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 Kate Bresner

Kate Bresner

Senior Technician, Division of Psychological Medicine and Clinical Neurosciences

School of Medicine

Email
bresnercm@cardiff.ac.uk
Telephone
+44 (0)29 2068 8362
Campuses
2.01 - Desk 50, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

I have worked at Cardiff University since 2010. During that time, I have been a member of a core facility and led a several laboratory research projects. 

Within my most recent role as Research Manager for the Alzheimer's Research Group, I am responsible for the operation of the Aleheimer’s Disease Genetics Team, planning, organising and delivering projects both within the University and in collaboration with world-renowned scientists.  I am also responsible for a large part of research funding and grant management.  I also provide professional advice and guidance on research sample management and Human Tissue Act compliance processes and procedures.

I am a member of the Institute of Science and Technology and have been awarded professional registration (RSci) by the Science Council.

2010 - present:  Cardiff University School of Medicine, Senior Technician (Neurodegeneneration)

Identification of variations in the genomic sequence which increase susceptibility to neurological disorders using a variety of sequencing techniques including:

  • Profiling post-translational modifications of histone proteins as a determiant of Parkonson's disease susceptibility in frozen brain tissue using ChIP-seq.
  • Epigenetic investigation using array-based methylation assays.
  • Sanger sequencing to identify Single Nucleotide Polymorhpisms (SNPs) and insertions / deletions (indels) using capillary electrophoresis
  • Competitive allele specific polymerase chain reaction (KASP) using Fluorescent Resonance Energy transfer (FRET) to identify specific SNPs and indels.
  • Multiplex ligation-dependent probe amplification assay (MLPA) for simultaneous detection of deletions and duplications in genes associated with disease.
  • Array-based assays which provide high throughput whole genome amplification allowing almost unlimited SNP detection and copy number variation (CNV) analysis.

2019

2018

2016

2015

I have focused my interest on the genetic basis of neurodegenerative disorders.  My recent research projects investigated the genetic basis of Parkinson's disease.  My roles to date have been laboratory-based, where I used a diverse range of complex techniques in order to generate high quality biological data which is then used for statistical analysis.

I am currently Research Manager with the Alzheimer's Disease Research Group and am involved in many projects related to Alzheimer's and Dementia research, both within Cardiff University and also large international collaborations.