Cancer Immunology Group
To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity.
Whilst seminal observations using immunocompromised mice have provided compelling evidence for tumour immunosurveillance, many fundamental questions remain unanswered in the field of tumour immunology.
The types of immune effector cells/molecules capable of controlling tumour growth in vivo have not yet been definitively identified. Furthermore, although many pathways of tumour-induced immunosuppression are thought to contribute to the overall paucity of anti-tumour immunity, these pathways remain poorly characterised.
- To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity. This information is essential to inform the design of successful cancer therapy.
Central to this aim, our grouping in Cardiff, through studies of prostate cancer, breast cancer, cervical cancer, colorectal cancer, mesothelioma, and leukaemia, focuses on:
- Engineering T cell receptors to enhance tumour recognition.
- Evaluating the impact of regulatory T cells on tumour progression.
- Exosomes in cancer immunology.
- Gamma/delta T cells for cellular immunotherapy.
- Therapies for chronic lymphocytic leukaemia.
- Immune recognition and evasion in cancer.
We use in vivo and in vitro models, including direct analyses of samples from cancer patients and clinical trials to test novel approaches for therapeutic intervention.
Yr Athro Paul Brennan
- +44 29 2068 7087
Yr Athro Aled Clayton
- Siarad Cymraeg
- +44 (0)29 2251 0589
Yr Athro Matthias Eberl
Reader, Division of Infection and Immunity. Engagement Lead, Systems Immunity Research Institute.
- +44 (0)29 2068 7011
Yr Athro Awen Gallimore
- Siarad Cymraeg
- +44 (0)29 2068 7012
Yr Athro Andrew Godkin
- +44 (0)29 2068 7003
Dr Stephen Man
- +44 29206 87056
Yr Athro Bernhard Moser
- +44 (0)29 2068 7058
Yr Athro Ann Ager
- +44 (0)29 2068 8872
Yr Athro Andrew Sewell
Dr Zsuzsanna Tabi
- +44 (0)29 2251 0550
A large amount of our research has been generously funded by grants provided by: