3d printing a skin model to investigate immunological control of skin cancer development
Unravelling the pathophysiological mechanisms of skin cancer development relies on representative skin models. However current laboratory models, either animal or cultured human skin, have acknowledged flaws that impede translation to the clinic. This is due, in part, to the highly heterogeneous and complex nature of skin cancer pathogenesis, which challenges the development of representative models. Research groups have previously developed 3D skin models using culture techniques (Schoop et al. 1999; Berning et al. 2015) or 3D printing (Lee et al. 2014; Kang et al. 2016) to provide more physiologically representative models of both healthy and diseased skin. We will build on the established ability to print droplets containing viable stem cell populations (Morgan et al. 2016), by developing and validating a 3D bioprinted human skin model including different types of skin cancer cells. Subsequent experiments will culture these skin cancer cells alongside artificial signalling cells (ASCs) (Baxani et al. 2016) , which are biocompatible synthetic cell mimics designed to be loaded with specific signalling molecules that can be released into the 3D cultured skin model in situ. This will allow us to dissect the role of individual signalling molecules associated with cancer pathophysiology, and thus allow the development of therapeutic strategies and novel treatments.
I obtained my Masters degree in the field of Integrative Biology, Physiology and Pathophysiology with honors at the University of Pierre et Marie Curie in France, Paris VI. I focused mostly on animal modern physiology during my undergraduate studies at the Université de Versailles Saint-Quentin, which I completed with the final semester at Seoul, South Korea, studying mostly fundamental Biology. During my masters, I chose to specialize in the understanding of different Pathophysiological mechanisms leading to various diseases.
I started my PhD at the School of Pharmacy in Cardiff University in April 2017 and am currently trying to develop a 3D bioprinted skin to elucidate skin cancer development.