Dr Peter Taylor
(he/him)

PhD, FRCP

Clinical Senior Lecturer

: TaylorPN@cardiff.ac.uk
: Main Hospital Building, Floor C2 Link, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN

: Available for postgraduate supervision

I undertake research in epidemiology and clinical trials in both thyroid disease and type-1 diabetes.

Thyroid Disease

My research is focussed on the consequences of how modest variation in thyroid status influences key health outcomes. This work broadly encompasses 3 themes

1) Thyroid hormone replacement, including alternatives to LT4 monotherapy such as long-acting LT3.

2) Treatment thresholds in hypothyroidism and whether this should be individuliased.

3) Thyroid status in pregnancy and key obstetric outcomes including screening for thyroid disease.

I also am involved in research regarding the pathogenesis of Graves' Orbitopathy (thyroid eye disease) and clinical trials to improve its outcomes. My epidemiology research also extends to the impact of iodine status on key health outcomes.

Type 1 Diabetes

This work is focussed on how best to utilise low-risk immunotherapy in individuals at risk of or with new onset type-1 diabetes. As well as being involved in clinical trials, I research which markers are best in determining beta cell function including utilising machine learning of continuous glucose monitoring (CGM) data.

Date
Type

2020

Pak, H. Y., Lansdown, A., Taylor, P., Rees, A. D., Davies, J. and Hayhurst, C. 2020. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care. Endocrine Connections 9(10), pp. 971-977. (10.1530/EC-20-0335)
Galloway, L., Ali, M., Lansdown, A., Taylor, P., Rees, A., Davies, J. S. and Hayhurst, C. 2020. The impact of endoscopic transsphenoidal pituitary adenoma surgery on endocrine function: a single-centre study. Acta Neurochirurgica 163(2), pp. 391-398. (10.1007/s00701-020-04609-x)
Zhou, W. et al. 2020. GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nature Communications 11, article number: 3981. (s41467-020-17718-z)
Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105(7), article number: dgaa129. (10.1210/clinem/dgaa129)
Taylor, P. N., Muller, I., Nana, M., Velasco, I. and Lazarus, J. H. 2020. Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. Best Practice and Research: Clinical Endocrinology and Metabolism 34(4), article number: 101436. (10.1016/j.beem.2020.101436)
Bianco, A. C. and Taylor, P. 2020. Levothyroxine treatment and cholesterol in hypothyroidism. Nature Reviews Endocrinology 16, pp. 193-194. (10.1038/s41574-020-0323-2)
Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
Taylor, P. N., Okosieme, O. E., Chatterjee, K. and Boelaert, K. 2020. Joint statement from the Society for Endocrinology and the British Thyroid Association regarding 'association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism'. Clinical Endocrinology 92(3), pp. 266-267. (10.1111/cen.14136)
Okosieme, O. E., Taylor, P. N. and Dayan, C. M. 2020. Should radioiodine now be first line treatment for Graves' disease?. Thyroid Research 13(1), article number: 3. (10.1186/s13044-020-00077-8)
Hayhurst, C., Taylor, P., Lansdown, A., Palaniappan, N., Rees, D. and Davis, J. 2020. Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment. Clinical Endocrinology 92(2), pp. 89-97. (10.1111/cen.14127)
Ved, R., Taylor, P., Stewart, P., Foulkes, J., Fields-Jewell, W., Davies, S. and Hayhurst, C. 2020. Vitamin D deficiency is endemic in neurosurgical patients and is associated with a longer length of inpatient stay. Endocrinology, Diabetes and Metabolism 3(1), article number: e00097. (10.1002/edm2.97)
Velasco, I., Sánchez-Gila, M., Manzanares, S., Taylor, P. and García-Fuentes, E. 2020. Iodine status, thyroid function, and birthweight: a complex relationship in high-risk pregnancies. Journal of Clinical Medicine 9(1), article number: 177. (10.3390/jcm9010177)
Prentice, M., Hickey, J., Vanderpump, M., Taylor, P. N. and Lazarus, J. H. 2020. Iodine and folate-essential for mothers to be. Lancet Diabetes and Endocrinology 8(1), pp. 9-10. (10.1016/S2213-8587(19)30380-8)

2019

Taylor, P. N. et al. 2019. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. Nature Reviews Endocrinology 16(2), pp. 104-116. (10.1038/s41574-019-0305-4)
Choudhury, M. et al. 2019. Association between HbA1c and the development of cystic fibrosis‐related diabetes. Diabetic Medicine 36(10), pp. 1251-1255. (10.1111/dme.13912)
Taylor, P. N., Eligar, V., Muller, I., Scholz, A., Dayan, C. and Okosieme, O. 2019. Combination thyroid hormone replacement; knowns and unknowns. Frontiers in Endocrinology 10, article number: 706. (10.3389/fendo.2019.00706)
Taylor, P. N. and Lazarus, J. H. 2019. Hypothyroidism in pregnancy. Endocrinology and Metabolism Clinics of North America 48(3), pp. 547-556. (10.1016/j.ecl.2019.05.010)
Medici, M., Peeters, R., Teumer, A. and Taylor, P. 2019. The importance of high-quality mendelian randomisation studies for clinical thyroidology. Lancet Diabetes and Endocrinology 7(9), pp. 665-667. (10.1016/S2213-8587(19)30145-7)
Taylor, P. and Bianco, A. C. 2019. Urgent need for further research in subclinical hypothyroidism. Nature Reviews Endocrinology 15(9), pp. 503-504. (10.1038/s41574-019-0239-x)
Korevaar, T. I. M. et al. 2019. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. Journal of the American Medical Association 322(7), pp. 632-641. (10.1001/jama.2019.10931)
Wilson, N. et al. 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20(11), article number: 2675. (10.3390/ijms20112675)
Okosieme, O. E. et al. 2019. Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study. Lancet Diabetes and Endocrinology 7(4), pp. 278-287. (10.1016/S2213-8587(19)30059-2)
Draman, M. S. et al. 2019. Prostaglandin F2-alpha eye drops (bimatoprost) in Graves' orbitopathy: a randomized controlled double-masked crossover trial (BIMA Trial). Thyroid Journal Program 29(4), pp. 563-572. (10.1089/thy.2018.0506)
Razvi, S., Korevaar, T. I. and Taylor, P. 2019. Trends, determinants, and associations of treated hypothyroidism in the United Kingdom, 2005-2014. Thyroid 29(2), pp. 174-182. (10.1089/thy.2018.0251)
Taylor, P. N., Razvi, S., Muller, I., Wass, J., Dayan, C. M., Chatterjee, K. and Boelaert, K. 2019. Liothyronine cost and prescriptions in England. Lancet Diabetes and Endocrinology 7(1), pp. 11-12. (10.1016/S2213-8587(18)30334-6)
Das, G., Taylor, P. N., Abusahmin, H., Ali, A., Tennant, B. P., Geen, J. and Okosieme, O. 2019. Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes. Annals of Clinical Biochemistry 56(1), pp. 155-162. (10.1177/0004563218797979)

2018

Muller, I. et al. 2018. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.. Thyroid 28(12), pp. 1682-1693. (10.1089/thy.2018.0232)
Roberts, M., Northmore, T., Shires, J., Taylor, P. and Hayhurst, C. 2018. Diffuse low grade glioma after the 2016 WHO update, seizure characteristics, imaging correlates and outcomes. Clinical Neurology and Neurosurgery 175, pp. 9-15. (10.1016/j.clineuro.2018.10.001)
Muller, I., Taylor, P. and Lazarus, J. 2018. Thyroid function in pregnancy. Annals of Thyroid (10.21037/aot.2018.10.05)
Just, S. A. et al. 2018. Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe. RMD Open 4(2), pp. e000799. (10.1136/rmdopen-2018-000799)
Taylor, P. N., Zouras, S., Min, T., Nagarahaj, K., Lazarus, J. and Okosieme, O. 2018. Thyroid screening in early pregnancy: Pros and cons. Frontiers in Endocrinology 9, article number: 626. (10.3389/fendo.2018.00626)
Derakhshan, A. et al. 2018. The association of maternal thyroid autoimmunity during pregnancy with child IQ. Journal of Clinical Endocrinology & Metabolism 103(10), pp. 3729-3736. (10.1210/jc.2018-00743)
Okosieme, O., Khan, I. and Taylor, P. N. 2018. Preconception management of thyroid dysfunction. Clinical Endocrinology 89(3), pp. 269-279. (10.1111/cen.13731)
Bakhsh, A. D. et al. 2018. An InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goiter. Thyroid 28(7), pp. 891-901. (10.1089/thy.2017.0312)
Taylor, P. N. and Davies, J. S. 2018. A review of the growing risk of vitamin D toxicity from inappropriate practice. British Journal of Clinical Pharmacology 84(6), pp. 1121-1127. (10.1111/bcp.13573)
Peterson, S. J. et al. 2018. An online survey of hypothyroid patients demonstrates prominent dissatisfaction. Thyroid 28(6), pp. 707. (10.1089/thy.2017.0681)
Taylor, P. N., Albrecht, D., Scholz, A., Gutierrez-Buey, G., Lazarus, J. H., Dayan, C. M. and Okosieme, O. E. 2018. Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews Endocrinology 14(5), pp. 301-316. (10.1038/nrendo.2018.18)
Taylor, P. 2018. Common variation in thyroid hormone status; effects on key health outcomes. PhD Thesis, Cardiff University.
Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103(4), pp. 1583-1591. (10.1210/jc.2017-02378)
Rajendram, R. et al. 2018. Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial. Lancet Diabetes and Endocrinology 6(4), pp. 299-309. (10.1016/S2213-8587(18)30021-4)
Dietrich, A. et al. 2018. Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial. Psychology, Health and Medicine 23(18), pp. 1341-1355. (10.1080/13548506.2018.1503693)
Das, G., Taylor, P. N., Javaid, H., Tennant, B. P., Geen, J., Aldridge, A. and Okosieme, O. 2018. Seasonal variation of vitamin D and serum thyrotropin levels and its relationship in a euthyroid caucasian population. Endocrine Practice 24(1), pp. 53-59. (10.4158/EP-2017-0058)
Velasco, I. and Taylor, P. 2018. Identifying and treating subclinical thyroid dysfunction in pregnancy: emerging controversies. European Journal of Endocrinology 178(1), pp. D1-D12. (10.1530/EJE-17-0598)
Dew, R. et al. 2018. Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study. BMJ Open 8(2), article number: e019970. (10.1136/bmjopen-2017-019970)

2017

Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102(7), pp. 2508-2515. (10.1210/jc.2016-3605)
Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
Dew, R. et al. 2017. Patients' attitudes and perceptions towards treatment of hypothyroidism in general practice: an in-depth qualitative interview study. BJGP Open, article number: BJGP-2017-0125. (10.3399/bjgpopen17X100977)
Lazarus, J., Smyth, P., Taylor, P., Weibel, S. and Zimmermann, M. 2017. Iodine in malt whiskey: A preliminary analysis. Thyroid 27(3), pp. 477-478. (10.1089/thy.2016.0596)

2016

Korevaar, T. I., Taylor, P., Dayan, C. and Peeters, R. P. 2016. An Invitation to Join the Consortium on Thyroid and Pregnancy [Letter]. European Thyroid Journal 5(4), pp. 277. (10.1159/000452331)
Korevaar, T. I. M., Taylor, P. N., Dayan, C. M. and Peeters, R. P. 2016. An invitation to join the consortium on thyroid and pregnancy. Obstetrics and Gynaecology 128(4), pp. 913. (10.1097/AOG.0000000000001670)
Eligar, V., Taylor, P. N., Okosieme, O., Leese, G. and Dayan, C. M. 2016. Thyroxine replacement: a clinical endocrinologists viewpoint. Annals of Clinical Biochemistry 53(4), pp. 421-433. (10.1177/0004563216642255)
Taylor, P. N. and Vaidya, B. 2016. Iodine supplementation in pregnancy - is it time?. Clinical Endocrinology 85(1), pp. 10-14. (10.1111/cen.13065)
Tabasum, A., Khan, I., Taylor, P., Das, G. and Okosieme, O. 2016. Thyroid antibody-negative euthyroid Graves' ophthalmopathy. Endocrinology, Diabetes & Metabolism Case Reports 2016(1), article number: EDM160008. (10.1530/EDM-16-0008)
Witczak, J. et al. 2016. Predicting malignancy in thyroid nodules: feasibility of a predictive model integrating clinical, biochemical, and ultrasound characteristics. Thyroid Research 9(1), article number: 4. (10.1186/s13044-016-0033-y)
Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101(2), pp. 730-738. (10.1210/jc.2015-3505)
Lazarus, J. and Taylor, P. 2016. Hypothyroxinaemia and brain development. Acta Endocrinologica 12(1), pp. 1-6. (10.4183/aeb.2016.1)

2015

Taylor, P. et al. 2015. Weekly intramuscular injection of Levothyroxine following Myxoedema: a practical solution to an old crisis. Case Reports in Endocrinology 2015, article number: 169194. (10.1155/2015/169194)
Stacey, M. J., Parsons, I. T., Woods, D. R., Taylor, P., Ross, D. and J Brett, S. 2015. Susceptibility to exertional heat illness and hospitalisation risk in UK military personnel. BMJ Open Sport & Exercise Medicine 1(1), pp. e000055. (10.1136/bmjsem-2015-000055)
Taylor, P. N., Okosieme, O. E., Premawardhana, L. and Lazarus, J. H. 2015. Should all women be screened for thyroid dysfunction in pregnancy?. Women's Health 11(3), pp. 295-307. (10.2217/whe.15.7)
Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6, article number: 5681. (10.1038/ncomms6681)

2014

Taylor, P. N. et al. 2014. Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the controlled antenatal thyroid study. Journal of Clinical Endocrinology and Metabolism 99(11), pp. 4291-4298. (10.1210/jc.2014-1901)
Taylor, P. et al. 2014. TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study. Journal of Clinical Endocrinology & Metabolism 99(10), pp. 3895-3902. (10.1210/jc.2014-1954)
Taylor, P. N. et al. 2014. Falling threshold for treatment of borderline elevated thyrotropin levels - balancing benefits and risks: evidence from a large community-based study. JAMA Internal Medicine 174(1), pp. 32-39. (10.1001/jamainternmed.2013.11312)
Taylor, P., Okosieme, O., Dayan, C. and Lazarus, J. 2014. Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. European Journal of Endocrinology 170(1), pp. R1-R15. (10.1530/EJE-13-0651)
Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14(1), article number: 95. (10.1186/1472-6823-14-95)

2013

Draman, M. et al. 2013. Effects of Prostaglandin F2a on adipocyte biology relevant to graves' orbitopathy. Thyroid: official journal of the American Thyroid Association 23(12), pp. 1600-1608. (10.1089/thy.2013.0194)
Taylor, P., Razvi, S., Pearce, S. H. and Dayan, C. 2013. A review of the clinical consequences of variation in thyroid function within the reference range. Journal of Clinical Endocrinology & Metabolism 98(9), pp. 3562-3571. (10.1210/jc.2013-1315)

I am a Clinical Senior Lecturer and Consultant Physician specialising in epidemiology and diabetes and endocrinology at Cardiff University and the University Hospital of Wales. I received my undergraduate medical degrees from St. Andrews University and the University of Manchester and undertook my core medical training in South Manchester and then at the two teaching hospitals in Edinburgh (Western General Hospital and Edinburgh Royal Infirmary).I commenced specialist training in diabetes and endocrinology in Bristol and Bath before receiving a prestigious MRC scholarship to undertake a masters in epidemiology at the London School of Hygiene and Tropical Medicine.

I then joined the Welsh Clinical Academic Training (WCAT) scheme. Here I completed my PhD in thyroid epidemiology under Professor Colin Dayan (Cardiff) and Professor Nicholas Timpson (Bristol). My PhD focused on the effects of common variation in thyroid status as well as thyroid hormone prescribing and thyroid screening in pregnancy. In my PhD I also undertook the first whole genome sequence based analysis of thyroid function in cohorts and the first Mendelian Randomization study in thyroidology. Following on from my PhD I have been heavily involved in the CATS (thyroid screening in pregnancy) and CIRTED (thyroid eye disease) trials. As well as continuing my research in thyroid disease I have extended my work into the immunology of type-1 diabetes and continuous glucose monitoring. I hope to utilise my research skills and expertise in clinical trials to develop platform trials to identify treatment regimes which preserve beta-cell function in individuals with and at risk of type-1 diabetes. I am also utilising continuous glucose monitoring to identify novel markers of beta cell function.

I have received awards at both national and international conferences for my work and have over 65 publications related to thyroid and diabetes including publications in JAMA, Lancet Diabetes and Endocrinology, JAMA Internal Medicine, Nature Reviews Endocrinology and Nature Communications.

Honours and awards

2022 Clinical Endocrinology Trust winner best clinical abstract Society for Endocrinology conference

2020 Rising star in Endocrinology, Society for Endocrinology

2018 Association of Physicians of Great Britain and Ireland - best oral abstract

2016 British Thyroid Association - best abstract

2014 Clinical Endocrinology Trust winner best clinical abstract Society for Endocrinology conference

2014 British Thyroid Association - best oral presentation

2010 British Thyroid Association - best oral presentation

2010 ECTS new investigator award

2009 IPSEN extraordinary award

Research themes

Specialisms

Diabetes
Thyroid
Epidemiology

Dr Peter Taylor
(he/him)

PhD, FRCP

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

Articles

Conferences

Other

Thesis

Honours and awards

Research themes

Specialisms

External profiles

Dr Peter Taylor (he/him) PhD, FRCP

Overview

Publication

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

Articles

Conferences

Other

Thesis

Biography

Honours and awards

Research themes

Specialisms

External profiles

Dr Peter Taylor
(he/him)

PhD, FRCP