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 Eva Periche Tomas

Eva Periche Tomas

Research student, School of Psychology

Email
perichetomase@cardiff.ac.uk
Campuses
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ

Why older individuals seem to be more susceptible to the cognitive and motivationally impairing effects of inflammation?

We know that in older adults, infection can lead to coginitive disturbance and when severe or chronic it can cause irreversible cognitive impairment and accelerate the progression of neurodegenerative diseases such Alzheimer's. However, little is understood about the mechanisms driving this susceptibility.

I aim to identify these mechanisms by using a combination of an experimental model of inflammation (Interferon-alfa) with a range of neuroimaging techniques (DCE, MR spectroscopy, rsfMRI and PET) to quantify how inflammation affects human brain function at the level of: BBB function, microglia morphometry, neuronal function (dopamine turnover) and functional connectivity.

Thesis

Towards a mechanistic understanding of how age increases susceptibility to inflammation-induced cognitive disturbance

Funding source

School of Psychology and Hodge Centre for Neuropsychiatric Immunology (School of Medicine)

Professor Neil Harrison

Professor Neil Harrison

Clinical Professor in Neuroimaging

Chris Marshall Headshot

Professor Christopher Marshall

Director of Wales Research and Diagnostic PET Imaging Centre

Simon Jones

Professor Simon Jones

Dean of Research; Research Theme Lead - Infection, Inflammation & Immunity