Pharmacology of vascular responses to dietary amines (see Research - Thesis)
I gained by bachelor’s degree in anatomical sciences at the University of Manchester in 2014. My final year project investigated defects in heart development due to a mutation of a spliceosome component PRPF8. Following this I undertook a Master of Research in Biomedical research at Cardiff University within the School of Medicine. I undertook three research projects:
- Developing an assay to assess the ability of anti-cancer agents to target breast cancer stem cells
- Investigating the role of Hepatocyte growth factor in mediating oral mucosal fibroblast wound healing responses
- Assessing the roles of epidermal growth factor and transferrin on the pro-wound healing effects of EBC-46 in epidermal keratinocytes
I then undertook work as a research technician in the laboratory of Professor Bernhard Moser in the School of Medicine, working on tissue-resident immune cells during homeostasis. I am currently in the 3rd year of my PhD Studies in the Cardiff University School of Pharmacy working on the pharmacology of vascular responses to trace amines.
December 2019: British Pharmacological Society annual meeting (Oral and Poster)
September 2019: 6th BHF Fellows meeting (Poster)
May 2019: School of Pharmacy PGR research day (Poster)
March 2019: Speaking of Science Interdisciplinary Conference (Oral)
December 2018: British Pharmacological Society annual meeting (Poster)
Education and Professional Qualifications:
2017-Present: PhD, Pharmacology of vascular responses to dietary amines, Cardiff University, School of Pharmacy
2014-2015: MRes Biomedical Research, Cardiff University, School of Medicine
2011-2014: BSc. (2:1 Honours) Anatomical Sciences, University of Manchester
2015-2017: Research Technician, Cardiff University, School of Medicine, Institute of Infection and Immunity
Cardiovascular Pharmacology/Physiology: trace amine associated receptors, research techniques, cannabinoids, hypertension.
Isolated blood vessels, wire myography, organ perfusion, pharmacology, cell culture, molecular biology, flow cytometry
Pint of Science City Coordinator 2020, Event Manager 2019
Brain Games 2018
Pharmacology of vascular responses to dietary amines
Trace amines are biologically active amines that occur naturally in the body but are also commonly ingested in the diet from foods such as cheeses, wine and chocolate. They are related to classical neurotransmitters such as adrenaline, noradrenaline, dopamine and serotonin. Elevated levels of trace amines in the circulation are associated with negative cardiovascular events including hypertension. The pressor response to trace amines is recognised as trace amines acting indirectly as sympathomimetic amines. This is achieved by promoting efflux of noradrenaline from sympathetic neurones causing activation of adrenoreceptors resulting in a sympathetic effect such as vasoconstriction. This may be an oversimplification as evidence has implicated that noradrenaline independent mechanisms play an important role. The trace amine-associated receptors (TAARs) are a likely candidate for this. However; it is unknown whether TAARs mediate the vascular response to trace amines. My project aims to identify a role for TAARs in mediating vasoconstriction and to characterise trace amine vascular responses in both conductance (aorta) and resistance (mesentery) vessels. This project is funded by the British Heart Foundation under the supervision of Dr William Ford.
British Heart Foundation