Overview
I have a long-standing interest in cancer metastasis and from 1987, my main research interest has been on the molecular and cellular basis of cancer invasion and metastasis and therapeutic aspects of targeting cancer metastasis. I have been particularly interested in the bone, peritoneal and brain metastasis from primary tumours including breast, prostate, lung, GI cancers. My research has been conducted in Cardiff's School of Medicine and I have collaborated widely with colleagues in the UK, China, Europe, North America and Asia.
Biography
Education and qualifications:
- 1995, MD research degree, University of Wales College of Medicine
- 1984, Primary medical degree (MB, BCh) in Clinical Medicine, Peking University Health Science Centre (Previously Beijing Medical University)
Career overview:
- 2014 - present: Dean of International, Cardiff University
- 2012 - present: Director of Cardiff China Medical Research Collaborative
- 2012 - present: Quality and Safety Improvement Faculty, National Health Service/UHB, National Health Service
- 2012 - present: Academic Director for International Relations, Cardiff University
- 2004 - present: Professor of Surgery and Tumour Biology, Cardiff University School of Medicine
- 2003 - 2004: Reader, University of Wales College of Medicine
- 1997 - 2003: Senior Lecturer, University of Wales College of Medicine
- 1996 - 1997: Senior Fellow, University of Wales College of Medicine
- 1989 - 1996: Research Fellow, University of Wales College of Medicine (currently Cardiff University's School of Medicine)
- 1987 - 1989: Chief Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing
- 1984 - 1987: Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing
Honours and awards
- Fellow of the Royal Society of Biology
- Fellow of the Royal Society of Medicine
- Honorary professorship at Peking University
- Honorary professorship at Capital Medical University
- Honorary professorship at Inner Mongolia University
- Honorary professorship at QingDao University
- International consultant for Beijing Lung Cancer Centre
Recent awards include:
- Member of the Most Excellent Order of the British Empire
- Marquis Who's Who as Prominent Cancer Researcher
- Outstanding Achievement Award, 19th World Congress of Oncology, Athens, Greece, October 2014
- Super Professor in America's Academic Row, June 2015
Professional memberships
- Member of the American Association for Cancer Research (AACR)
- Member of the British Association for Cancer Research (BACR)
- Member of the European Association for Cancer Research (EACR)
Academic positions
- 2014 - present: Dean of International, Cardiff University
- 2012 - present: Director of Cardiff China Medical Research Collaborative
- 2012 - present: Quality and Safety Improvement Faculty, National Health Service/UHB, National Health Service
- 2012 - present: Academic Director for International Relations, Cardiff University
- 2004 - present: Professor of Surgery and Tumour Biology, Cardiff University School of Medicine
- 2003 - 2004: Reader, University of Wales College of Medicine
- 1997 - 2003: Senior Lecturer, University of Wales College of Medicine
- 1996 - 1997: Senior Fellow, University of Wales College of Medicine
- 1989 - 1996: Research Fellow, University of Wales College of Medicine (currently Cardiff University's School of Medicine)
- 1987 - 1989: Chief Surgical Resident, Department of General Surgery, Peking University First Hospital, Beijing
- 1984 - 1987: Surgical Resident, Department of General Surgery, Peking UniversityFirst Hospital, Beijing
Speaking engagements
Recent speaking engagements include:
- 2017: International Gastic Cancer Conference
- 2016: Gordon Conference, Gerona, Spain
- 2016: British Society of Pharmacology
- 2016: GOC 2016, Prague
- 2016: 12th International Conference on Collateral Disease (Oncology Forum), Shanghai, China
- 2015: 11th International Conference on Collateral Disease, Shijiazhuang, China
- 2014: Peking University Postgraudate Society
- 2014: 19th World Congress on Advances in Oncology, Athens
- 2014: 9th International Conference of Anticancer Research, Sithonia
- 2013: Phoenix TV, Chinese Medicine in cancer therapies
- 2013: BBC report on new medicine in cancer treatment
Committees and reviewing
- 2014 - present: Member of the University International Board
Other academic activities:
Editorship:
- Editor-in-Chief: World Journal of Oncology
- Editor-in-Chief: Cancer Metastasis, Biology and Treatment http://www.springer.com/series/5761
- Editor-in-Chief: Journal of Molecular and Genetic Medicine http://www.omicsonline.com/open-access/molecular-genetic-medicine.php
Editorial Board membership includes:
- Member of the editorial board of the International Journal of Molecular Medicine, from 1999
- Advisory Board Member, ‘Advances in Therapy’, from 2008
- Editorial Board Member, ‘Current Oncology’, from 2008
- Editorial Board Member, ‘Journal of Surgical Oncology’, from 2008
- Editorial Board Member, ‘Current Signal Transduction Therapy’, from 2009
- Editorial Board Member, ‘World Journal of Gastroenterology’, from 2009
- Editorial Board Member, ‘Experimental and Therapeutic Medicine’, from 2009
- Editorial Board Member, ‘World Journal of Clinical Oncology’, From 2010
- Editorial Board Member, ‘World Journal of Oncology’, From 2010
- Editorial Board Member, ‘Chinese Journal of Cancer Research’, From 2010
- Editorial Board Member, ‘Current Cancer Therapy Reviews’, From 2010
- Editorial Board Member, ‘International Journal of Oncology'', from 2011
- Editorial Board Member, ‘Translational Medicine: Current Research'', from 2011
- Editorial Board Member, ‘Translational Gastrointestinal Cancer'', from 2011
- Editorial Board Member, ‘Biomedical Reports'', from 2012
- Editorial Board Member, ‘World Journal of Medical Genetics (WJMG)'', from 2012
- Academic consultant, 'Antitumour Pharmacy', from 2012
- Editorial Board Member: 'Journal of Cancer Research and Therapy', from 2012
- Editorial Board Member: 'Angiology', from 2012
- Editorial Board Member: 'AO Translational Research', from 2013
- Editorial Board Member: 'Chinese Journal of Biology', from 2013
- Editorial Board Member: 'Academic Journal of Capital Medical University', from 2013
- Editorial Board Member: 'Cancer Genomics and Proteomics', from 2014
- Editorial Board Member: 'Insight of Medical Physics', from 2015
- Editorial Board Member: 'Cancer Translational Medicine', from 2015
- Editorial Board Member: 'Biochemical and Biophysical Acta (BBA) Clinical'', from 2015
- Editorial Board Member: 'Cancer Hypothesis', from 2016
Books published
- ‘Cancer Metastasis, molecular and cellular basis and clinical intervention’, Editors Wen G Jiang and Robert E Mansel, Kluwer Academic Publishers, 2000 (ISBN 0-7923-6395-7). (http://www.springer.com/gb/book/9780792363958)
- ‘Growth Factors and their receptors in cancer metastasis’, Editors Wen G Jiang, Toshikazu Nakamura and Kunio Matsumoto, Kluwer Academic Publishers, 2001 (ISBN 0-7923-7141-0) (http://www.springer.com/gb/book/9780792371410)
- ‘Breast Cancer Metastasis’, Editors Robert E Mansel, Oystein Fodstad and Wen G Jiang, Spinger Publishers, 2007, ISBN: 978-1-4020-5866-0. (http://www.springer.com/gb/book/9781402058660)
- 'Electric Cell-Substrate Sensing in the investigation of cancer and cancer metastasis'. Wen G Jiang. Springer Publishers, 2012. ISBN 978-94-007-4926-9 (http://www.springer.com/biomed/cancer/book/978-94-007-4926-9)
- 'Tight junctions in cancer metastasis'. TA Martin and WG Jiang. Springer Publishers, March 2013 (ISBN 978-94-007-6027-1). (http://www.springer.com/gb/book/9789400760271)
Publications
2021
- Gong, W.et al. 2021. Location, function and role of stromal cell-derived factors and possible implications in cancer. International Journal of Molecular Medicine 47(2), pp. 435-443. (10.3892/ijmm.2020.4811)
- Kourti, M.et al. 2021. Structural modifications on CORM-3 lead to enhanced anti-angiogenic properties against triple-negative breast cancer cells. Medicinal Chemistry 17(1), pp. 40-59. (10.2174/1573406415666191206102452)
- Cui, Y.et al. 2021. Lead DEAD/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer. Computational and Structural Biotechnology Journal 19, pp. 261-278. (10.1016/j.csbj.2020.12.007)
- Martin, T. A.et al. 2021. NUPR1 and its potential role in cancer and pathological conditions. International Journal of Oncology
2020
- Gong, W.et al. 2020. Influence of anaesthetics on the production of cancer cell motogens, stromal cell-derived factor-1 and hepatocyte growth factor by fibroblasts. Oncology Letters 21(2), article number: 140. (10.3892/ol.2020.12401)
- Liu, C.et al. 2020. The role of SIPA1 in the development of cancer and metastases (Review). Molecular and Clinical Oncology 13(4), article number: 32. (10.3892/mco.2020.2102)
- Cong, Y.et al. 2020. Tim-3 promotes cell aggressiveness and paclitaxel resistance through the NF-κB /STAT3 signalling pathway in breast cancer cells. Chinese Journal of Cancer Research 32(5), pp. 564-579. (10.21147/j.issn.1000-9604.2020.05.02)
- Cong, Y.et al. 2020. Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells. Bioscience Reports 40(10), article number: BSR20202130. (10.1042/BSR20202130)
- Cong, Y.et al. 2020. Calcium-binding protein S100P promotes tumor progression but enhances chemosensitivity in breast cancer. Frontiers in Oncology 10, article number: 566302. (10.3389/fonc.2020.566302)
- Hao, C.et al. 2020. PD-L1 expression in glioblastoma, the clinical and prognostic significance: a systematic literature review and meta-analysis. Frontiers in Oncology 10, article number: 1015. (10.3389/fonc.2020.01015)
- Sun, Z.et al. 2020. Noggin is associated with a poor prognosis of gastric cancer by promoting the proliferation of gastric cancer cells via the upregulation of EGFR. International Journal of Oncology 57(3), pp. 813-824. (10.3892/ijo.2020.5081)
- Wazir, U.et al. 2020. Stratification using hTERT and stem cell markers confers a good prognosis in invasive breast cancer. Cancer Genomics and Proteomics 17(2), pp. 169-174. (10.21873/cgp.20177)
- Yang, F.et al. 2020. Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers. BMC Cancer 20(1), pp. -., article number: 202. (10.1186/s12885-020-6687-9)
- Zhao, Z.et al. 2020. Abstract P2-07-01: Kidins220 (kinase D interacting substrate 220) has a connection with neutrotrophic related factors, BDNF and NGF, in human breast cancer. Presented at: San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 10-14 December 2019, Vol. 80. Vol. 4, Sup. pp. P2-07-01., (10.1158/1538-7445.SABCS19-P2-07-01)
- Zhao, Z.et al. 2020. Abstract P3-01-18: Kinase D interacting substrate 220 (Kidins220) and disease progression of breast cancer, the role of heat shock protein90 (HSP90). Presented at: San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 10-14 December 2019, Vol. 80. Vol. 4, Sup. American Association for Cancer Research pp. P3-01-18., (10.1158/1538-7445.SABCS19-P3-01-18)
- Sun, Z.et al. 2020. Increased expression of Gremlin1 promotes proliferation and epithelial mesenchymal transition in gastric cancer cells and correlates with poor prognosis of patients with gastric cancer. Cancer Genomics and Proteomics 17(1), pp. 49-60. (10.21873/cgp.20167)
- Liu, J.et al. 2020. Increased expression of Psoriasin is correlated with poor prognosis of bladder transitional cell carcinoma by promoting invasion and proliferation. Oncology Reports 43(2), pp. 562-570. (10.3892/or.2019.7445)
- Cheng, X.et al. 2020. TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer. Cell Death and Disease 11, pp. -., article number: 92. (10.1038/s41419-020-2272-z)
- Dart, D. A., Ashelford, K. and Jiang, W. G. 2020. AR mRNA Stability is increased with AR-antagonist resistance via 3' UTR variants. Endocrine Connections 9(1), pp. 9-19. (10.1530/EC-19-0340)
- Yin, J.et al. 2020. EphB2 represents an independent prognostic marker in patients with gastric cancer and promotes tumour cell aggressiveness. Journal of Cancer 11(10), pp. 2778-2787. (10.7150/jca.38098)
- Sun, Z.et al. 2020. Deregulated bone morphogenetic proteins and their receptors are associated with disease progression of gastric cancer. Computational and Structural Biotechnology Journal 18, pp. 177-188. (10.1016/j.csbj.2019.12.014)
- Zeng, Y.et al. 2020. Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer. American Journal of Cancer Research 10(12), pp. 4211-4233.
2019
- Liu, J.et al. 2019. HOXB2 is a putative tumour promotor in human bladder cancer. Anticancer Research 39(12), pp. 6915-6921. (10.21873/anticanres.13912)
- Hao, C.et al. 2019. OPN promotes the aggressiveness of non-small-cell lung cancer cells through the activation of the RON tyrosine kinase. Scientific Reports 9(1), article number: 18101. (10.1038/s41598-019-54843-2)
- Tan, W.et al. 2019. Incorporating MicroRNA into molecular phenotypes of circulating tumor cells enhances the prognostic accuracy for patients with metastatic breast cancer. Oncologist 24, pp. e1044-e1054. (10.1634/theoncologist.2018-0697)
- Huang, J.et al. 2019. Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells. Cancer Cell International 19(1), article number: 306. (10.1186/s12935-019-1033-5)
- Sanders, A.et al. 2019. Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination. Oncotarget 10(59), pp. 6362-6377. (10.18632/oncotarget.27279)
- Dart, D. A.et al. 2019. MiR-221 is specifically elevated in PC3 cells and its deletion reduces adhesion, motility and growth. Anticancer Research 39(10), pp. 5311-5327. (10.21873/anticanres.13724)
- Bosanquet, D. C.et al. 2019. Development and validation of a gene expression test to identify hard-to-heal chronic venous leg ulcers. British Journal of Surgery 106(8), pp. 1035-1042. (10.1002/bjs.11161)
- Zhao, C.et al. 2019. Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer. Cancer Letters 453, pp. 107-121. (10.1016/j.canlet.2019.03.043)
- Xu, Y.et al. 2019. BDNF activates TrkB/PLCγ1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. European Review for Medical and Pharmacological Sciences 23(12), pp. 5093-5100. (10.26355/eurrev_201906_18173)
- Zhong, W.et al. 2019. Effect of younger age on survival outcomes in T1N0M0 breast cancer: A propensity score matching analysis. Journal of Surgical Oncology 119(8), pp. 1039-1046. (10.1002/jso.25457)
- Wazir, U.et al. 2019. Correlation of TERT and stem cell markers in the context of human breast cancer. Cancer Genomics and Proteomics 16(2), pp. 121-127. (10.21873/cgp.20117)
- Li, S.et al. 2019. Differential expression and functions of Ehm2 transcript variants in lung adenocarcinoma. International Journal of Oncology (10.3892/ijo.2019.4732)
- Fosu-Mensah, N. A.et al. 2019. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein-protein interaction. Medicinal Chemistry Research 28(2), pp. 182-202. (10.1007/s00044-018-2275-9)
- Kourti, M.et al. 2019. Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer. Oncotarget 10(10), pp. 1132-1148. (10.18632/oncotarget.26638)
2018
- Yang, W.et al. 2018. Effects of lidocaine and ropivacaine on gastric cancer cells through down-regulation of ERK1/2 phosphorylation in vitro. Anticancer Research 38(12), pp. 6729-6735. (10.21873/anticanres.13042)
- Flamini, V.et al. 2018. Distinct mechanisms by which two forms of miR-140 suppress the malignant properties of lung cancer cells. Oncotarget 2018(9) (10.18632/oncotarget.26356)
- Collins, R.et al. 2018. Mechanistic insights of epithelial protein lost in neoplasm in prostate cancer metastasis. International Journal of Cancer 143(10), pp. 2537-2550. (10.1002/ijc.31786)
- Zhao, H.et al. 2018. DOK7V1 influences the malignant phenotype of lung cancer cells through PI3K/AKT/mTOR and FAK/paxillin signaling pathways. International Journal of Oncology (10.3892/ijo.2018.4624)
- Gera, R.et al. 2018. mRNA Expression of CDK2AP1 in human breast cancer: correlation with clinical and pathological parameters. Cancer Genomics and Proteomics 15(6), pp. 447-452. (10.21873/cgp.20103)
- Dart, D. A.et al. 2018. Novel trifluoromethylated enobosarm analogues with potent antiandrogenic activity in vitro and tissue selectivity in vivo. Molecular Cancer Therapeutics 17(9), pp. 1846-1858. (10.1158/1535-7163.MCT-18-0037)
- Li, L.et al. 2018. Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer. International Journal of Oncology 53(3), pp. 1171-1182. (10.3892/ijo.2018.4455)
- Harries, R. L.et al. 2018. Impact of pigment epithelium-derived factor on colorectal cancer in vitro and in vivo. Oncotarget 9(27), pp. 19192-19202. (10.18632/oncotarget.24953)
- Ma, S.et al. 2018. CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood-brain barrier permeability in tumor brain metastasis. Oncology Reports 39(3), pp. 1441-1453. (10.3892/or.2018.6208)
- Jia, J.et al. 2018. Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. International Journal of Molecular Medicine 41(1), pp. 275-283. (10.3892/ijmm.2017.3224)
- Owen, S.et al. 2018. Key factors in breast cancer dissemination and establishment at the bone: past, present and future perspectives. In: Song, E. and Hu, H. eds. Translational Research in Breast Cancer:Biomarker Diagnosis, Targeted Therapies and Approaches to Precision., Vol. 1026. Advances in Experimental Medicine and Biology Singapore: Kluwer, pp. 197-216., (10.1007/978-981-10-6020-5_9)
- Riaz, S. K.et al. 2018. Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer. Cell Communication and Signaling 16, article number: 3. (10.1186/s12964-017-0213-y)
- Xie, M.et al. 2018. MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer. Gastric Cancer 21(1), pp. 41-54. (10.1007/s10120-017-0721-x)
2017
- Laprevotte, E.et al. 2017. The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway. Oncotarget 8, pp. 113360-113372. (10.18632/oncotarget.23008)
- Ma, S.et al. 2017. Claudin-5 regulates blood-brain barrier permeability by modifying brain microvascular endothelial cell proliferation, migration, and adhesion to prevent lung cancer metastasis. CNS Neuroscience & Therapeutics 23(12), pp. 947-960. (10.1111/cns.12764)
- Xin, L.et al. 2017. The era of multigene panels comes? The clinical utility of Oncotype DX and MammaPrint. World Journal of Oncology 8(2), pp. 34-40. (10.14740/wjon1019w)
- Yuan, Z.et al. 2017. Lessons From managing the breast malignant adenomyoepithelioma and the discussion on treatment strategy. World Journal of Oncology 8(4), pp. 126-131. (10.14740/wjon1055e)
- Tao, T.et al. 2017. PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation. Oncogene 36, pp. 6119-6131. (10.1038/onc.2017.199)
- Zabkiewicz, C.et al. 2017. Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance. Endocrine-Related Cancer 24(10), pp. R349-R366. (10.1530/ERC-17-0139)
- Zhao, H.et al. 2017. The effect of aurora kinase inhibitor on adhesion and migration in human breast cancer cells and clinical implications. World Journal of Oncology 8(5), pp. 151-161. (10.14740/wjon1062w)
- Dart, A. D., Uysal-Onganer, P. and Jiang, W. G. 2017. Prostate-specific PTen deletion in mice activates inflammatory microRNA expression pathways in the epithelium early in hyperplasia development. Oncogenesis 6(12), article number: 400. (10.1038/s41389-017-0007-5)
- Cai, S.et al. 2017. Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). International Journal of Molecular Medicine 40(4), pp. 965-971. (10.3892/ijmm.2017.3093)
- Zabkiewicz, C.et al. 2017. Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival. Cancer Genomics and Proteomics 14(4), pp. 241-251. (10.21873/cgp.20035)
- Zhao, Z.et al. 2017. Reduced expression of RanBPM Is associated with poorer survival from lung cancer and increased proliferation and invasion of lung cancer cells in vitro. Anticancer Research 37(8), pp. 4389-4397. (10.21873/anticanres.11833)
- Zhao, Q.et al. 2017. Protein of vascular endothelial growth inhibitor 174 inhibits epithelial-mesenchymal transition in renal cell carcinoma in vivo. Anticancer Research 37(8), pp. 4269-4275. (10.21873/anticanres.11819)
- Cui, Y.et al. 2017. Knockdown of EPHA1 using CRISPR/CAS9 suppresses aggressive properties of ovarian cancer cells. Anticancer Research 37(8), pp. 4415-4424. (10.21873/anticanres.11836)
- Yuan, Z.et al. 2017. Application of localization and needle placement guided by mammographic, ultrasound and fiberoptic ductoscopy for resection of non-palpable breast lesions. Anticancer Research 37(8), pp. 4523-4527. (10.21873/anticanres.11849)
- Du, P.et al. 2017. Reduced expression of Metastasis Suppressor-1 (MTSS1) accelerates progression of human bladder uroepithelium cell carcinoma. Anticancer Research 37(8), pp. 4499-4505. (10.21873/anticanres.11846)
- Yin, J.et al. 2017. Overexpression of EPHB4 Is associated with poor survival of patients with gastric cancer. Anticancer Research 37(8), pp. 4489-4497. (10.21873/anticanres.11845)
- Kiran Riaz, S.et al. 2017. Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population. Anticancer Research 37(8), pp. 4449-4454. (10.21873/anticanres.11840)
- Yang, F.et al. 2017. NHERF1 suppresses lung cancer cell migration by regulation of epithelial-mesenchymal transition. Anticancer Research 37(8), pp. 4405-4414. (10.21873/anticanres.11835)
- Li, L.et al. 2017. Clinical correlation between WISP2 and β--Catenin in gastric cancer. Anticancer Research 37(8), pp. 4469-4473. (10.21873/anticanres.11842)
- Uhercik, M.et al. 2017. Clinical significance of PD1 and PDL1 in human breast cancer. Anticancer Research 37(8), pp. 4249-4254. (10.21873/anticanres.11817)
- Liang, G.et al. 2017. HIF1α-associated circDENND4C promotes proliferation of breast cancer cells in hypoxic environment. Anticancer Research 37(8), pp. 4337-4343. (10.21873/anticanres.11827)
- Sobkowicz, A. D.et al. 2017. Potential implication of Paxillin in cancer establishment within the bone environment. Anticancer Research 37(8), pp. 4255-4268. (10.21873/anticanres.11818)
- Flamini, V., Jiang, W. G. and Cui, Y. 2017. Therapeutic role of MiR-140-5p for the treatment of non-small cell lung cancer. Anticancer Research 37(8), pp. 4319-4327. (10.21873/anticanres.11825)
- Yu, Z.et al. 2017. Expression of osteoprotegrin is enhanced in lung cancer tissues and promotes aggressive cellular traits in H3122 lung cancer cells. Anticancer Research 37(8), pp. 4277-4283. (10.21873/anticanres.11820)
- Liu, Z.et al. 2017. High-efficient screening method for identification of key genes in breast cancer through microarray and bioinformatics. Anticancer Research 37(8), pp. 4329-4335. (10.21873/anticanres.11826)
- Zheng, F.et al. 2017. The axis of CXCR4/SDF-1 plays a role in colon cancer cell adhesion through regulation of the AKT and IGF1R signalling pathways. Anticancer Research 37(8), pp. 4361-4369. (10.21873/anticanres.11830)
- Zhao, Q.et al. 2017. Identification of novel proteins interacting with vascular endothelial growth inhibitor 174 in renal cell carcinoma. Anticancer Research 37(8), pp. 4379-4388. (10.21873/anticanres.11832)
- Tong, S.et al. 2017. MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma. Scientific Reports 7(1), article number: 5599. (10.1038/s41598-017-06098-y)
- Liu, Z.et al. 2017. Hepatitis B virus reactivation in breast cancer patients undergoing chemotherapy: A review and meta-analysis of prophylaxis management. Journal of Viral Hepatitis 24(7), pp. 561-572. (10.1111/jvh.12672)
- Hu, T.et al. 2017. Overexpression of activin receptor-like kinase 7 in breast cancer cells is associated with decreased cell growth and adhesion.. Anticancer Research 37, pp. 3441-3451. (10.21873/anticanres.11712)
- Lopes-Bastos, B.et al. 2017. Association of breast carcinoma growth with a non-canonical axis of IFNγ/IDO1/TSP1. Oncotarget (10.18632/oncotarget.18781)
- Cui, Y.et al. 2017. MicroRNA-7 suppresses the homing and migration potential of human endothelial cells to highly metastatic human breast cancer cells. British Journal of Cancer 117, pp. 89-101. (10.1038/bjc.2017.156)
- Malik, M. F. A.et al. 2017. Role of Plexin B1 in a breast cancer cohort of Pakistani patients and its contribution towards cancer metastasis as indicated by an in vitro model. Anticancer Research 37(8), pp. 4483-4488. (10.21873/anticanres.11844)
- Yang, W.et al. 2017. The effects of anesthetics on recurrence and metastasis of cancer, and clinical implications. World Journal of Oncology 8(3), pp. 63-70. (10.14740/wjon1031e)
- Jia, S.et al. 2017. Association of Wnt1-inducible signaling pathway protein-1 with the proliferation, migration and invasion in gastric cancer cells. Tumor Biology 39(6) (10.1177/1010428317699755)
- Owen, S.et al. 2017. The clinical and biological implications of the focal adhesion kinase pathway in ShenLingLan mediated suppression of cellular migration of ovarian cancer cells. Journal of Cancer Research & Therapy 5, pp. 24-31. (10.14312/2052-4994.2017-5)
- Koushyar, S.et al. 2017. The prohibitin-repressive interaction with E2F1, is rapidly inhibited by androgen signalling in prostate cancer cells. Oncogenesis 6, pp. e3333. (10.1038/oncsis.2017.32)
- Rangaraj, A.et al. 2017. Molecular and cellular impact of Psoriasin (S100A7) on the healing of human wounds. Experimental and Therapeutic Medicine 13(5), pp. 2151-2160. (10.3892/etm.2017.4275)
- Liu, Z.et al. 2017. Hey factors at the crossroad of tumorigenesis and clinical therapeutic modulation of Hey for anticancer treatment. Molecular Cancer Therapeutics 16(5), pp. 775-786. (10.1158/1535-7163.MCT-16-0576)
- Hao, C.et al. 2017. OPN-a splicing variant expression in non-small cell lung cancer and its effects on the bone metastatic abilities of lung cancer cells in vitro. Anticancer Research 37(5), pp. 2245-2254. (10.21873/anticanres.11561)
- Chen, G.et al. 2017. The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancer. Oncology Reports 37(5), pp. 2695-2701. (10.3892/or.2017.5538)
- Liu, Y.et al. 2017. Psoriasin promotes invasion, aggregation and survival of pancreatic cancer cells; association with disease progression. International Journal of Oncology 50(5), pp. 1491-1500. (10.3892/ijo.2017.3953)
- Hao, C.et al. 2017. Human osteopontin: potential clinical applications in cancer (Review). International Journal of Molecular Medicine (10.3892/ijmm.2017.2964)
- Ahmad, A.et al. 2017. KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer. PLoS ONE 12(4), article number: e0175058. (10.1371/journal.pone.0175058)
- Sun, P.et al. 2017. Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors. International Journal of Oncology 50(4), pp. 1127-1135. (10.3892/ijo.2017.3884)
- Ismail, A. F.et al. 2017. PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells. Biochemical Journal 474(8), pp. 1333-1346. (10.1042/BCJ20160875)
- Frugtniet, B. A.et al. 2017. Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. BMC Cancer 17(1), article number: 224. (10.1186/s12885-017-3219-3)
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2015
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2014
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2013
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2012
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2011
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2010
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2009
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2008
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2007
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2005
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2004
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2003
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2002
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2001
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2000
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1999
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1998
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1997
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- Jiang, W. G. and Hiscox, S. 1997. Expression of E-cadherin, alpha, beta and gamma-catenin in human colorectal cancer. Anticancer Research 17, pp. 1349-1354.
- Hiscox, S. and Jiang, W. G. 1997. Interleukin-12, an emerging anti-tumour cytokine. In Vivo -Athens- 11, pp. 125-132.
- Jiang, W. G. and Bryce, R. P. 1997. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. Prostaglandins Leukotrienes & Essential Fatty Acids 56, pp. 307-316.
- Jiang, W. G. and Bryce, R. P. 1997. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochemical and Biophysical Research Communications 244, pp. 414-420.
- Hiscox, S. E.et al. 1997. Expression of the HGF/SF Receptor, c-met, and its ligand in human colorectal cancers. Cancer Investigation 15(6), pp. 513-521. (10.3109/07357909709047592)
1996
- Jiang, W. G.et al. 1996. Inhibition of membrane ruffling and ezrin translocation by gamma linolenic acid. International Journal of Oncology 9(2), pp. 279-284. (10.3892/ijo.9.2.279)
- Jiang, W. G.et al. 1996. Inhibition of neutrophil respiratory burst and cytokine priming by γ-linolenic acid. British Journal of Surgery 83(5), pp. 659-664. (10.1002/bjs.1800830523)
- Jiang, W. G. and Hiscox, S. E. 1996. Cytokine regulation of ezrin expression in the human colon cancer cell line HT29.. Anticancer Research 16(2), pp. 861-865.
- Jiang, W. G.et al. 1996. Gamma linolenic acid inhibits tyrosine phosphorylation of focal adhesion kinase and paxillin and tumour cell matrix interaction. International Journal of Oncology 8(3), pp. 583-587. (10.3892/ijo.8.3.583)
- Puntis, M. C. A. and Jiang, W. G. 1996. Plasma cytokine levels and monocyte activation in patients with obstructive jaundice. Journal of Gastroenterology and Hepatology 11, pp. 7-13. (10.1111/j.1440-1746.1996.tb00003.x)
- Jiang, W. G. and Puntis, M. C. 1996. Monocyte and blood interleukin-12 levels in patients with obstructive jaundice. Hpb Surgery 9(4), pp. 209-221.
- Jiang, W. G. 1996. E-cadherin and its associated protein catenins, cancer invasion and metastasis. British Journal of Surgery 83, pp. 437-446.
- Jiang, W. G.et al. 1996. Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell-matrix interactions. Oncology Reports 3(5), pp. 819-823. (10.3892/or.3.5.819)
- Han, Z.et al. 1996. Inhibition of motility and invasion of human lung cancer cells by invasion inhibiting factor 2. Surgical Oncology 5(2), pp. 77-84. (10.1016/S0960-7404(96)80004-1)
1995
- Jiang, W. G.et al. 1995. Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). Cancer Research 55, pp. 5043-5048.
- Jiang, W. G.et al. 1995. Gamma linolenic acid up-regulates e-cadherin expression in human cancer cells. British Journal of Surgery 82(11), pp. 1565-1565.
- Jiang, W. G.et al. 1995. Expression of catenins in human cancer cells and its regulation by n-6 polyunsaturated fatty acids. Anticancer Research 15(6B), pp. 2569-2573.
- Jiang, W. G.et al. 1995. Inhibition of HGF/SF-induced membrane ruffling and cell motility by transient elevation of cytosolic free Ca2+. Experimental Cell Research 220(2), pp. 424-433. (10.1006/excr.1995.1334)
- Jiang, W. G.et al. 1995. Regulation of motility and invasion of cancer cells by human monocytic cells. Anticancer Research 15(4), pp. 1303-1310.
- Jiang, W. G.et al. 1995. Inhibition of HGF/SF-induced tumor-cell membrane ruffling by calcium signalling. British Journal of Surgery 82(5), pp. 682-683.
- Jiang, W. G.et al. 1995. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. British Journal of Cancer 71(4), pp. 744-752. (10.1038/bjc.1995.145)
- Jiang, W. G. 1995. Membrane ruffling of cancer cells: a parameter of tumour cell motility and invasion. European Journal of Surgical Oncology (EJSO) 21, pp. 307-309. (10.1016/S0748-7983(95)91690-3)
- Hiscox, S.et al. 1995. Inhibition of cancer cell motility and invasion by interleukin-12. Clinical & Experimental Metastasis 13(5), pp. 396-404. (10.1007/BF00121916)
- Jiang, W. G.et al. 1995. Induction of tyrosine phosphorylation and translocation of ezrin by hepatocyte growth factor/scatter factor (HGF/SF). Biochemical and Biophysical Research Communications 217(3), pp. 1062-1069. (10.1006/bbrc.1995.2877)
1994
- Jiang, W.et al. 1994. Induction of motility and invasion by interleukin-3 on human colonic-cancer cells. British Journal of Surgery 81(5), pp. 761-761.
- Jiang, W. G., Puntis, M. C. A. and Hallett, M. B. 1994. Neutrophil priming by cytokines in patients with obstructive jaundice.. HPB Surgery 7(4), pp. 281-289. (10.1155/1994/74202)
- Jiang, W. G. 1994. In-vitro models of cancer invasion and metastasis: recent developments. European Journal of Surgical Oncology (EJSO) 20, pp. 493-499.
- Jiang, W. G., Puntis, M. C. A. and Hallett, M. B. 1994. Molecular and cellular basis of cancer invasion and metastasis: Implications for treatment. British Journal of Surgery 81(11), pp. 1576-1590. (10.1002/bjs.1800811107)
- Jiang, W. G. and Puntis, M. D. A. 1994. Effects of gamma linolenic acid and lithium linolinate on human monocytes and hepatoma. In: Horrobin, D. F. ed. New approaches to cancer treatment: Unsaturated lipids and photodynamic therapy. Edinburgh: Churchill-Livingstone, pp. 40-67.
1993
- Jiang, W. G.et al. 1993. Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor. Clinical & Experimental Metastasis 11(3), pp. 235-242. (10.1007/BF00121166)
- Jiang, W. G. and Puntis, M. C. 1993. Monocyte secretion of beta-hexosaminidase in patients with obstructive jaundice. HPB Surgery 7, pp. 15-23.
- Jiang, W. G., Hallett, M. B. and Puntis, M. C. A. 1993. Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastasis. British Journal of Surgery 80(11), pp. 1368-1373. (10.1002/bjs.1800801104)
1992
- Jiang, W. G.et al. 1992. Neutrophil priming by hepatocyte growth factor, a novel cytokine. Immunology 77(1), pp. 147-149.
- Jiang, W. G., Puntis, M. and Hallett, M. B. 1992. U937 cells stimulated with opsonised zymozan particles provide a convenient laboratory source of tumour necrosis factor α. Journal of Immunological Methods 152(2), pp. 201-207. (10.1016/0022-1759(92)90141-F)
Teaching
- Molecular Pathology Module
- HGF/cMET in the osteoblastic metastasis of prostate cancer, molecular, cellular and therapeutic implications, in collaboration with Professor Malcolm D Mason
- Molecular finger printing of genes linked to cancer progression
- Novel molecular wound healing signature, in collaboration with Professor Keith Harding
- The molecular, cellular and clinical impacts of SOCS, suppressor of cytokine signalling, in human wound healing, in collaboration with Professor Keith Harding
- Anti-metastasis (including peritoneal metastasis) medicines, in collaboration with Peking University and Yiling Research Institute (Professor Jiafu Ji and Professor Yiling Wu)
- Brain Metastasis Research Platform, in collaboration with Capital Medical University (Professors Junqi He and Wei Ding)
- Evaluation of transglutaminase-4 as a therapeutic target and diagnostic tool in human prostate cancer, in collaboration with Professor Malcolm D Mason and Professor Richard J Ablin (University of Arizona)
- Biomarkers in human colorectal cancer research programme, in collaboration with Capital Medical University (Professors Junqi He and Wei Ding)
- Cancer Metastasis Platform, in collaboration with Wales Life Science Network