Dr Alexander Shaw
Research Associate
- Available for postgraduate supervision
Overview
Research summary
My research combines multimodal imaging techniques (e.g. MEG, EEG, MRI, MRS) with computational modelling (e.g. DCM) and machine learning methods to better characterise healthy and diseased brain function on a multi-scale level. I am particularly interested in understanding the link between synaptic physiology and neural oscillations.
My experimental imaging studies to date have included the study of psychiatric (MDD, SABP, Schizophrenia) and neurological (frontal-temporal dementia, progressive supra-nuclear palsy) disorders, as well as placebo-controlled pharmacological imaging studies (ketamine, tiagabine, propofol).
Publications
2021
- Shaw, A.et al. 2021. In vivo assay of cortical microcircuitry in frontotemporal dementia: a platform for experimental medicine studies. Cerebral Cortex 31(3), pp. 1837-1847. (10.1093/cercor/bhz024)
- Sumner, R. L., Spriggs, M. J. and Shaw, A. D. 2021. Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex. PLoS Computational Biology 17(1), article number: e1008414. (10.1371/journal.pcbi.1008414)
2020
- Shaw, A. D.et al. 2020. Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. NeuroImage 221, article number: 117189. (10.1016/j.neuroimage.2020.117189)
- Egerton, A.et al. 2020. Dopamine and glutamate in antipsychotic-responsive compared with antipsychotic-nonresponsive psychosis: a multicenter positron emission tomography and magnetic resonance spectroscopy study (STRATA). Schizophrenia Bulletin (10.1093/schbul/sbaa128)
- Routley, B.et al. 2020. Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity. Epilepsy Research 163, article number: 106324. (10.1016/j.eplepsyres.2020.106324)
- Shaw, A. D.et al. 2020. GABAA receptor mapping in human using non-invasive electrophysiology. BioRxiv
- Adams, N. E.et al. 2020. GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco- magnetoencephalography. Journal of Neuroscience 40(8), pp. 1640-1649. (10.1523/JNEUROSCI.1689-19.2019)
2019
- Shaw, A. D.et al. 2019. Oscillatory, computational and behavioural evidence for impaired GABAergic inhibition in schizophrenia. Schizophrenia Bulletin 46(2), pp. 345-353. (10.1093/schbul/sbz066)
2018
- Sumner, R. L.et al. 2018. Peak visual gamma frequency is modified across the healthy menstrual cycle. Human Brain Mapping 39(8), pp. 3187-3202. (10.1002/hbm.24069)
2017
- Shaw, A. D.et al. 2017. Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma. NeuroImage 161, pp. 19-31. (10.1016/j.neuroimage.2017.08.034)
2015
- Robson, S. E.et al. 2015. Structural and neurochemical correlates of individual differences in gamma frequency oscillations in human visual cortex. Journal of Anatomy 227(4), pp. 409-417. (10.1111/joa.12339)
- Shaw, A. D.et al. 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25(8), pp. 1136-1146. (10.1016/j.euroneuro.2015.04.012)
- Muthukumaraswamy, S. D.et al. 2015. Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. Journal of Neuroscience 35(33), pp. 11694-11706. (10.1523/JNEUROSCI.0903-15.2015)
- Brealy, J.et al. 2015. Increased visual gamma power in schizoaffective bipolar disorder. Psychological Medicine -London- 45(4), pp. 783-794. (10.1017/S0033291714001846)
2014
- Shaw, A. 2014. GABA, glutamate and beyond: In vivo measures and models of neurochemistry and network dynamics in healthy subjects and clinical populations. PhD Thesis, Cardiff University.
2013
- Shaw, A.et al. 2013. Marked reductions in visual evoked responses but not y-aminobutyric acid concentrations or y-band measures in remitted depression. Biological Psychiatry 73(7), pp. 691-698. (10.1016/j.biopsych.2012.09.032)
Research collaborators
Krish Singh (Cardiff)
James B Rowe (Cambridge)
Rosalyn Moran (Bristol)
Suresh Muthukumaraswamy (Aukland)
Neeraj Saxena (Cardiff)