Adam Brelsford

Research student, School of Psychology

Email:
brelsfordar1@cardiff.ac.uk
Location:
Tower Building, 70 Park Place, Cardiff, CF10 3AT

Research summary

Alzheimer’s disease (AD) is a progressive  neurodegenerative condition, featuring symptoms of dementia such as memory  loss, impaired communication and diminished visuospatial skills, and is  pathologically characterised by toxic amyloid-β (Aβ) plaques and  hyperphosphorylated tau 'tangles’ in the brain. Depression too can arise in AD,  and the two conditions appear to inter-relate in a manner which is poorly  understood.
My  research will probe the link between amyloid processing and depression in two  murine models of AD. As well as establishing whether disrupting amyloid  processing has an impact on cognitive and hedonic state in these models, the  work may also encompass using antidepressants or other pharmacological agents to  gauge their utility in addressing both depressive- and dementia-like phenomena.

Teaching summary

Laboratory demonstrating in Pharmacy.

Research interests

Research topics and related papers

Alzheimer’s disease (AD) is a progressive  neurodegenerative condition, featuring symptoms of dementia such as memory  loss, impaired communication and diminished visuospatial skills, and is  pathologically characterised by toxic amyloid-β (Aβ) plaques and  hyperphosphorylated tau 'tangles’ in the brain. Depression too can arise in AD,  and the two conditions appear to inter-relate in a manner which is poorly  understood.
My  research will probe the link between amyloid processing and depression in two  murine models of AD. As well as establishing whether disrupting amyloid  processing has an impact on cognitive and hedonic state in these models, the  work may also encompass using antidepressants or other pharmacological agents to  gauge their utility in addressing both depressive- and dementia-like phenomena.

Funding

School of Psychology

School of Pharmacy

Research group

Neuroscience, Behavioural Neuroscience

Research collaborators

Professor Mark Good
Dr Dominic Dwyer
Dr Emma Kidd
Dr Rhian Thomas