Overview
If you are a patient, thank you for reaching out to me after seeing the article about our research. It is at an early stage and although we are hopeful that these new cells will be therapeutically valuable, they have yet to be tested and approved for clinical trials. For more support please contact a cancer support group in your local area.
Publication
2023
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
2022
- Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
2021
- Martini, V. et al. 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206(2), article number: ji2001086. (10.4049/jimmunol.2001086)
2020
- Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11, article number: 1587. (10.3389/fimmu.2020.01587)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
- Yeo, L. et al. 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199(3), pp. 263-277. (10.1111/cei.13391)
- Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21, pp. 178 - 185. (10.1038/s41590-019-0578-8)
- Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11, article number: 296. (10.3389/fimmu.2020.00296)
- Bagaev, D. V. et al. 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48(D1), pp. D1057-D1062., article number: gkz874. (10.1093/nar/gkz874)
2019
- MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9, article number: 5487. (10.1038/s41598-019-41811-z)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)
2018
- Yeo, L. et al. 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128(8), pp. 3460-3474. (10.1172/JCI120555)
- Zhao, X. et al. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9, article number: 2716. (10.1038/s41467-018-05288-0)
- Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9, article number: 1378. (10.3389/fimmu.2018.01378)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Rius, C. et al. 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200(7), pp. 2263-2279. (10.4049/jimmunol.1700242)
- Bovay, A. et al. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48(2), pp. 258-272. (10.1002/eji.201747082)
- Legut, M., Dolton, G., Mian, A., Ottmann, O. and Sewell, A. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131(3), pp. 311-322. (10.1182/blood-2017-05-787598)
- Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)
2017
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8, article number: 1503. (10.3389/fimmu.2017.01503)
- Jones, N. et al. 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8, article number: 1516. (10.3389/fimmu.2017.01516)
- Donia, M. et al. 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23(19), pp. 5779-5788. (10.1158/1078-0432.CCR-16-1692)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
- Tan, M. et al. 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187(1), pp. 124-137. (10.1111/cei.12828)
2016
- Watson, H. A. et al. 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94(8) (10.1038/icb.2016.45)
- Pageon, S. V. et al. 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113(37), pp. E5454-E5463. (10.1073/pnas.1607436113)
- Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197(3), pp. 971-982. (10.4049/jimmunol.1501402)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291(17), pp. 8951-8959. (10.1074/jbc.M115.707414)
- Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430, pp. 43-50. (10.1016/j.jim.2016.01.014)
2015
- Holland, C. J. et al. 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195(12), pp. 5827-5836. (10.4049/jimmunol.1402787)
- Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146(1), pp. 11-22. (10.1111/imm.12499)
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
- Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
- Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194(1), pp. 463-474. (10.4049/jimmunol.1401785)
- Knight, R. R. et al. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179(1), pp. 100-107. (10.1111/cei.12436)
2014
- Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177(1), pp. 47-63. (10.1111/cei.12339)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15(4), pp. 471-483. (10.1016/j.chom.2014.03.003)
2013
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
2012
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
2011
- Nunes, C. T., Miners, K. L., Dolton, G. M., Pepper, C. J., Fegan, C. D., Mason, M. D. and Man, S. T. 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71(16), pp. 5435-5444. (10.1158/0008-5472.CAN-11-0393)
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
2010
- Cuff, S., Dolton, G. M., Matthews, R. J. and Gallimore, A. M. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184(2), pp. 607-614. (10.4049/jimmunol.0804089)
- Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)
2007
- Sathish, J. G., Dolton, G. M., Leroy, F. G. and Matthews, R. J. 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. Journal of immunology 178, pp. 330-337.
Articles
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
- Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Martini, V. et al. 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206(2), article number: ji2001086. (10.4049/jimmunol.2001086)
- Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11, article number: 1587. (10.3389/fimmu.2020.01587)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
- Yeo, L. et al. 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199(3), pp. 263-277. (10.1111/cei.13391)
- Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21, pp. 178 - 185. (10.1038/s41590-019-0578-8)
- Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11, article number: 296. (10.3389/fimmu.2020.00296)
- Bagaev, D. V. et al. 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48(D1), pp. D1057-D1062., article number: gkz874. (10.1093/nar/gkz874)
- MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9, article number: 5487. (10.1038/s41598-019-41811-z)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)
- Yeo, L. et al. 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128(8), pp. 3460-3474. (10.1172/JCI120555)
- Zhao, X. et al. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9, article number: 2716. (10.1038/s41467-018-05288-0)
- Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9, article number: 1378. (10.3389/fimmu.2018.01378)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Rius, C. et al. 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200(7), pp. 2263-2279. (10.4049/jimmunol.1700242)
- Bovay, A. et al. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48(2), pp. 258-272. (10.1002/eji.201747082)
- Legut, M., Dolton, G., Mian, A., Ottmann, O. and Sewell, A. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131(3), pp. 311-322. (10.1182/blood-2017-05-787598)
- Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8, article number: 1503. (10.3389/fimmu.2017.01503)
- Jones, N. et al. 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8, article number: 1516. (10.3389/fimmu.2017.01516)
- Donia, M. et al. 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23(19), pp. 5779-5788. (10.1158/1078-0432.CCR-16-1692)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
- Tan, M. et al. 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187(1), pp. 124-137. (10.1111/cei.12828)
- Watson, H. A. et al. 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94(8) (10.1038/icb.2016.45)
- Pageon, S. V. et al. 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113(37), pp. E5454-E5463. (10.1073/pnas.1607436113)
- Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197(3), pp. 971-982. (10.4049/jimmunol.1501402)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291(17), pp. 8951-8959. (10.1074/jbc.M115.707414)
- Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430, pp. 43-50. (10.1016/j.jim.2016.01.014)
- Holland, C. J. et al. 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195(12), pp. 5827-5836. (10.4049/jimmunol.1402787)
- Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146(1), pp. 11-22. (10.1111/imm.12499)
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
- Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
- Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194(1), pp. 463-474. (10.4049/jimmunol.1401785)
- Knight, R. R. et al. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179(1), pp. 100-107. (10.1111/cei.12436)
- Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177(1), pp. 47-63. (10.1111/cei.12339)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15(4), pp. 471-483. (10.1016/j.chom.2014.03.003)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
- Nunes, C. T., Miners, K. L., Dolton, G. M., Pepper, C. J., Fegan, C. D., Mason, M. D. and Man, S. T. 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71(16), pp. 5435-5444. (10.1158/0008-5472.CAN-11-0393)
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
- Cuff, S., Dolton, G. M., Matthews, R. J. and Gallimore, A. M. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184(2), pp. 607-614. (10.4049/jimmunol.0804089)
- Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)
- Sathish, J. G., Dolton, G. M., Leroy, F. G. and Matthews, R. J. 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. Journal of immunology 178, pp. 330-337.
