Professor Mark Good
The medial temporal lobe and particularly the hippocampus has long been associated with memory function in humans and non-human animals. This region is often involved in psychiatric and neurodegenerative conditions, such as schizophrenia and Alzheimer’s disease. My current research is aimed at addressing two main questions:
- What role does the hippocampus and associated brain structures play in memory?
- How do neurodegenerative conditions influence the function of the hippocampus?
In addressing these questions I use preclinical models of brain pathology synaptic including genetic models of heritable neurodegenerative conditions, such as Alzheimer’s disease and frontotemporal dementia.
Current projects include:
- assessment of the psychological and neural substrates of configural and episodic-like memory, characterisation of transgenic models of Alzheimer’s disease;
- investigation of the psychological and neural benefits of dietary supplements on Alzheimer’s pathology;
- assessment of a novel antibody treatment for amyloid pathology;
- investigation of cannabinoid receptors in memory and neurodegenerative diseases;
- the role of maternal priming in the onset of Alzheimer’s disease in later life.
My teaching includes: lectures on biological psychology to level 2 undergraduate students; a complete level 3 module on the neuroscience of learning and memory; lectures to neuroscience students and medical students on preclinical models of Alzheimer’s disease and higher cortical function in humans, respectively.
BSc. Psychology (2.1) University of London
DPhil. Behavioural Neuroscience University of York
1990-1994. University of Edinburgh. Post-doc. associate.
1994-to present. Lecturer, Reader and Personal Chair Cardiff University
BBSRC: Attention and predictive learning (John Pearce) £574,671, 2010-2013
KTP: Improved lipid containing neutraceuticals (John Harwood) £208,748, 2009-2011
Alzheimer’s Society Studentship: Evaluation of a novel antibody therapy for AD (Emma Kidd) £75,000, 2009-1011
Alzheimer’s Research Trust: Molecular basis for beneficial effects of omega-3 fatty acids (John Harwood £296,000, 2007-2011
NIH service contract: with Prof Steve Goldberg: Cannabinoid receptor modulation of GABA activity in APP mice $20,000 pa, 2010-11
Professor Robert Honey (Cardiff University)
Professor John Harwood (Cardiff University)
Professor John Pearce (Cardiff University)
Dr. Emma Kidd (Cardiff University)
Dr. David Bannerman (Oxford University)
Dr. Robert Williams (University of Bath)
Postgraduate research interests
Postgraduate students currently carry out research directed at investigating the neural substrates of animal cognition and or evaluating putative therapies for amyloid pathology (see below)
If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.
John Anderson – (writing up) The role of insulin resistance in the development of amyloid pathology. BBSRC/GSK CASE award
Katie Hall (current) The infuence of dietary supplements on memory and amyloid pathology in mouse models of Alzheimer’s Disease
Martha Hvoslefeide – (current) The effect of steric hindrance of Ab processing on cognition in APP mice
Laura Middleton (current) Maternal priming & Alzheimer’s Disease:The influence of diet and exercise on amyloid pathology in a mouse model of Alzheimer’s Disease
Caroline O’Hagan (current) The influence of probiotics on emotion and executive function in rodents
Alice Palmer (current) Amyloid pathology and hippocampal synaptic plasticity in mouse models of Alzheimer’s Disease
Phil Barnes – (submitted)Characterisation of a transgenic mouse model of Alzheimer’s disease. MRC
Cecile Bascoul – (submitted) Inflammatory processes in Alzheimer’s Disease: Investigation of dietary doxosahexanoec acid supplements in a mouse transgenic model. Department funded.
Dean Burnett – (submitted) Episodic-like memory in rats. BBSRC
James Dachtler- (submitted) GluR-1 roles in learning and synaptic plasticity
Mark Day – (submitted) The role of oestrogen in cognition. GSK
Gemma Hale – (submitting) Memory processes in a mouse transgenic model of Alzheimer’s disease. MRC
Andrew Hayward – (submitted) Cue competition in spatial learning. BBSRC
Alex Johnson – (submitted) The role of GluR1A receptors in learning and memory. Department funded
Peter Jones – (submitted) The role of the hippocampus in processing the geometry of the environment. Department funded
Mariah Lelos – (submitted) Frontal-amygdala interactions in an APP model of Alzheimer’s disease. MRC
Jo Oswald – (submitted) An analysis of entorhinal cortex function in the rat. MRC
Pippa Pugh – (submitted) Models of inflammation in Alzheimer’s disease. GlaxoSmithKline
Amy Reichelt – (submitted) Neurobiology of response conflict resolution- BBSRC/Eli Lilly
Kristina Wilton – (submitted) The effects of protein phosphorylation inhibition on tau production and cognition in rats. MRC