My PhD studies will investigate the importance of innate immune mechanisms of neurodegeneration in models of Alzheimer’s disease to determine the extent to which activation of the innate immune system exacerbates neuronal damage. The neuronal connectome has been a topic of intense interest with regard to Alzheimer’s since the loss of neuronal interconnectioins (dendrites in particular) is a key pathophysiological event in the early stage of the disease. We will use a range of techniques to label and analysis dendritic and synaptic structure in the retina and will correlate these measurements with those from the hippocampus. Using these techniques we hope to understand in greater depth the extent to which innate immune activation, as triggered by chronic(systemic) inflammation is a trigger for early Alzheimer’s degeneration.
Honours and Awards
2017: Swansea University Medical School: Postgraduate Conference Poster Presentation Winner
2016: Swansea University Medical School: Graduates Prize in Biochemistry
2017: Swansea University Medical School Postgraduate Conference
Educational and Professional Qualifications
2017 – Present: PhD, Innate immune mechanisms of neurodegeneration in Alzheimer’s disease, Cardiff University.
2016 – 2017: MSc By Research, Cortical demyelination and meningeal inflammation in multiple sclerosis, Swansea University.
2013 – 2016: First Class Honours in Medical Biochemistry, Swansea University.
2016 – 2017: Student Demonstrator, Medical School, Swansea University
2015 – 2016: Research Internships, Medical School, Swansea University
2016: British Neuropathological Society- small grant application valued £3,400
2016: Swansea University Postgraduate MSc By Research Scholarship valued £3,000
2015 - 2016: Swansea University Internships Funding valued £2,000
Dr O. W. Howell, Medical School, Swansea University, Cortical demyelination and meningeal inflammation in multiple sclerosis.