Dr Terence Davis

2019

• Davis, T. 2019. Premature ageing in Werner syndrome - A central role for genomic instability induced-cellular senescence via p38 MAPK activation. In: Bernhardt, L. V. ed. Advances in Medicine and Biology: Volume 143. New York: Nova Science, pp. 141-199.

2018

• Umbayev, B.et al. 2018. Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells. Biogerontology 19(3-4), pp. 287-301. (10.1007/s10522-018-9757-5)
• Alimbetov, D.et al. 2018. Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells. International Journal of Molecular Sciences 19(6), pp. 1690. (10.3390/ijms19061690)

2016

• Davis, T.et al. 2016. Evaluating the role of p38 MAPK in the accelerated cell senescence of Werner syndrome fibroblasts. Pharmaceuticals 9(2), article number: 23. (10.3390/ph9020023)
• Alimbetov, D.et al. 2016. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 17, article number: 305. (10.1007/s10522-015-9610-z)
• Bagley, M. C.et al. 2016. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Organic & Biomolecular Chemistry 14(3), pp. 947-956. (10.1039/C5OB02229K)

2015

• Bagley, M.et al. 2015. Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner Syndrome Cells. Pharmaceuticals 8(2), pp. 257-276. (10.3390/ph8020257)
• Davis, T.et al. 2015. Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence. Biogerontology 16(1), pp. 43-51. (10.1007/s10522-014-9530-3)

2014

• Mark, B.et al. 2014. Microwave-assisted Synthesis of Inhibitors of MK2 for Targeting p38 MAP Kinase Signalling in Werner Syndrome Cells. In: John, S. and Mark, B. eds. Microwaves in Drug Discovery and Development: Recent Advances. London: Future Medicine Ltd, pp. 86-104., (10.4155/fseb2013.13.130)
• Davis, T. 2014. Progeroid syndromes: role of accelerated fibroblast senescence and p38 activation. In: Hayat, M. A. ed. Tumor Dormancy and Cellular Quiescence and Senescence, Volume 3: Aging, Cancer, and Noncancer Pathologies. Berlin: Springer Verlag, pp. 25-39., (10.1007/978-94-017-9325-4_3)
• Cox, L. S.et al. 2014. Understanding ageing: biological and social constructions. In: Walker, A. ed. The New Science of Ageing. Bristol: Policy Press

2013

• Bagley, M. C.et al. 2013. Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors. Tetrahedron 69(39), pp. 8429-8438. (10.1016/j.tet.2013.07.055)
• Tivey, H. S. E.et al. 2013. p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes. Biogerontology 14(1), pp. 47-62. (10.1007/s10522-012-9407-2)
• Davis, T.et al. 2013. The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. Chemistry Central Journal 7, article number: 18. (10.1186/1752-153X-7-18)
• Davis, T.et al. 2013. Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome. AGE 35(5), pp. 1767-1783. (10.1007/s11357-012-9476-9)
• Tivey, H. S. E.et al. 2013. Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 68(9), pp. 1001-1009. (10.1093/gerona/gls336)

2011

• Davis, T.et al. 2011. Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors. Chemistry Central Journal 5(1), pp. 83-88. (10.1186/1752-153X-5-83)
• Bagley, M. C.et al. 2011. The contribution of biogerontology to quality ageing. Quality in Ageing and Older Adults 12(1), pp. 26-32. (10.5042/qiaoa.2011.0142)
• Latimer, J. E.et al. 2011. Ageing science, health care and social inclusion of older people. Quality in Ageing and Older Adults 12(1), pp. 11-16. (10.5042/qiaoa.2011.0140)
• Faragher, R. G. A.et al. 2011. Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. AGE 33(4), pp. 555-564. (10.1007/s11357-010-9201-5)

2010

• Bagley, M. C.et al. 2010. Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome. Future Medicinal Chemistry 2(9), pp. 1417-1427. (10.4155/fmc.10.217)
• Bagley, M. C.et al. 2010. Use of p38 MAPK inhibitors for the treatment of Werner Syndrome. Pharmaceuticals 3(6), pp. 1842-1872. (10.3390/ph3061842)
• Bagley, M. C.et al. 2010. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Medicinal Chemistry 2(2), pp. 193-201. (10.4155/fmc.09.163)
• Bagley, M. C.et al. 2010. Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells. Future Medicinal Chemistry 2(2), pp. 203-213. (10.4155/fmc.09.160)
• Davis, T.et al. 2010. Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1197(1), pp. 45-48. (10.1111/j.1749-6632.2010.05195.x)

2009

• Davis, T., Tivey, H. S. E. and Kipling, D. 2009. Telomere dynamics and biology in human progeroid syndromes. In: Mancini, L. ed. Telomeres: Function, Shortening and Lengthening. New York: Nova Science Publishers, Inc., pp. 1-75.
• Davis, T. and Kipling, D. G. 2009. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts. Biogerontology 10(3), pp. 253-266. (10.1007/s10522-008-9179-x)
• Bagley, M. C.et al. 2009. Microwave-assisted Ullmann C-S bond formation: synthesis of the P38 alpha MAPK clinical candidate VX-745. Journal of Organic Chemistry 74(21), pp. 8336-8342. (10.1021/jo9017155)

2008

• Bagley, M. C.et al. 2008. Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 18(13), pp. 3745-3748. (10.1016/j.bmcl.2008.05.037)

2007

• Bagley, M. C.et al. 2007. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Biorganic and Medicinal Chemistry Letters 17(18), pp. 5107-5110. (10.1016/j.bmcl.2007.07.016)
• Davis, T.et al. 2007. The Role of Cellular Senescence in Werner Syndrome: Toward Therapeutic Intervention in Human Premature Aging. Annals of the New York Academy of Sciences 1100, pp. 455-469. (10.1196/annals.1395.051)
• Davis, T.et al. 2007. Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38 alpha(MAPK) inhibitors in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 17(24), pp. 6832-6835. (10.1016/j.bmcl.2007.10.036)
• Davis, T. and Kipling, D. G. 2007. Werner syndrome, telomeres, and stress signaling: implications for future therapies?. In: Rudolph, K. L. ed. Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. Springer, pp. 285-308.

2006

• Bagley, M. C.et al. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
• Bagley, M. C.et al. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38 inhibitor BIRB 796 for study into accelerated cell ageing. Organic & biomolecular chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
• Davis, T. and Kipling, D. G. 2006. Werner Syndrome as an example of inflamm-aging: Possible therapeutic opportunities for a progeroid syndrome?. Rejuvenation Research 9(3), pp. 402-407. (10.1089/rej.2006.9.402)
• Davis, T.et al. 2006. Prevention of accelerated cell aging in the Werner syndrome. Annals of the New York Academy of Sciences 1067(1), pp. 243-247. (10.1196/annals.1354.031)

2005

• Davis, T. and Kipling, D. G. 2005. Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing. Biogerontology 6(6), pp. 371-385. (10.1007/s10522-005-4901-4)
• Davis, T.et al. 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60(11), pp. 1386-93.
• Davis, T.et al. 2005. Replicative senescence in sheep fibroblasts is a p53 dependent process. Experimental Gerontology 40(1-2), pp. 17-26. (10.1016/j.exger.2004.09.004)

2004

• Kipling, D. G.et al. 2004. What can progeroid syndromes tell us about human aging?. Science 305(5689), pp. 1426-1431. (10.1126/science.1102587)
• Baird, D. M.et al. 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13(14), pp. 1515-1524. (10.1093/hmg/ddh159)
• Davis, T.et al. 2004. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1019(1), pp. 274-277. (10.1196/annals.1297.046)

2003

• Davis, T. 2003. Use of cross-species genome comparison to deduce possible importance of the various D. melanogaster fruitless transcripts: a putative vital function for the type C transcription factor?. Drosophila Information Service 86, pp. 133-136.
• Davis, T. 2003. The genes of the elbow-no-ocelli genetic complex in D. melanogaster. Drosophila Information Service 86, pp. 126-128.
• Davis, T.et al. 2003. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. Journal of Cell Science (JCS) 116(7), pp. 1349-57. (10.1242/jcs.00331)

2002

• Davis, T. 2002. Comparison of the sexual behaviour gene fruitless between D. melanogaster and two sympatric Hawaiian species, D. heteroneura and D. silvestris. Drosophila Information Service 85, pp. 25-28.

2001

• Edwards, K.et al. 2001. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Gene 275(2), pp. 195-205. (10.1016/S0378-1119(01)00686-2)
• Davis, T. and Ito, H. 2001. Genomic structure of the sexual behaviour gene fruitless. Drosophila Information Service 84, pp. 65-66.

2000

• Gailey, D. A.et al. 2000. Brief report a phylogeny of the Drosophilidae using the sex-behaviour gene fruitless. Hereditas 133(1), pp. 81-83. (10.1111/j.1601-5223.2000.00081.x)
• Davis, T. 2000. On the relationship between the Scaptomyza and the Hawaiian Drosophila [Brief report]. Hereditas 132(3), pp. 257-259. (10.1111/j.1601-5223.2000.00257.x)
• Davis, T., Kurihara, J. and Yamamoto, D. 2000. Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura. Gene 246(1-2), pp. 143-149. (10.1016/S0378-1119(00)00064-0)
• Davis, T.et al. 2000. Genomic organisation of the neural sex determination gene fruitless (fuu) in the Hawaiian species Drosophila siluestris and the conservation of the fru BTB protein-protein-binding domain throughout evolution. Hereditas 132(1), pp. 67-78. (10.1111/j.1601-5223.2000.00067.x)

1999

• Ashburner, M.et al. 1999. An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153(1), pp. 179-219.

1998

• Helps, N. R.et al. 1998. Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. Journal of Cell Science 111(10), pp. 1331-1340.

1997

• Trikka, D.et al. 1997. Human COL6A1: Genomic characterization of the globular domains, structural and evolutionary comparison with COL6A2. Mammalian Genome 8(5), pp. 342-345. (10.1007/s003359900436)
• Davis, T.et al. 1997. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Dvosophila melanogaster. Hereditas 126(1), pp. 67-75. (10.1111/j.1601-5223.1997.00067.x)
• Faragher, R. G. A.et al. 1997. Cycling Werner's syndrome fibroblasts display calcium-dependent potassium currents. Experimental Cell Research 231(1), pp. 119-122. (10.1006/excr.1996.3437)
• Davis, T. and Shall, S. 1997. Characterisation and expression of a chicken erythroblast mono(ADP-ribosyl)transferase gene [Meeting abstract]. Biochemical Society Transactions 25(1), pp. 80S-80S. (10.1042/bst025080s)
• Davis, T.et al. 1997. Purification, characterisation, and molecular cloning of a chicken erythroblast mono(ADP-ribosyl)transferase. Advances in Experimental Medicine and Biology 419, pp. 145-154. (10.1007/978-1-4419-8632-0_17)

1996

• McNabb, S., Grieg, S. and Davis, T. 1996. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. Genetics 143(2), pp. 897-911.
• Davis, T. and Ashburner, M. 1996. The chromosomal organisation of the alcohol dehydrogenase region of the genome of Drosophila melanogaster [Communication]. Biochemical Society Transactions 24(1), pp. 109S-109S. (10.1042/bst024109s)

1995

• Davis, T. and Shall, S. 1995. Sequence of a chicken erythroblast mono(ADP-ribosyl)transferase-encoding gene and its upstream region [Brief note]. Gene 164(2), pp. 371-372. (10.1016/0378-1119(95)00504-Y)
• Davis, T. and Shall, S. 1995. Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene [Communication]. Biochemical Society Transactions 23(2), pp. 207S-207S. (10.1042/bst023207s)

1994

• Davis, T. and Lineruth, K. 1994. The characterisation of a P-element insert into the Gsα G protein gene in Drosophila melanogaster [Communication]. Biochemical Society Transactions 22(2), pp. 134S-134S. (10.1042/bst022134s)

1992

• Lineruth, K. and Davis, T. 1992. The isolation and characterization of P-element insertions into G protein genes [Communication]. Biochemical Society Transactions 20(3), pp. 261S-261S. (10.1042/bst020261s)

1990

• Gubb, D.et al. 1990. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Genetics 126(1), pp. 167-176.
• Davis, T., Trenear, J. and Ashburner, M. 1990. The molecular analysis of the el-noc complex of Drosophila melanogaster. Genetics 126(1), pp. 105-119.

1987

• Adams, R. L. P.et al. 1987. CpG deficiency, dinucleotide distributions and nucleosome positioning. European Journal of Biochemistry 165(1), pp. 107-115. (10.1111/j.1432-1033.1987.tb11200.x)

1986

• Davis, T.et al. 1986. Methylation of chromatin in vitro. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 866(4), pp. 233-241. (10.1016/0167-4781(86)90048-5)

1985

• Davis, T.et al. 1985. Delayed methylation and the matrix bound DNA methylase. Biochemical and Biophysical Research Communications 126(2), pp. 678-684. (10.1016/0006-291X(85)90238-4)

1984

• Adams, R. L.et al. 1984. Eukaryotic DNA methylase--properties and action on native DNA and chromatin. Current Topics in Microbiology and Immunology 108, pp. 143-156. (10.1007/978-3-642-69370-0_10)