.springer.com/series/5761
Editor-in-Chief: Journal of Molecular and Genetic Medicine http://www.omicsonline.com/open-access/molecular-genetic-medicine.php

Editorial Board membership includes:

Member of the editorial board of the International Journal of Molecular Medicine, from 1999
Advisory Board Member, ‘Advances in Therapy’, from 2008
Editorial Board Member, ‘Current Oncology’, from 2008
Editorial Board Member, ‘Journal of Surgical Oncology’, from 2008
Editorial Board Member, ‘Current Signal Transduction Therapy’, from 2009
Editorial Board Member, ‘World Journal of Gastroenterology’, from 2009
Editorial Board Member, ‘Experimental and Therapeutic Medicine’, from 2009
Editorial Board Member, ‘World Journal of Clinical Oncology’, From 2010
Editorial Board Member, ‘World Journal of Oncology’, From 2010
Editorial Board Member, ‘Chinese Journal of Cancer Research’, From 2010
Editorial Board Member, ‘Current Cancer Therapy Reviews’, From 2010
Editorial Board Member, ‘International Journal of Oncology'', from 2011
Editorial Board Member, ‘Translational Medicine: Current Research'', from 2011
Editorial Board Member, ‘Translational Gastrointestinal Cancer'', from 2011
Editorial Board Member, ‘Biomedical Reports'', from 2012
Editorial Board Member, ‘World Journal of Medical Genetics (WJMG)'', from 2012
Academic consultant, 'Antitumour Pharmacy', from 2012
Editorial Board Member: 'Journal of Cancer Research and Therapy', from 2012
Editorial Board Member: 'Angiology', from 2012
Editorial Board Member: 'AO Translational Research', from 2013
Editorial Board Member: 'Chinese Journal of Biology', from 2013
Editorial Board Member: 'Academic Journal of Capital Medical University', from 2013
Editorial Board Member: 'Cancer Genomics and Proteomics', from 2014
Editorial Board Member: 'Insight of Medical Physics', from 2015
Editorial Board Member: 'Cancer Translational Medicine', from 2015
Editorial Board Member: 'Biochemical and Biophysical Acta (BBA) Clinical'', from 2015
Editorial Board Member: 'Cancer Hypothesis', from 2016

Books published

‘Cancer Metastasis, molecular and cellular basis and clinical intervention’, Editors Wen G Jiang and Robert E Mansel, Kluwer Academic Publishers, 2000 (ISBN 0-7923-6395-7). (http://www.springer.com/gb/book/9780792363958)

‘Growth Factors and their receptors in cancer metastasis’, Editors Wen G Jiang, Toshikazu Nakamura and Kunio Matsumoto, Kluwer Academic Publishers, 2001 (ISBN 0-7923-7141-0) (http://www.springer.com/gb/book/9780792371410)

‘Breast Cancer Metastasis’, Editors Robert E Mansel, Oystein Fodstad and Wen G Jiang, Spinger Publishers, 2007, ISBN: 978-1-4020-5866-0. (http://www.springer.com/gb/book/9781402058660)

'Electric Cell-Substrate Sensing in the investigation of cancer and cancer metastasis'. Wen G Jiang. Springer Publishers, 2012. ISBN 978-94-007-4926-9 (http://www.springer.com/biomed/cancer/book/978-94-007-4926-9)

'Tight junctions in cancer metastasis'. TA Martin and WG Jiang. Springer Publishers, March 2013 (ISBN 978-94-007-6027-1). (http://www.springer.com/gb/book/9789400760271)

2007

Salhob, M.et al. 2007. The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinicopathological parameters and clinical outcome. Breast Cancer Research and Treatment 106, pp. S283-S283.
Davies, S. R., Mansel, R. E. and Jiang, W. G. 2007. The potential prognostic value of osteoprotegrin in ductal carcinoma of the breast. Breast Cancer Research and Treatment 106, pp. S172-S172.
Davies, S. R., Mansel, R. E. and Jiang, W. G. 2007. Osteocalcin as a prognostic indicator in ductal mammary carcinoma. Breast Cancer Research and Treatment 106, pp. S164-S164.
Sun, J.et al. 2007. Dysregulation of cofactor of BRCA1 expression in breast cancers. Breast Cancer Research and Treatment 106, pp. S282-S282.
Zia, M. K.et al. 2007. The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells. International Journal of Molecular Medicine 20(4), pp. 605-611. (10.3892/ijmm.20.4.605)
Chhabra, A.et al. 2007. Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis. Oncology Reports 18(4), pp. 953-958.
Sanders, A. J.et al. 2007. Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro. International Journal of Molecular Medicine 20(4), pp. 613-619.
Subramanian, A.et al. 2007. Evidence for a tumour suppressive function of IGFI-binding proteins in human breast cancer. Anticancer Research 27(5B), pp. 3513-3518.
Parr, C.et al. 2007. Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients. Clinical Cancer Research 13(12), pp. 3568-3576. (10.1158/1078-0432.CCR-06-2357)
Conway, K. P.et al. 2007. The role of vascular endothelial growth inhibitor in wound healing. International Wound Journal 4(1), pp. 55-64. (10.1111/j.1742-481X.2006.00295.x)
Fernando, H. S.et al. 2007. Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer. Oncology 73(5-6), pp. 376-383.
Martin, T. A.et al. 2007. N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. Clinical & Experimental Metastasis 25(2), pp. 97-108. (10.1007/s10585-007-9120-8)
Conway, K. P.et al. 2007. Hepatocyte growth factor regulation: an integral part of why wounds become chronic. Wound Repair and Regeneration 15(5), pp. 683-692. (10.1111/j.1524-475X.2007.00296.x)
Al-Rawi, M. A. and Jiang, W. G. 2007. Lymphangiogenesis and metastatic spread of breast cancer. In: Mansel, R. E., Fodstad, O. and Jiang, W. G. eds. Metastasis of Breast Cancer. Cancer Metastasis, Biology and Treatment (CMBT) Vol. 11. Dordrecht: Springer, pp. 219-240., (10.1007/978-1-4020-5867-7)
Mansel, R. E., Fodstad, O. and Jiang, W. G. 2007. Metastasis of breast cancer: an introduction. In: Mansel, R. E., Fodstad, O. and Jiang, W. G. eds. Metastasis of Breast Cancer. Cancer Metastasis - Biology and Treatment (CMBT) Vol. 11. Dordrecht: Springer, pp. 1-5., (10.1007/978-1-4020-5867-7_1)
Parr, C. and Jiang, W. G. 2007. The role of the HGF regulatory factors in breast cancer. In: Mansel, R. E., Fodstad, O. and Jiang, W. G. eds. Metastasis of Breast Cancer. Cancer Metastasis, Biology and Treatment (CMBT) Vol. 11. Dordrecht: Springer, pp. 171-202.

2006

Lane, J., Martin, T. A. and Jiang, W. G. 2006. Novel protein binding partners for Rho-associated serine-threonine protein kinases (ROCKS) in breast cancer cells [Abstract]. Breast Cancer Research and Treatment 100(1 Supp), pp. S298-S298., article number: 6127.
Hiscox, S. E.et al. 2006. Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions. Endocrine-Related Cancer 13(4), pp. 1085-1099. (10.1677/erc.1.01270)
Jiang, W. G.et al. 2006. Com-1/p8 acts as a putative tumour suppressor in prostate cancer. International Journal of Molecular Medicine 18(5), pp. 981-986.
Salhab, M.et al. 2006. The role of aromatase and 17-beta-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer. Breast Cancer Research and Treatment 99(2), pp. 155-162.
Cai, J.et al. 2006. Decreased pigment epithelium-derived factor expression in human breast cancer progression. Clinical Cancer Research 12(11), pp. 3510-3517. (10.1158/1078-0432.CCR-06-0094)
Hanavadi, S.et al. 2006. Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer. Annals of Surgical Oncology 13(6), pp. 802-808.
Zhang, L. J.et al. 2006. Expression of pigment epithelial derived factor is reduced in non-small cell lung cancer and is linked to clinical outcome. International Journal of Molecular Medicine 17(5), pp. 937-944.
Jiang, W. G.et al. 2006. Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. International Journal of Molecular Medicine 17(4), pp. 583-590.
Jiang, W. G., Douglas-Jones, A. G. and Mansel, R. E. 2006. Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer. Prostaglandins Leukotrienes & Essential Fatty Acids 74(2), pp. 125-134.
Hiscox, S. E.et al. 2006. Tamoxifen-resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of [beta]-catenin phosphorylation. International journal of cancer 118(2), pp. 290-301. (10.1002/ijc.21355)
Harrison, G.et al. 2006. The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells. Oncology Reports 15(1), pp. 199-206. (10.3892/or.15.1.199)
Sanders, A. J.et al. 2006. Genetic reduction of matriptase-1 expressionj is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo. Journal of Experimental Therapeautics and Oncology 6(1), pp. 39-48.
Sanders, A. J.et al. 2006. Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo. Journal of Experimental Therapeutics and Oncology 6(1), pp. 39-48.
Jiang, W. G.et al. 2006. EPLIN (epithelial protein lost in neoplasm) affects matrix adhesion and cellular motility of breast cancer cells, the role of ezrin [Abstract]. Breast Cancer Research and Treatment 100, pp. S161-S161.
Congiatu, C.et al. 2006. Novel potential anticancer naphthyl phosphoramidates of BVdU: Separation of diastereoisomers and assignment of the absolute cConfiguration of the phosphorus center. Journal of Medicinal Chemistry 49(2), pp. 452-455. (10.1021/jm0509896)
Conway, K. P.et al. 2006. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair and Regeneration 14(1), pp. 2-10. (10.1111/j.1743-6109.2005.00081.x)

2005

Jiang, W. G.et al. 2005. Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status. International Journal of Cancer 117(5), pp. 730-737. (10.1002/ijc.21221)
Cai, J.et al. 2005. Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of Vascular Endothelial Growth Factor Receptor 1. The Journal of Biological Chemistry 281(6), pp. 3604-3613. (10.1074/jbc.M507401200)
Lane, J., Martin, T. A. and Jiang, W. G. 2005. ROCK inhibitor Y-27632 suppresses the effect of HGF in human breast cancer cells [Abstract]. Breast Cancer Research and Treatment 94(1 Supp), pp. S193-S194., article number: 4082.
Lane, J., Martin, T. and Jiang, W. G. 2005. Targeting Rho-C by way of ribozyme transgene in human breast cancer cells and its impact on cancer invasion. Breast Cancer Research and Treatment 94(1), pp. S188-S189., article number: 4068. (10.1007/s10549-005-1234-6)
Parr, C.et al. 2005. Placenta growth factor is over-expressed and has prognostic value in human breast cancer. European Journal of Cancer 41(18), pp. 2819-2827.
Martin, T. A., Watkins, G. and Jiang, W. G. 2005. KiSS-1 expression in human breast cancer. Clinical & Experimental Metastasis 22(6), pp. 503-511.
Kang, H.et al. 2005. The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer. The Breast 14(5), pp. 360-367. (10.1016/j.breast.2004.12.007)
Martin, T. A., Watkins, G. and Jiang, W. G. 2005. The Coxsackie-adenovirus receptor has elevated expression in human breast cancer. Clinical and Experimental Medicine 5(3), pp. 122-128.
Leris, A. C. A.et al. 2005. Evidence for a tumour suppressive function of APRG1 in breast cancer. Breast Cancer Research and Treatment 93(2), pp. 97-100.
Jiang, W. G.et al. 2005. Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy. Clinical Cancer Research 11(16), pp. 6012-6019. (10.1158/1078-0432.CCR-05-0275)
Jiang, W. G.et al. 2005. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genes. European Journal of Cancer 41(11), pp. 1628-1636. (10.1016/j.ejca.2005.03.023)
Hawizy, A.et al. 2005. Differential expression of Wnt-induced secreted proteins (WISPs) in prostate tissues and cancer cell lines and their role in the action of HGF/SF induced in vitro invasion. Bju International 95, pp. 81-82.
Conway, K.et al. 2005. Is the hepatocyte growth factor regulatory system the reason for wounds becoming chronic?. British Journal of Surgery 92, pp. 45-45.
Martin, T. A.et al. 2005. Assessing microvessels and angiogenesis in human breast cancer, using VE-cadherin. Histopathology 46(4), pp. 422-430. (10.1111/j.1365-2559.2005.02104.x)
Leris, A. C. A.et al. 2005. WNT5A expression in human breast cancer. Anticancer Research 25(2A), pp. 731-734.
Martin, T. A.et al. 2005. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Annals of Surgical Oncology 12(6), pp. 488-496. (10.1245/ASO.2005.04.010)
Parr, C., Watkins, G. and Jiang, W. G. 2005. Hepsin expression is inversely correlated with patient prognosis in human breast cancer. Breast Cancer Research and Treatment 94, pp. S137-S137.
Lane, J., Martin, T. A. and Jiang, W. G. 2005. The ROCK Inhibitor Y-27632 supresses the effect of HGF in human breast cancer cells. Breast Cancer Research and Treatment 94, pp. S193-S194.
Parr, C.et al. 2005. Vascular endothelial growth inhibitor (VEGI), an antiangiogenic factor, in human breast cancer. Breast Cancer Research and Treatment 94, pp. S74-S74.
Jiang, W.et al. 2005. EPLIN, epithelial protein lost in neoplasm, is aberrantly expressed in human breast cancer and is related to clinical outcomes. Breast Cancer Research and Treatment 94(Supp 1), pp. S184.
Jiang, W.et al. 2005. Manipulation of expression of MMP-14 and its impact on the invasivess and progression of breast cancer cells [Abstract]. Breast Cancer Research and Treatment 94, pp. S187-S187.
Jiang, W. G.et al. 2005. Autophophorylation of the hepatocyte growth factor receptor, cMET in human breast cancer. Breast Cancer Research and Treatment 94, pp. S192-S192.
Hiscox, S. E.et al. 2005. Elevated c-met expression accompanies endocrine resistance in MCF7 breast cancer cells and promotes in vitro cell migration and invasion. Breast Cancer Research and Treatment 94(Supp 1), pp. S161-S161.

2004

Jiang, W. G.et al. 2004. Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer. Endocrine Related Cancer 11(4), pp. 781-791. (10.1677/erc.1.00825)

2003

Jiang, W. G.et al. 2003. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clinical cancer research 9, pp. 6432-40.
Cai, J.et al. 2003. Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. Diabetes 52(12), pp. 2959-2968. (10.2337/diabetes.52.12.2959)
Jiang, W. G.et al. 2003. Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET. Clinical Cancer Research 9(11), pp. 4274-4281.
Davies, G.et al. 2003. The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesisin vivo. International Journal of Cancer 106(3), pp. 348-354. (10.1002/ijc.11220)
Lane, J., Mansel, R. E. and Jiang, W. G. 2003. Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. International Journal of Molecular Medicine 12(2), pp. 253-257. (10.3892/ijmm.12.2.253)
Al-Rawi, M. A. A., Mansel, R. E. and Jiang, W. G. 2003. Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. Histology and Histopathology 18(3), pp. 911-923.
Martin, T. A.et al. 2003. Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis 24(8), pp. 1317-1323. (10.1093/carcin/bgg072)
Cai, J.et al. 2003. Placenta growth factor upregulates VE-cadherin expression in microvascular endothelial cells. Investigative Ophthalmology & Visual Science 44(E-Abst)

2002

Gomez, K.et al. 2002. From PCR to RCA: a surgical trainee's guide to the techniques of genetic amplification. European Journal of Surgical Oncology (EJSO) 28(5), pp. 554-556. (10.1053/ejso.2002.1288)
Kim, N. D.et al. 2002. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Research and Treatment 71(3), pp. 203-217.
Boulton, M. E.et al. 2002. Role of placenta growth factor (PIGF) and PIGF/VEGF heterodimer in the regulation of in vitro angiogenesis. Investigative Ophthalmology & Visual Science 43(E-Abst)

2001

Cunnick, G.et al. 2001. Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model. Biochemical and Biophysical Research Communications 288(4), pp. 1043-1046. (10.1006/bbrc.2001.5869)
Parr, C. and Jiang, W. G. 2001. Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. International Journal of Oncology 19, pp. 857-863. (10.3892/ijo.19.4.857)
Davies, G., Jiang, W. G. and Davies, M. D. 2001. Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clinical Cancer Research 7, pp. 3289-3297.
Parr, C.et al. 2001. The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant.. Biochemical and Biophysical Research Communications 285(5), pp. 1330-1337. (10.1006/bbrc.2001.5307)
Jiang, W. G.et al. 2001. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clinical Cancer Research 7, pp. 2555-2562.
Parr, C.et al. 2001. Inhibition of HGF/SF-induced cell-matrix adhesion, invasion, migration & paxillin phosphorylation, in prostate cancer by the HGF/SF antagonist, NK4. British Journal of Cancer 85(Supp 1), pp. 86-86. (10.1054/bjoc.2001.1918)
Davies, G., Jiang, W. G. and Mason, M. D. 2001. HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells.. International Journal of Molecular Medicine 7, pp. 385-388. (10.3892/ijmm.7.4.385)
Davies, G., Jiang, W. G. and Mason, M. D. 2001. The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer.. International Journal of Oncology 18(4), pp. 843-847. (10.3892/ijo.18.4.843)
Martin, T. A., Mansel, R. E. and Jiang, W. G. 2001. Hepatocyte growth factor modulates vascular endothelial-cadherin expresssion in human endothelial cells. Clinical Cancer Research 7(3), pp. 734-737.
Stephens, P.et al. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
Parr, C. and Jiang, W. G. 2001. Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention.. Histology and Histopathology 16(1), pp. 251-268.
Martin, T. A., Harding, K. G. and Jiang, W. G. 2001. Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin. European Journal of Clinical Investigation 31(11), pp. 931-938. (10.1046/j.1365-2362.2001.00914.x)
Martin, T. A. and Jiang, W. G. 2001. Tight junctions and their role in cancer metastasis.. Histology and Histopathology 16, pp. 1183-1195.

2000

Jiang, W. G., Eynard, A. R. and Mansel, R. E. 2000. The pathology of essential fatty acid deficiency: is it cell adhesion mediated?. Medical Hypothesis 55, pp. 257-262. (10.1054/mehy.1998.1191)
Davies, G., Jiang, W. G. and Mason, M. D. 2000. Cell-cell adhesion molecules and signaling intermediates and their role in the invasive potential of prostate cancer cells.. Journal of Urology 163(3), pp. 985-992.
Jiang, W. G.et al. 2000. Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells.. Prostaglandins Leukotrienes & Essential Fatty Acids 62(2), pp. 119-127. (10.1054/plef.1999.0131)
Parr, C.et al. 2000. NK4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells. International Journal of Cancer 85(4), pp. 563-570. (10.1002/(SICI)1097-0215(20000215)85:4<563::AID-IJC19>3.0.CO;2-D)
Hiscox, S. E.et al. 2000. Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4. British Journal of Cancer 59(3), pp. 245-254. (10.1023/A:1006348317841)
Hoppe, A.et al. 2000. Interactive image processing system for assessment of cell movement.. Medical and Biological Engineering and Computing 37(4), pp. 419-423.
Jiang, W. G. and Mansel, R. E. 2000. E-cadherin complex and its abnormalities in human breast cancer. Surgical Oncology 9, pp. 151-171.
Jiang, W. G. and Mansel, R. E. 2000. Metastatic cascade, molecular/cellular events. In: Jiang, W. G. and Mansel, R. E. eds. Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Cancer Metastasis - Biology and Treatment Vol. 1. Dordrecht, Netherlands: Kluwer Academic Publishers, pp. 1-18.
Jiang, W. G.et al. 2000. Polyunsaturated fatty acids and their role in cancer invasion and metastasis. In: Jiang, W. G. and Mansel, R. E. eds. Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Cancer Metastasis - Biology and Treatment Vol. 1. Dordrecht, Netherlands: Kluwer Academic Publishers, pp. 225-253.
Jiang, W. G., Martin, T. and Mansel, R. E. 2000. Tight junction, a critical structure in the control of cancer invasion and metastasis. In: Jiang, W. G. and Mansel, R. E. eds. Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Cancer Metastasis - Biology and Treatment Vol. 1. Dordrecht, Netherlands: Kluwer Academic Publishers, pp. 195-214.

1999

Jiang, W. G.et al. 1999. Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells.. Journal of Cellular Physiology 181(2), pp. 219-329. (10.1002/(SICI)1097-4652(199911)181:2<319::AID-JCP14>3.0.CO;2-S)
Jiang, W. G.et al. 1999. Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells. Clinical Cancer Research 5(11), pp. 3695-3703.
Hiscox, S. E., Mansel, R. E. and Jiang, W. G. 1999. Ezrin regulates cell-cell adhesion and motility and associates with intercellular junctional proteins in cancer cells. British Journal of Cancer 81(4), pp. 579-579. (10.1038/sj.bjc.6690733)
Hiscox, S. E. and Jiang, W. G. 1999. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. Journal of Cell Science 112(18), pp. 3081-3090.
Cai, J., Jiang, W. and Mansel, R. 1999. Phosphorylation and disorganization of vascular-endothelial cadherin in interaction between breast cancer and vascular endothelial cells. International Journal of Molecular Medicine 4(2), pp. 191-195. (10.3892/ijmm.4.2.191)
Hiscox, S. E. and Jiang, W. G. 1999. Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. Biochemical and Biophysical Research Communications 261(2), pp. 406-411. (10.1006/bbrc.1999.1002)
Davies, E. L.et al. 1999. The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. European Journal of Cancer 35(6), pp. 902-907. (10.1016/S0959-8049(99)00031-3)
Cai, J., Jiang, W. and Mansel, R. 1999. Inhibition of the expression of VE-cadherin/catenin complex by gamma linolenic acid in human vascular endothelial cells, and its impact on angiogenesis. Biochemical and Biophysical Research Communications 258(1), pp. 113-118. (10.1006/bbrc.1999.0596)
Jiang, W. G.et al. 1999. Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer. Critical Reviews in Oncology/Hematology 29(3), pp. 209-248.
Cai, J., Jiang, W. and Mansel, R. 1999. Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid. Prostaglandins Leukotrienes & Essential Fatty Acids 60(1), pp. 21-29. (10.1054/plef.1998.0004)
Davies, G., Jiang, W. G. and Mason, M. D. 1999. Cell-cell adhesion molecules and their associated proteins in bladder cancer cells and their role in mitogen induced cell-cell dissociation and invasion.. Anticancer Research 19(1A), pp. 547-552.
Hiscox, S. E. and Jiang, W. G. 1999. Hepatocyte growth factor scatter factor disrupts epithelial tumour cell-cell adhesion: involvement of beta-catenin. Anticancer Research 19(1A), pp. 509-517.
Davies, G.et al. 1999. HGF/SF influences the interaction between APC, GSK3 beta and beta-catenin, its impact on cell adhesion and in vitro invasion in prostate cancer. British Journal of Cancer 80(Supp 2), pp. 36-36.

1998

Eynard, A. R., Jiang, W. G. and Mansel, R. E. 1998. Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro.. Prostagladins Leukotrienes and Essential Fatty Acids 59(6), pp. 371-377. (10.1016/S0952-3278(98)90098-9)
Davies, G., Jiang, W. G. and Mason, M. D. 1998. E-cadherin and associated molecules in the invasion and progression of prostate cancer. Oncology Reports 5(6), pp. 1567-1576. (10.3892/or.5.6.1567)
Jiang, W. G.et al. 1998. gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells.. International Journal of Oncology 13(3), pp. 611-617.
Davies, E. L.et al. 1998. The expression of desmoglein-2 in primary breast cancer and its relation to a series of prognostic markers [Abstract]. British Journal of Cancer 78(2), pp. 149. (10.1038/bjc.1998.457)
Hiscox, S. E., Davies, E. and Jiang, W. G. 1998. Up-regulation of the expression of hepatocyte growth factor activator (HGFA) in breast cancer. British Journal of Cancer 78(2), pp. 150-150. (10.1038/bjc.1998.457)
Jiang, W. G.et al. 1998. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. British Journal of Cancer 77(5), pp. 731-738. (10.1038/bjc.1998.120)
Cai, J., Jiang, W. and Mansel, R. 1998. Gap junctional communication and the tyrosine phosphorylation of connexin 43 in interaction between breast cancer and endothelial cells. International Journal of Molecular Medicine 1(1), pp. 273-278. (10.3892/ijmm.1.1.273)
Jiang, W. G. and Bryce, R. P. 1998. Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Critical Reviews in Oncology/Hematology 27, pp. 179-209.
Hoppe, A. and Jiang, W. G. 1998. A system for computer analysis of cancer cell movement. Anticancer Research 18, pp. 2691-2694.
Jiang, W. G. and Hiscox, S. 1998. Association of PTPmu with catenins in cancer cells: a possible role for E-cadherin. International Journal of Oncology 13, pp. 1077-1080.
Jiang, W. G. 1998. Regulation of cell adhesion, a central mechanism in the anticancer action of essential fatty acids. International Journal of Molecular Medicine 1(3), pp. 621-625.
Jiang, W. G. and Harding, K. G. 1998. Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblast (dermagraft), a role of hepatocyte growth factor/scatter factor. International Journal of Molecular Medicine 2, pp. 203-210.
Jiang, W. G. 1998. Cell adhesion molecules in the formation of liver metastasis. Journal of Hepato-Biliary-Pancreatic Surgery 5(4), pp. 371-377. (10.1007/s005340050061)
Jiang, W. G.et al. 1998. Essential fatty acids regulate the expression of tumour suppressor genes in cancer cells. Presented at: Fourth International Congress on Essential Fatty Acids and Eicosanoids, Edinburgh, UK, 20-24 July 1997 Presented at Riemersma, R. A. et al. eds.Essential fatty acids and eicosanoids: invited papers from the Fourth International Congress. Champaign, Illinois: AOCS Press pp. 303-311.
Eynard, A. R., Jiang, W. G. and Mansel, R. E. 1998. Eicosatrienoic acid (20:3, n-9) regulate the expression of E-cadherin and desmoglein in squamous cell carcinoma. Presented at: 17th International Cancer Congress, Rio de Janeiro, Brazil, 24-28 August 1998 Presented at Moraes, M., Brentani, R. and Bevilacqua, R. eds.Proceedings of the 17th International Cancer Congress. Bologna: Medimond pp. 233-238.

1997

Jiang, W. G.et al. 1997. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. Clinical and Experimental Metastasis 15(6), pp. 593-602. (10.1023/A:1018435229087)
Jiang, W. G. and Hiscox, S. E. 1997. beta-catenin-cell adhesion and beyond (review). International Journal of Oncology 11(3), pp. 635-641.
Jiang, W. G.et al. 1997. Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. Biochemical and Biophysical Research Communications 237(3), pp. 639-644. (10.1006/bbrc.1997.7154)
Davies, E.et al. 1997. The role of desmoglein 2 and E-cadherin in the invasion and motility of human breast cancer cells. International Journal of Oncology 11(2), pp. 415-419.
Hiscox, S. E. and Jiang, W. G. 1997. Regulation of endothelial CD44 expression and endothelium-tumour cell interactions by hepatocyte growth factor/scatter factor. Biochemical and Biophysical Research Communications 233(1), pp. 1-5. (10.1006/bbrc.1997.6388)
Jiang, W. G. and Hiscox, S. E. 1997. Hepatocyte growth factor/scatter factor, a cytokine playing multiple and converse roles. Histology and Histopathology 12(2), pp. 537-555.
Jiang, W. G. and Hiscox, S. 1997. Quantification of tumour cell-endothelial cell attachment by 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine (DiI). Cancer Letters 112(2), pp. 209-217. (10.1016/S0304-3835(96)04573-9)
Jiang, W. G. and Puntis, M. C. 1997. Immune dysfunction in patients with obstructive jaundice, mediators and implications for treatments. HPB Surgery 10, pp. 129-142.
Jiang, W. G. and Hiscox, S. 1997. Expression of E-cadherin, alpha, beta and gamma-catenin in human colorectal cancer. Anticancer Research 17, pp. 1349-1354.
Hiscox, S. and Jiang, W. G. 1997. Interleukin-12, an emerging anti-tumour cytokine. In Vivo -Athens- 11, pp. 125-132.
Jiang, W. G. and Bryce, R. P. 1997. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. Prostaglandins Leukotrienes & Essential Fatty Acids 56, pp. 307-316.
Jiang, W. G. and Bryce, R. P. 1997. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochemical and Biophysical Research Communications 244, pp. 414-420.
Hiscox, S. E.et al. 1997. Expression of the HGF/SF Receptor, c-met, and its ligand in human colorectal cancers. Cancer Investigation 15(6), pp. 513-521. (10.3109/07357909709047592)

1996

Jiang, W. G.et al. 1996. Inhibition of membrane ruffling and ezrin translocation by gamma linolenic acid. International Journal of Oncology 9(2), pp. 279-284. (10.3892/ijo.9.2.279)
Jiang, W. G.et al. 1996. Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid. British Journal of Surgery 83(5), pp. 659-664. (10.1002/bjs.1800830523)
Jiang, W. G. and Hiscox, S. E. 1996. Cytokine regulation of ezrin expression in the human colon cancer cell line HT29.. Anticancer Research 16(2), pp. 861-865.
Jiang, W. G.et al. 1996. Gamma linolenic acid inhibits tyrosine phosphorylation of focal adhesion kinase and paxillin and tumour cell matrix interaction. International Journal of Oncology 8(3), pp. 583-587. (10.3892/ijo.8.3.583)
Puntis, M. C. A. and Jiang, W. G. 1996. Plasma cytokine levels and monocyte activation in patients with obstructive jaundice. Journal of Gastroenterology and Hepatology 11, pp. 7-13. (10.1111/j.1440-1746.1996.tb00003.x)
Jiang, W. G. and Puntis, M. C. 1996. Monocyte and blood interleukin-12 levels in patients with obstructive jaundice. Hpb Surgery 9(4), pp. 209-221.
Jiang, W. G. 1996. E-cadherin and its associated protein catenins, cancer invasion and metastasis. British Journal of Surgery 83, pp. 437-446.
Jiang, W. G.et al. 1996. Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell-matrix interactions. Oncology Reports 3(5), pp. 819-823. (10.3892/or.3.5.819)
Han, Z.et al. 1996. Inhibition of motility and invasion of human lung cancer cells by invasion inhibiting factor 2. Surgical Oncology 5(2), pp. 77-84. (10.1016/S0960-7404(96)80004-1)

1995

Jiang, W. G.et al. 1995. Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). Cancer Research 55, pp. 5043-5048.
Jiang, W. G.et al. 1995. Gamma linolenic acid up-regulates e-cadherin expression in human cancer cells. British Journal of Surgery 82(11), pp. 1565-1565.
Jiang, W. G.et al. 1995. Expression of catenins in human cancer cells and its regulation by n-6 polyunsaturated fatty acids. Anticancer Research 15(6B), pp. 2569-2573.
Jiang, W. G.et al. 1995. Inhibition of HGF/SF-induced membrane ruffling and cell motility by transient elevation of cytosolic free Ca2+. Experimental Cell Research 220(2), pp. 424-433. (10.1006/excr.1995.1334)
Jiang, W. G.et al. 1995. Regulation of motility and invasion of cancer cells by human monocytic cells. Anticancer Research 15(4), pp. 1303-1310.
Jiang, W. G.et al. 1995. Inhibition of HGF/SF-induced tumor-cell membrane ruffling by calcium signalling. British Journal of Surgery 82(5), pp. 682-683.
Jiang, W. G.et al. 1995. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. British Journal of Cancer 71(4), pp. 744-752. (10.1038/bjc.1995.145)
Jiang, W. G. 1995. Membrane ruffling of cancer cells: a parameter of tumour cell motility and invasion. European Journal of Surgical Oncology (EJSO) 21, pp. 307-309. (10.1016/S0748-7983(95)91690-3)
Hiscox, S.et al. 1995. Inhibition of cancer cell motility and invasion by interleukin-12. Clinical & Experimental Metastasis 13(5), pp. 396-404. (10.1007/BF00121916)
Jiang, W. G.et al. 1995. Induction of tyrosine phosphorylation and translocation of ezrin by hepatocyte growth factor/scatter factor (HGF/SF). Biochemical and Biophysical Research Communications 217(3), pp. 1062-1069. (10.1006/bbrc.1995.2877)

1994

Jiang, W.et al. 1994. Induction of motility and invasion by interleukin-3 on human colonic-cancer cells. British Journal of Surgery 81(5), pp. 761-761.
Jiang, W. G., Puntis, M. C. A. and Hallett, M. B. 1994. Neutrophil priming by cytokines in patients with obstructive jaundice.. HPB Surgery 7(4), pp. 281-289. (10.1155/1994/74202)
Jiang, W. G. 1994. In-vitro models of cancer invasion and metastasis: recent developments. European Journal of Surgical Oncology (EJSO) 20, pp. 493-499.
Jiang, W. G., Puntis, M. C. A. and Hallett, M. B. 1994. Molecular and cellular basis of cancer invasion and metastasis: Implications for treatment. British Journal of Surgery 81(11), pp. 1576-1590. (10.1002/bjs.1800811107)
Jiang, W. G. and Puntis, M. D. A. 1994. Effects of gamma linolenic acid and lithium linolinate on human monocytes and hepatoma. In: Horrobin, D. F. ed. New approaches to cancer treatment: Unsaturated lipids and photodynamic therapy. Edinburgh: Churchill-Livingstone, pp. 40-67.

1993

Jiang, W. G.et al. 1993. Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor. Clinical & Experimental Metastasis 11(3), pp. 235-242. (10.1007/BF00121166)
Jiang, W. G. and Puntis, M. C. 1993. Monocyte secretion of beta-hexosaminidase in patients with obstructive jaundice. HPB Surgery 7, pp. 15-23.
Jiang, W. G., Hallett, M. B. and Puntis, M. C. A. 1993. Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastasis. British Journal of Surgery 80(11), pp. 1368-1373. (10.1002/bjs.1800801104)

1992

Jiang, W. G.et al. 1992. Neutrophil priming by hepatocyte growth factor, a novel cytokine. Immunology 77(1), pp. 147-149.
Jiang, W. G., Puntis, M. and Hallett, M. B. 1992. U937 cells stimulated with opsonised zymozan particles provide a convenient laboratory source of tumour necrosis factor α. Journal of Immunological Methods 152(2), pp. 201-207. (10.1016/0022-1759(92)90141-F)

Molecular Pathology Module

HGF/cMET in the osteoblastic metastasis of prostate cancer, molecular, cellular and therapeutic implications, in collaboration with Professor Malcolm D Mason
Molecular finger printing of genes linked to cancer progression
Novel molecular wound healing signature, in collaboration with Professor Keith Harding
The molecular, cellular and clinical impacts of SOCS, suppressor of cytokine signalling, in human wound healing, in collaboration with Professor Keith Harding
Anti-metastasis (including peritoneal metastasis) medicines, in collaboration with Peking University and Yiling Research Institute (Professor Jiafu Ji and Professor Yiling Wu)
Brain Metastasis Research Platform, in collaboration with Capital Medical University (Professors Junqi He and Wei Ding)
Evaluation of transglutaminase-4 as a therapeutic target and diagnostic tool in human prostate cancer, in collaboration with Professor Malcolm D Mason and Professor Richard J Ablin (University of Arizona)
Biomarkers in human colorectal cancer research programme, in collaboration with Capital Medical University (Professors Junqi He and Wei Ding)
Cancer Metastasis Platform, in collaboration with Wales Life Science Network

Professor Wen Jiang

Overview

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2008