Dr Kevin Ashelford

2021

• Lewis, T. et al. 2021. Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers. Haematologica 106(4), pp. 958-967. (10.3324/haematol.2019.238584)

2020

• Lang, F. et al. 2020. A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia. BMC Pharmacology and Toxicology 21(1), article number: 70. (10.1186/s40360-020-00446-x)
• Badder, L. M. et al. 2020. 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors. PLoS ONE 15(8), article number: e0235319. (10.1371/journal.pone.0235319)
• Scurr, M. J. et al. 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research (10.1158/1078-0432.CCR-19-3087)
• Dart, D. A., Ashelford, K. and Jiang, W. G. 2020. AR mRNA Stability is increased with AR-antagonist resistance via 3' UTR variants. Endocrine Connections 9(1), pp. 9-19. (10.1530/EC-19-0340)

2019

• Escudero, L., Cleal, K., Ashelford, K., Fegan, C., Pepper, C., Liddiard, K. and Baird, D. M. 2019. Telomere fusions associate with coding sequence and copy number alterations in CLL. Leukemia 33, pp. 2093-2097. (10.1038/s41375-019-0423-y)
• Liddiard, K., Ruis, B., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2019. DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase. Nucleic Acids Research 47(5), pp. 2402-2424. (10.1093/nar/gky1279)

2017

• Thomas, L. E. et al. 2017. Burden and profile of somatic mutation in duodenal adenomas from patients with familial adenomatous- and MUTYH-associated polyposis. Clinical Cancer Research 23(21), pp. 6721-6732. (10.1158/1078-0432.CCR-17-1269)
• Sohier, P. et al. 2017. Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors. Genes, Chromosomes and Cancer 56(5), pp. 421-426. (10.1002/gcc.22446)

2016

• Penselin, D. et al. 2016. Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses. BMC Genomics 17(1), article number: 953. (10.1186/s12864-016-3299-5)
• Liddiard, K., Ruis, B., Takasugi, T., Harvey, A., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2016. Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Research 26, pp. 588-600. (10.1101/gr.200840.115)

2014

• Bryant, D. et al. 2014. mRNA sequencing of novel cell lines from human papillomavirus type-16 related vulval intraepithelial neoplasia: Consequences of expression of HPV16 E4 and E5. Journal of Medical Virology 86(9), pp. 1534-1541. (10.1002/jmv.23994)
• Jones, R. E. et al. 2014. Escape from telomere-driven crisis is DNA Ligase III dependent. Cell Reports 8(4), pp. 1063-1076. (10.1016/j.celrep.2014.07.007)

2013

• Yang, R. et al. 2013. Genomic characterisation of invasive non-typhoidal salmonella enterica subspecies enterica serovar bovismorbificans isolates from Malawi. PLOS Neglected Tropical Diseases 7(11), article number: e2557. (10.1371/journal.pntd.0002557)
• Horn, M. et al. 2013. Exploring the diversity of arcobacter butzleri from cattle in the UK using MLST and whole genome sequencing. PLoS ONE 8(2), article number: e55240. (10.1371/journal.pone.0055240)

2012

• Pascoal, S. et al. 2012. Transcriptomics andin vivotests reveal novel mechanisms underlying endocrine disruption in an ecological sentinel, Nucella lapillus. Molecular Ecology 22(6), pp. 1589-1608. (10.1111/mec.12137)

2011

• Ashelford, K. E. et al. 2011. Genomic variations define divergence of water/wildlife-associated Campylobacter jejuniniche specialists from common clonal complexes. Environmental Microbiology 13(6), pp. 1549-1560. (10.1111/j.1462-2920.2011.02461.x)
• Ashelford, K. E. et al. 2011. Full genome re-sequencing reveals a novel circadian clock mutation in Arabidopsis. Genome Biology 12(3), article number: R28. (10.1186/gb-2011-12-3-r28)
• Ashelford, K. E. et al. 2011. Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections. Journal of Clinical Microbiology 49(3), pp. 993-1003. (10.1128/JCM.02036-10)

2010

• Gilbert, J. A. et al. 2010. Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns. PLoS ONE 5(1), article number: e8875. (10.1371/journal.pone.0008875)

2009

• Ashelford, K. E., Weynberg, K. D., Allen, M. J., Scanlan, D. J. and Wilson, W. H. 2009. From small hosts come big viruses: the complete genome of a second Ostreococcus taurivirus, OtV-1. Environmental Microbiology 11(11), pp. 2821-2839. (10.1111/j.1462-2920.2009.01991.x)
• Ashelford, K. E., Bontell, I., Hall, N., Dubey, J. P., Boyle, J. P., Lindh, J. and Smith, J. E. 2009. Whole genome sequencing of a natural recombinant Toxoplasma gondii strain reveals chromosome sorting and local allelic variants. Genome Biology 10(5), article number: R53. (10.1186/gb-2009-10-5-r53)

2006

• Ashelford, K. E., Chuzhanova, N. A., Fry, J. C., Jones, A. J. and Weightman, A. J. 2006. New screening software shows that most recent large 16S rRNA gene clone libraries contain chimeras. Applied and Environmental Microbiology 72(9), pp. 5734-5741. (10.1128/AEM.00556-06)

2003

• Ashelford, K. E., Day, M. J. and Fry, J. C. 2003. Elevated abundance of bacteriophage infecting bacteria in soil. Applied and Environmental Microbiology 69(1), pp. 285-289. (10.1128/AEM.69.1.285-289.2003)

2002

• Ashelford, K. E., Bailey, M. J., Fry, J. C. and Day, M. J. 2002. Characterization of Serratia isolates from soil, ecological implications and transfer of Serratia proteamaculans subsp. quinovora Grimont et al. 1983 to Serratia quinivorans corrig., sp. nov.. International Journal of Systematic and Evolutionary Microbiology 52(6), pp. 2281-2289. (10.1099/00207713-52-6-2281)
• Ashelford, K. E. 2002. PRIMROSE: a computer program for generating and estimating the phylogenetic range of 16S rRNA oligonucleotide probes and primers in conjunction with the RDP-II database. Nucleic Acids Research 30(15), pp. 3481-3489. (10.1093/nar/gkf450)

2001

• Ashelford, K., Learner, M. A. and Fry, J. C. 2001. Gene transfer and plasmid instability within pilot-scale sewage filter beds and the invertebrates that live in them. FEMS Microbiology Ecology 35(2), pp. 197-205. (10.1111/j.1574-6941.2001.tb00804.x)

2000

• Ashelford, K. E., Norris, S. J., Fry, J. C., Bailey, M. J. and Day, M. J. 2000. Seasonal Population Dynamics and Interactions of Competing Bacteriophages and Their Host in the Rhizosphere. Applied and Environmental Microbiology 66(10), pp. 4193-4199. (10.1128/AEM.66.10.4193-4199.2000)

1997

• Ashelford, K. E. et al. 1997. Using microcosms to study gene transfer in aquatic habitats. FEMS Microbiology Ecology 23(2), pp. 81-94. (10.1111/j.1574-6941.1997.tb00393.x)