Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
Development of a multiplex sensing platform for the accurate and rapid diagnosis of sepsis
Sepsis is a complex, rapidly evolving condition resulting from uncontrolled and prolonged activation of host immune system as a result of pathogenic insult. Pathogen and host immune mediators act concertedly to induce an exaggerated and catastrophic systemic immune response completely disproportionate to the initial infection. Fatalities result either from systemic hyper-inflammation leading to multi-organ failure or from secondary complications and infection arising as a result of a subsequent period of profound immune suppression. It is a highly complicated condition involving activation and suppression of numerous signalling pathways temporally related in what is now known to be a highly variable, patient dependent manner. Unfortunately, clinical symptoms, such as raised temperature, increased pulse or breathing rate, and current laboratory diagnostics, such as white blood cell count or bacterial culture are relatively non-specific and lack the sensitivity necessary for a definitive early diagnosis. Delay in diagnosis impacts hugely on clinical outcome with mortality increasing by 6-10 % for every hour delay in delivering appropriate therapy. Despite these startling figures, there exists neither a disease-specific therapy nor clinically useful diagnostic tool. There is a critical and unmet clinical need to develop diagnostic technologies capable of rapidly and accurately diagnosing sepsis. This project focuses on the development of a multiplex electrochemical sensing platform, capable of detecting both pathogen associated and host immune markers, using Molecularly Imprinted Polymers.
Publications: 1. Demertzis N, Fotopoulou-Stamatelou A, Gkinis S, Kyriazi M, Karalis E, Papaiwannou G Th, Melliou E, Kourounakis A, Magiatis P, Black S H, Rallis M. (2018) Effect of Olive Oil Phenolics on Lipidemic Profile and Oxidative Stress in Mice. J Food Nutri Diete 2(1): 114. 2. Martha-Spyridoula Katsarou, Maria Giakoumaki, Andriana Papadimitriou, Nikolaos Demertzis, Vasileios Androutsopoulos, Nikolaos Drakoulis: Genetically driven antioxidant capacity in a Caucasian Southeastern European population. Mechanisms of Ageing and Development 08/2017;, DOI:10.1016/j.mad.2017.08.010
3. Martha-Spyridoula Katsarou, Konstantinos Karakonstantis, Nikolaos Demertzis, Emmanouil Vourakis, Aspasia Skarpathioti, Aleksandr E. Nosyrev, Aristidis Tsatsakis, Theodoris Kalogridis, Nikolaos Drakoulis: Effect of single-nucleotide polymorphisms in ADH1B , ADH4 , ADH1C , OPRM1 , DRD2 , BDNF , and ALDH2 genes on alcohol dependence in a Caucasian population. 08/2017; 5(4):e00326., DOI:10.1002/prp2.326
4. A Lymberopoulos, C Demopoulou, M Kyriazi, MS Katsarou, N Demertzis, S Hatziandoniou, H Maswadeh, G Papaioanou, C Demetzos, H Maibach, M Rallis: Liposome percutaneous penetration in vivo. 01/2017; 1:239784731772319., DOI:10.1177/2397847317723196
5. Martha‑Spyridoula Katsarou, Rosana Latsi, Maria Papasavva, Nikolaos Demertzis, Thodoris Kalogridis, Aristides M Tsatsakis, Demetrios A Spandidos, Nikolaos Drakoulis: Population-based analysis of the frequency of HFE gene polymorphisms: Correlation with the susceptibility to develop hereditary hemochromatosis. Molecular Medicine Reports 05/2016; 14(1)., DOI:10.3892/mmr.2016.5317
6. N Goutzourelas, D Stagos, N Demertzis, P Mavridou, H Karterolioti, S Georgadakis, E Kerasioti, N Aligiannis, L Skaltsounis, A Statiri, A Tsioutsiouliti, Am Tsatsakis, Aw Hayes, D Kouretas: Effects of polyphenolic grape extract on the oxidative status of muscle and endothelial cells. Human & Experimental Toxicology 09/2014; 33(11)., DOI:10.1177/0960327114533575
Member of various Scientific Societies. Currently elected as Secretary of the Board of the Hellenic Society of Pharmacogenomics and Personalised Diagnosis and Therapy (EEPHARM) (http://esptnet-eu.gr/en/).