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Dr Dobril Ivanov

Dr Dobril Ivanov

Sêr Cymru II Fellow, Dementia Research Institute

School of Medicine

Email
ivanovd1@cardiff.ac.uk
Campuses
1st floor, office 9, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

Overview

With a background in molecular biology, genetics and biostatistics/bioinformatics, Dr Dobril Ivanov joined the UK DRI at Cardiff with a Sêr Cymru Rising Star fellowship by the ERDF through the Welsh Government.

Dobril did an MSc in molecular biology followed by a wet-lab scholarship to study neurodevelopmental disorders at the MRC Centre in Cardiff. This project was one of the earliest to accurately estimate the frequency of VCFS deletions in patients with psychosis (https://doi.org/10.1192/bjp.183.5.409).

Dr Ivanov obtained his PhD in bioinformatics from Cardiff University in 2010, with one of the first studies to fully explore the similarities and differences of germline/somatic mutations in human tumour suppressor genes in a variety of cancers (https://doi.org/10.1002/humu.21483). During his first postdoc (MRC CNGG Cardiff University) he developed a novel computational approach that led to the observation that rare CNVs substantially increase one’s susceptibility to developing schizophrenia (https://doi.org/10.1038/mp.2011.154).

Dr Ivanov completed his postdoctoral training at the European Bioinformatics Institute in Cambridge in Prof. Janet Thornton’s group investigating neurodegenerative disorders and signalling mechanisms and biochemical processes by which insulin/IGF-1 signalling modulates lifespan in model organisms (https://doi.org/10.1016/j.celrep.2016.03.041). As a UK DRI Emerging Leader, Dr Ivanov leads research to link gene-expression profiles to a wide-range of Alzheimer-related phenotypes in humans, animal and iPSC models.

Biography

Previous Academic Positions

2018 - present: The Welsh Government Sêr Cymru II "Rising Star" fellow (UK Dementia Research Institute @ Cardiff University)

2012 - 2018: Postdoctoral Fellow - Thornton group (EMBL-EBI, European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Cambridge)

2011 - 2012: Research Associate in Bioinformatics (Biostatistics and Bioinformatics Unit, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)

2008 - 2011: Research Associate in Statistical Genetics (Biostatistics and Bioinformatics Unit, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)

2005 - 2010: PhD in Bioinformatics/Biostatistics ("Comparative analysis of Germline and Somatic micro-lesion mutational spectra in 17 human tumour-suppressor genes", Institute of Medical Genetics, Cardiff University)

2003 - 2005: Research Assistant (Department of Psychological Medicine and Neurology; MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)

2002 - 2003: Visiting Scholarship (Study on Juvenile Onset Psychosis, Cardiff University)

Honours and awards

2021: Emerging leader status (UK Dementia Research Institute)

2018 - present: The Welsh Government Sêr Cymru II "Rising Star" fellowship (Deconvoluting the Dementia Phenotype Using Functional Genomics and Computational Approaches)

2015: Experimental validation of lifespan extension of GWAS top hits (EMBL-EBI)

2011: Early Career Researcher Award (BSRA)

2002 - 2003: Visiting Scholarship, Study on Juvenile Onset Psychosis (Cardiff University)

Professional memberships

2018 - present: Alzheimer Research UK (ARUK) Wales Network member

2016 - present: British Society of Research on Ageing (BSRA) member

Publications

2021

2020

2019

2017

2016

2015

2013

2012

2011

2010

2009

2008

2006

2005

2004

2003

Teaching

2008 - 2011 Module leader of "Introduction to statistical approaches in life sciences" (postgraduate course, MSc module, MRC Centre in Neuropsychiatric Genetics and Genomics, Cardiff University)