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Professor Nicholas Francis

Professor Nicholas Francis

Professor of Primary Care Research

School of Medicine

+44 (0)29 2068 7133
Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS

I am an academic general practitioner and my research interests are around improving the management of problems commonly seen in general practice.

My research has primarily focused around four main areas:

1) Infections, complications of infections, and antimicrobial use and resistance.

2) Skin conditions, including eczema, acne, skin infections and molluscum contagiosum.

3) Respiratory conditions, including respiratory infections, COPD and asthma.

4) Urinary / renal problems.
















I lead a module on common infections that forms part of the Clinical Epidemiology Intercalated BSc for Medical Students.

I also contribute to the undergraduate medical education curriculum by teaching medical epidemiolgy, examining ISCEs, and acting as a mentor.

Current Research Projects

PACE: General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit.

I am co-Chief Investigator of this NIHR-HTA funded trial of CRP point of care testing to guide the use of antibiotics for acute exacerbation of COPD.

OSTRICH: Oral Steroids for the Resolution of Otitis media with effusion in Children

I am co-Chief Investigator of this NIHR-HTA funded trial of oral steroids to improve hearing loss in children with persistent otitis media with effusion.

CEDAR: Children's Ear Pain Study

I am the Principal Investigator for Wales for this NIHR-HTA funded trial of analgesic ear drops to reduce the use of antibiotics in children with acute otitis media.

PREPARE: Platform for European Preparedness Against (Re-)Emerging Epidemics

This is a large EU-funded project that aims to conduct large-scale clinical research studies on infectious diseases, and is prepared to rapidly respond to any severe infectious disease outbreak. I am involved in work package 1, which seeks to identify and implement solutions to any ethical, administrative, regulatory or legal bottlenecks to conducting research in an infectious disease pandemic. I am also on the trial management group for the ALIC4E trial ( which forms work package 4.