4th generation aromatase inhibitors for the treatment of breast cancer: design, synthesis, biochemical and molecular biology studies
The project will focus initially on drug design through computational studies and subsequent drug synthesis with optimisation of both docking and design and synthesis of the aromatase inhibitors directed by the CYP19 enzyme assay i.e. this is an iterative optimisation process with feedback through the design/synthesis/enzyme inhibition cycle. Lead aromatase inhibitors for further evaluation will be identified and processed for toxicity (MTT assays) and selectivity (CYP panel). Aromatase inhibitors that ‘pass’ these assays will be subject to more detailed molecular biology investigations to investigate the antiproliferative activity and effect on the steroidogenic pathway.
Currently PhD student at Cardiff University School of Pharmacy & Pharmaceutical Sciences. Graduated in 2011 from Zagazig University (Egypt). Had my masters degree from Zagazig University in 2016 after completing the one year research project in Dr. Claire Simons lab at Cardiff University.