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 Natalie Meeson

Natalie Meeson

Research student, School of Medicine

Thesis

Exploring the relationship between schizophrenia risk genes and adult hippocampal plasticity

Schizophrenia is a debilitating psychiatric condition which affects around 1% of the general population. It is a highly heritable condition, and several genetic changes have been linked to the development of the disorder. Copy Number Variants (CNVs), are one such group of genetic changes in which microscopic pieces of DNA are deleted or duplicated, leading to altered gene dosage. Previously, large-scale analyses have linked CNVs with an increased risk of developing schizophrenia. Similarly, work from our lab has found that schizophrenia associated CNVs have a particular effect on pathways activated during extinction learning in the CA1 region of the hippocampus. The aim of this project is to further investigate the association between genetic risk for schizophrenia and associative learning, using large-scale analyses and behavioural learning in rats.

Funding source

Wellcome Trust PhD Studentship

Professor Jeremy Hall

Professor Jeremy Hall

Director, Division of Psychological Medicine and Clinical Neurosciences; Director/Clinical Professor, Neuroscience & Mental Health Research Institute

Dr Kerrie Thomas

Dr Kerrie Thomas

Reader, Operations Director Neuroscience and Mental Health Research Institute (NMHRI), Co-Director of the Hodge Centre for Neuropsychiatric Immunology in Cardiff

Clifton, Nick

Dr Nicholas Clifton

Research Fellow, NMHRI