
Dr Polina Prokopovich
Lecturer
Trosolwg
Qualifications
- PhD in Chemical Engineering from Loughborough University (2006)
- MSc (1st Class Honours) in Physical, Colloid and Surface Science from St Petersburg State University, Russia (2002)
- BSc (1st Class Honours) in Chemistry from St Petersburg State University, Russia (2000)
Related websites
Positions available
A number of Projects (both experimental and computational modelling) are available for Erasmus and self-funded PhD students.
Bywgraffiad
- 2011 - present: Cardiff Academic Fellow with subsequent appointment to Lecturer, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK.
- 2010 - 2011: Research Fellow, Institute of Medical and Biological Engineering, Leeds University, UK.
- 2008 – 2010: Research Associate sponsored by Astra Zeneca, Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, UK
- 2007: Scientist, 3M Health Care Ltd, UK.
- 2003 - 2006 PhD, Chemical Engineering Department, Loughborough University, UK.
- 2000 - 2002 MSc, Physical, Colloid and Surface Science, St Petersburg State University, Russia.
- 1997 - 2000 BSc, Chemistry Department, St Petersburg State University, Russia.
Cyhoeddiadau
2023
- Perni, S., Bojan, B. and Prokopovich, P. 2023. A retrospective study of risk factors, causative micro-organisms and healthcare resources consumption associated with prosthetic joint infections (PJI) using the Clinical Practice Research Datalink (CPRD) Aurum database. PLoS ONE 18(3), article number: e0282709. (10.1371/journal.pone.0282709)
- Larissa, P. et al. 2023. Development, characterization and antimicrobial activity of multilayer silica nanoparticles with chlorhexidine incorporated into dental composites. Dental Materials (10.1016/j.dental.2023.03.005)
2022
- Assylbekova, G. et al. 2022. Sunlight induced synthesis of silver nanoparticles on cellulose for the preparation of antimicrobial textiles. Journal of Photochemistry and Photobiology 11, article number: 100134. (10.1016/j.jpap.2022.100134)
- Perni, S. and Prokopovich, P. 2022. Feasibility and application of machine learning enabled fast screening of poly-beta-amino-esters for cartilage therapies. Scientific Reports 12(1), article number: 14215. (10.1038/s41598-022-18332-3)
2021
- Al Thaher, Y., Alotaibi, H. F., Yang, L. and Prokopovich, P. 2021. PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers. PLoS ONE 16(9), article number: e0257947. (10.1371/journal.pone.0257947)
- Saeedi, T. and Prokopovich, P. 2021. Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment. Journal of Materials Chemistry B: Materials for biology and medicine 9(29), pp. 5837-5847. (10.1039/D1TB01024G)
- Perni, S., Preedy, E. C. and Prokopovich, P. 2021. Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs). Scientific Reports 11(1), article number: 7275. (10.1038/s41598-021-86773-3)
2020
- Bojan, B., Perni, S. and Prokopovich, P. 2020. Systematic review and meta-analysis of tobacco use as a risk factor for prosthetic joint infection after total hip replacement. Arthroplasty Today 6(4), pp. 959-971. (10.1016/j.artd.2020.07.011)
- Saeedi, T., Alotaibi, H. F. and Prokopovich, P. 2020. Polymer colloids as drug delivery systems for the treatment of arthritis. Advances in Colloid and Interface Science 285, article number: 102273. (10.1016/j.cis.2020.102273)
- Perni, S. and Prokopovich, P. 2020. Rheometer enabled study of cartilage frequency-dependent properties. Scientific Reports 10(1), article number: 20696. (10.1038/s41598-020-77758-9)
- Perni, S., Alotaibi, H. F., Yergeshov, A. A., Dang, T., Abdullin, T. I. and Prokopovich, P. 2020. Long acting anti-infection constructs on titanium. Journal of Controlled Release 326, pp. 91-105. (10.1016/j.jconrel.2020.06.013)
- Perni, S. and Prokopovich, P. 2020. Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage. Journal of Materials Chemistry. B 8(23), pp. 5096-5108. (10.1039/C9TB02778E)
2019
- Alotaibi, H. F., Perni, S. and Prokopovich, P. 2019. Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention. International Journal of Nanomedicine 2019(14), pp. 7309. (10.2147/IJN.S217112)
- Perni, S., Caserta, S., Pasquino, R., Jones, S. A. and Prokopovich, P. 2019. Prolonged antimicrobial activity of PMMA bone cement with embedded gentamicin-releasing silica nanocarriers. ACS Applied Bio Materials 2(5), pp. 1850-1861. (10.1021/acsabm.8b00752)
- Rivera, M., Perni, S., Sloan, A. and Prokopovich, P. 2019. Anti-inflammatory drug-eluting implant model system to prevent wear particles induced periprosthetic osteolysis. International Journal of Nanomedicine 14, pp. 1069-1084. (10.2147/IJN.S188193)
2018
- Al Thaher, Y., Yang, L., Jones, S. A., Perni, S. and Prokopovich, P. 2018. LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity. PLoS ONE 13(12), article number: e0207753. (10.1371/journal.pone.0207753)
- Perni, S., Yang, L., Preedy, E. C. and Prokopovich, P. 2018. Cobalt and Titanium nanoparticles influence on human osteoblast mitochondrial activity and biophysical properties of their cytoskeleton. Journal of Colloid and Interface Science 531, pp. 410-420. (10.1016/j.jcis.2018.07.028)
- Al Thaher, Y., Latanza, S., Perni, S. and Prokopovich, P. 2018. Role of poly-beta-amino-esters hydrolysis and electrostatic attraction in Gentamicin release from Layer-by-Layer coatings. Journal of Colloid and Interface Science 526, pp. 35-42. (10.1016/j.jcis.2018.04.042)
- Alotaibi, H. F., Al Thaher, Y., Perni, S. and Prokopovich, P. 2018. Role of processing parameters on surface and wetting properties controlling the behaviour of layer-by-layer coated nanoparticles. Current Opinion in Colloid and Interface Science 36, pp. 130-142. (10.1016/j.cocis.2018.02.008)
- Perni, S., Martini-Gilching, K. and Prokopovich, P. 2018. Controlling release kinetics of gentamicin from silica nano-carriers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 541, pp. 212-221. (10.1016/j.colsurfa.2017.04.063)
2017
- Abdurazova, P. et al. 2017. Preparation of photochemical coatings of metal films (copper, silver and gold) on dielectric surfaces and studying their antimicrobial properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects 532, pp. 63-69. (10.1016/j.colsurfa.2017.06.070)
- Al Thaher, Y., Perni, S. and Prokopovich, P. 2017. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material. Advances in Colloid and Interface Science 249, pp. 234-247. (10.1016/j.cis.2017.04.017)
- Preedy, E. C., Perni, S. and Prokopovich, P. 2017. Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity. Colloids and Surfaces B: Biointerfaces 157, pp. 146-156. (10.1016/j.colsurfb.2017.05.019)
- Sataev, M. S. et al. 2017. A low-temperature gold coating of the dielectric surfaces employing phosphine gas as a reducing agent. Colloids and Surfaces A: Physicochemical and Engineering Aspects 521, pp. 86-91. (10.1016/j.colsurfa.2016.11.029)
- Perni, S. and Prokopovich, P. 2017. Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage. Nanomedicine: Nanotechnology, Biology and Medicine 13(2), pp. 539-548. (10.1016/j.nano.2016.10.001)
2016
- Perni, S., Drexler, S., Ruppel, S. and Prokopovich, P. 2016. Lethal photosensitisation of bacteria using Silica-TBO nanoconjugates. Colloids and Surfaces A: Physicochemical and Engineering Aspects 510, pp. 293-299. (10.1016/j.colsurfa.2016.06.022)
- Giacomo, T., Perni, S. and Prokopovich, P. 2016. An injectable hydrogel as bone graft material with added antimicrobial properties. Tissue Engineering: Parts A, B, and C 22(11-12), pp. 862-872. (10.1089/ten.tea.2016.0014)
- Preedy, E. C., Perni, S. and Prokopovich, P. 2016. Nanomechanical and surface properties of rMSCs post exposure to CAP treated UHMWPE wear particles. Nanomedicine: Nanotechnology, Biology and Medicine 12(3), pp. 723-734. (10.1016/j.nano.2015.10.006)
- Perni, S., Preedy, E. C., Landini, P. and Prokopovich, P. 2016. Influence of csgD and ompR on nanomechanics, adhesion forces and curli properties of E. coli. Langmuir 32(31), pp. 7965-7974. (10.1021/acs.langmuir.6b02342)
2015
- Perni, S., Thenault, V., Abdo, P., Margulis, K., Magdassi, S. and Prokopovich, P. 2015. Antimicrobial activity of bone cements embedded with organic nanoparticles. International Journal of Nanomedicine 10, pp. 6317-6329. (10.2147/IJN.S86440)
- Preedy, E. C., Perni, S. and Prokopovich, P. 2015. Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity. RSC Advances 5, pp. 83885-83898. (10.1039/C5RA15390E)
- Sataev, M. S., Koshkarbaeva, S. T., Perni, S., Nauryzova, S. Z. and Prokopovich, P. 2015. A galvanic-chemical method for preparing diamond containing coatings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480, pp. 384-389. (10.1016/j.colsurfa.2014.09.014)
- Gustaite, S., Kazlauske, J., Bobokalonov, J., Perni, S., Dutschk, V., Liesiene, J. and Prokopovich, P. 2015. Characterization of cellulose based sponges for wound dressings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480, pp. 336-342. (10.1016/j.colsurfa.2014.08.022)
- Perni, S. and Prokopovich, P. 2015. Multi-asperity elliptical JKR model for adhesion of a surface with non-axially symmetric asperities. Tribology International 88, pp. 107-114. (10.1016/j.triboint.2015.03.001)
- González-Sánchez, M. I., Perni, S., Tommasi, G., Morris, N. G., Hawkins, K., López-Cabarcos, E. and Prokopovich, P. 2015. Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering C 50, pp. 332-340. (10.1016/j.msec.2015.02.002)
- Prokopovich, P., Kobrick, M., Brousseau, E. B. J. P. and Perni, S. 2015. Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 103(2), pp. 273-281. (10.1002/jbm.b.33196)
2014
- Prokopovich, P. 2014. Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches. Advances in Colloid and Interface Science 213, pp. 36-47. (10.1016/j.cis.2014.09.001)
- Perni, S., Hakala, V. and Prokopovich, P. 2014. Biogenic synthesis of antimicrobial silver nanoparticles capped with L-cysteine. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460, pp. 219-224. (10.1016/j.colsurfa.2013.09.034)
- Preedy, E. C., Brousseau, E. B. J. P., Evans, S. L., Perni, S. and Prokopovich, P. 2014. Adhesive forces and surface properties of cold gas plasma treated UHMWPE. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460, pp. 83-89. (10.1016/j.colsurfa.2014.03.052)
- Perni, S. and Prokopovich, P. 2014. Continuous release of gentamicin from gold nanocarrier. RSC Advances 4(94), pp. 51904-51910. (10.1039/C4RA10023A)
- Ramadan, Y. et al. 2014. Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction-diffusion method. Materials Science and Engineering C 42, pp. 696-704. (10.1016/j.msec.2014.06.017)
- Preedy, E. C., Perni, S., Nipic, D., Bohinc, K. and Prokopovich, P. 2014. Surface roughness mediated adhesion forces between borosilicate glass and gram-positive bacteria. Langmuir 30(31), pp. 9466-9476. (10.1021/la501711t)
- Omar, F., Brousseau, E., Elkaseer, A., Kolew, A., Prokopovich, P. and Dimov, S. 2014. Development and experimental validation of an analytical model to predict the demoulding force in hot embossing. Journal of Micromechanics and Microengineering 24(5), pp. -., article number: 55007. (10.1088/0960-1317/24/5/055007)
- Perni, S., Preedy, E. C. and Prokopovich, P. 2014. Success and failure of colloidal approaches in adhesion of microorganisms to surfaces. Advances in Colloid and Interface Science 206, pp. 265-274. (10.1016/j.cis.2013.11.008)
- Pandiyaraj, K. N. et al. 2014. Influence of operating parameters on surface properties of RF glow discharge oxygen plasma treated TiO2/PET film for biomedical application. Materials Science and Engineering C 36, pp. 309-319. (10.1016/j.msec.2013.12.018)
- Sataev, M. S., Koshkarbaeva, S. T., Tleuova, A. B., Perni, S., Aidarova, S. B. and Prokopovich, P. 2014. Novel process for coating textile materials with silver to prepare antimicrobial fabrics. Colloids and Surfaces A: Physicochemical and Engineering Aspects 442, pp. 146-151. (10.1016/j.colsurfa.2013.02.018)
2013
- Khan, I. M. et al. 2013. In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials 34(5), pp. 1478-1487. (10.1016/j.biomaterials.2012.09.076)
- Omar, F., Elkaseer, A., Brousseau, E., Kolew, A. and Prokopovich, P. 2013. Demoulding forces in hot embossing: Model development and validation. Presented at: 8th International Conference on MicroManufacturing (ICOMM2013), Victoria, Canada, 25-28 March 2013Proceedings of the 8th International Conference on MicroManufacturing (ICOMM2013). pp. 642-649.
- Prokopovich, P., Leech, R., Carmalt, C. J., Parkin, I. P. and Perni, S. 2013. A novel bone cement impregnated with silver-tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties. International Journal of Nanomedicine 8(1), pp. 2227-2237. (10.2147/IJN.S42822)
- Prokopovich, P. and Perni, S. 2013. Contact interactions of aorta against PVC catheters. Tribology International 66, pp. 157-164. (10.1016/j.triboint.2013.03.009)
- Perni, S. and Prokopovich, P. 2013. Micropatterning with conical features can control bacterial adhesion on silicone. Soft Matter 9(6), pp. 1844-1851. (10.1039/c2sm26828k)
2012
- Vicars, R., Prokopovich, P., Brown, T. D., Tipper, J. L., Ingham, E., Fisher, J. and Hall, R. M. 2012. The Effect of Anterior-Posterior Shear on the Wear of Charité TDR. Spine 37(9), pp. E528-E534. (10.1097/BRS.0b013e31823cbd6e)
- Perni, S., Kong, M. G. and Prokopovich, P. 2012. Cold atmospheric pressure gas plasma enhances the wear performance of ultra-high molecular weight polyethylene. Acta Biomaterialia 8(3), pp. 1357-1365. (10.1016/j.actbio.2011.12.007)
- Noimark, S. et al. 2012. Incorporation of methylene blue and nanogold into polyvinyl chloride catheters; a new approach for light-activated disinfection of surfaces. Journal of Materials Chemistry 22(30), pp. 15388-15396. (10.1039/C2JM31987J)
- Prokopovich, P. 2012. A dimensionless analysis of the effect of material and surface properties on adhesion. applications to medical device design. In: Starov, V. and Griffiths, P. eds. Progress in Colloid and Polymer Sceinve., Vol. 139. Springer Verlag, pp. 59-65., (10.1007/978-3-642-28974-3_11)
2011
- Prokopovich, P., Perni, S., Fisher, J. and Hall, R. M. 2011. Spatial variation of wear on Charité lumbar discs. Acta Biomaterialia 7(11), pp. 3914-3926. (10.1016/j.actbio.2011.06.036)
- Prokopovich, P. and Starov, V. 2011. Adhesion models: From single to multiple asperity contacts. Advances in Colloid and Interface Science 168(1-2), pp. 210-222. (10.1016/j.cis.2011.03.004)
- Prokopovich, P. and Perni, S. 2011. Comparison of JKR- and DMT-based multi-asperity adhesion model: Theory and experiment. Colloids and Surfaces A: Physicochemical and Engineering Aspects 383(1-3), pp. 95-101. (10.1016/j.colsurfa.2011.01.011)
- Perni, S., Pratten, J., Wilson, M., Piccirillo, C., Parkin, I. P. and Prokopovich, P. 2011. Antimicrobial Properties of Light-activated Polyurethane Containing Indocyanine Green. Journal of Biomaterials Applications 25(5), pp. 387-400. (10.1177/0885328209352701)
- Perni, S., Prokopovich, P., Pratten, J., Parkin, I. P. and Wilson, M. 2011. Nanoparticles: their potential use in antibacterial photodynamic therapy. Photochemical and Photobiological Sciences 10(5), pp. 712-720. (10.1039/C0PP00360C)
2010
- Prokopovich, P. and Perni, S. 2010. Multiasperity contact adhesion model for universal asperity height and radius of curvature distributions. Langmuir 26(22), pp. 17028-17036. (10.1021/la102208y)
- Perni, S., Prokopovich, P., Parkin, I. P., Wilson, M. and Pratten, J. 2010. Prevention of biofilm accumulation on a light-activated antimicrobial catheter material. Journal of Materials Chemistry 20(39), pp. 8668-8673. (10.1039/C0JM01891K)
- Prokopovich, P., Theodossiades, S., Rahnejat, H. and Hodson, D. 2010. Nano- and component level friction of rubber seals in dispensing devices. Presented at: ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, San Diego, CA, USA, 30 August-2 September 2009ASME Power Transmission and Gearing Conference; 3rd International Conference on Micro- and Nanosystems; 11th International Conference on Advanced Vehicle and Tire Technologies. ASME Conference Proceedings Vol. 6. New York: ASME pp. 339-344., (10.1115/DETC2009-86035)
- Prokopovich, P., Theodossiades, S., Rahnejat, H. and Hodson, D. 2010. Friction in ultra-thin conjunction of valve seals of pressurised metered dose inhalers. Wear 268(5-6), pp. 845-852. (10.1016/j.wear.2009.12.003)
- Prokopovich, P. and Perni, S. 2010. Prediction of the frictional behavior of mammalian tissues against biomaterials. Acta Biomaterialia 6(10), pp. 4052-4059. (10.1016/j.actbio.2010.05.007)
- Prokopovich, P., Perni, S., Piccirillo, C., Pratten, J., Parkin, I. P. and Wilson, M. 2010. Frictional Properties of Light-activated Silicone and Polyurethane against blood vessels. Journal of Materials Science: Materials in Medicine 21(2), pp. 815-821. (10.1007/s10856-009-3882-2)
2009
- Perni, S., Prokopovich, P., Piccirillo, C., Pratten, J., Parkin, I. P. and Wilson, M. 2009. Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light. Journal of Materials Chemistry 19(18), pp. 2715-2723. (10.1039/B820561B)
- Perni, S., Piccirillo, C., Pratten, J., Prokopovich, P., Chrzanowski, W., Parkin, I. P. and Wilson, M. 2009. The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30(1), pp. 89-93. (10.1016/j.biomaterials.2008.09.020)
- Prokopovich, P. and Perni, S. 2009. An investigation of microbial adhesion to natural and synthetic polysaccharide-based films and its relationship with the surface energy components. Journal of Materials Science: Materials in Medicine 20(1), pp. 195-202. (10.1007/s10856-008-3555-6)
- Piccirillo, C., Perni, S., Gil-Thomas, J., Prokopovich, P., Wilson, M., Pratten, J. and Parkin, I. P. 2009. Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface. Journal of Materials Chemistry 19(34), pp. 6167-6171. (10.1039/b905495b)
2007
- Dmitrieva, I. B., Tikhomolova, K. P., Chukhno, A. S., Prokopovich, P. and Starov, V. M. 2007. Investigation of the electrosurface properties of NiO and Fe2O3 in azole solutions. Colloids and Surfaces A: Physicochemical and Engineering Aspects 300(3), pp. 315-320. (10.1016/j.colsurfa.2007.01.046)
2006
- Holdich, R., Starov, V. M., Prokopovich, P., Njobuenwu, D. O., Rubio, R. G., Zhdanov, S. and Velarde, M. G. 2006. Spreading of liquid drops from a liquid source. Colloids and Surfaces A: Physicochemical and Engineering Aspects 282-83, pp. 247-255. (10.1016/j.colsurfa.2005.11.023)
- Prokopovich, P., Starov, V., Holdich, R. G. and Hilal, N. 2006. Concentration of potassium cations in the permeate solution in the presence of N,N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride homopolymer using dead-end nano-or ultrafiltration. Colloid Journal c/c of Kolloidnyi Zhurnal 68(2), pp. 211-216. (10.1134/S1061933X0602013X)
2005
- Churaev, N. V., Holdich, R. G., Prokopovich, P., Starov, V. M. and Vasin, S. I. 2005. Reversible adsorption inside pores of ultrafiltration membranes. Journal of Colloid and Interface Science 288(1), pp. 205-212. (10.1016/j.jcis.2005.02.072)
- Prokopovich, P., Starov, V. and Holdich, R. G. 2005. Concentration of inorganic salts in the permeate during nano- or ultrafiltration promoted by water-soluble polyelectrolytes in the feed solution. Industrial & Engineering Chemistry Research 44(5), pp. 1358-1369. (10.1021/ie049696l)
2004
- Dmitrieva, I. B., Prokopovich, P., Tikhomolova, K. P. and Starov, V. M. 2004. Specific adsorption of barbituric acid on ferric(III) and nickel(II) oxides. Colloids and Surfaces A: Physicochemical and Engineering Aspects 239(1-3), pp. 19-24. (10.1016/j.colsurfa.2003.12.033)
Addysgu
- PH1122 The role of the pharmacist in professional practice
- PH1123 Structure and function of cells and microbes
- PH1124 Human body systems
- PH3114 Design, formulation and quality assurance of medicinal products
- PH3202 Research methodology
- PH4116 Pharmacy research or scholarship project
Research interests
- Novel biomedical materials with functional properties for total joint and disc replacement.
- Surface modification techniques to improve wear performance and biocompatibility of materials for arthroplasty.
- Mechanical and surface characterisation of materials and pharmaceuticals (nano- and macro scale).
- Medical devices (inhalers, catheters and implants) and Microbial infection.
- Phenomena of adhesion and bioadhesion.
- Intermolecular and intersurface forces, friction and wear of biological systems (native tissues and cells).
- Drug delivery devices: from formulation to mechanics of the devices.
- Biocolloids.