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Dr Bastiaan Hoogendoorn

Lecturer

School of Medicine

Email
hoogendoornb@cardiff.ac.uk
Telephone
+44 29206 87151
Campuses
Neuadd Meirionnydd

Overview

I am a member of the Infections & Antimicrobial Resistance Research Group in the Division of Population Medicine. Research in which I am primarily involved is in infections and the use of novel technologies in the application of point of care tests and the diagnosis and management of infectious conditions. My particular interest is in using genomic and proteomic techniques in the search for clinically relevant mechanisms of host response to infection with antimicrobial resistant bacteria and the identification of useful biomarkers. We are also in the process of developing a point-of-care diagnostic device for the detection of bacterial pneumonia in exhaled breath. This device will be targeted at low and middle income developing countries.

Biography

Education and qualifications

1998: PhD (Molecular Biology) BBSRC/University of Hertfortshire, UK.

1994: BSc & MSc(Plant Pathology/Nematology) Wageningen Agricultural University, Wageningen, The Netherlands.

1984: BSc (Zoology and Microbiology/Plant Pathology) University of Natal, Pietermaritzburg, South Africa.

Career overview

From 2012 to end 2015 Lecturer in the Infections and Antimicrobial Resistance research theme group in the Institute for Primary Care and Public Health. From January 2006 to Jan 2012 Lecturer at the Centre for Health and Environmental Research in the Institute of Primary Care and Public Health. Before that (from 2003) I was a non-clinical lecturer and Alzheimer’s Society Research Fellow in the Department of Psychological Medicine. I joined the College of Medicine in 1997 as post-doc and in 2000 was awarded a UWCM Senior Research Fellowship.

Honours and awards

Bill and Melinda Gates Foundation. $100,000. The development of a point of care instrument for rapid diagnosis of pneumonia. From November 2015 to May 2017. Bastiaan Hoogendoorn, Colin Powell, Clive Gregory (School of Medicine), Jenna Bowen, Chris Allender (School of Pharmacy).

PhD Studentship 2015, "Project to determine the feasibility of measuring bacterial load in exhaled breath of children with pneumonia and empyema using a novel point-of-care test." Start 5 October 2015. CU School of Medicine/Institute of Primary Care and Public Health PhD Studentship. Supervisor: Bastiaan Hoogendoorn; Co-supervisors: Colin Powell, Clive Gregory, Chris Allender.

Bill and Melinda Gates Foundation. $100,000. The development of a cheap and simple to use self-administrable micro-needle patch device for population-wide of sampling of small volumes of blood. From 1 May 2012 for 24 months. Prof I Matthews, Dr J Gallacher, Dr C Gregory, Dr B Hoogendoorn (School of Medicine) Prof D Barrow (School of Engineering) & Dr C Allender (School of Pharmacy).

MRC/NERC project. £143,065. An exploratory study investigating the primary physico-chemical characteristics of respirable ambient air particulates which are responsible for the dysregulation of pulmonary genes and related proteins. From July 2007 for 1 year. Prof I Matthews, Dr B Hoogendoorm, Dr J Gregory, Dr K Berube, Dr T Jones.

Alzheimer’s Society Research Project. £131,314. Continuation of Comparative proteome analysis of the transgenic Alzheimer’s disease mouse model Tg2576. From October 2005 for 2 years. B Hoogendoorn, PI; AL Jones, MJ Owen, MC O’Donovan, Co-PI.

PhD studentship from UWCM awarded to Ms Mia Deschepper (B Hoogendoorn and AL Jones). Proteomic analysis of mouse models of Huntington’s disease. From October 2003 for 3 years.

Alzheimer’s Society Research Fellowship. £173,314. Comparative proteome analysis of the transgenic Alzheimer’s disease mouse model Tg2576. From October 2002 for 3 years.

Professional memberships

Fellow of the Higher Education Academy

British Society for Proteome Research

The Genetics Society

Publications

2016

2013

2012

2010

2005

2004

2003

2002

2001

2000

1999

Teaching

Module Leader: organise and run (including lecturing and assessment) the ME3036 Molecular Genetics and Cell Biology module for the Medical Intercalated Degree Scheme, BSc in Medical Pharmacology and BSc Biomedical Sciences (Pharmacology).

PhD supervisor for PhD Studentship 2015, "Project to determine the feasibility of measuring bacterial load in exhaled breath of children with pneumonia and empyema using a novel point-of-care test."

Member of the Population Medicine Task and Finish Group responsible for the planning, development and introduction of the Population Medicine contribution to the C21 Evidence Based Medicine module for the C21 undergraduate curriculum.

Delivery and assessment for Evidence Based Medicine coursework (C21) for years 1, 2 and 3.

Supervision of SSC projects.

Supervision, assessment and project marking of MPH Programme & Medical Intercalated BSc course – Clinical Epidemiology Route.

I have been a personal mentor since 2007 and have enjoyed helping students with personal, academic and non-academic problems. Mostly this requires being able to listen, understand and discuss what is needed to provide genuine and practical assistance in solving difficulties and requests; whether this means hooking them up with the right people/office/department or writing references and recommendations. I look forward to continuing in the expanded role of personal and academic mentor.

We have been awarded a grant from the Bill and Melinda Gates Foundation Grand Challenges Explorations Phase I, 2015, to develop a new tool capable of rapidly diagnosing pneumonia (towards improving pneumonia diagnosis). We have designed and constructed a point-of-care prototype breath sampling device and we are recruiting paediatric patients.