Dr David Griffiths

2023

• Shorning, B., Trent, N., Griffiths, D. F., Worzfeld, T., Offermanns, S., Smalley, M. J. and Williamson, M. 2023. Plexin-B1 mutation drives metastasis in prostate cancer mouse models. Cancer Research Communications 3(3), pp. 444-458. (10.1158/2767-9764.CRC-22-0480)

2020

• McClatchey, M. A. et al. 2020. Focal segmental glomerulosclerosis and mild intellectual disability in a patient with a novel de novo truncating TRIM8 mutation. European Journal of Medical Genetics 63(9), article number: 103972. (10.1016/j.ejmg.2020.103972)

2017

• Jefferies, M. T. et al. 2017. PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243(4), pp. 442-456. (10.1002/path.4977)

2015

• Campbell, L., Jasani, B., Griffiths, D. F. R. and Gumbleton, M. 2015. Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. American Journal of Cancer Research 5(9), pp. 2838-2848.
• Yang, J. et al. 2015. Renal tumours in a Tsc2+/- mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin. Oncogene 34, pp. 922-931. (10.1038/onc.2014.17)

2013

• Campbell, L. et al. 2013. Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease. Journal of Translational Medicine 11(1), article number: 255. (10.1186/1479-5876-11-255)

2011

• Shorning, B., Griffiths, D. F. R. and Clarke, A. R. 2011. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS ONE 6(1), article number: e16209. (10.1371/journal.pone.0016209)
• Searchfield, L., Price, S., Betton, G., Jasani, B., Riccardi, D. and Griffiths, D. F. R. 2011. Glutathione S-transferases as molecular markers of tumour progression and prognosis in renal cell carcinoma. Histopathology 58(2), pp. 180-190. (10.1111/j.1365-2559.2010.03733.x)
• Carrington, C. P., Williams, A., Griffiths, D. F., Riley, S. G. and Donovan, K. 2011. Adult day-case renal biopsy: a single-centre experience. Nephrology Dialysis Transplantation 26(5), pp. 1559-1563. (10.1093/ndt/gfq571)

2010

• Chandra, A., Griffiths, D. F. R. and McWilliam, L. J. 2010. Best practice: gross examination and sampling of surgical specimens from the urinary bladder. Journal of Clinical Pathology 63(6), pp. 475-479. (10.1136/jcp.2009.071191)

2009

• Campbell, L., Nuttall, R., Griffiths, D. F. R. and Gumbleton, M. 2009. Activated Extracellular Signal-Regulated Kinase Is an Independent Prognostic Factor in Clinically Confined Renal Cell Carcinoma. Cancer 115(15), pp. 3457-3467. (10.1002/cncr.24389)

2008

• Campbell, L., Jasani, B., Edwards, K., Gumbleton, M. and Griffiths, D. F. R. 2008. Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma. British Journal of Cancer 98(5), pp. 931-940. (10.1038/sj.bjc.6604243)

2005

• Sansom, O. J., Griffiths, D. F. R., Reed, K. R., Winton, D. J. and Clarke, A. R. 2005. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24, pp. 8205-8210. (10.1038/sj.onc.1208956)
• Wilson, C. H. et al. 2005. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human Molecular Genetics 14(13), pp. 1839-1850. (10.1093/hmg/ddi190)
• Dudderidge, T. J., Stoeber, K., Loddo, M., Atkinson, G., Fanshawe, T., Griffiths, D. F. R. and Williams, G. H. 2005. Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. Clinical cancer research 11(7), pp. 2510-2517. (10.1158/1078-0432.CCR-04-1776)

2004

• Morris-Stiff, G. et al. 2004. Transmission of donor melanoma to multiple organ transplant recipients. American Journal of Transplantation 4(3), pp. 444-446. (10.1111/j.1600-6143.2004.00335.x)

2003

• Campbell, L., Gumbleton, M. and Griffiths, D. F. R. 2003. Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. British Journal of Cancer 89(10), pp. 1909-1913. (10.1038/sj.bjc.6601359)

2001

• Hateboer, N. et al. 2001. Confirmation of a gene locus for medullary cystic kidney disease (MCKD2) on chromosome 16p12. Kidney International 60(4), pp. 1233-1239. (10.1046/j.1523-1755.2001.00932.x)

2000

• Gupta, S., Golash, A., Thomas, J. A., Cochlin, D., Griffiths, D. F. R. and Jenkins, B. J. 2000. Epidermoid cysts of the testis: the case for conservative surgery. Annals of the Royal College of Surgeons of England 82(6), pp. 411-413.

1999

• Morris-Stiff, G. et al. 1999. What is the true incidence of acute rejection (AR) in renal transplant recipients receiving calcineurin inhibitors?. Transplantation 67(9), pp. s547. (10.1097/00007890-199905150-00042)

1997

• Barrington, J. W., Fulford, S., Griffiths, D. F. R. and Stephenson, T. P. 1997. Tumors in bladder remnant after augmentation enterocystoplasty. The Journal of Urology 157(2), pp. 485-486. (10.1016/s0022-5347(01)65181-4)

1994

• Thomas, J. A., Matanhelia, S. S., Griffiths, D. F. R. and Matthews, P. N. 1994. Clitoral metastasis secondary to transitional cell carcinoma of the bladder. British Journal of Urology 74(4), pp. 524-525. (10.1111/j.1464-410x.1994.tb00441.x)

1991

• Rooney, I. A. et al. 1991. The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells. Clinical and Experimental Immunology 83(2), pp. 251-256. (10.1111/j.1365-2249.1991.tb05623.x)