
Dr Julia M.W. Gee
Breast Cancer Campaign Senior Research Fellow
Ysgol Fferylliaeth a Gwyddorau Fferyllol
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
Qualifications
- BSc. (Hons) Physiological Sciences, University of Newcastle, 1985
- PhD in Cancer Biology, University of Wales, 1991
Funding bodies which support our work
Bywgraffiad
I received a BSc (Hons) in 1985 in Physiological Sciences from the University of Newcastle-Upon-Tyne and was awarded the University's Physiology prize for that year. I then undertook a Medical Research Council-funded PhD studentship at the University of Wales College of Medicine in the then Tenovus Institute (breast cancer laboratory, PhD awarded 1991).
I held 3 consecutive postdoctoral positions in the Tenovus Institute between 1991-2000 (including one with Dept. Surgery, University of Wales College of Medicine), becoming a Senior Researcher in 1995.
Between 2000-April 2007, I took up the position of Senior Research Associate & Research Co-ordinator for the Tenovus Centre for Cancer Research within the School of Pharmacy and Pharmaceutical Sciences, where the programme of work focussed around anti‑hormone resistance and progression in breast cancer. Alongside contributing to the management of (and defining research strategies for) the Tenovus group, my role was to oversee the Clinical Immunocytochemistry Team, extending to analysing signalling elements using activation-specific antibodies in several phase II breast cancer trials.
I also lead the group's Gene Discovery Team applying microarrays and bioinformatics to reveal new signalling in resistant breast cancer, and receiving a gold medal in this area at the 9th World Congress on Advances in Oncology/7th International Symposium on Molecular Medicine. I was subsequently funded until Sept. 2010 as Principal Investigator on a Tenovus Charity programme grant investigating and targeting anti‑hormone-induced signalling during the drug responsive phase of ER+ breast cancer.
Most recently, I successfully secured a prestigious 5-year Breast Cancer Campaign-funded Senior Scientific Fellowship (2010-2015), based in the School of Pharmacy and Pharmaceutical Sciences, to examine the impact of prolonged antihormone exposure on the acquired resistant phenotype in ER+ disease to define targets potentially relevant following adjuvant antihormone relapse in the clinic.
Alongside defining research strategies for further funding bids, my current role extends to formulating new hypotheses and contributing to management and implementing projects, development and strategic planning for our research group. I am also responsible for securing supportive external grant funding and for sustaining various existing (and securing new) collaborations with key academic groups and pharmaceutical companies.
I am principal investigator/co-applicant on several industrial-funded studies exploring new therapeutic agents within breast cancer models.
Relationship with practitioners
Alongside contributing to mentoring of several Cardiff and Nottingham-based MD studentships, I have managed research assays for immunocytochemical markers in the Tenovus Centre for Cancer Research, notably monitoring steroid receptors and growth factor receptor signalling pathway elements in several clinical trials in breast cancer (collaborating substantially with Prof. John Robertson at Dept. Surgery, Nottingham City Hospital).
These have included studies with (i) the anti‑hormone Faslodex (Fulvestrant) in breast cancer (e.g. Study 41; NEWEST trial) and (ii) Gefitinib in Tamoxifen resistant breast cancer and also DCIS.
My team was a key player in the Phase II clinical biomarker studies that provided primary evidence for FDA/EU approval of Faslodex in advanced breast cancer.
Currently we are contributing to biomarker analysis in the multicentre ABC tamoxifen relapse breast cancer study and have strong local collaborations with breast cancer oncologist Prof. Peter Barrett-Lee at Velindre Hospital.
Aelodaethau proffesiynol
- British Breast Group elected member.
- Invited member of Editorial Board for Journal of Hormone Molecular Biology and Clinical Investigation 2010
- Invited member of Editorial Board for BMC Cancer Journal 2010
- Invited member of Editorial Board for Endocrinology Journal 2009-2012
- Co-editor for 1st-3rd Tenovus/AstraZeneca Workshops (2005, 2006, 2008).
- I served as an invited Reporter for Breast Cancer Research Online 2003-2006.
- Regular referee & peer reviewer for scientific journals including JNCI, Nature journals, Breast Cancer Research, Endocrinology, & for funding bodies including
CR-UK (TRICC), MRC, Yorkshire Cancer Research; Irish Cancer Fund; Breast Cancer Campaign; Weston Park Hospital Sheffield
Ymrwymiadau siarad cyhoeddus
"Anti-Hormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance", 1st International Symposium of Journal of Hormone Molecular Biology and Clinical investigation, Seefeld, Austria, Sept 2010.
Public engagement
- Interaction with Breast Cancer Campaign and "In The Pink" charities & fundraisers.
- Presenting Breast Cancer Researcher (Biomarkers) at CR-UK Centre Cardiff public launch October 2009
- Contributor to Breast Cancer Campaign "History of Breast Cancer" public document 2010
Pwyllgorau ac adolygu
- Postdoctoral representative on School of Pharmacy and Pharmaceutical Sciences Research Committee from 2010
- Founder Member of School of Pharmacy and Pharmaceutical Sciences Postdoctoral Researchers College
- Active member of Wales Cancer Institute Breast Group, Cardiff CRUK-ECMC group, & Sartre Cardiff/Bristol Cancer group
- Current member (& named co-applicant) of ABC breast cancer trial (TRICC tamoxifen relapse) study group
- British Breast Group elected member, and recently-elected Scientific Programme Committee member from 2010
- Invited Member of Tissue Bank Access Committee for Breast Cancer Campaign Charity from 2010
- British Breast Cancer Research Conference Scientific Board member, Nottingham UK, from January 2010
- Breast Cancer Campaign Scientific Meeting Organising Committee member since 2006. Also Committee Member for (and co-author of resulting document for) National Gap Analysis in breast cancer instigated by Breast Cancer Campaign. This highlighted priority areas for breast cancer scientific research in the UK. Thompson A, Brennan K, Cox A, Gee J, Harcourt D, Harris A, Harvie M, Holen I, Howell A, Nicholson R, Steel M, Streuli C. Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Res. 2008;10(2):R26.
- Organising Committee member Tenovus/AstraZeneca Workshops on Cancer (1st, 2005; 2nd, 2006; 3rd, Workshop "Therapeutic Resistance to anti-hormonal drugs in breast cancer: new molecular aspects and targets" May 2008, Cardiff). Proceedings from these Workshops were published as supplements in the journal Endocrine Related Cancer and in the Springer book publication (2009) "Therapeutic resistance to anti-hormonal drugs in breast cancer: new molecular aspects and their potential as targets".
- Previous Scientific Advisory Board member for Breast Cancer Campaign (2004-2007)
- Previous member of Oncopool ("Pooling of European Data to Harmonise Translational Research in Breast Cancer") European Breast Cancer Study Group (2002-2004)
- NEQAS Immunocytochemistry Co-ordinator for Tenovus Centre for Cancer Research (2001-2008)
- Previously served on AstraZeneca Pathology Review & Molecular Targets in Breast Cancer Advisory Panels (2001; April 2008)
Cyhoeddiadau
2022
- Saunus, J. M. et al. 2022. Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer 8, article number: 57. (10.1038/s41523-022-00425-x)
- Jones, S., Farr, G., Nimmanon, T., Ziliotto, S., Gee, J. M. and Taylor, K. M. 2022. The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer. Exploration of Targeted Anti-tumor Therapy 3, pp. 224-239. (10.37349/etat.2022.00080)
2020
- Campbell, C. et al. 2020. Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance. Translational Breast Cancer Research 1, article number: 29. (10.21037/tbcr-20-31)
- Nimmanon, T. et al. 2020. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. Cellular and Molecular Life Sciences 78, pp. 1781-1798. (10.1007/s00018-020-03616-6)
- Robertson, J. F. et al. 2020. Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT). Clinical Cancer Research 26(7), pp. 1574-1585. (10.1158/1078-0432.CCR-19-3053)
- Achinger-Kawecka, J. et al. 2020. Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer. Nature Communications 11(1), article number: 320. (10.1038/s41467-019-14098-x)
2019
- Ziliotto, S., Gee, J. M. W., Ellis, I. O., Green, A. R., Finlay, P., Gobbato, A. and Taylor, K. M. 2019. Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer. Metallomics 11(9), pp. 1579-1592. (10.1039/C9MT00136K)
- Santiago-Gómez, A. et al. 2019. PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer. Cancer Letters 458, pp. 66-75. (10.1016/j.canlet.2019.05.014)
- Milevskiy, M. J. G. et al. 2019. MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. British Journal of Cancer 120, pp. 621-632. (10.1038/s41416-019-0395-8)
2018
- Piggott, L. et al. 2018. Acquired resistance of ER-positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP. Clinical Cancer Research 24(10), pp. 2452-2463. (10.1158/1078-0432.CCR-17-1381)
2016
- Milevskiy, M. J. et al. 2016. Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics 25(15), pp. 3269-3283., article number: ddw177. (10.1093/hmg/ddw177)
- Bellerby, R. et al. 2016. Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance. Frontiers in Oncology 6, article number: 145. (10.3389/fonc.2016.00145)
- Agrawal, A., Robertson, J. F., Cheung, K. L., Gutteridge, E., Ellis, I. O., Nicholson, R. I. and Gee, J. M. 2016. Biological effects of fulvestrant on estrogen receptor positive human breast cancer: short, medium and long-term effects based on sequential biopsies. International Journal of Cancer 138(1), pp. 146-159. (10.1002/ijc.29682)
- Abdulkareem, Z. A., Gee, J. M. W., Cox, C. and Wann, K. T. 2016. Knockdown of the small conductance Ca2+-activated K+ channels is potently cytotoxic in breast cancer cell lines. British Journal of Pharmacology 173(1), pp. 177-190. (10.1111/bph.13357)
2015
- Gallego-Ortega, D. et al. 2015. ELF5 drives lung metastasis in luminal breast cancer through recruitment of Gr1+ CD11b+ myeloid-derived suppressor cells. PLoS Biology 13(12), article number: e1002330. (10.1371/journal.pbio.1002330)
- Simões, B. et al. 2015. Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity. Cell Reports 12(12), pp. 1968-1977. (10.1016/j.celrep.2015.08.050)
- Stone, A. et al. 2015. DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer. Nature Communications 6, article number: 7758. (10.1038/ncomms8758)
- Gee, J. M. et al. 2015. A new cell panel to study oestrogen receptor loss in acquired endocrine resistant breast cancer. Cancer Research 75(9), article number: P3-05-19.
2014
- Robertson, J. F., Lindemann, J., Garnett, S., Anderson, E., Nicholson, R. I., Kuter, I. and Gee, J. M. W. 2014. A good drug made better: the Fulvestrant Dose Response Story. Clinical Breast Cancer 14(6), pp. 381-389. (10.1016/j.clbc.2014.06.005)
- Gee, J. M. W. et al. 2014. Increased Ret signalling and impact of vandetanib in acquired tamoxifen resistant breast cancer. Cancer Research 74(19), article number: 738. (10.1158/1538-7445.AM2014-738)
- Britton, D. et al. 2014. Quantification of pancreatic cancer proteome and phosphorylome: Indicates molecular events likely contributing to cancer and activity of drug targets. PLoS ONE 9(3), article number: e90948. (10.1371/journal.pone.0090948)
- Jordan, N. J. et al. 2014. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Research 16(1), pp. -., article number: R12. (10.1186/bcr3604)
2013
- McCloy, R. A. et al. 2013. Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells. British Journal of Cancer 109(12), pp. 3034-3041. (10.1038/bjc.2013.693)
- Browne, B. C. et al. 2013. Global characterization of signalling networks associated with tamoxifen resistance in breast cancer. FEBS Journal 280(21), pp. 5237-5257. (10.1111/febs.12441)
- Stone, A. et al. 2013. BCL-2 Hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Molecular Cancer Therapeutics 12(9), pp. 1874-1885. (10.1158/1535-7163.MCT-13-0012)
- Robertson, J. F. R. et al. 2013. A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancer. Breast Cancer Research 15(2), article number: R18. (10.1186/bcr3393)
- Eccles, S. A. et al. 2013. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research 15(5), pp. R92. (10.1186/bcr3493)
2012
- Kalyuga, M. et al. 2012. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biology 10(12), article number: e1001461. (10.1371/journal.pbio.1001461)
- Hiscox, S. E. et al. 2012. Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan. BMC Cancer 12, article number: 458. (10.1186/1471-2407-12-458)
- Kuter, I. et al. 2012. Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study. Breast Cancer Research and Treatment 133(1), pp. 237-246. (10.1007/s10549-011-1947-7)
- Caldon, C. E. et al. 2012. Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Molecular Cancer Therapeutics 11(7), pp. 1488-1499. (10.1158/1535-7163.MCT-11-0963)
- Stone, A. et al. 2012. Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer. PLoS ONE 7(7), article number: e40466. (10.1371/journal.pone.0040466)
2011
- Taylor, K. M., Gee, J. M. W. and Kille, P. 2011. Zinc and cancer. In: Rink, L. ed. Zinc in Human Health. Biomedical and Health Research Vol. 76. Amsterdam: IOS Press, pp. 283-304.
- Hutcheson, I. R. et al. 2011. Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1. Breast Cancer Research 13(2), article number: R29. (10.1186/bcr2848)
- Gee, J. M. W. et al. 2011. Antihormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance. Hormone Molecular Biology and Clinical Investigation 5(2), pp. 67-77. (10.1515/HMBCI.2011.009)
- Knowlden, J. M., Gee, J. M. W., Barrow, D., Robertson, J. F., Ellis, I. O., Nicholson, R. I. and Hutcheson, I. R. 2011. erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines. Breast Cancer Research 13(5), article number: R93. (10.1186/bcr3018)
- Nicholson, R. I. et al. 2011. Abstract P2-06-19: Transferrin Receptor (CD71) identifies poor response to Tamoxifen in oestrogen receptor positive breast cancer patients [Abstract]. Cancer Research 70(24 Sup), pp. P2-P6. (10.1158/0008-5472.SABCS10-P2-06-19)
- Gee, J. M. W. et al. 2011. Abstract P2-09-37: Immunohistochemical markers progesterone receptor, HER2, Ki67 and bcl-2-Associated Athanogene 1 and prediction of adjuvant Tamoxifen treatment outcome in ER+ early breast cancer [Abstract]. Cancer Research 70(24 Sup), pp. P2-09. (10.1158/0008-5472.SABCS10-P2-09-37)
- Habashy, H. O. et al. 2011. A review of the biological and clinical characteristics of luminal-like oestrogen receptor-positive breast cancer. Histopathology 60(6), pp. 854-863. (10.1111/j.1365-2559.2011.03912.x)
2010
- Knowlden, J. M., Gee, J. M. W., Barrow, D., Robertson, J. F., Ellis, I. O., Nicholson, R. I. and Hutcheson, I. R. 2010. O-36 Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract]. EJC Supplements 8(6), pp. 13-14. (10.1016/j.ejcsup.2010.06.037)
- Knowlden, J. M., Gee, J. M. W., Barrow, D., Robertson, J. F., Ellis, I. O., Nicholson, R. I. and Hutcheson, I. R. 2010. Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells [Abstract]. Breast Cancer Research 12(S1), pp. S15. (10.1186/bcr2546)
- Hutcheson, I. R., Goddard, L., Gee, J. M. W., Barrow, D. and Nicholson, R. I. 2010. Fulvestrant-induced expression of erbB3 and erbB4 sensitizes ER-positive breast cancer cells to heregulins [Abstract]. Breast Cancer Research 12(S1), article number: P13. (10.1186/bcr2510)
- Gutteridge, E., Agrawal, A., Nicholson, R. I., Cheung, K. L., Robertson, J. and Gee, J. M. W. 2010. The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: a phase II study. International Journal of Cancer 126(8), pp. 1806-1816. (10.1002/ijc.24884)
- Robertson, J. F. R. et al. 2010. Biological activity of a combination of fulvestrant 500 mg (F500) plus anastrozole versus F500 alone or anastrozole alone as neoadjuvant treatment for breast cancer [Abstract]. EJC Supplements 8(3), pp. 63-63. (10.1016/S1359-6349(10)70050-1)
- Agrawal, A., Robertson, J. F. R., Gutteridge, E., Cheung, K. L., Ellis, I. O., Nicholson, R. I. and Gee, J. M. W. 2010. 182 Long-term effect of fulvestrant on hormone receptors and proliferation marker in breast cancer [Abstract]. EJC Supplements 8(3), pp. 111-111. (10.1016/S1359-6349(10)70213-5)
- Thomas, N. B. P., Hutcheson, I. R., Campbell, L., Gee, J. M. W., Taylor, K. M., Nicholson, R. I. and Gumbleton, M. 2010. Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Research and Treatment 119(3), pp. 575-591. (10.1007/s10549-009-0355-8)
- Habashy, H. O. et al. 2010. Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen. Breast Cancer Research and Treatment 119(2), pp. 283-293. (10.1007/s10549-009-0345-x)
- Blamey, R. W. et al. 2010. ONCOPOOL - A European database for 16,944 cases of breast cancer. European Journal of Cancer 46(1), pp. 56-71. (10.1016/j.ejca.2009.09.009)
2009
- Robertson, J. F. R. et al. 2009. Tumor biomarker changes following pre-surgical treatment with 500 mg Fulvestrant plus Anastrozole Versus 500 mg Fulvestrant Alone and 1 mg Anastrozole Alone [Abstract]. Cancer Research 69(24S), pp. 491S. (10.1158/0008-5472.SABCS-09-24)
- Morgan, L. D. et al. 2009. Elevated Src kinase activity attenuates tamoxifen response in vitro and is associated with poor prognosis clinically. Cancer Biology and Therapy 8(16), pp. 1550-1558. (10.4161/cbt.8.16.8954)
- Kuter, I., Anderson, E., Emeribe, U., Finlay, P., Nicholson, R. I. and Gee, J. M. W. 2009. Comparison of methods for detection of fulvestrant-induced changes in breast tumor estrogen and progesterone receptor expression in a neoadjuvant trial (NEWEST) [Abstract]. Journal of Clinical Oncology 27(15S), article number: e11602.
- Elsheikh, S. E., Green, A. R., McClelland, R. A., Hutcheson, I. R., Gee, J. M. W., Nicholson, R. I. and Ellis, I. O. 2009. 162 Altered Histone Modifications and their regulating enzymes in Fulvestrant resistant breast cancer cell line In Vitro [Abstract]. Laboratory Investigation 89(S1), pp. 38A-39A. (10.1038/labinvest.2008.132)
- Nicholson, R. I., Hutcheson, I. R., Hiscox, S. E., Taylor, K. M. and Gee, J. M. W. 2009. Experimental endocrine resistance: concepts and strategies. In: Hiscox, S. E., Gee, J. M. W. and Nicholson, R. I. eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential. Dordrecht: Springer, pp. 1-26., (10.1007/978-1-4020-8526-0_1)
- Gee, J. M. W. et al. 2009. The dark side of antihormonal action in breast cancer. In: Hiscox, S. E., Gee, J. M. W. and Nicholson, R. I. eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential. Dordrecht: Springer, pp. 63-84., (10.1007/978-1-4020-8526-0_4)
- Hiscox, S. E., Jordan, N. J., Morgan, L. D., Smith, C., Goddard, L., Gee, J. . M. W. and Nicholson, R. 2009. Adverse features of acquired antihormone resistance and their targeting. In: Hiscox, S. E., Gee, J. M. W. and Nicholson, R. eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets. London: Springer, pp. 139-160., (10.1007/978-1-4020-8526-0_8)
- Gee, J. M. W. et al. 2009. Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival. The Journal of Pathology 217(1), pp. 32-41. (10.1002/path.2430)
- Hiscox, S. E., Jordan, N. J., Crandon-Lewis, A., Jiang, W., Nicholson, R. I. and Gee, J. M. W. 2009. Overexpression of L1CAM accompanies acquired endocrine resistance and is associated with the development of an aggressive cell phenotype [Abstract]. Cancer Research 69(2), pp. 213S-213S. (10.1158/0008-5472.SABCS-3028)
- Shou, J., Osborne, K. C., Gee, J. M. W., Nicholson, R. I. and Schiff, R. 2009. Akt-dependent phosphorylation on AIB1 serine 967 contributes to breast cancer tamoxifen resistance [Abstract]. Cancer Research 69(2), pp. 211S-211S. (10.1158/0008-5472.SABCS-3021)
- Elsheikh, S. E., Green, A. R., McClelland, R. A., Hutcheson, I. R., Gee, J. M. W., Nicholson, R. I. and Ellis, I. O. 2009. Altered Histone Modifications and Their Regulating Enzymes in Fulvestrant Resistant Breast Cancer Cell Line In Vitro [Abstract]. Modern Pathology 22(S1), pp. 38A-39A., article number: 162. (10.1038/modpathol.2008.210)
- Jasani, B., Gee, J. M. W., Hutcheson, I. R., Clarkson, R. W. E., Bartlett, J. and Barrett-Lee, P. 2009. Resistance to HER2-directed trastuzumab therapy in breast cancer. Advances in Breast Cancer 6(3), pp. 11-18.
- Kuter, I., Anderson, E., Emeribe, U., Finlay, P., Nicholson, R. I. and Gee, J. M. W. 2009. Comparison of Methods for Detection of Fulvestrant-Induced Changes in Breast Tumor Estrogen and Progesterone Receptor Expression in a Neoadjuvant Trial (NEWEST). Cancer Research 69(24), pp. 566S-567S.
- O'Brien, C. S., Howell, S. J., Gee, J. M. W., Lykkesfeldt, A. E., Nicholson, R. I. and Clarke, R. B. 2009. Tamoxifen resistance in Estrogen Receptor Positive (ER plus ) breast cancer is driven by Estrogen Receptor Negative (ER-) cancer stem-like cells [Abstract]. Cancer Research 69(24), pp. 807S.
2008
- Law, J. H. et al. 2008. Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Research 68(24), pp. 10238-10246. (10.1158/0008-5472.CAN-08-2755)
- Davison, Z., Dutkowski, C. M., Gee, J. M. W., Nicholson, R. I. and Heard, C. M. 2008. In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/eicosapentaenoic acid combinations and their simultaneous delivery across skin. Pharmaceutical Research 25(11), pp. 2516-2525. (10.1007/s11095-008-9665-5)
- Knowlden, J. M., Jones, H. E., Barrow, D., Gee, J. M. W., Nicholson, R. I. and Hutcheson, I. R. 2008. Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib ('Iressa') response and resistance. Breast Cancer Research and Treatment 111(1), pp. 79-91. (10.1007/s10549-007-9763-9)
- Hiscox, S. E., Goddard, L., Jordan, N. J., Smith, C., Harper, M. E., Nicholson, R. I. and Gee, J. M. W. 2008. Overexpression of CD44 in acquired tamoxifen-resistant breast cancer cells augments their migratory response to heregulin beta 1 [Abstract]. Breast Cancer Research 10(S2), article number: P34. (10.1186/bcr1918)
- Stone, A., Jones, H., Giles, M., Gee, J. M. W. and Nicholson, R. I. 2008. Anti-oestrogen therapy switches off tumour suppressors and proapoptotic genes in breast cancer and reveals a new therapeutic opportunity [Abstract]. Breast Cancer Research 10(s2), article number: P41. (10.1186/bcr1925)
- Bensmail, A., Hutcheson, I. R., Giles, M., Gee, J. M. W. and Nicholson, R. I. 2008. Loss of oestrogen receptor alpha in long-term antioestrogen-resistant cells: reversal by a c-src inhibitor [Abstract]. Breast Cancer Research 10(S2), article number: O3. (10.1186/bcr1883)
- Borley, A. C., Hiscox, S. E., Gee, J. M. W., Smith, C., Shaw, V., Barrett-Lee, P. and Nicholson, R. I. 2008. Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells. Breast Cancer Research 10(6), article number: R103. (10.1186/bcr2206)
- Habashy, H. O. et al. 2008. Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance. European Journal of Cancer 44(11), pp. 1541-1551. (10.1016/j.ejca.2008.04.020)
- Rakha, E. A. et al. 2008. Invasive lobular carcinoma of the breast: Response to hormonal therapy and outcomes. European Journal of Cancer 44(1), pp. 73-83. (10.1016/j.ejca.2007.10.009)
- Taylor, K. M., Jordan, N. J., Hiscox, S. E., Gee, J. M. W. and Nicholson, R. I. 2008. Zinc transporter HKE4 as a new target in antihormone resistance of breast cancer [Abstract]. Breast Cancer Research 10(s2), article number: P42. (10.1186/bcr1926)
- Thompson, A. et al. 2008. Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Research 10(2), article number: R26. (10.1186/bcr1983)
- Nicholson, R. I., Hutcheson, I. R., Jones, H. E., Taylor, K. M., Hiscox, S. E. and Gee, J. M. W. 2008. Compensatory signalling induced by anti-hormone and anti-growth factor therapies in breast cancer: a starting point for the development of resistance to targeted therapies.. In: Pasqualini, J. R. ed. Breast cancer: prognosis, treatment and prevention. 2nd ed. London: Informa Healthcare, pp. 123-136.
- Hutcheson, I. R., Gee, J. M. W. and Nicholson, R. I. 2008. MAP Kinase family members and endocrine response and survival in breast cancer. In: Walker, R. A. and Thompson, A. M. eds. Prognostic and predictive factors in breast cancer. 2nd ed.. London: Informa Healthcare, pp. 122-138.
2007
- Borley, A. C., Barrett-Lee, P., Gee, J. M. W., Show, V. E., Nicholson, R. and Hiscox, S. E. 2007. Anti-estrogens promote an invasive phenotype in intercellular adhesion deficient breast cancer cells. Breast Cancer Research and Treatment 106(Supp 1), pp. S7-S8.
- Rampaul, R. S. et al. 2007. O-105 erbB Signalling in breast cancer. EJC Supplements 5(3), pp. 32. (10.1016/S1359-6349(07)71795-0)
- Assender, J. W., Gee, J. M. W., Lewis, I., Ellis, I. O., Robertson, J. F. R. and Nicholson, R. I. 2007. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. Journal of Clinical Pathology 60(11), pp. 1216-1221. (10.1136/jcp.2006.041616)
- Greco, F., Vicent, M. J., Gee, S., Jones, A. T., Gee, J. M. W., Nicholson, R. I. and Duncan, R. 2007. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release 117(1), pp. 28-39. (10.1016/j.jconrel.2006.10.012)
- Hutcheson, I. R. et al. 2007. Heregulin beta 1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. Breast Cancer Research 9(4), article number: R50. (10.1186/bcr1754)
- Nicholson, R. I., Hutcheson, I. R., Jones, H. E., Hiscox, S. E., Giles, M., Taylor, K. M. and Gee, J. M. W. 2007. Growth factor signalling in endocrine and anti-growth factor resistant breast cancer. Reviews in Endocrine and Metabolic Disorders 8(3), pp. 241-253. (10.1007/s11154-007-9033-5)
- Rakha, E. A. et al. 2007. Biologic and clinical characteristics of breast cancer with single hormone receptor-positive phenotype. Journal of Clinical Oncology 25(30), pp. 4772-4778. (10.1200/jco.2007.12.2747)
- Rampaul, R. S. et al. 2007. Assessment of Her-2 status using a panel of antibodies and FISH. EJC Supplements 5(3), pp. 17.
- Robertson, J. F. R. et al. 2007. Effects of fulvestrant 250 mg in premenopausal women with oestrogen receptor-positive primary breast cancer. European Journal of Cancer 43(1), pp. 64-70. (10.1016/j.ejca.2006.08.019)
2006
- Hutcheson, I. R. et al. 2006. Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocrine-Related Cancer 13(S1), pp. S89-S97. (10.1677/erc.1.01279)
- Gee, J. M. W., Shaw, V. E., Hiscox, S. E., McClelland, R. A., Rushmere, N. K. and Nicholson, R. I. 2006. Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications. Endocrine-Related Cancer 13(S1), pp. S77-S88. (10.1677/erc.1.01274)
- Jones, H. E., Gee, J. M. W., Hutcheson, I. R., Knowlden, J. M., Barrow, D. and Nicholson, R. I. 2006. Growth factor receptor interplay and resistance in cancer. Endocrine-Related Cancer 13(S1), pp. S45-S51. (10.1677/erc.1.01275)
- Nicholson, R. I., Gee, J. M. W., Harris, A. and Anderson, E. 2006. Consensus Statement. Endocrine-Related Cancer 13(S1), pp. S1-S2. (10.1677/erc.1.01323)
- Burmi, R. S., McClelland, R. A., Barrow, D., Ellis, I. O., Robertson, J. F. R., Nicholson, R. I. and Gee, J. M. W. 2006. Microarray studies reveal novel genes associated with endocrine resistance in breast cancer [Abstract]. Breast Cancer Research 8(S2), article number: S11. (10.1186/bcr1554)
- Sarwar, N. et al. 2006. Phosphorylation of ER alpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ER alpha phosphorylation in breast cancer progression. Endocrine-Related Cancer 13(3), pp. 851-861. (10.1677/erc.1.01123)
- Jones, H. E., Gee, J. M. W., Barrow, D., Tonge, D., Holloway, B. and Nicholson, R. I. 2006. Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. British Journal of Cancer 95(2), pp. 172-180. (10.1038/sj.bjc.6603237)
- Jones, H. E., Gee, J. M. W., Hutcheson, I. R. and Nicholson, R. I. 2006. Growth factor pathway switching: implications for the use of gefitinib and trastuzumab. Breast Cancer Online 9(7), article number: e27. (10.1017/S1470903106005451)
- Hiscox, S. E., Morgan, L. D., Green, T. P., Barrow, D., Gee, J. M. W. and Nicholson, R. I. 2006. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast cancer research and treatment 97(3), pp. 263-274. (10.1007/s10549-005-9120-9)
- Britton, D. J. et al. 2006. Bidirectional cross talk between ER alpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Research and Treatment 96(2), pp. 131-146. (10.1007/s10549-005-9070-2)
- Jasani, B., Douglas-Jones, A. G., Rhodes, A., Wozniak, S., Barrett-Lee, P., Gee, J. M. W. and Nicholson, R. I. 2006. Measurement of estrogen receptor status by immunocytochemistry in paraffin wax sections. In: Brooks, S. A. and Harris, A. eds. Breast Cancer Research Protocols. Methods in Molecular Medicine Vol. 120. Totowa, NJ: Humana Press, pp. 127-146., (10.1385/1-59259-969-9:127)
- Jones, H. E., Gee, J. M. W., Barrow, D., Holloway, B., Tonge, D. and Nicholson, R. I. 2006. Maintenance of EGFR phosphorylation by the IGF-1R in the presence of gefitinib in lung cancer cells: Co-targeting the EGFR and IGF-1R maximises anti-tumour effects [Abstract]. Annals of Oncology 17(S3), pp. iii39. (10.1093/annonc/mdl919)
- Ali, S. et al. 2006. Immunohistochemical determination of estrogen receptor-alpha phosphorylation in activation function AF1 in primary and tamoxifen-resistant breast cancer is indicative of a complex role for estrogen receptor-alpha phosphorylation in breast cancer progression [Abstract]. Breast Cancer Research and Treatment 100(S1), pp. S36-S37. (10.1007/s10549-006-5678-0)
2005
- Knowlden, J. M., Hutcheson, I. R., Barrow, D., Gee, J. M. W. and Nicholson, R. I. 2005. Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor. Endocrinology 146(11), pp. 4609-4618. (10.1210/en.2005-0247)
- Nicholson, R. I., Hutcheson, I. R., Hiscox, S. E., Knowlden, J. M., Giles, M. G., Barrow, D. and Gee, J. M. W. 2005. Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer. Endocrine-Related Cancer 12(S1), pp. S29-S36. (10.1677/erc.1.00991)
- Gee, J. M. W. et al. 2005. Consensus statement. Endocrine-Related Cancer 12(S1), pp. S1-S7. (10.1677/erc.1.01054)
- Jones, H. E., Gee, J. M. W., Taylor, K. M., Barrow, D., Williams, H. D., Rubini, M. and Nicholson, R. I. 2005. Development of strategies for the use of anti-growth factor treatments. Endocrine-Related Cancer 12(S1), pp. S173-S182. (10.1677/erc.1.01004)
- Agrawal, A., Gutteridge, E., Gee, J. M. W., Nicholson, R. I. and Robertson, J. F. R. 2005. Overview of tyrosine kinase inhibitors in clinical breast cancer. Endocrine-Related Cancer 12(S1), pp. S135-S144. (10.1677/erc.1.01059)
- Staka, C. M., Nicholson, R. I. and Gee, J. M. W. 2005. Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model. Endocrine-Related Cancer 12(S1), pp. S85-S97. (10.1677/erc.1.01006)
- Gee, J. M. W., Robertson, J. F., Gutteridge, E., Ellis, I. O., Pinder, S. E., Rubini, M. and Nicholson, R. I. 2005. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocrine-Related Cancer 12(S1), pp. S99-S111. (10.1677/erc.1.01005)
- Gutteridge, E., Gee, J. M. W., Nicholson, R. I. and Robertson, J. F. R. 2005. Biological markers associated with response to gefitinib ('Iressa') in patients with breast cancer [Abstract]. British Journal of Surgery 92(S1), pp. 13-17. (10.1002/bjs.5008)
- Green, A. R., Paish, E. C., Gee, J. M. W., Nicholson, R. I., Cheung, K. L., Robertson, J. F. R. and Ellis, I. O. 2005. Oestrogen receptor variant expression as potential selectors for adjuvant endocrine therapy in breast cancer patients [Abstract]. Journal of Pathology 205(S1), pp. 5A. (10.1002/path.1762)
- Nicholson, R. I. et al. 2005. Growth factor signalling networks in breast cancer and resistance to endocrine agents: new therapeutic strategies. The Journal of Steroid Biochemistry and Molecular Biology 93(2-5), pp. 257-262. (10.1016/j.jsbmb.2004.12.006)
- Gee, J. M. W. and Hutcheson, I. R. 2005. Understanding endocrine resistance: the critical need for sequential samples from clinical breast cancer and novel in vitro models [Viewpoint]. Breast Cancer Research 7(5), pp. 187-189. (10.1186/bcr1289)
- Giles, M. G., Fiegl, H., Widschwendter, M., Gee, J. M. W., Wakeling, A. E. and Nicholson, R. I. 2005. Loss of estrogen receptor (ER) expression in MCF-7 cells following long-term exposure to fulvestrant [Abstract]. Breast Cancer Research and Treatment 94(S1), pp. S243. (10.1007/s10549-005-1234-6)
2004
- Nicholson, R. I., Staka, C., Boyns, F. E., Hutcheson, I. R. and Gee, J. M. W. 2004. Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy. Endocrine-Related Cancer 11(4), pp. 623-641. (10.1677/erc.1.00778)
- Jones, H. E. et al. 2004. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocrine-Related Cancer 11(4), pp. 793-814. (10.1677/erc.1.00799)
- Jordan, N. J., Gee, J. M. W., Barrow, D., Wakeling, A. E. and Nicholson, R. I. 2004. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Research and Treatment 87(2), pp. 167-180. (10.1023/B:BREA.0000041623.21338.47)
- Gutteridge, E., Gee, J. M. W., Nicholson, R. I. and Robertson, J. F. R. 2004. Biological markers associated with response to gefitinib (ZD1839) in patients with breast cancer [Abstract]. Journal of Clinical Oncology 22(14S), article number: 648.
- Rushmere, N. K., Knowlden, J. M., Gee, J. M. W., Harper, M. E., Robertson, J. F. R., Morgan, B. P. and Nicholson, R. I. 2004. Analysis of the level of mRNA expression of the membrane regulators of complement, Cd59, Cd55 and Cd46, in breast, cancer. International Journal of Cancer 108(6), pp. 930-936. (10.1002/ijc.11606)
- Hutcheson, I. R., Gee, J. M. W., Barrow, D., Jones, H. E., Wakeling, A. E. and Nicholson, R. I. 2004. Treatment of tamoxifen-resistant MCF-7 breast cancer cells with either gefitinib ('Iressa') or trastuzumab (Herceptin((R))) generates cross-resistant phenotypes [Abstract]. Breast Cancer Research and Treatment 88(S1), pp. S145-S146. (10.1007/s10549-004-3602-z)
- Nicholson, R. et al. 2004. Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination. Clinical Cancer Research 10(1), pp. 346s-354s. (10.1158/1078-0432.CCR-031206)
- Gee, J. M. W., Gutteridge, E., Robertson, J. F., Wakeling, A. E., Jones, H. E. and Nicholson, R. I. 2004. Biological markers during early treatment of tamoxifen resistant breast cancer with gefitinib ('Iressa')[Abstract]. Breast Cancer Research and Treatment 88(S1), pp. S32. (10.1007/s10549-004-3602-z)
- Gee, J. M. W., Giles, M. G. and Nicholson, R. I. 2004. Extreme growth factor signalling can promote oestrogen receptor-alpha loss: therapeutic implications in breast cancer. Breast Cancer Research 6(4), pp. 162-163. (10.1186/bcr904)
- Giles, M. G., Gee, J. M. W., Wakeling, A. E. and Nicholson, R. I. 2004. Characterization of ER alpha and cofactor recruitment during fulvestrant treatment and resistance in breast cancer using chromatin immunoprecipitation [Abstract]. Breast Cancer Research and Treatment 88(S1), pp. S216-S217. (10.1007/s10549-004-3602-z)
- Nicholson, R. et al. 2004. Chapter 16: beyond antihormones in the targeted therapy of breast cancer. In: Ingle, J. N. and Dowsett, M. eds. Endocrine Therapy for Breast Cancer Proceedings of the 2003 Gleneagles Conference. New York: Marcel Dekker, pp. 249-258.
2003
- Gee, J. M. W., Harper, M., Hurcheson, I. and Madden, T. 2003. The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 144(11), pp. 5105-5117. (10.1210/en.2003-0705)
- Hutcheson, I. R., Knowlden, J. M., Madden, T., Barrow, D., Gee, J. M. W., Wakeling, A. E. and Nicholson, R. I. 2003. Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells. Breast Cancer Research and Treatment 81(1), pp. 81-93. (10.1023/A:1025484908380)
- Knowlden, J. M. et al. 2003. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144(3), pp. 1032-1044. (10.1210/en.2002-220620)
- Britton, D. J., Hutcheson, I. R., Barrow, D., McClelland, R. A., Gee, J. M. W. and Nicholson, R. I. 2003. Oestrogen receptor phosphorylation in hormone sensitive and anti-hormone resistant breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82(S1), pp. S61. (10.1023/A:1026252325164)
- Nicholson, R. I., Gee, J. M. W., Knowlden, J. M., McClelland, R. A., Madden, T., Barrow, D. and Hutcheson, I. R. 2003. The biology of antihormone failure in breast cancer. Breast Cancer Research and Treatment 80(S1), pp. 29-34. (10.1023/A:1025467500433)
- Nicholson, R. I. et al. 2003. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib ('Iressa', ZD1839) in MCF-7 human breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82(S1), pp. S171. (10.1023/A:1026252325164)
- Hutcheson, I. R., Knowlden, J. M., Barrow, D., Gee, J. M. W., Robertson, J. F., Wakeling, A. E. and Nicholson, R. I. 2003. Heregulin-induced AKT activation promotes growth of gefitinib ('Iressa', ZD1839)-treated, tamoxifen-resistant breast cancer cells [Abstract]. Breast Cancer Research and Treatment 82(S1), pp. S170. (10.1023/A:1026252325164)
- Gee, J. M. W., Rubini, M., Robertson, J. F., Ellis, I. O., Gutteridge, E. and Nicholson, R. I. 2003. Type 1 insulin-like growth factor receptor expression and activation in clinical breast cancer [Abstract]. Breast Cancer Research and Treatment 82(S1), pp. S102., article number: 429. (10.1023/A:1026252325164)
- Gee, J. M. W. and Nicholson, R. I. 2003. Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: radiosensitization [Commentary]. Breast Cancer Research 5(3), pp. 126-129. (10.1186/bcr584)
- Gee, J. M. W. and Knowlden, J. M. 2003. ADAM metalloproteases and EGFR signalling [Viewpoint]. Breast Cancer Research 5(5), pp. 223-224. (10.1186/bcr637)
- Hutcheson, I. R., Gee, J. M. W. and Nicholson, R. I. 2003. MAP Kinase family members and endocrine response and survival in breast cancer. In: Walker, R. A. ed. Prognostic and Predictive Factors in Breast Cancer. London: Martin Dunitz, pp. 147-166.
2002
- Gee, J. M. W. et al. 2002. ZD1839 ('Iressa') improves the antitumour activity of tamoxifen ('Nolvadex') and ICI 182, 780 ('Faslodex') in antihormone responsive breast cancer [Abstract]. European Journal of Cancer 38(S7), pp. S59. (10.1016/S0959-8049(02)80835-8)
- Nicholson, R. I., Hutcheson, I. R. and Gee, J. M. W. 2002. Targeting of oestrogen and growth factor signalling pathways in the therapy of breast cancer: Implications for chemoprevention [Abstract]. European Journal of Cancer 38(S3), pp. S43-S44. (10.1016/S0959-8049(02)81245-X)
- Nicholson, R. I. et al. 2002. Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. In: Castagnetta, L. et al. eds. Hormone-Related Tumors: Novel Approaches to Prevention and Treatment. Annals of the New York Academy of Sciences Vol. 963. New York: The New York Academy of Sciences, pp. 104-115., (10.1111/j.1749-6632.2002.tb04101.x)
- Albanell, J. et al. 2002. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. Journal of Clinical Oncology 20(1), pp. 110-124. (10.1200/JCO.20.1.110)
- Chan, K. C., Knox, W. F., Gee, J. M. W., Morris, J., Nicholson, R. I., Potten, C. S. and Bundred, N. J. 2002. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Research 62, pp. 122-128.
2001
- Wakeling, A. E., Nicholson, R. I. and Gee, J. M. W. 2001. Prospects for combining hormonal and nonhormonal growth factor inhibition. Clinical Cancer Research 7(12), pp. 4350S-4355S.
- Nicholson, R. I. et al. 2001. ZD1839 (Iressa) improves the antitumor activity of tamoxifen (Nolvadex) in antihormone-responsive breast cancer cells [Abstract]. Clinical Cancer Research 7(S), pp. 3766S.
- Glynne-Jones, E. M. et al. 2001. TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence. International Journal of Cancer 94(2), pp. 178-184. (10.1002/ijc.1450)
- Nicholson, R. I., Gee, J. M. W. and Harper, M. E. 2001. EGFR and cancer prognosis. European Journal of Cancer 37(S4), pp. 9-15. (10.1016/S0959-8049(01)00231-3)
- Nicholson, R. I. et al. 2001. Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocrine-Related Cancer 8(3), pp. 175-182. (10.1677/erc.0.0080175)
- Robertson, J. F. et al. 2001. Comparison of the short-term biological effects of 7 alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17 beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Research 61(18), pp. 6739-6746.
- McClelland, R. A. et al. 2001. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 142(7), pp. 2776-2788. (10.1210/en.142.7.2776)
- Gee, J. M. W., Ellis, I., Nicholson, R. and Robertson, J. 2001. Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. International Journal of Cancer 95(4), pp. 247-54. (10.1002/1097-0215(20010720)95:4<247::AID-IJC1042>3.0.CO;2-S)
- Kenny, F. S. et al. 2001. Effect of dietary GLA plus /-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. International Journal of Cancer 92(3), pp. 342-347. (10.1002/ijc.1213)
- Kenny, F. S., Willsher, P. C., Gee, J. M. W., Nicholson, R. I., Pinder, S. E., Ellis, I. O. and Robertson, J. F. R. 2001. Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer. Breast Cancer Research and Treatment 65(2), pp. 135-144. (10.1023/A:1006469627067)
2000
- Yip, S. S. et al. 2000. Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression. International Journal of Cancer 88(3), pp. 363-368. (10.1002/1097-0215(20001101)88:3<363::AID-IJC7>3.0.CO;2-4)
- Madden, T., Barrow, D., McClelland, R. A., Gee, J. M. W. and Nicholson, R. I. 2000. Modulation of oestrogen action by receptor gene inhibition. European Journal of Cancer 36(S4), pp. 34-35. (10.1016/S0959-8049(00)00216-1)
- Kenny, F. S., Pinder, S. E., Ellis, I. O., Gee, J. M. W., Nicholson, R. I., Bryce, R. P. and Robertson, J. F. R. 2000. Gamma linolenic acid with tamoxifen as primary therapy tn breast cancer. International Journal of Cancer 85(5), pp. 643-648. (10.1002/(SICI)1097-0215(20000301)85:5<643::AID-IJC8>3.0.CO;2-Z)
- Knowlden, J. M., Gee, J. M. W., Robertson, J. F. R., Ellis, I. O. and Nicholson, R. I. 2000. A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer. International Journal of Cancer 89(2), pp. 209-212. (10.1002/(SICI)1097-0215(20000320)89:2<209::AID-IJC17>3.0.CO;2-6)
- Gee, J. M. W., Barroso, A. F., Ellis, I. O., Robertson, J. F. R. and Nicholson, R. I. 2000. Biological and clinical associations of c-jun activation in human breast cancer. International Journal of Cancer 89(2), pp. 177-186. (10.1002/(SICI)1097-0215(20000320)89:2<177::AID-IJC13>3.0.CO;2-0)
- Nicholson, R. I. and Gee, J. M. W. 2000. Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer. British Journal of Cancer 82(3), pp. 501-513. (10.1054/bjoc.1999.0954)
- Gee, J. M. W., Robertson, J. F. R., Ellis, I. O. and Nicholson, R. I. 2000. Abstract P13: Impact of activation of MAP kinase family members on endocrine response and survival in clinical breast cancer [Abstract]. European Journal of Cancer 36(S4), pp. 105. (10.1016/S0959-8049(00)00259-8)
1999
- Gee, J. M. W., Robertson, J. F. R., Ellis, I. O., Nicholson, R. I. and Hurst, H. C. 1999. Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. Journal of Pathology 189(4), pp. 514-520. (10.1002/(SICI)1096-9896(199912)189:4<514::AID-PATH463>3.0.CO;2-9)
- Seery, L. T., Knowlden, J. M., Gee, J. M. W., Robertson, J. F. R., Kenny, F. S., Ellis, I. O. and Nicholson, R. I. 1999. [Corrigendum] BRCA1 expression levels predict distant metastasis of sporadic breast cancer (vol 84, pg 258, 1999). International Journal of Cancer 84(5), pp. 544-544. (10.1002/(SICI)1097-0215(19991022)84:5<544::AID-IJC18>3.0.CO;2-9)
- Nicholson, R. I., McClelland, R. A., Robertson, J. F. R. and Gee, J. M. W. 1999. Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer. Endocrine-Related Cancer 6(3), pp. 373-387. (10.1677/erc.0.0060373)
- Kenny, F. S. et al. 1999. Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clinical Cancer Research 5(8), pp. 2069-2076.
- McClelland, R. A., Gee, J. M. W., O'Sullivan, L. A., Barnes, D. M., Robertson, J. F. R., Ellis, I. O. and Nicholson, R. I. 1999. p21(WAF1) expression and endocrine response in breast cancer. Journal of Pathology 188(2), pp. 126-132. (10.1002/(SICI)1096-9896(199906)188:2<126::AID-PATH340>3.0.CO;2-O)
- Seery, L. T., Knowlden, J. M., Gee, J. M. W., Robertson, J. F. R., Kenny, F. S., Ellis, I. O. and Nicholson, R. I. 1999. BRCA1 expression levels predict distant metastasis of sporadic breast cancers. International Journal of Cancer 84(3), pp. 258-262. (10.1002/(SICI)1097-0215(19990621)84:3<258::AID-IJC10>3.0.CO;2-H)
- Davies, E. L., Gee, J. M. W., Cochrane, R. A., Jiang, W. G., Sharma, A. K., Nicholson, R. I. and Mansel, R. E. 1999. The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. European Journal of Cancer 35(6), pp. 902-907. (10.1016/S0959-8049(99)00031-3)
- Gee, J. M. W., Willsher, P. C., Kenny, F. S., Robertson, J. F. R., Pinder, S. E., Ellis, I. O. and Nicholson, R. I. 1999. Endocrine response and resistance in breast cancer: A role for the transcription factor Fos. International Journal of Cancer 84(1), pp. 54-61. (10.1002/(SICI)1097-0215(19990219)84:1<54::AID-IJC11>3.0.CO;2-X)
1998
- Knowlden, J. M. et al. 1998. C-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer. Oncogene 17(15), pp. 1949-1957.
- Kenny, F. S., Willsher, P. C., Gee, J. M. W., Nicholson, R. I., Ellis, I. O. and Robertson, J. F. R. 1998. Change in expression of ER and BCL-2 predict for quality and duration of response in endocrine sensitive breast cancer [Abstract]. European Journal of Cancer 34(S5), pp. S82. (10.1016/S0959-8049(98)80345-6)
- Willsher, P. C. et al. 1998. c-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer. Anticancer Research 18(5B), pp. 3695-3698.
- Davies, E. L., Gee, J. M. W., Cochrane, R. A., Nicholson, R. I., Sharma, A. K., Jiang, W. G. and Mansel, R. E. 1998. The expression of desmoglein-2 in primary breast cancer and its relation to a series of prognostic markers [Abstract]. British Journal of Cancer 78(2), pp. 149. (10.1038/bjc.1998.457)
- McClelland, R. A. et al. 1998. Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy. British Journal of Cancer 77(10), pp. 1653-1656. (10.1038/bjc.1998.457)
1997
- Knowlden, J. M. et al. 1997. Use of reverse transcription-polymerase chain reaction methodology to detect estrogen-regulated gene expression in small breast cancer specimens. Clinical Cancer Research 3(11), pp. 2165-2172.
- Dewhurst, L. O., Gee, J. M. W., Rennie, I. G. and MacNeil, S. 1997. Tamoxifen, 17 beta-oestradiol and the calmodulin antagonist J8 inhibit human melanoma cell invasion through fibronectin. British Journal of Cancer 75(6), pp. 860-868. (10.1038/bjc.1997.153)
- Jones, H. E., Eaton, C. L., Barrow, D., Dutkowski, C. M., Gee, J. M. W. and Griffiths, K. 1997. Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-alpha and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines. Prostate 30(4), pp. 219-231. (10.1002/(SICI)1097-0045(19970301)30:4<219::AID-PROS1>3.0.CO;2-G)
- Nicholson, R. I., Gee, J. M. W., Harper, M. E., Ellis, I. O., Willsher, P. and Robertson, J. F. R. 1997. erbB signalling in clinical breast cancer: relationship to endocrine sensitivity. Endocrine-Related Cancer 4(3), pp. 297-305. (10.1677/erc.0.0040297)
1996
- Sharma, A. K. et al. 1996. Analysis of the genes for oestrogen and epidermal growth factor receptors in human breast cancer. The Breast 5(5), pp. 344-350. (10.1016/S0960-9776(96)90002-8)
- Sharma, A. K., Grimshaw, D., Horgan, K., Mansel, R. E., Gee, J. M. W. and Nicholson, R. I. 1996. Mechanisms responsible for oestrogen receptor expression in primary human breast cancer. The Breast 5(4), pp. 237-243. (10.1016/S0960-9776(96)90017-X)
- Nicholson, R. I., Francis, A. B., Kyme, S. R. and Gee, J. M. W. 1996. Properties and mode of action of pure antioestrogens in breast cancer in vitro. The Breast 5(3), pp. 175-180. (10.1016/S0960-9776(96)90089-2)
- McClelland, R. A., Gee, J. M. W., Francis, A. B., Robertson, J. F. R., Blamey, R. W., Wakeling, A. E. and Nicholson, R. I. 1996. Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer. European Journal of Cancer 32(3), pp. 413-416. (10.1016/0959-8049(95)00517-X)
- Nicholson, R. I. et al. 1996. Pure antiestrogens - The most important advance in the endocrine therapy of breast cancer since 1896?. In: Castagnetta, L., Nenci, I. and Bradlow, H. L. eds. Basis for Cancer Management. Annals of the New York Academy of Sciences Vol. 784. New York: New York Academy of Sciences, pp. 325-335., (10.1111/j.1749-6632.1996.tb16247.x)
- McClelland, R. A. et al. 1996. Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes. Breast Cancer Research and Treatment 41(1), pp. 31-41. (10.1007/BF01807034)
- Gupta, S. K., Pace, D., Gee, J. M. W., Douglas-Jones, A. G., Morgan, J. M. and Mansel, R. E. 1996. Epithelial markers in lobular carcinoma [Abstract]. Journal of Pathology 179(S1), pp. 16A. (10.1002/path.1996.1711790502)
1995
- Gee, J. M. W., Douglas-Jones, A. G., Hepburn, P., Sharma, A. K., McClelland, R. A., Ellis, I. O. and Nicholson, R. I. 1995. A cautionary note regarding the application of Ki-67 antibodies to paraffin-embedded breast cancers. Journal of Pathology 177(3), pp. 285-293. (10.1002/path.1711770311)
- Nicholson, R. I., McClelland, R. A. and Gee, J. M. W. 1995. Steroid hormone receptors and their clinical significance in cancer. Journal of Clinical Pathology 48(10), pp. 890-895. (10.1136/jcp.48.10.890)
- Gee, J. M. W. et al. 1995. Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. International Journal of Cancer 64(4), pp. 269-273. (10.1002/ijc.2910640410)
- Robertson, J. F. R., Gee, J. M. W., McClelland, R. A., Ellis, I. O., Willsher, P., Blamey, R. W. and Nicholson, R. I. 1995. BCL2 Expression In Breast-Cancer - Identification Of Patients Who Should Not Receive Endocrine Therapy [Abstract]. British Journal of Surgery 82(5), pp. 698. (10.1002/bjs.1800820540)
- Hepburn, P. J., Glynne-Jones, E., Goddard, L., Gee, J. M. W. and Harper, M. E. 1995. Cell proliferation in prostatic carcinoma: comparative analysis of Ki-67, MIB-1 and PCNA. Histochemical Journal 27(3), pp. 196-203. (10.1007/BF00177586)
- Manning, D. L. et al. 1995. Differential expression of estrogen-regulated genes in breast-cancer. Acta Oncologica 34(5), pp. 641-646.
- Nicholson, R. I., Gee, J. M. W., Francis, A. B., Manning, D. L., Wakeling, A. E. and Katzenellenbogen, B. S. 1995. Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growth-independent (K3) human breast cancer cells. Endocrine-Related Cancer 2(1), pp. 115-121. (10.1677/erc.0.0020115)
- Nicholson, R. I., Gee, J. M. W., Manning, D. L., Wakeling, A. E., Montano, M. M. and Katzenellenbogen, B. S. 1995. Responses to Pure Antiestrogens (ICI 164384, ICI182780) in Estrogen-Sensitive and-Resistant Experimental and Clinical Breast Cancer. In: Philibert, D. et al. eds. Steroid Receptors and Antihormones. Annals of the New York Academy of Sciences Vol. 761. New York: New York Academy of Sciences, pp. 148-163., (10.1111/j.1749-6632.1995.tb31376.x)
1994
- Gee, J. M. W. et al. 1994. Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. International Journal of Cancer 59(5), pp. 619-628. (10.1002/ijc.2910590508)
- Nicholson, R. I. et al. 1994. Transforming growth factor-α and endocrine sensitivity in breast cancer. Cancer Research 54(7), pp. 1684-1689.
- Nicholson, R. I. et al. 1994. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy. Breast Cancer Research and Treatment 29(1), pp. 117-125. (10.1007/BF00666187)
- Manning, D. L. et al. 1994. Oestrogen-regulated genes in breast cancer: Association of pLIV1 with lymph node involvement. European Journal of Cancer 30(5), pp. 675-678. (10.1016/0959-8049(94)90543-6)
- Nicholson, R. I., Francis, A. B., McClelland, R. A., Manning, D. L. and Gee, J. M. W. 1994. Pure anti-oestrogens (ICI 164384 and ICI 182780) and breast cancer: is the attainment of complete oestrogen withdrawal worthwhile?. Endocrine-Related Cancer 1(4), pp. 5-17. (10.1677/erc.0.0010005)
- Ghandour, F. A., Attanoos, R. L., Nahar, K., Gee, J. M. W., Bigrigg, A. and Ismail, S. M. 1994. Immunocytochemical localization of oestrogen and progesterone receptors in primary adenocarcinoma of the cervix. Histopathology 24(1), pp. 49-55. (10.1111/j.1365-2559.1994.tb01270.x)
- Nicholson, R. I. et al. 1994. Pure antioestrogens in breast cancer - experimental and clinical observations. Presented at: Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects: International Symposium, Milano, Italy, 10-14 April 1994 Presented at Motta, M. and Serio, M. eds.Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects: Proceedings of an International Symposium, Milano, Italy, 10-14 April 1994. International Congress Series Vol. 1064. Amsterdam: Elsevier Science pp. 347-360.
1993
- Schmid, K. W. et al. 1993. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchovs Archiv 422(2), pp. 153-159. (10.1007/BF01607167)
- Manning, D. L., McClelland, R. A., Gee, J. M. W., Chan, C. M. W., Green, C. D., Blamey, R. M. and Nicholson, R. I. 1993. The role of four oestrogen-responsive genes, pLIV1, pS2, pSYD3 and pSYD8, in predicting responsiveness to endocrine therapy in primary breast cancer. European Journal of Cancer 29(10), pp. 1462-1468. (10.1016/0959-8049(93)90021-7)
1992
- Jasani, B., Thomas, N. D., Navabi, H., Millar, D. M., Newman, G. R., Gee, J. M. W. and Williams, E. D. 1992. Dinitrophenyl (DNP) hapten sandwich staining (DHSS) procedure: A 10 year review of its principle reagents and applications. Journal of Immunological Methods 150(1-2), pp. 193-198. (10.1016/0022-1759(92)90078-8)
1991
- Gee, J. M. W., Amselgruber, W. M., Jasani, B. and Nicholson, R. I. 1991. Use of the dinitrophenyl hapten sandwich staining procedure (DHSS) to localize estrogen receptors in paraffin-embedded tissues. Journal of Histochemistry & Cytochemistry 39(12), pp. 1659-1670. (10.1177/39.12.1719072)
1990
- Nicholson, R. I., Walker, K. J., Bouzubar, N., Wills, R. J., Gee, J. M. W., Rushmere, N. K. and Davies, P. 1990. Estrogen Deprivation in Breast Cancer: Clinical, Experimental, and Biological Aspects. In: Castagnetta, L. et al. eds. Steroid Formation, Degradation, and Action in Peripheral Tissues. Annals of the New York Academy of Sciences Vol. 595. New York: New York Academy of Sciences, pp. 316-327., (10.1111/j.1749-6632.1990.tb34305.x)
- Gee, J. M. W., Nicholson, R. I., Jasani, B., Newman, G. R. and Amselgruber, W. M. 1990. An immunocytochemical method for localization of estrogen receptors in rat tissues using a dinitrophenyl (DNP)-labeled rat monoclonal primary antibody. Journal of Histochemistry & Cytochemistry 38(1), pp. 69-78. (10.1177/38.1.1688451)
1988
- Nicholson, R. I., Gotting, K. E., Gee, J. M. W. and Walker, K. J. 1988. Actions of oestrogens and antioestrogens on rat mammary gland development: Relevance to breast cancer prevention. Journal of Steroid Biochemistry 30(1-6), pp. 95-103. (10.1016/0022-4731(88)90081-7)
Addysgu
- PH3101 Optimisation of drug design
- PH3114 Design, formulation and quality assurance of medicinal products
- PH3202 Research methodology
Research interests
- Anti‑hormone-induced signalling in ER + breast cancer.
- Mechanisms of anti‑hormone and anti-growth factor resistant breast cancer growth and progression.
- Novel target discovery and evaluation of new therapies using breast cancer cells in vitro.
- (Signal transduction and biomarker studies in clinical cancer.
My research interests have principally been directed towards gaining a fuller appreciation of breast cancer biology, mechanisms of failure of anti‑hormonal agents and the associated gain of poorer prognosis. In my PhD, I used electron microscopy and immunocytochemistry to examine the impact of anti‑oestrogens on the normal breast. The studentship included optimising novel immunocytochemical procedures to monitor oestrogen receptor in breast cancer, a protein now routinely measured in the clinic. My subsequent postdoctoral positions focussed around monitoring signal transduction deregulation in clinical DCIS, and then in my position as Senior Research Associate for the Tenovus Centre for Cancer Research within invasive breast cancer, determining growth factor signal transduction underlying resistance to anti‑hormones and anti-growth factors in experimental models and clinical disease. The aim of these latter studies was not only to reveal novel drug failure biomarkers, but also new therapeutic targets including providing landmark data demonstrating the success of anti-EGFR therapy alongside anti‑hormones in ER+ breast cancer in vitro.
More recently, I have been interested in deciphering and evaluating targeting of oncogenic signalling induced by anti-hormones during the drug responsive phase of ER+ breast cancer that may limit maximal initial growth-inhibitory response. This novel research area, pioneered by our group, stemmed from our studies demonstrating compensatory induction of erbB signalling by antihormones and landmark data demonstrating the value of co-targeting induced EGFR alongside such agents in ER+ breast cancer. Our in vitro findings using multiple breast cancer models indicate the immense potential for targeting of compensatory signalling such as EGFR, HER2 and Src irrespective of genetic background, potentially further influenced by paracrine environment. Through such studies the aim is to reveal new signalling targets for pharmacological inhibitors that can be used in "intelligent" treatment combination strategies with anti-hormones to improve initial response and delay/prevent resistance. My Fellowship will now consider the ability of extended antihormonal exposure to radically re-programme ER+ breast cancer and will encompass in vitro and clinical breast cancer studies. As part of the Fellowship, I will also undertake training with Dr. Graham Ball, Reader in Bioinformatics at Nottingham Trent University. The Fellowship will deepen my resistance knowledge, enhance my bioinformatics skills, allow me to further flourish as an independent researcher in breast cancer and consolidate my team's reputation at the forefront of translational research in breast cancer.
Current research interests
Resistance mechanisms during prolonged anti-hormones
Breast Cancer Campaign funded Scientific Fellowship. Studies of acquired anti-hormone resistance in breast cancer commonly use relatively short-term (~12month) antihormone-treated in vitro models, implicating erbB receptors, downstream kinases and ER crosstalk. However, targeting such candidate signalling has generally proved disappointing clinically and 2nd-line endocrine agents also have limited benefit. Our group's recent studies indicate long-term (~3year) acquired antioestrogen-resistant breast cancer cells can recruit novel alternative growth/invasion pathways, gain signalling that decreases/silences ER, and are highly-aggressive, with diminished 2nd-line agent efficacy. The hypothesis for my Fellowship, to be explored using in vitro models and clinical samples, is that the prolonged adjuvant anti-hormone exposure prior to clinical relapse is critical in promoting the resistance mechanism and phenotype. In deciphering mechanism, the aim is to discover new therapeutic targets which could ultimately prove superior to treat clinical breast cancer relapse.
AstraZeneca-funded projects
- Exploration of new targeted therapeutic agents in breast cancer models (e.g. Zactima; pan-erbB inhibitor; mTOR inhibitor
- novel gene discovery during response and in resistance to the breast cancer drug Faslodex using microarrays and bioinformatics.
Study of anti‑hormone impact on tumour suppressors in breast cancer (epigenetics)
Study of GFR-alpha co-receptor family members in breast cancer
Breast Cancer Campaign and ECMC funded studies.
Investigation and exploitation of new biomarkers in clinical breast cancer
This currently includes participation in Cardiff ECMC-funded cancer initiatives and TRICC-funded ABC trial Tamoxifen Late Relapse Study in Breast Cancer. Further biomarker studies are supported locally by a WORD Translational Health Research Platform Award (e.g. bag-1) and by the "In the Pink" Charity (e.g. CD44 and its variants).
Gene expression profiling in novel "triple negative" breast cancer model
Pilot study funded by CR-UK Cardiff Centre Development Fund.
Collaborators
Current collaborations within the School of Pharmacy and Pharmaceutical Sciences:
- Dr Stephen Hiscox
- Dr Kathryn Taylor
- Professor RI Nicholson.
Current national / international collaborators
- Prof. J. Robertson, Dr. I Ellis & Dr A. Green (Professorial Unit of Surgery & Dept. Immunopathology, Nottingham City Hospital).
- Dr. P. Barrett-Lee (Velindre Hospital) and Dr. B. Jasani (School of Medicine, Cardiff University).
- Dr. G. Ball (Dept. Bioinformatics, School of Biomedical and Natural Sciences The Nottingham Trent University).
- Dr. I. Hutcheson (Dept Pharmacology, School of Medicine, Cardiff University)
- Dr. R. Clarkson (Dept. Biosciences, Cardiff University)
- Drs. R. Clarke & S. Howell (Breast Biology Group, University of Manchester. Division of Cancer Studies, Paterson Institute for Cancer Research).
- Dr E. Musgrove, Dr. A. Butt (Apoptosis Research Group), Dr. A. Stone and Prof R. Sutherland (Garvan Institute of Medical Research, Darlinghurst, Australia)
- Dr. S Dunn (B.C. Research Institute for Children's and Women's Health, Vancouver, Canada).
- C. Huang (Baylor College, Houston, USA).
- Prof. Xiaojiang Cui (John Wayne Cancer Institute, USA)
- Dr. H. Feigl (University of Innsbruck)
- Dr. M. Moe (Medicine, University of Swansea).
- Dr. P. Darbre (School of Biological Sciences, Reading University)
- Prof. A. Thompson (Dept. Surgery, Dundee University);
Key expertise
- Breast cancer & clinical and experimental endocrine resistance biology
- Steroid receptor & growth factor receptor signal transduction;
- Novel biomarker & target discovery
- Clinical and experimental immunocytochemistry.
- Gene Microarrays & associated bioinformatics.
Current research funding
- Breast Cancer Campaign 5 year Scientific Fellowship award (from Oct. 2010): "Resistance mechanisms during prolonged anti-hormones", £519,657. This is further supported by a School award of a full-time research technician.
Current Student
Ertefai, Benyamin