Ewch i’r prif gynnwys
Dr Sion Coulman

Dr Sion Coulman

Senior Lecturer

Ysgol Fferylliaeth a Gwyddorau Fferyllol

Qualifications

  • Registered pharmacist 2002-present
  • PhD in drug delivery, Cardiff University, 2007
  • MPharm, University of Wales, Cardiff, 2001

Career profile

I graduated from the University of Wales, Cardiff in 2001 with an MPharm degree and subsequently moved into my pre-registration year in community pharmacy. In the summer of 2002 I became a member of the Royal Pharmaceutical Society Great Britain and began professional practice as a locum pharmacist, working part-time in the community sector. This coincided with the beginning of my PhD studies at Cardiff University where I spent three years investigating novel transdermal delivery systems for the delivery and expression of exogenous plasmid DNA in human skin. In 2005, whilst completing my PhD studies, I began a short contract at Cardiff University as a Teaching Fellow. In the summer of 2006 I took up a Lectureship at the School of Pharmacy and Pharmaceutical Sciences and I am now a Senior Lecturer.

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2006

2005

  • PH1122  The role of the pharmacist in professional practice
  • PH1124  Human body systems
  • PH2107  Formulation science
  • PH3110  Optimisation of pharmaceutical care
  • PH3114  Design, formulation and quality assurance of medicinal products
  • PH3202  Research methodology
  • PH4116  Pharmacy research or scholarship project
  • PH4117  Pharmaceutical sciences, pharmacy practice and the population
  • PH4118  Pharmaceutical sciences, pharmacy practice and the patient

Research interests

My principal research interest is the development of the microneedle device as a non-invasive method for trans/intra-dermal delivery of novel and existing medicines, and the translation of microneedle technology from a laboratory prototype to a clinically useful device. The microneedle device bridges engineering, pharmaceutics and healthcare disciplines and therefore I am part of multi-disciplinary teams that include academic and non-academic colleagues from the UK, Europe and the USA. The technology is now approaching clinical usefulness and over the forthcoming years will hopefully facilitate non-invasive delivery of a number of therapeutics and hence offer a range of new therapeutic opportunities.

I also have an active research interest in the performance and use of capsule-based dry powder inhalers (DPIs), stimulated by a growing interest in the potential of DPIs as a means to deliver labile macromolecular drugs to the lung. Our research evaluates the performance of these devices, both in the laboratory and in the hands of the user.

I also have a pedagogic interest in numeracy and medicines-based calculations, with a particular focus on the education of pharmacy students and pharmacists in this area. In collaboration with colleagues from Mathematics at Cardiff and Pharmacy in Brighton I have developed a contextualized diagnostic numeracy test that is currently being used at UK Schools of Pharmacy and Medicine.

Scientific research

  • The skin as a target and gateway for drug delivery
  • Microneedle devices
  • Capsule based dry powder inhalers
  • The patient-device interface

Pedagogic research

  • Pharmaceutical education and training particularly in medicines-based calculations

Novel drug delivery devices to enhance the delivery of therapeutics through the skin barrier

The passage of therapeutic molecules into or across the skin is significantly impeded by the inherent barrier properties of the outermost layer of skin, the stratum corneum. However sophisticated engineering techniques have resulted in the emergence of a number of novel transdermal drug delivery devices such as the microneedle array. These minimally invasive devices can create microchannels in the skin to facilitate localised delivery of drug molecules. Current investigations in our laboratory are developing and examining the performance of microneedle devices for the delivery of of macromolecular therapeutics including peptides, proteins and nucleic acids. Our research uses excised human skin that is maintained in organ culture and also human volunteers to provide results that are predictive of the clinical setting.

Pharmacy education

I have a pedagogic interest in numeracy and medicines-based calculations, with a particular focus on the education of pharmacy students and pharmacists in this area. In collaboration with colleagues from Mathematics at Cardiff and Pharmacy in Brighton I have developed a contextualized diagnostic numeracy test that is currently being used at UK Schools of Pharmacy and Medicine.

Key expertise

  • Physicochemical characterisation of nanoparticle drug delivery systems
  • In vitro transdermal delivery studies
  • Ex vivo human skin studies
  • Compressive tests for needle penetration (microneedle and DPI)
  • Optical Coherence Tomography (microneedle and DPI)
  • Non-invasive human volunteer studies (microneedle and DPI)
  • Patient and public engagement with drug delivery devices (microneedle and DPI)

Post-doctoral researchers

  • Lleceu Davies
  • Maria Dul
  • Xin Zhao
  • Current PhD students
  • Farah Arikat
  • Bethan Copp
  • Matthew Ivory

Research funding 

An applicant in projects that total more than £6million and are supported by research councils, charitable bodies, government organizations and the Pharmaceutical Industry

Goruchwyliaeth gyfredol

siamacparker

Siamac Parker

Research student