Dr Alexander Shaw

Research Associate

School of Psychology

: shawa10@cardiff.ac.uk
: +44 (0)29 2068 8759

: Available for postgraduate supervision

Research summary

My research combines multimodal imaging techniques (e.g. MEG, EEG, MRI, MRS) with computational modelling (e.g. DCM) and machine learning methods to better characterise healthy and diseased brain function on a multi-scale level. I am particularly interested in understanding the link between synaptic physiology and neural oscillations.

My experimental imaging studies to date have included the study of psychiatric (MDD, SABP, Schizophrenia) and neurological (frontal-temporal dementia, progressive supra-nuclear palsy) disorders, as well as placebo-controlled pharmacological imaging studies (ketamine, tiagabine, propofol).

2018

Sumner, R. L.et al. 2018. Peak visual gamma frequency is modified across the healthy menstrual cycle. Human Brain Mapping 39(8), pp. 3187-3202. (10.1002/hbm.24069)

2017

Shaw, A. D.et al. 2017. Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma. NeuroImage 161, pp. 19-31. (10.1016/j.neuroimage.2017.08.034)

2015

Robson, S. E.et al. 2015. Structural and neurochemical correlates of individual differences in gamma frequency oscillations in human visual cortex. Journal of Anatomy 227(4), pp. 409-417. (10.1111/joa.12339)
Muthukumaraswamy, S. D.et al. 2015. Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. Journal of Neuroscience 35(33), pp. 11694-11706. (10.1523/JNEUROSCI.0903-15.2015)
Shaw, A.et al. 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25(8), pp. 1136-1146. (10.1016/j.euroneuro.2015.04.012)
Brealy, J.et al. 2015. Increased visual gamma power in schizoaffective bipolar disorder. Psychological Medicine -London- 45(4), pp. 783-794. (10.1017/S0033291714001846)

2014

Shaw, A. 2014. GABA, glutamate and beyond: In vivo measures and models of neurochemistry and network dynamics in healthy subjects and clinical populations. PhD Thesis, Cardiff University.

2013

Shaw, A.et al. 2013. Marked reductions in visual evoked responses but not y-aminobutyric acid concentrations or y-band measures in remitted depression. Biological Psychiatry 73(7), pp. 691-698. (10.1016/j.biopsych.2012.09.032)

Research collaborators

Krish Singh (Cardiff)
James B Rowe (Cambridge)
Rosalyn Moran (Bristol)
Suresh Muthukumaraswamy (Aukland)
Neeraj Saxena (Cardiff)