Overview
I am a member of the Infections & Antimicrobial Resistance Research Group in the Division of Population Medicine. Research in which I am primarily involved is in infections and the use of novel technologies in the application of point of care tests and the diagnosis and management of infectious conditions. My particular interest is in using genomic and proteomic techniques in the search for clinically relevant mechanisms of host response to infection with antimicrobial resistant bacteria and the identification of useful biomarkers. We are also in the process of developing a point-of-care diagnostic device for the detection of bacterial pneumonia in exhaled breath. This device will be targeted at low and middle income developing countries.
Biography
Education and qualifications
1998: PhD (Molecular Biology) BBSRC/University of Hertfortshire, UK.
1994: BSc & MSc(Plant Pathology/Nematology) Wageningen Agricultural University, Wageningen, The Netherlands.
1984: BSc (Zoology and Microbiology/Plant Pathology) University of Natal, Pietermaritzburg, South Africa.
Career overview
From 2012 to end 2015 Lecturer in the Infections and Antimicrobial Resistance research theme group in the Institute for Primary Care and Public Health. From January 2006 to Jan 2012 Lecturer at the Centre for Health and Environmental Research in the Institute of Primary Care and Public Health. Before that (from 2003) I was a non-clinical lecturer and Alzheimer’s Society Research Fellow in the Department of Psychological Medicine. I joined the College of Medicine in 1997 as post-doc and in 2000 was awarded a UWCM Senior Research Fellowship.
Honours and awards
Bill and Melinda Gates Foundation. $100,000. The development of a point of care instrument for rapid diagnosis of pneumonia. From November 2015 to May 2017. Bastiaan Hoogendoorn, Colin Powell, Clive Gregory (School of Medicine), Jenna Bowen, Chris Allender (School of Pharmacy).
PhD Studentship 2015, "Project to determine the feasibility of measuring bacterial load in exhaled breath of children with pneumonia and empyema using a novel point-of-care test." Start 5 October 2015. CU School of Medicine/Institute of Primary Care and Public Health PhD Studentship. Supervisor: Bastiaan Hoogendoorn; Co-supervisors: Colin Powell, Clive Gregory, Chris Allender.
Bill and Melinda Gates Foundation. $100,000. The development of a cheap and simple to use self-administrable micro-needle patch device for population-wide of sampling of small volumes of blood. From 1 May 2012 for 24 months. Prof I Matthews, Dr J Gallacher, Dr C Gregory, Dr B Hoogendoorn (School of Medicine) Prof D Barrow (School of Engineering) & Dr C Allender (School of Pharmacy).
MRC/NERC project. £143,065. An exploratory study investigating the primary physico-chemical characteristics of respirable ambient air particulates which are responsible for the dysregulation of pulmonary genes and related proteins. From July 2007 for 1 year. Prof I Matthews, Dr B Hoogendoorm, Dr J Gregory, Dr K Berube, Dr T Jones.
Alzheimer’s Society Research Project. £131,314. Continuation of Comparative proteome analysis of the transgenic Alzheimer’s disease mouse model Tg2576. From October 2005 for 2 years. B Hoogendoorn, PI; AL Jones, MJ Owen, MC O’Donovan, Co-PI.
PhD studentship from UWCM awarded to Ms Mia Deschepper (B Hoogendoorn and AL Jones). Proteomic analysis of mouse models of Huntington’s disease. From October 2003 for 3 years.
Alzheimer’s Society Research Fellowship. £173,314. Comparative proteome analysis of the transgenic Alzheimer’s disease mouse model Tg2576. From October 2002 for 3 years.
Professional memberships
Fellow of the Higher Education Academy
British Society for Proteome Research
The Genetics Society
Publications
2016
- Clark, J., Gregory, C. J., Matthews, I. P. and Hoogendoorn, B. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540)
2013
- Matthews, I. P., Gregory, C. J., Aljayyoussi, G., Morris, C. J., McDonald, I., Hoogendoorn, B. and Gumbleton, M. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002)
- Elvidge, T., Matthews, I. P., Gregory, C. and Hoogendoorn, B. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
2012
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
2010
- Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
2005
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
2004
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
2003
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
2002
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
2001
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
2000
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Jones, A. C., Sampson, J. R., Hoogendoorn, B., Cohen, D. and Cheadle, J. P. 2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106(6), pp. 663-668. (10.1007/s004390000316)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
1999
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
Teaching
Module Leader: organise and run (including lecturing and assessment) the ME3036 Molecular Genetics and Cell Biology module for the Medical Intercalated Degree Scheme, BSc in Medical Pharmacology and BSc Biomedical Sciences (Pharmacology).
PhD supervisor for PhD Studentship 2015, "Project to determine the feasibility of measuring bacterial load in exhaled breath of children with pneumonia and empyema using a novel point-of-care test."
Member of the Population Medicine Task and Finish Group responsible for the planning, development and introduction of the Population Medicine contribution to the C21 Evidence Based Medicine module for the C21 undergraduate curriculum.
Delivery and assessment for Evidence Based Medicine coursework (C21) for years 1, 2 and 3.
Supervision of SSC projects.
Supervision, assessment and project marking of MPH Programme & Medical Intercalated BSc course – Clinical Epidemiology Route.
I have been a personal mentor since 2007 and have enjoyed helping students with personal, academic and non-academic problems. Mostly this requires being able to listen, understand and discuss what is needed to provide genuine and practical assistance in solving difficulties and requests; whether this means hooking them up with the right people/office/department or writing references and recommendations. I look forward to continuing in the expanded role of personal and academic mentor.
We have been awarded a grant from the Bill and Melinda Gates Foundation Grand Challenges Explorations Phase I, 2015, to develop a new tool capable of rapidly diagnosing pneumonia (towards improving pneumonia diagnosis). We have designed and constructed a point-of-care prototype breath sampling device and we are recruiting paediatric patients.