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Dr Meike Heurich-Sevcenco

Dr Meike Heurich-Sevcenco

Lecturer

School of Pharmacy and Pharmaceutical Sciences

Available for postgraduate supervision

Meike Heurich joined the School of Pharmacy and Pharmaceutical Sciences as a Lecturer  in January 2017. A biochemist by training (Potsdam University, Germany),  she gained her PhD (Cranfield University, 2008) in applied biochemistry and biosensor devlopment. She then spend 4 years as a post-doctoral researcher at the School of Medicine, Cardiff University, studying innate immune defence mechanisms of the complement system. In 2012, she was awarded an independent career development fellowship  (NISCHR, now Health and Care Research Wales) investigating the cross-talk mechanisms of complement with the coagulation system. Her research interests span the in-depth charactersation of cross-talk between the immune system and coagulation/clotting in health and disease, involving biomolecular analysis, clinical biomarker discovery and pathway-targeted therapeutics development. (117words)

Research keywords: Immunity;  complement system; coagulation system; biomolecular interaction; binding affinity; biomarkers; pathway-targeted therapeutics

Grants and Awards

£19.682 Welcome Trust ISSF3 Seeds for Seed Award (December 2018)

£3,822 Research Development Fund, School of Pharmacy, equipment (June 2017)

£9,850 University Cardiff Incoming Visiting Fellowship Scheme & International Collaboration Seedcorn Fund (June 2017)

£13,710 New Investigator Award, Intensive Care Foundation; (Co-Principal Investigator, 2014 - June 2017)

£360,000 Equipment Award, Biacore T200, Research Infrastructure Framework grant from Cardiff University (Co-applicant, 2014)

Professional Memberships

2017 - present                        British Pharmacological Society

2012 – present                        International Society on Thrombosis and Haemostasis

2009 – present                        British Society for Immunology

2008 – present                       International Complement Society

Public Engagement

I am involved in the British Society for Immunology vaccine ambassdor scheme, which is a pilot project we ran this year in London and hope to roll out locally in due course.

More information can be found here:

https://www.immunology.org/public-information/all-about-vaccines

and here:

https://www.immunology.org/public-information/all-about-vaccines/vaccine-ambassador-scheme

2017 – present

Lecturer at School of Pharmacy and Pharmaceutical Sciences, Cardiff University

2012 – 2016

Career Development Research Fellow (NISCHR, National Institute of Social Care and Health Research, now Health and Care Research Wales) Institute of Infection & Immunity, School of Medicine, Cardiff University.

“Cross-interaction of the innate immune response (complement system) with coagulation proteins in blood disorders”.

2013 – 2014

Lecturer (fixed-term), Cardiff University Independent Researcher Secondment Scheme, School of Medicine, Cardiff University.

2011 – 2012

Post-Doctoral Research Associate, Institute of Psychological Medicine & Clinical Neurosciences and Institute of Infection & Immunity, School of Medicine, Cardiff University. “The role of complement regulators in Alzheimer’s disease”.

2008 – 2011

Post-Doctoral Research Associate, Department of Infection, Immunity & Biochemistry, School of Medicine, Cardiff University. “The role and diagnosis of complement dysregulation in disease” & “The Complotype: dictating risk for inflammation and infection”.

2004 – 2008

PhD in Applied Biochemistry, Cranfield Biotechnology Centre, Cranfield University. “Development of a screen-printed voltametric electrochemical sensor for the immunosuppressant mycotoxin ochratoxin A”.

1997 – 2003

Diploma (Univ.) Biochemistry, Potsdam University, Germany.

Research thesis (March-September 2003) at the Institute of Biomedicine and Chemistry, Kalmar University, Sweden. “Development of a diagnostic tool for markers of ischemic heart disease for early diagnosis of acute myocardial infarction using weak affinity chromatography and SPR/Biacore analysis.

2019

2018

2016

2015

2014

2013

2012

2011

2010

Module Lead PH1123

Cell biology and the cytoskeleton PH1123

Immunology PH1124

Drugs and Diseases II PH3113

MSc Cancer Biology

Research Focus

  • Mechanisms of complement and coagulation cross-talk in health
  • Complement and coagulation cross-talk in psychotic disorder
  • Clinical biomarker studies
  • Cross-talk targeted therapeutics

My past research has largely focussed on the characterisation of structure-function mechanisms leading to dysregulation of the complement system, part of the innate immune defence. 

Recent research focussed on the molecular characterisation of cross-talk between the two innate defence systems against pathogen invasion and bleeding, complement and coagulation. Both complement and coagulation systems are structurally and organisationally similar protein cascades that are activated by defined triggers, often in parallel. Dysregulation of these systems have been associated with many diseases with pro-inflammatory and/or pro-coagulant pathology.

We are currently studying complement and coagulation cross-talk on the protein and cellular level in vitro and investigating in vivo mechanisms.

i) With clinical colleagues at the UHW Cardiff, a clinical biomarker study in a severe sepsis patient cohort is identifying key cross-talking complement and coagulation protein biomarkers as tools to predict disease severity.

ii) In collaboration with RCSI Dublin, we are are further studying the impact of plasma protein changes (of the complement and coagulation system) in individuals who develop psychotic experiences or psychotic disorders.

iii) Dr Heurich's group is targeting complement and coagulation cross-talk to design and develop novel dual-function therapeutics.

PhD opportunities

(SELF-FUNDED ONLY)

An exciting new PhD studentship opportunity (beginning in October 2019) supervised by Dr Heurich Prof. Collins (School of Medicine, Cardiff):

Characterising the interaction of coagulation and innate immunity in people being treated for bleeding disorder haemophilia A

A novel treatment for haemophilia patients has been associated with thrombosis in small blood vessels in the kidney. This is also found in a rare kidney disorder caused by impaired immune function of blood proteins. This project will determine the mechanisms of this treatment on coagulation and immune system by in vitro tests and clinical samples.

Please email heurichm@cardiff.ac.uk for further inquiries.

External profiles