Dr Terence Davis

Research Fellow

School of Medicine

: davist2@cardiff.ac.uk
: +44 292068 8102
: Cochrane Building, Heath Park, Cardiff, CF14 4YU

I am a Teaching Facilitator in the Division of Medical Education.

Career Overview

2020 - present: Lecturer, School of Medicine, Cardiff University, UK

2006 - 2019: Research Fellow, School of Medicine, Cardiff University, UK

2002 - 2006: BBSRC Recognised Researcher, Cardiff University School of Medicine, UK

1999 - 2006: Research Associate, Pathology Department, Cardiff University School of Medicine, UK (UWCM until 2004)

1997 - 1999: Assistant Researcher, CCRT, University of Hawaii, USA

1996: Research Associate, Imperial College, University of London, UK

1992 - 1995: Research Associate, Biology Dept, University of Sussex, UK

1991: Research Assistant, Genetics Dept, University of Glasgow, UK

1985 - 1990: Research Assistant, Genetics Dept, University of Cambridge, UK

Education and Qualifications

Ph.D. Biochemistry, University of Glasgow, 1984

B.Sc. (Hons:2i) Biochemistry, University of Dundee, 1980

Professional memberships

Fellow of The Royal Society of Biology

Member of the British Society for Research into Ageing

Member of The Genetical Society

2014

Mark, B.et al. 2014. Microwave-assisted Synthesis of Inhibitors of MK2 for Targeting p38 MAP Kinase Signalling in Werner Syndrome Cells. In: John, S. and Mark, B. eds. Microwaves in Drug Discovery and Development: Recent Advances. London: Future Medicine Ltd, pp. 86-104., (10.4155/fseb2013.13.130)
Davis, T. 2014. Progeroid syndromes: role of accelerated fibroblast senescence and p38 activation. In: Hayat, M. A. ed. Tumor Dormancy and Cellular Quiescence and Senescence, Volume 3: Aging, Cancer, and Noncancer Pathologies. Berlin: Springer Verlag, pp. 25-39., (10.1007/978-94-017-9325-4_3)
Cox, L. S.et al. 2014. Understanding ageing: biological and social constructions. In: Walker, A. ed. The New Science of Ageing. Bristol: Policy Press

2013

Bagley, M. C.et al. 2013. Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors. Tetrahedron 69(39), pp. 8429-8438. (10.1016/j.tet.2013.07.055)
Tivey, H. S. E.et al. 2013. p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes. Biogerontology 14(1), pp. 47-62. (10.1007/s10522-012-9407-2)
Davis, T.et al. 2013. The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. Chemistry Central Journal 7, article number: 18. (10.1186/1752-153X-7-18)
Davis, T.et al. 2013. Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome. AGE 35(5), pp. 1767-1783. (10.1007/s11357-012-9476-9)
Tivey, H. S. E.et al. 2013. Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 68(9), pp. 1001-1009. (10.1093/gerona/gls336)

2011

Davis, T.et al. 2011. Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors. Chemistry Central Journal 5(1), pp. 83-88. (10.1186/1752-153X-5-83)
Bagley, M. C.et al. 2011. The contribution of biogerontology to quality ageing. Quality in Ageing and Older Adults 12(1), pp. 26-32. (10.5042/qiaoa.2011.0142)
Latimer, J. E.et al. 2011. Ageing science, health care and social inclusion of older people. Quality in Ageing and Older Adults 12(1), pp. 11-16. (10.5042/qiaoa.2011.0140)
Faragher, R. G. A.et al. 2011. Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. AGE 33(4), pp. 555-564. (10.1007/s11357-010-9201-5)

2010

Bagley, M. C.et al. 2010. Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome. Future Medicinal Chemistry 2(9), pp. 1417-1427. (10.4155/fmc.10.217)
Bagley, M. C.et al. 2010. Use of p38 MAPK inhibitors for the treatment of Werner Syndrome. Pharmaceuticals 3(6), pp. 1842-1872. (10.3390/ph3061842)
Bagley, M. C.et al. 2010. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Medicinal Chemistry 2(2), pp. 193-201. (10.4155/fmc.09.163)
Bagley, M. C.et al. 2010. Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells. Future Medicinal Chemistry 2(2), pp. 203-213. (10.4155/fmc.09.160)
Davis, T.et al. 2010. Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1197(1), pp. 45-48. (10.1111/j.1749-6632.2010.05195.x)

2009

Davis, T., Tivey, H. S. E. and Kipling, D. 2009. Telomere dynamics and biology in human progeroid syndromes. In: Mancini, L. ed. Telomeres: Function, Shortening and Lengthening. New York: Nova Science Publishers, Inc., pp. 1-75.
Davis, T. and Kipling, D. G. 2009. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts. Biogerontology 10(3), pp. 253-266. (10.1007/s10522-008-9179-x)
Bagley, M. C.et al. 2009. Microwave-assisted Ullmann C-S bond formation: synthesis of the P38 alpha MAPK clinical candidate VX-745. Journal of Organic Chemistry 74(21), pp. 8336-8342. (10.1021/jo9017155)

2008

Bagley, M. C.et al. 2008. Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 18(13), pp. 3745-3748. (10.1016/j.bmcl.2008.05.037)

2007

Bagley, M. C.et al. 2007. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Biorganic and Medicinal Chemistry Letters 17(18), pp. 5107-5110. (10.1016/j.bmcl.2007.07.016)
Davis, T.et al. 2007. The Role of Cellular Senescence in Werner Syndrome: Toward Therapeutic Intervention in Human Premature Aging. Annals of the New York Academy of Sciences 1100, pp. 455-469. (10.1196/annals.1395.051)
Davis, T.et al. 2007. Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38 alpha(MAPK) inhibitors in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 17(24), pp. 6832-6835. (10.1016/j.bmcl.2007.10.036)
Davis, T. and Kipling, D. G. 2007. Werner syndrome, telomeres, and stress signaling: implications for future therapies?. In: Rudolph, K. L. ed. Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. Springer, pp. 285-308.

2006

Bagley, M. C.et al. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
Bagley, M. C.et al. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38 inhibitor BIRB 796 for study into accelerated cell ageing. Organic & biomolecular chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
Davis, T. and Kipling, D. G. 2006. Werner Syndrome as an example of inflamm-aging: Possible therapeutic opportunities for a progeroid syndrome?. Rejuvenation Research 9(3), pp. 402-407. (10.1089/rej.2006.9.402)
Davis, T.et al. 2006. Prevention of accelerated cell aging in the Werner syndrome. Annals of the New York Academy of Sciences 1067(1), pp. 243-247. (10.1196/annals.1354.031)

2005

Davis, T. and Kipling, D. G. 2005. Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing. Biogerontology 6(6), pp. 371-385. (10.1007/s10522-005-4901-4)
Davis, T.et al. 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60(11), pp. 1386-93.
Davis, T.et al. 2005. Replicative senescence in sheep fibroblasts is a p53 dependent process. Experimental Gerontology 40(1-2), pp. 17-26. (10.1016/j.exger.2004.09.004)

2004

Kipling, D. G.et al. 2004. What can progeroid syndromes tell us about human aging?. Science 305(5689), pp. 1426-1431. (10.1126/science.1102587)
Baird, D. M.et al. 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13(14), pp. 1515-1524. (10.1093/hmg/ddh159)
Davis, T.et al. 2004. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1019(1), pp. 274-277. (10.1196/annals.1297.046)

2003

Davis, T. 2003. Use of cross-species genome comparison to deduce possible importance of the various D. melanogaster fruitless transcripts: a putative vital function for the type C transcription factor?. Drosophila Information Service 86, pp. 133-136.
Davis, T. 2003. The genes of the elbow-no-ocelli genetic complex in D. melanogaster. Drosophila Information Service 86, pp. 126-128.
Davis, T.et al. 2003. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. Journal of Cell Science (JCS) 116(7), pp. 1349-57. (10.1242/jcs.00331)

2002

Davis, T. 2002. Comparison of the sexual behaviour gene fruitless between D. melanogaster and two sympatric Hawaiian species, D. heteroneura and D. silvestris. Drosophila Information Service 85, pp. 25-28.

2001

Edwards, K.et al. 2001. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Gene 275(2), pp. 195-205. (10.1016/S0378-1119(01)00686-2)
Davis, T. and Ito, H. 2001. Genomic structure of the sexual behaviour gene fruitless. Drosophila Information Service 84, pp. 65-66.

2000

Gailey, D. A.et al. 2000. Brief report a phylogeny of the Drosophilidae using the sex-behaviour gene fruitless. Hereditas 133(1), pp. 81-83. (10.1111/j.1601-5223.2000.00081.x)
Davis, T. 2000. On the relationship between the Scaptomyza and the Hawaiian Drosophila [Brief report]. Hereditas 132(3), pp. 257-259. (10.1111/j.1601-5223.2000.00257.x)
Davis, T., Kurihara, J. and Yamamoto, D. 2000. Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura. Gene 246(1-2), pp. 143-149. (10.1016/S0378-1119(00)00064-0)
Davis, T.et al. 2000. Genomic organisation of the neural sex determination gene fruitless (fuu) in the Hawaiian species Drosophila siluestris and the conservation of the fru BTB protein-protein-binding domain throughout evolution. Hereditas 132(1), pp. 67-78. (10.1111/j.1601-5223.2000.00067.x)

1999

Ashburner, M.et al. 1999. An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153(1), pp. 179-219.

1998

Helps, N. R.et al. 1998. Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. Journal of Cell Science 111(10), pp. 1331-1340.

1997

Trikka, D.et al. 1997. Human COL6A1: Genomic characterization of the globular domains, structural and evolutionary comparison with COL6A2. Mammalian Genome 8(5), pp. 342-345. (10.1007/s003359900436)
Davis, T.et al. 1997. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Dvosophila melanogaster. Hereditas 126(1), pp. 67-75. (10.1111/j.1601-5223.1997.00067.x)
Faragher, R. G. A.et al. 1997. Cycling Werner's syndrome fibroblasts display calcium-dependent potassium currents. Experimental Cell Research 231(1), pp. 119-122. (10.1006/excr.1996.3437)
Davis, T. and Shall, S. 1997. Characterisation and expression of a chicken erythroblast mono(ADP-ribosyl)transferase gene [Meeting abstract]. Biochemical Society Transactions 25(1), pp. 80S-80S. (10.1042/bst025080s)
Davis, T.et al. 1997. Purification, characterisation, and molecular cloning of a chicken erythroblast mono(ADP-ribosyl)transferase. Advances in Experimental Medicine and Biology 419, pp. 145-154. (10.1007/978-1-4419-8632-0_17)

1996

McNabb, S., Grieg, S. and Davis, T. 1996. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. Genetics 143(2), pp. 897-911.
Davis, T. and Ashburner, M. 1996. The chromosomal organisation of the alcohol dehydrogenase region of the genome of Drosophila melanogaster [Communication]. Biochemical Society Transactions 24(1), pp. 109S-109S. (10.1042/bst024109s)

1995

Davis, T. and Shall, S. 1995. Sequence of a chicken erythroblast mono(ADP-ribosyl)transferase-encoding gene and its upstream region [Brief note]. Gene 164(2), pp. 371-372. (10.1016/0378-1119(95)00504-Y)
Davis, T. and Shall, S. 1995. Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene [Communication]. Biochemical Society Transactions 23(2), pp. 207S-207S. (10.1042/bst023207s)

1994

Davis, T. and Lineruth, K. 1994. The characterisation of a P-element insert into the Gsα G protein gene in Drosophila melanogaster [Communication]. Biochemical Society Transactions 22(2), pp. 134S-134S. (10.1042/bst022134s)

1992

Lineruth, K. and Davis, T. 1992. The isolation and characterization of P-element insertions into G protein genes [Communication]. Biochemical Society Transactions 20(3), pp. 261S-261S. (10.1042/bst020261s)

1990

Gubb, D.et al. 1990. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Genetics 126(1), pp. 167-176.
Davis, T., Trenear, J. and Ashburner, M. 1990. The molecular analysis of the el-noc complex of Drosophila melanogaster. Genetics 126(1), pp. 105-119.

1987

Adams, R. L. P.et al. 1987. CpG deficiency, dinucleotide distributions and nucleosome positioning. European Journal of Biochemistry 165(1), pp. 107-115. (10.1111/j.1432-1033.1987.tb11200.x)

1986

Davis, T.et al. 1986. Methylation of chromatin in vitro. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 866(4), pp. 233-241. (10.1016/0167-4781(86)90048-5)

1985

Davis, T.et al. 1985. Delayed methylation and the matrix bound DNA methylase. Biochemical and Biophysical Research Communications 126(2), pp. 678-684. (10.1016/0006-291X(85)90238-4)

1984

Adams, R. L.et al. 1984. Eukaryotic DNA methylase--properties and action on native DNA and chromatin. Current Topics in Microbiology and Immunology 108, pp. 143-156. (10.1007/978-3-642-69370-0_10)