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Professor Derek Blake

Professor of Neuroscience, Division of Psychological Medicine and Clinical Neurosciences

School of Medicine

Email:
blakedj@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8468
Location:
2.52, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Media commentator

The Blake laboratory investigates the molecular pathology of various neuromuscular, neuropsychiatric and neurological diseases. We study diseases such as the muscular dystrophies, dystonia and schizophrenia that have a have a strong genetic component. My laboratory is particularly interested in the effects of inherited mutations and polymorphisms on the function of proteins implicated in these diseases.

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Our group uses molecular cell biology techniques to study different diseases and cellular pathways. Specifically, we use mass spectrometry and the yeast two-hybrid system to identify proteins complexes that may be altered in the aforementioned diseases. Our recent studies have shown that the ubiquitin proteasome system can modulate the stability and trafficking of proteins associated with this diverse group of disorders. Additionally, we use fluorescence and confocal imaging systems to study physiological processes in live cells and to create cellular models of disease.

Areas of expertise