![Kate Langley](https://profiles-cardiff.imgix.net/attachments/3019?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Kate Langley
Senior Lecturer
- LangleyK@cardiff.ac.uk
- +44 29208 76259
- Tower Building, 70 Park Place, Cardiff, CF10 3AT
Overview
Research summary
Mental health problems in childhood can have far reaching consequences for the individual, their family and society. I am interested in risk factors for such problems, specifically Attention Deficit Hyperactivity Disorder (ADHD), Conduct Disorder and co-occurring problems (such as Autism Spectrum Disorders). I am also interested in how the presentation of these problems changes with age and how different risk factors are associated with the developmental course of disorder.
Teaching summary
I currently teach on Developmental Psychology within the 2nd Year Undergraduate programme. I also teach on the MSc in Children's Psychological Disorders and am module coordinator for the modules Neurodevelopmental Disorders 1: Neurobiology.
Publication
2024
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry
- Anning, K. L., Langley, K., Hobson, C., De Sonneville, L. and Van Goozen, S. H. 2024. Inattention symptom severity and cognitive processes in children at risk of ADHD: The moderating role of separation anxiety. Child Neuropsychology 30(2), pp. 264-288. (10.1080/09297049.2023.2190964)
- Agha, S. S. et al. 2024. Young adult ADHD symptoms in the general population and neurocognitive impairment. Journal of Attention Disorders 28(1), pp. 89-98. (10.1177/10870547231201870)
- Anning, K. L., Langley, K., Hobson, C. and van Goozen, S. H. 2024. Cool and hot executive function problems in young children: Linking self-regulation processes to emerging clinical symptoms. European Child and Adolescent Psychiatry (10.1007/s00787-023-02344-z)
2023
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Anning, K. L., Langley, K., Hobson, C. and Van Goozen, S. H. M. 2023. Dimensional associations between executive function processes and symptoms of ADHD, ASD, oppositional defiance and anxiety in young school-referred children. Cortex 167, pp. 132-147. (10.1016/j.cortex.2023.06.005)
- Langley, K., Pozo-Banos, M., Daalsgard, S., Paranjothy, S., Riglin, L., John, A. and Thapar, A. 2023. Can a nation-wide e-cohort of ADHD and ASD in childhood be established using Welsh routinely available datasets?. BMJ Open 13, article number: e071851. (10.1136/bmjopen-2023-071851)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Broughton, T., Langley, K., Tilling, K. and Collishaw, S. 2023. Relative age in the school year and risk of mental health problems in childhood, adolescence, and young adulthood. Journal of Child Psychology and Psychiatry 64(1), pp. 185-196. (10.1111/jcpp.13684)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
2022
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Tobarra‐Sanchez, E., Riglin, L., Agha, S. S., Stergiakouli, E., Thapar, A. and Langley, K. 2022. Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study. JCPP Advances 2(3), article number: e12099. (10.1002/jcv2.12099)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Adegboye, D. et al. 2022. Understanding de novo onset of anxiety during COVID-19: Pre-pandemic socio-emotional functioning in vulnerable children. JCPP Advances 2(2), article number: e12076. (10.1002/jcv2.12076)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Current Topics in Behavioral Neurosciences. Berlin, Heidelberg:, pp. 1-26., (10.1007/7854_2022_338)
- Cooper, M., Gale, K., Langley, K., Broughton, T., Massey, T. H., Hall, N. J. and Jones, C. R. 2022. How to do it: the neurological consultation with an autistic patient. Practical Neurology 22, pp. 120-125. (10.1136/practneurol-2020-002856)
- Turnock, A., Langley, K. and Jones, C. R. 2022. Understanding stigma in autism: a narrative review and theoretical model. Autism in Adulthood 4(1), pp. 76-91. (10.1089/aut.2021.0005)
- Colonna, S., Eyre, O., Agha, S. S., Thapar, A., van Goozen, S. and Langley, K. 2022. Investigating the associations between irritability and hot and cool executive functioning in those with ADHD. BMC Psychiatry 22, article number: 166. (10.1186/s12888-022-03818-1)
- Riglin, L. et al. 2022. Assessment of age-at-onset criterion for adult attention-deficit hyperactivity disorder. British Journal of Psychiatry 220(2), pp. 73-75. (10.1192/bjp.2021.122)
- Warne, N. et al. 2022. Collecting genetic samples and linked mental health data from adolescents in schools: protocol co-production and a mixed-methods pilot of feasibility and acceptability. BMJ Open 12(2), article number: e049283. (10.1136/bmjopen-2021-049283)
- van Goozen, S. H. M., Langley, K. and Hobson, C. W. 2022. Childhood antisocial behavior: a neurodevelopmental problem. Annual Review of Psychology 73, pp. 353-377. (10.1146/annurev-psych-052621-045243)
- Wimberley, T. et al. 2022. Early-life injuries and the development of attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry 83(1) (10.4088/JCP.21m14033)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
2021
- Eyre, O. et al. 2021. Validation of the short Mood and Feelings Questionnaire in young adulthood. Journal of Affective Disorders 294, pp. 883-888. (10.1016/j.jad.2021.07.090)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Riglin, L. et al. 2021. Variable emergence of Autism Spectrum Disorder symptoms from childhood to early adulthood. American Journal of Psychiatry 178(8), pp. 752-760. (10.1176/appi.ajp.2020.20071119)
- Riglin, L. et al. 2021. Investigating the validity of the strengths and difficulties questionnaire to assess ADHD in young adulthood. Psychiatry Research 301, article number: 113984. (10.1016/j.psychres.2021.113984)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Adegboye, D. et al. 2021. Understanding why the COVID-19 pandemic-related lockdown increases mental health difficulties in vulnerable young children. Journal of Child Psychology and Psychiatry Advances 1(1), article number: e12005. (10.1111/jcv2.12005)
2020
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2020. Parent psychopathology and neurocognitive functioning in children with ADHD. Journal of Attention Disorders 24(13), pp. 1836-1846. (10.1177/1087054717718262)
- Wimberle, T. et al. 2020. Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction 115(7), pp. 1368-1377. (10.1111/add.14910)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
- Fry, C., Langley, K. and Shelton, K. 2020. Executive functions in homeless young people: working memory impacts on short-term housing outcomes. Child Neuropsychology 26(1), pp. 27-53. (10.1080/09297049.2019.1628930)
- Caye, A. et al. 2020. A risk calculator to predict adult Attention-Deficit/Hyperactivity Disorder: generation and external validation in three birth cohorts and one clinical sample. Epidemiology and Psychiatric Sciences 29, article number: e37. (10.1017/S2045796019000283)
2019
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Demontis, D. et al. 2019. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
2018
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Airdrie, J. N., Langley, K., Thapar, A. and van Goozen, S. H. M. 2018. Facial emotion recognition and eye gaze in attention-deficit/hyperactivity disorder with and without comorbid conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 57(8), pp. 561-570. (10.1016/j.jaac.2018.04.016)
- Rice, F., Langley, K., Woodford, C., Davey Smith, G. and Thapar, A. 2018. Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. Development and Psychopathology 30(3), pp. 1107-1128. (10.1017/S0954579418000421)
- Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
- Hurt, L., Langley, K., North, K., Southern, A., Copeland, L., Gillard, J. and Williams, S. J. 2018. Understanding and improving the care pathway for children with autism. International Journal of Health Care Quality Assurance 32(1), pp. 208-223. (10.1108/IJHCQA-08-2017-0153)
2017
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Langley, K., Collishaw, S., Williams, M. and Shelton, K. H. 2017. An investigation of changes in children′s mental health in Wales between 2007/2008 and 2012/2013. Social Psychiatry and Psychiatric Epidemiology 52, pp. 639-642. (10.1007/s00127-017-1378-9)
- Eyre, O., Langley, K., Stringaris, A., Leibenluft, E., Collishaw, S. and Thapar, A. 2017. Irritability in ADHD: Associations with depression liability. Journal of Affective Disorders 215, pp. 281-287. (10.1016/j.jad.2017.03.050)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
- Gustavson, K. et al. 2017. Smoking in pregnancy and child ADHD. Pediatrics 139(2), pp. e20162509. (10.1542/peds.2016-2509)
- Fry, C., Langley, K. and Shelton, K. H. 2017. A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or poverty. Child Neuropsychology 23(8), pp. 907-934. (10.1080/09297049.2016.1207758)
2016
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. 2016. Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct Disorder. Psychiatry Research 242, pp. 130-136. (10.1016/j.psychres.2016.05.052)
- Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57(4), pp. 481-490. (10.1111/jcpp.12465)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Sellers, R. et al. 2016. Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sample. Journal of Abnormal Psychology 125(2), pp. 256-266. (10.1037/abn0000080)
2015
- Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. 2015. Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorder. Brain Sciences 5(3), pp. 369-386. (10.3390/brainsci5030369)
- Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. 2015. Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traits. PloS ONE 10(7), article number: e0134417. (10.1371/journal.pone.0134417)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
2014
- Cooper, M., Langley, K. and Thapar, A. 2014. Antenatal Acetaminophen use and attention-deficit/hyperactivity disorder. JAMA Pediatrics 168(4), pp. 306-307. (10.1001/jamapediatrics.2013.5292)
- Langley, K. and Thapar, A. 2014. Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathways. International Journal of Epidemiology 43(1), pp. 91-93. (10.1093/ije/dyt275)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
2013
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2013. Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?. European Child & Adolescent Psychiatry 22(6), pp. 369-377. (10.1007/s00787-013-0378-x)
- Thapar, A., Langley, K. and Muñoz-Solomando, A. 2013. The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'. Journal of Family Therapy 35(2), pp. 219-223. (10.1111/j.1467-6427.2012.00608.x)
- Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. 2013. Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Social Psychiatry and Psychiatric Epidemiology 48(2), pp. 337-344. (10.1007/s00127-012-0530-9)
- Thapar, A., Cooper, M., Eyre, O. and Langley, K. 2013. Practitioner review: what have we learnt about the causes of ADHD?. Journal of Child Psychology and Psychiatry 54(1), pp. 3-16. (10.1111/j.1469-7610.2012.02611.x)
2012
- Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. 2012. Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. American Journal of Epidemiology 176(3), pp. 261-268. (10.1093/aje/kwr510)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
2011
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Hassan, A., Agha, S. S., Langley, K. and Thapar, A. 2011. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. British Journal of Psychiatry 198(3), pp. 195-198. (10.1192/bjp.bp.110.078741)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
2010
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
2009
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
2008
- Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. 2008. Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosis. Child and Adolescent Mental Health 13(3), pp. 122-129. (10.1111/j.1475-3588.2007.00466.x)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
- Brookes, K. J. et al. 2008. Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 94-99. (10.1002/ajmg.b.30562)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
2007
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. 2007. Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 46(2), pp. 179-187. (10.1097/01.chi.0000246066.00825.53)
- Thapar, A., Langley, K., Asherson, P. and Gill, M. 2007. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 190(1), pp. 1-3. (10.1192/bjp.bp.106.027003)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
2006
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
2005
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. 2005. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry 46(10), pp. 1081-1088. (10.1111/j.1469-7610.2005.01533.x)
- Langley, K. 2005. A genetic study of attention deficit hyperactivity disorder: examining environmental influences and phenotypic variation.. PhD Thesis, Cardiff University.
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Potter, R., Langley, K. and Sakhuja, D. 2005. All things to all people: what referrers want from their child and adolescent mental health service. Psychiatric Bulletin 29(7), pp. 262. (10.1192/pb.29.7.262)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
2004
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Holmes, J. et al. 2004. The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity. British Journal of Psychiatry 184(1), pp. 74-78. (10.1192/bjp.184.1.74)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
2003
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
2002
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
Articles
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry
- Anning, K. L., Langley, K., Hobson, C., De Sonneville, L. and Van Goozen, S. H. 2024. Inattention symptom severity and cognitive processes in children at risk of ADHD: The moderating role of separation anxiety. Child Neuropsychology 30(2), pp. 264-288. (10.1080/09297049.2023.2190964)
- Agha, S. S. et al. 2024. Young adult ADHD symptoms in the general population and neurocognitive impairment. Journal of Attention Disorders 28(1), pp. 89-98. (10.1177/10870547231201870)
- Anning, K. L., Langley, K., Hobson, C. and van Goozen, S. H. 2024. Cool and hot executive function problems in young children: Linking self-regulation processes to emerging clinical symptoms. European Child and Adolescent Psychiatry (10.1007/s00787-023-02344-z)
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Anning, K. L., Langley, K., Hobson, C. and Van Goozen, S. H. M. 2023. Dimensional associations between executive function processes and symptoms of ADHD, ASD, oppositional defiance and anxiety in young school-referred children. Cortex 167, pp. 132-147. (10.1016/j.cortex.2023.06.005)
- Langley, K., Pozo-Banos, M., Daalsgard, S., Paranjothy, S., Riglin, L., John, A. and Thapar, A. 2023. Can a nation-wide e-cohort of ADHD and ASD in childhood be established using Welsh routinely available datasets?. BMJ Open 13, article number: e071851. (10.1136/bmjopen-2023-071851)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Broughton, T., Langley, K., Tilling, K. and Collishaw, S. 2023. Relative age in the school year and risk of mental health problems in childhood, adolescence, and young adulthood. Journal of Child Psychology and Psychiatry 64(1), pp. 185-196. (10.1111/jcpp.13684)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Tobarra‐Sanchez, E., Riglin, L., Agha, S. S., Stergiakouli, E., Thapar, A. and Langley, K. 2022. Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study. JCPP Advances 2(3), article number: e12099. (10.1002/jcv2.12099)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Adegboye, D. et al. 2022. Understanding de novo onset of anxiety during COVID-19: Pre-pandemic socio-emotional functioning in vulnerable children. JCPP Advances 2(2), article number: e12076. (10.1002/jcv2.12076)
- Cooper, M., Gale, K., Langley, K., Broughton, T., Massey, T. H., Hall, N. J. and Jones, C. R. 2022. How to do it: the neurological consultation with an autistic patient. Practical Neurology 22, pp. 120-125. (10.1136/practneurol-2020-002856)
- Turnock, A., Langley, K. and Jones, C. R. 2022. Understanding stigma in autism: a narrative review and theoretical model. Autism in Adulthood 4(1), pp. 76-91. (10.1089/aut.2021.0005)
- Colonna, S., Eyre, O., Agha, S. S., Thapar, A., van Goozen, S. and Langley, K. 2022. Investigating the associations between irritability and hot and cool executive functioning in those with ADHD. BMC Psychiatry 22, article number: 166. (10.1186/s12888-022-03818-1)
- Riglin, L. et al. 2022. Assessment of age-at-onset criterion for adult attention-deficit hyperactivity disorder. British Journal of Psychiatry 220(2), pp. 73-75. (10.1192/bjp.2021.122)
- Warne, N. et al. 2022. Collecting genetic samples and linked mental health data from adolescents in schools: protocol co-production and a mixed-methods pilot of feasibility and acceptability. BMJ Open 12(2), article number: e049283. (10.1136/bmjopen-2021-049283)
- van Goozen, S. H. M., Langley, K. and Hobson, C. W. 2022. Childhood antisocial behavior: a neurodevelopmental problem. Annual Review of Psychology 73, pp. 353-377. (10.1146/annurev-psych-052621-045243)
- Wimberley, T. et al. 2022. Early-life injuries and the development of attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry 83(1) (10.4088/JCP.21m14033)
- Eyre, O. et al. 2021. Validation of the short Mood and Feelings Questionnaire in young adulthood. Journal of Affective Disorders 294, pp. 883-888. (10.1016/j.jad.2021.07.090)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Riglin, L. et al. 2021. Variable emergence of Autism Spectrum Disorder symptoms from childhood to early adulthood. American Journal of Psychiatry 178(8), pp. 752-760. (10.1176/appi.ajp.2020.20071119)
- Riglin, L. et al. 2021. Investigating the validity of the strengths and difficulties questionnaire to assess ADHD in young adulthood. Psychiatry Research 301, article number: 113984. (10.1016/j.psychres.2021.113984)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Adegboye, D. et al. 2021. Understanding why the COVID-19 pandemic-related lockdown increases mental health difficulties in vulnerable young children. Journal of Child Psychology and Psychiatry Advances 1(1), article number: e12005. (10.1111/jcv2.12005)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2020. Parent psychopathology and neurocognitive functioning in children with ADHD. Journal of Attention Disorders 24(13), pp. 1836-1846. (10.1177/1087054717718262)
- Wimberle, T. et al. 2020. Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction 115(7), pp. 1368-1377. (10.1111/add.14910)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
- Fry, C., Langley, K. and Shelton, K. 2020. Executive functions in homeless young people: working memory impacts on short-term housing outcomes. Child Neuropsychology 26(1), pp. 27-53. (10.1080/09297049.2019.1628930)
- Caye, A. et al. 2020. A risk calculator to predict adult Attention-Deficit/Hyperactivity Disorder: generation and external validation in three birth cohorts and one clinical sample. Epidemiology and Psychiatric Sciences 29, article number: e37. (10.1017/S2045796019000283)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Demontis, D. et al. 2019. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Airdrie, J. N., Langley, K., Thapar, A. and van Goozen, S. H. M. 2018. Facial emotion recognition and eye gaze in attention-deficit/hyperactivity disorder with and without comorbid conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 57(8), pp. 561-570. (10.1016/j.jaac.2018.04.016)
- Rice, F., Langley, K., Woodford, C., Davey Smith, G. and Thapar, A. 2018. Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. Development and Psychopathology 30(3), pp. 1107-1128. (10.1017/S0954579418000421)
- Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
- Hurt, L., Langley, K., North, K., Southern, A., Copeland, L., Gillard, J. and Williams, S. J. 2018. Understanding and improving the care pathway for children with autism. International Journal of Health Care Quality Assurance 32(1), pp. 208-223. (10.1108/IJHCQA-08-2017-0153)
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Langley, K., Collishaw, S., Williams, M. and Shelton, K. H. 2017. An investigation of changes in children′s mental health in Wales between 2007/2008 and 2012/2013. Social Psychiatry and Psychiatric Epidemiology 52, pp. 639-642. (10.1007/s00127-017-1378-9)
- Eyre, O., Langley, K., Stringaris, A., Leibenluft, E., Collishaw, S. and Thapar, A. 2017. Irritability in ADHD: Associations with depression liability. Journal of Affective Disorders 215, pp. 281-287. (10.1016/j.jad.2017.03.050)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
- Gustavson, K. et al. 2017. Smoking in pregnancy and child ADHD. Pediatrics 139(2), pp. e20162509. (10.1542/peds.2016-2509)
- Fry, C., Langley, K. and Shelton, K. H. 2017. A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or poverty. Child Neuropsychology 23(8), pp. 907-934. (10.1080/09297049.2016.1207758)
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. 2016. Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct Disorder. Psychiatry Research 242, pp. 130-136. (10.1016/j.psychres.2016.05.052)
- Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57(4), pp. 481-490. (10.1111/jcpp.12465)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Sellers, R. et al. 2016. Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sample. Journal of Abnormal Psychology 125(2), pp. 256-266. (10.1037/abn0000080)
- Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. 2015. Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorder. Brain Sciences 5(3), pp. 369-386. (10.3390/brainsci5030369)
- Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. 2015. Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traits. PloS ONE 10(7), article number: e0134417. (10.1371/journal.pone.0134417)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Cooper, M., Langley, K. and Thapar, A. 2014. Antenatal Acetaminophen use and attention-deficit/hyperactivity disorder. JAMA Pediatrics 168(4), pp. 306-307. (10.1001/jamapediatrics.2013.5292)
- Langley, K. and Thapar, A. 2014. Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathways. International Journal of Epidemiology 43(1), pp. 91-93. (10.1093/ije/dyt275)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2013. Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?. European Child & Adolescent Psychiatry 22(6), pp. 369-377. (10.1007/s00787-013-0378-x)
- Thapar, A., Langley, K. and Muñoz-Solomando, A. 2013. The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'. Journal of Family Therapy 35(2), pp. 219-223. (10.1111/j.1467-6427.2012.00608.x)
- Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. 2013. Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Social Psychiatry and Psychiatric Epidemiology 48(2), pp. 337-344. (10.1007/s00127-012-0530-9)
- Thapar, A., Cooper, M., Eyre, O. and Langley, K. 2013. Practitioner review: what have we learnt about the causes of ADHD?. Journal of Child Psychology and Psychiatry 54(1), pp. 3-16. (10.1111/j.1469-7610.2012.02611.x)
- Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. 2012. Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. American Journal of Epidemiology 176(3), pp. 261-268. (10.1093/aje/kwr510)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Hassan, A., Agha, S. S., Langley, K. and Thapar, A. 2011. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. British Journal of Psychiatry 198(3), pp. 195-198. (10.1192/bjp.bp.110.078741)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
- Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. 2008. Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosis. Child and Adolescent Mental Health 13(3), pp. 122-129. (10.1111/j.1475-3588.2007.00466.x)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
- Brookes, K. J. et al. 2008. Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 94-99. (10.1002/ajmg.b.30562)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. 2007. Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 46(2), pp. 179-187. (10.1097/01.chi.0000246066.00825.53)
- Thapar, A., Langley, K., Asherson, P. and Gill, M. 2007. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 190(1), pp. 1-3. (10.1192/bjp.bp.106.027003)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. 2005. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry 46(10), pp. 1081-1088. (10.1111/j.1469-7610.2005.01533.x)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Potter, R., Langley, K. and Sakhuja, D. 2005. All things to all people: what referrers want from their child and adolescent mental health service. Psychiatric Bulletin 29(7), pp. 262. (10.1192/pb.29.7.262)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Holmes, J. et al. 2004. The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity. British Journal of Psychiatry 184(1), pp. 74-78. (10.1192/bjp.184.1.74)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
Book sections
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Current Topics in Behavioral Neurosciences. Berlin, Heidelberg:, pp. 1-26., (10.1007/7854_2022_338)
Books
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
Thesis
- Langley, K. 2005. A genetic study of attention deficit hyperactivity disorder: examining environmental influences and phenotypic variation.. PhD Thesis, Cardiff University.
Research
Research topics and related papers
Using both clinical samples of children with Attention Deficit Hyperactivity Disorder (ADHD) and other mental health problems (e.g. Conduct disorder, Autism Spectrum Disorders) and epidemiological samples, I am interested in how presentation of disorder and co-morbid problems are influenced by genetic and environmental risk factors.
I am also interested in the developmental course of ADHD and how presentation changes with age, the individual and societal impact of continued problems as well as the risk factors involved with the continuation or remittance of symptoms .
Research collaborators
MRC Centre for Neuropsychiatric Genetics and Genomics
National Centre for Mental Health (NCMH)
Child & Adolescent Psychiatry Group, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University
Biography
Undergraduate education
2000: BA(Hons.) Psychology, Durham University (2:1)
Postgraduate education
2005: PhD, Cardiff University
Thesis title: “A genetic study of ADHD: Examining environmental influences and phenotypic variation”
2016: Postgraduate Certificate in Learning and teaching – Distinction 2015-2016, Cardiff University, UK
Employment
Following my undergraduate degree at Durham University, I started working as a Research Psychologist (2001-2003) with Prof Anita Thapar at the University of Wales College of Medicine (now Cardiff University School of Medicine) on a Wellcome Trust funded project investigating susceptibility genes for Attention Deficit Hyperactivity Disorder (ADHD). The project ignited my interest in mental health and understanding the genetic and environmental risk factors associated with such disorders.
This led to my embarking on a PhD, supervised by Prof Thapar and Prof Peter Holmans, investigating how genetic and environmental risk factors for ADHD influence the clinical presentation of the disorder and the interactions between these factors. My work was extended through a Wellcome Trust VIP Fellowship Award (2005-2006).
Whilst continuing to work in the field of genetic and other risk factors for ADHD and other childhood mental health problems, during my post-doctoral position at the School of Medicine (2006-2011), Cardiff University, I became interested in using natural experimental designs to investigate causal pathways between genetic, cognitive and social risk factors and childhood behaviour problems.
After working with Prof Nick Craddock as part of the team establishing the National Centre for Mental Health (NCMH), the first Biomedical Research Centre in Wales (2012-2013), I took up a lecturer post in the School of Psychology, Cardiff University, in August 2013 and was promoted to Senior Lecutrer in 2017.
Honours and awards
Awards/external committees
- 2018-2020: Member of Welsh Government T4CHYP Neurodevelopmental Steering Group
- 2015-current: Associate editor, BMC Psychiatry
- 2010-current: Advisory Board member, Journal of Child Psychology & Psychiatry
- 2009-current: Member of the MRC Centre for Neropsychiatric Genetics & Genomics
- 2005-2006: Wellcome Trust VIP Fellowship, Cardiff University
Graduate Member of the British Psychological Society; Member ADHD working group of International Psychiatric Genetics Consortium; Member Eunethydis European ADHD Network
Professional memberships
Professional Memberships
- British Psychological Society;
- ADHD working group of International Psychiatric Genetics Consortium;
- Eunethydis European ADHD Network
Supervisions
Postgraduate research interests
If you are interested in applying for a PhD, or for further information regarding my research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.
Current students
- Silvia Colonna 2016-2020 (submitted), Thesis title: The importance of emotional self-control in persistent childhood ADHD
- Rebecca Ellis 2018-2021, Thesis title: Co-producing an intervention to improve care for children wtih Autism Spectrum Disorders: A cross-disciplinary mixed-methods study. Co-supervisor with Prof Sharon Williams (Swansea University) and Lisa Hurt (School of Medicine)
- Thomas Broughton 2019-2022, Thesis title: Testing the role of relative age within school yer on mental health in children with neurodevelopmental vulnerability. Co-supervisor with Prof Stephan Collishaw (School of Medicine) and Prof Kate Tilling (University of Bristol)
- Lorna Ushaw 2019-2023, Thesis title: Optimizing adult mental health outcomes in children with neurodevelopmental problems: Interplay of social and genetic factors. Co-supervisor with Prof Stephan Collishaw (School of Medicine), Prof Jon Heron (University of Bristol) and Dr Gemma Hammerton (University of Bristol)
Past students
- Sharifah Shameem Syed Salim Agha: Awarded 2017, Thesis title: Exploring the role of parental psychopathology in a sample of children with ADHD: Investigating influences on child phenotype and the family environment
- Charlotte Fry: Awarded 2018, Thesis title: Executive Functions, creativity and mental health in homeless young people: implications for housing outcome. Co-supervisor with Prof Katherine Shelton
- Zoe Williams: Awarded 2018, Thesis Title: The overlap between Attention-deficit/hyperactivity disorder and Autism Spectrum Disorder symptoms and thier association with reading skills and social cognition ability.