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 Rebecca Gwyther

Rebecca Gwyther

Research student, School of Biosciences

Overview

Bacterial resistance to antibiotics is one of the most significant crises in modern healthcare. By far the main mechanism bacteria use to confer beta-lactam resistance is the production of beta-lactamases (BLs) that inactivate the antibiotic and thus removing its therapeutic value. A gap in modern antimicrobial treatment is a companion diagnostic for improving antibiotic use based on detecting the presence of key AMR markers. 


My project takes a vital step towards filling this gap by combining synthetic biology with nanotechnology to generate a new detection system. I hope to link highly sensitive carbon nanotubes (CNTs) to the unique molecular signatures of BL proteins. To achieve this I will be engineering a protein called BLIP-II, that binds to a wide variety of BLs, to precisely interface with CNTs. By monitoring the conductance of CNTs, we hope to sense the BLIP-II--BL interactions.

Research

Thesis

TACKLING ANTIBIOTIC RESISTANCE BY COMBINING SYNTHETIC BIOLOGY AND NANOTECHNOLOGY: DEVELOPMENT OF NEW BIOSENSING SYSTEMS

Funding source

BBSRC

Supervisors

Image of Prof Emyr Macdonald

Professor J Emyr Macdonald

Condensed Matter and Photonics Group