Ewch i’r prif gynnwys

Cancer Immunology Group

To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity.

Whilst seminal observations using immunocompromised mice have provided compelling evidence for tumour immunosurveillance, many fundamental questions remain unanswered in the field of tumour immunology.

The types of immune effector cells/molecules capable of controlling tumour growth in vivo have not yet been definitively identified. Furthermore, although many pathways of tumour-induced immunosuppression are thought to contribute to the overall paucity of anti-tumour immunity, these pathways remain poorly characterised.

Amcanion

  • To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity. This information is essential to inform the design of successful cancer therapy.

Central to this aim, our grouping in Cardiff, through studies of prostate cancer, breast cancer, cervical cancer, colorectal cancer, mesothelioma, and leukaemia, focuses on:

  • Engineering T cell receptors to enhance tumour recognition.
  • Evaluating the impact of regulatory T cells on tumour progression.
  • Exosomes in cancer immunology.
  • Gamma/delta T cells for cellular immunotherapy.
  • Therapies for chronic lymphocytic leukaemia.
  • Immune recognition and evasion in cancer.

We use in vivo and in vitro models, including direct analyses of samples from cancer patients and clinical trials to test novel approaches for therapeutic intervention.

Staff academaidd

Dr Paul Brennan

Dr Paul Brennan

Reader

Email
brennanp@caerdydd.ac.uk
Telephone
+44 29 2068 7087
Yr Athro Aled Clayton

Yr Athro Aled Clayton

Senior Lecturer

Email
claytona@caerdydd.ac.uk
Telephone
+44 (0)29 2251 0589
Yr Athro Matthias Eberl

Yr Athro Matthias Eberl

Reader, Division of Infection and Immunity. Engagement Lead, Systems Immunity Research Institute.

Email
eberlm@caerdydd.ac.uk
Telephone
+44 (0)29 2068 7011
Yr Athro Awen Gallimore

Yr Athro Awen Gallimore

Professor

Email
gallimoream@caerdydd.ac.uk
Telephone
+44 (0)29 2068 7018
Yr Athro Andrew Godkin

Yr Athro Andrew Godkin

Clinical Professor

Email
godkinaj@caerdydd.ac.uk
Telephone
+44 (0)29 2068 7003
Dr Stephen Man

Dr Stephen Man

Reader

Email
mans@caerdydd.ac.uk
Telephone
+44 29206 87056
Yr Athro Bernhard Moser

Yr Athro Bernhard Moser

Professor

Email
moserb@caerdydd.ac.uk
Telephone
+44 (0)29 2068 7058
Yr Athro Ann Ager

Yr Athro Ann Ager

Reader

Email
agera@caerdydd.ac.uk
Telephone
+44 (0)29 2068 8872
Dr Zsuzsanna Tabi

Dr Zsuzsanna Tabi

Senior Lecturer

Email
tabiz@caerdydd.ac.uk
Telephone
+44 (0)29 2251 0550