Dr Edward Sayers
Postdoctoral Research Associate
Ysgol Fferylliaeth a Gwyddorau Fferyllol
- sayersej@cardiff.ac.uk
- +44 (0)29 2251 0139
- Adeilad Redwood , Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Trosolwg
2015 Biology Rocks
Biology rocked at National Museum Cardiff on Saturday 11th October, when over 3000 visitors joined scientists from Amgueddfa Cymru, Cardiff University and the Society of Biology to celebrate National Biology Week and Earth Science Week. Dr Jen Wymant and Dr Edd Sayers engaged showing how to "hit" cancer cells with a targeted therapy game where there's an outline of a patient in cups and the visitors try and throw balls into the coloured cups which denote "cancer" and try to avoid the clear cups which are the normal/healthy parts of the body. The visitors are then given tongs to put the balls in which is much easier and demonstrates how research aims to develop tools to help medicines specifically target cancer cells.
Cyhoeddiadau
2022
- Aikman, B. et al. 2022. Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies. Dalton Transactions 51(19), pp. 7476-7490. (10.1039/D2DT00337F)
- Sayers, E. J., Palmer, I., Hope, L., Hope, P., Watson, P. and Jones, A. T. 2022. Fluid-phase endocytosis and lysosomal degradation of bovine lactoferrin in lung cells. Pharmaceutics 14(4), article number: 855. (10.3390/pharmaceutics14040855)
- Sayers, E. J., Barlow, V. L., Tsai, Y. and Jones, A. T. 2022. Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in nonadherent cells. In: Cell Penetrating Peptides., Vol. 2383. Methods in Molecular Biology book series Springer, pp. 211-228., (10.1007/978-1-0716-1752-6_14)
2021
- Padalino, G. et al. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226, article number: 113823. (10.1016/j.ejmech.2021.113823)
2020
- Nödling, A. et al. 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56(34), pp. 4672-4675. (10.1039/C9CC07931A)
- Wymant, J. M., Sayers, E. J., Muir, D. and Jones, A. T. 2020. Strategic trastuzumab mediated crosslinking driving concomitant HER2 and HER3 endocytosis and degradation in breast cancer. Journal of Cancer 11(11), pp. 3288-3302. (10.7150/jca.32470)
- Giannakopoulou, N. et al. 2020. Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells. Nanoscale 12(7), pp. 4622-4635. (10.1039/C9NR08512B)
- Eissa, N., Sayers, E., Birch, D., Patel, S., Tsai, Y., Nielsen, H. M. and Jones, A. 2020. EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide. Biochemical Journal 477(1), pp. 45-60. (10.1042/BCJ20190452)
2019
- Sayers, E. J. et al. 2019. Endocytic profiling of cancer cell models reveals critical factors influencing lipid nanoparticle mediated mRNA delivery and protein expression. Molecular Therapy 27(11), pp. 1950-1962. (10.1016/j.ymthe.2019.07.018)
- Woods, B. et al. 2019. Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. Journal of Inorganic Biochemistry 199, article number: 110781. (10.1016/j.jinorgbio.2019.110781)
- Lorenzer, C. et al. 2019. Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics 141, pp. 37-50. (10.1016/j.ejpb.2019.05.015)
- Patel, S. G. et al. 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9(1), pp. -., article number: 6298. (10.1038/s41598-019-42456-8)
2018
- He, L., Sayers, E. J., Watson, P. and Jones, A. T. 2018. Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates. Scientific Reports 8(1), article number: 7318. (10.1038/s41598-018-25600-8)
- Sayers, E. J. et al. 2018. Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles. Bioconjugate Chemistry 29(4), pp. 1030-1046. (10.1021/acs.bioconjchem.7b00704)
2017
- Roberts-Dalton, H. D. et al. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9(36), pp. 13693-13706. (10.1039/C7NR04128D)
- Wymant, J., Moody, P., Sayers, E. and Jones, A. T. 2017. Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer. Presented at: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimising Immuno and Targeted Therapies From Cancer Biology to the Clinic, Florence, Italy, 24-27 June 2017.
2015
- Moody, P. R., Sayers, E. J., Magnusson, J. P., Alexander, C., Borri, P., Watson, P. and Jones, A. T. 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23(12), pp. 1888-1898. (10.1038/mt.2015.178)
- Bahnsen, J. S., Franzyk, H., Sayers, E. J. and Jones, A. T. 2015. Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharmaceutical Research 32(5), pp. 1546-1556. (10.1007/s11095-014-1550-9)
2014
- Sayers, E. J., Cleal, K., Eissa, N. G., Watson, P. D. and Jones, A. T. 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195, pp. 55-62. (10.1016/j.jconrel.2014.07.055)
2012
- Jones, A. T. and Sayers, E. J. 2012. Cell entry of cell penetrating peptides and tales of tails wagging dogs. Journal of Controlled Release 161(2), pp. 582-591. (10.1016/j.jconrel.2012.04.003)
- Sayers, E. J. 2012. An encoded microwell array for multi-image analysis of cells. PhD Thesis, Cardiff University.
2011
- Watkins, C. L., Sayers, E. J., Allender, C. J., Barrow, D. A., Fegan, C. D., Brennan, P. and Jones, A. T. 2011. Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy 19(12), pp. 2124-2132. (10.1038/mt.2011.175)
