Kate Bresner
Senior Technician (Genome Hub)
- bresnercm@cardiff.ac.uk
- Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Overview
I have worked at Cardiff University since 2010. Within my current role I am responsible for the generation of high-quality Next-Generation sequencing data for a diverse range of projects from biomedicine to ecology.
My previous role was Research Manager for the Alzheimer's Research Group, I was responsible for the operation of the Alzheimer’s Disease Genetics Team, planning, organising and delivering projects both within the University and in collaboration with world-renowned scientists. I was also responsible for a large part of research funding and grant management and provided professional advice and guidance on research sample management and Human Tissue Act compliance processes and procedures.
Prior to my management role, I was primarily laboratory based, as member of a core facility, and led several laboratory research projects for the Parkinson's Research Team.
I am a member of the Institute of Science and Technology and have been awarded professional registration (RSci) by the Science Council.
Biography
2020 - present: Senior Technician (Genome Research Hub), School of Biosciences.
The Genomics Research Hub acts as a focus and provides support for a community of genomics researchers, with particular expertise in metagenomics, de novo genome assembly, transcriptome analysis, chromatin mapping and epigenetics
We utilise linked technology platforms that support user-driven, next-generation sequencing for a wide-range of users and applications including:
- small genome assembly
- genome re-sequencing
- metagenomics
- RNA-seq
- ChIP-seq
- chromatin-seq.
We also help researchers develop novel genomics methods when required.
2010 - 2020: Cardiff University School of Medicine, Division of Psychological Medicine & Clinical Neurosciences
2019 - 2020: Research Manager, Alzheimer's Research Group
2018 - 2019: Sample Co-Ordinator, Alzheimer's Research Group
2012 - 2018: Senior Research Technician, Parkinson's Research Group
2010 - 2012: Research Technician, Core Facility
Honours and awards
Registered Scientist (RSci), awarded by Science Council (2018)
Professional memberships
Member of the Institute of Science and Technology
Publications
2022
- Willett, B. J. et al. 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7, pp. 1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al. 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22(1), article number: 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12(1), article number: 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al. 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12(1), article number: 10904. (10.1038/s41598-022-14016-0)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Aggarwal, D. et al. 2022. Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications 13, article number: 1012. (10.1038/s41467-022-28371-z)
- Aggarwal, D. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications 13(1), article number: 751. (10.1038/s41467-021-27942-w)
- Real, R. et al. 2022. Association between the LRP1B and APOE loci in the development of Parkinson’s disease dementia. Brain
- Winchester, L. et al. 2022. Identification of a possible proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF. Brain Communications
2021
- de Rojas, I. et al. 2021. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications 12(1), article number: 3417. (10.1038/s41467-021-22491-8)
- Lythgoe, K. A. et al. 2021. SARS-CoV-2 within-host diversity and transmission. Science 372(6539), article number: eabg0821. (10.1126/science.abg0821)
- Davies, N. G. et al. 2021. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 372(6538), article number: eabg3055. (10.1126/science.abg3055)
- Tan, M. M. et al. 2021. Genome-wide association studies of cognitive and motor progression in Parkinson's disease. Movement Disorders 36(2), pp. 424-433. (10.1002/mds.28342)
2020
- Alm, E. et al. 2020. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance 25(32), article number: 2001410. (10.2807/1560-7917.ES.2020.25.32.2001410)
2019
- Tan, M. M. et al. 2019. Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study. Brain 142(9), pp. 2828-2844. (10.1093/brain/awz191)
2018
- Malek, N. et al. 2018. Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study. Journal of Neurology, Neurosurgery and Psychiatry 89(7), pp. 702-709. (10.1136/jnnp-2017-317348)
2016
- Malek, N. et al. 2016. Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica 134(4), pp. 271-276. (10.1111/ane.12538)
2015
- Malek, N. et al. 2015. Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease 5(4), pp. 947-959. (10.3233/JPD-150662)
I have recently taken a role within the Genome Hub at Cardiff School of Biosciences, generating Next-Generation sequencing data for a diverse range of projects from biomedicine to ecology.
As Research Manager with the Alzheimer's Disease Research Group I was involved in many projects related to Alzheimer's and Dementia research, both within Cardiff University and also large international collaborations.
Prior to my management role, my research projects investigated the genetic basis of Parkinson's disease, where I used a diverse range of complex techniques in order to generate high quality biological data which is then used for statistical analysis.