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Miss Elena Meuser

Research student, Cancer & Genetics, School of Medicine

I am an affiliated member of the Inherited Tumour Syndromes Research Group (ITSRG).

The aim of my research is to facilitate better or novel approaches to diagnosis, treatment and prevention of inherited tumours.

Research interests

During my PhD, I have worked on a project dealing with the mechanisms underlying duodenal tumourigenesis in the two inherited polyposis syndromes familial adenomatous polypsis (FAP) and MUTYH-associated polyposis (MAP). To find driver genes and pathways that might lead to intestinal cancers as well as characterise molecular adenoma evolution in different gastrointestinal regions, I have made use of high throughput omics technology and bioinformatics. In a side project, I have also established 3D in vitro models from patient tissue samples.

My work has addressed gaps in the current knowledge about the molecular mechanisms underlying duodenal tumourigenesis in both disorders hoping to find opportunities for targeted prevention and treatment interventions in FAP and MAP duodenal disease.

Thesis

Molecular mechanisms of duodenal tumourigenesis in familial adenomatous polyposis and MUTYH-associated polyposis

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