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Dr Carlotta Olivero

Dr Carlotta Olivero

Marie Sklodowska-Curie Fellow

School of Biosciences

Email
oliveroc@cardiff.ac.uk
Telephone
+44 (0)29 2068 8520
Campuses
Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

In my career I have always been interested in studying viruses that cause cancer. Specifically, I study the relationship between the infection of HPV (Human Papillomavirus) with cutaneous tropism and the development of skin cancer. Beta-HPV (a subgroup of the large HPV family) infects the skin from the early days of our life with asintomatic effects, and it is maintained under control by the immunosystem. When immunosuppression occurs (for example after a transplantation) the virus reactivates and triggers cell proliferation. This action is the starting point of a lesion formation.

In my research, I study which molecular mechanisms the virus uses to enhance cell proliferation and tumour formation.

I was born in Cuneo the 13th of July 1989.

In 2008 I joined the Bachelor in Biology at Turin University, Italy.

In 2013 I obtained the Master in Molecular and Cellular Biology at Turin University,Italy.

In 2017 I graduated as a PhD in the University of Eastern Piedmont, Italy. During this period I went to ECSCRI, Cardiff University for 6 months as a visiting student.

In 2018 I won a Marie Curie Action fellowship to start a project in ECSCRI, Cardiff University for 2 years.

2020

2018

2017

I am a Marie Curie Fellow in ECSCRI, Cardiff University. In my research, I study the molecular mechanisms that are involved in Beta HPV infection and the progression in skin cancer. In the mouse model we use (where the early region genes of HPV8, a betaHPV, are under the control of the epitelial promoter K14), there is an expansion of  Lrig1 keratinocyte stem cell population (KSC) located in the hair follicle. It seems that beta HPV trigger the proliferation of a KSC population located in the HF that is involve in the enlargment of the inferfollicular epidermis and may cause the lesion. Also, in human settings we have observed that there is the same pattern associated with beta HPV reactivation and proliferation of interfollicular epidermis.

Currently I am focused on the molecular mechanism used by HPV to trigger the proliferation.

Past projects

Supervisor of undergraduate, PTY (Professional Training Year), MSc, and PhD students (research-laboratory training, and thesis supervision).

- MSc thesis title: “Defining the role of human beta papillomavirus infection in the development of skin cancer in the immunocompromised host”.

- PTY thesis title: “Field Cancerisation in the βHPV8 transgenic mouse model, and its relation to p63 expression in human carcinogenesis”