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Dr Marsh Durban is investigating the process of metastasis in melanoma skin cancers. In particular, she is interested in determining whether cancer stem cell characteristics are required for the successful metastatic dissemination of melanoma cells, and for their subsequent growth at secondary sites. Research overview
Research division
Cyhoeddiadau
2016
- Deevi, R. K. et al. 2016. Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype. Oncotarget 7, pp. 49042-49064. (10.18632/oncotarget.8863)
2015
- Deuker, M. M., Marsh Durban, V., Phillips, W. A. and McMahon, M. 2015. PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma. Cancer Discovery 5(2), pp. 143. (10.1158/2159-8290.CD-14-0856)
2014
- Davies, E. J., Marsh Durban, V., Meniel, V., Williams, G. T. and Clarke, A. R. 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233(1), pp. 27-38. (10.1002/path.4312)
- Marsh Durban, V., Jansen, M., Davies, E. J., Morsink, F. H., Offerhaus, G. J. A. and Clarke, A. R. 2014. Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. American Journal of Pathology 184(1), pp. 86-91. (10.1016/j.ajpath.2013.10.003)
2013
- Marsh Durban, V., Deuker, M. M., Bosenberg, M. W., Phillips, W. and McMahon, M. 2013. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. The Journal of Clinical Investigation 123(12), pp. 5104-5118. (10.1172/JCI69619)
- Trejo, C. L., Green, S., Marsh Durban, V., Collisson, E. A., Iezza, G., Phillips, W. A. and McMahon, M. 2013. Mutationally activated PIK3CAH1047R cooperates with BRAFV600E to promote lung cancer progression. Cancer Research 73(21), pp. 6448-6461. (10.1158/0008-5472.CAN-13-0681)
- Marsh Durban, V., Davies, E. J., Williams, G. T. and Clarke, A. R. 2013. PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. The Journal of Pathology 230(2), pp. 165-173. (10.1002/path.4189)
2011
- Davies, E. J., Marsh Durban, V. and Clarke, A. R. 2011. Origin and maintenance of the intestinal cancer stem cell. Molecular Carcinogenesis 50(4), pp. 254-263. (10.1002/mc.20631)
2010
- Ashton, G. H. et al. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19(2), pp. 259-269. (10.1016/j.devcel.2010.07.015)
2008
- Marsh Durban, V., Winton, D. J., Williams, G. T., Dubois, N., Trumpp, A., Sansom, O. J. and Clarke, A. R. 2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40(12), pp. 1436-1444. (10.1038/ng.256)
- Reed, K. R., Meniel, V., Marsh Durban, V., Cole, A., Sansom, O. J. and Clarke, A. R. 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8, article number: 162. (10.1186/1471-2407-8-162)
- Marsh, V. 2008. Analysing the role of Pten in the murine small intestine. PhD Thesis, Cardiff University.
2007
- Marsh Durban, V. and Clarke, A. R. 2007. Intestinal homeostasis and neoplasia studied using conditional transgenesis. Expert Review of Anticancer Therapy 7(4), pp. 519-531. (10.1586/14737140.7.4.519)
2006
- Sansom, O. J. et al. 2006. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences 103(38), pp. 14122-14127. (10.1073/pnas.0604130103)